Skip to main content

Diphenhydramine for Allergic Reactions User Reviews

Brand names: Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Diphen, Unisom SleepGels, Nytol, Sominex, Benadryl Children's Allergy, Dicopanol, Buckley's Bedtime, Diphenydramine Quick Melt, Unisom SleepMelts, Snooze Fast, Bydramine, Aler-Dryl, Diphenadryl, Valu-Dryl, Nytol Caplet, Compoz Nighttime Sleep Aid, Histaprin, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, ConRx Allergy, Hyrexin, Hydramine Cough Syrup, Diphenhist, Diphedryl, Diphen AF, Diphen Cough, DPH, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Aller-G-Time, Sleep Tab II, Nytol QuickCaps, Trux-adryl, Diphenyl, Altaryl, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Hydramine, Silphen Cough, Diphenylin, Hydramine Compound, Sleepinal, Help I Can't Sleep, Allermax Diphendryl Twilite Banaril Aler-Tab Siladryl Allergy Sleep-ettes D Diphenmax Ben-Tann Dytan Vanamine PD Pharbedryl Z-Sleep Simply Sleep Complete Allergy Relief Dytuss Dormin Miles Nervine Scot-Tussin Allergy Sleepwell 2-nite …show all brand names

Diphenhydramine has an average rating of 7.8 out of 10 from a total of 41 reviews for the treatment of Allergic Reactions. 66% of reviewers reported a positive experience, while 12% reported a negative experience.

Diphenhydramine rating summary

7.8/10 average rating

41 ratings from 48 user reviews.

Compare all 75 medications used in the treatment of Allergic Reactions.

10
49%
9
10%
8
7%
7
10%
6
10%
5
0%
4
2%
3
0%
2
0%
1
12%

Reviews for Diphenhydramine

  • Just...
  • Taken for less than 1 month
  • May 9, 2020

Benadryl (diphenhydramine) "This is an old thread but thought I would share. I was in the hospital in labor. I developed a reaction to the epidural that caused severe itchiness. They gave me something that didn't help and after several hours of itching, a nurse gave me iv benedryl. I immediately couldn't breathe and felt like someone kicked me in the chest. I was warm all over, nauseous and on the edge of passing out. An ekg also showed I had a heart arrhythmia from it. I've taken oral benadryl in the past with no problems. Now it's on my list of allergies and I tell every doc I see. Most terrifying experience."

1 / 10
Was this helpful?YesNo
32 Report
  • Amensus
  • Taken for 10 years or more
  • April 28, 2016

Benadryl (diphenhydramine) "I take one before bed which keeps me breathing easily during the night despite my allergies. It also helps me get to sleep and stay asleep. The active ingredient, dyphenhydramine HCL, you will find is the main ingredient in quite a few over the counter sleep medications so that should tell us something. And Benadryl or a generic drugstore brand are cheaper and just as effective. Have been taking this for over 20 years and have no side effects"

9 / 10
Was this helpful?YesNo
43 Report
  • Anonymous
  • August 10, 2021

Benadryl (diphenhydramine) "Took benadryl for eight months on advice of PCP and Pulmonary specialist. I quit taking it because I began having short term memory problems. Checked it out on internet and found it should not be given to senior citizens. A neurologist at University Of North Carolina Memory Disorders unit said it should probably not be given to anyone as there are safer alternatives. I had nervous breakdown and spent several days in a mental hospital. Had two MRIs of my brain. Second showed small area that was due to the Diaphenhydramine use. Alienated my family because of things I said . Without the Benadryl I wouldn't be the most heart-broken 74 yr. old lady around."

1 / 10
Was this helpful?YesNo
17 Report

Frequently asked questions

  • Anonymous
  • Taken for 10 years or more
  • May 5, 2015

Benadryl Allergy (diphenhydramine) "I have a severe dairy allergy and I have had it for all of my life. My doctor (who has been a doctor for more than 20 years) told me I had the worst case he has ever seen. If I touch it, I break out into hives, if I eat it or just put it in my mouth and then spit it back out, I go into anaphylactic shock. (where my lungs close up and I stop breathing) I always carry around the liquid Benadryl (because it works faster than the pills) in my purse. On many occasions, a double dose of it has saved my life and delayed the reaction from getting worse until I could get to the emergency room. Literally a life saver."

10 / 10
Was this helpful?YesNo
37 Report
  • use...
  • October 28, 2014

Benadryl (diphenhydramine) "I was given Benadryl at the hospital for an allergic reaction. It instantly shot my heart rate up to 217 bpm and instantly my mouth got dry I couldn't swallow my chest felt hot like an elephant was sitting on it and I got really cold. It put me into shock my body wouldn't stop shaking, I could breath. It was so scary I thought I was dead thanks to the doctors quick response he saved me but it almost killed me. "

8 / 10
Was this helpful?YesNo
37 Report

Are you taking this medicine?

  • Nic
  • Taken for less than 1 month
  • October 19, 2020

Benadryl (diphenhydramine) "Received Benadryl via IV in prep for a biologic infusion. My throat starting swelling and my blood pressure skyrocketed. An immunologist tested me, and I showed strongly allergic to Benadryl, so it can happen."

1 / 10
Was this helpful?YesNo
17 Report
  • Anonymous
  • October 23, 2010

Benadryl (diphenhydramine) "I like this medicine, but unfortunately developed an allergy to it, yes contrary to ANYONE'S belief I AM allergic to Benadryl. My legs started to get really, really hot and felt like I just had to stretch them and run them under freezing cold water, then I woke up with hives all over."

6 / 10
Was this helpful?YesNo
42 Report

More FAQ

  • Son...
  • Taken for less than 1 month
  • October 15, 2016

Benadryl (diphenhydramine) "My adult size teenage son was given Benadryl IV, 50mg, *along with Compazine IV as a "headache cocktail" in an emergency room in September of 2016. While there is no way to know for certain if Compazine or Benadryl caused the severe reaction he experienced, he has tolerated oral Benadryl just fine in the past. However, it seems important to share our experience based on the severity of his reaction that day and that multiple reports of similar exist. I do not recommend the "headache cocktail" of Benadryl and Compazine together and hope the number of similar reports are looked into."

6 / 10
Was this helpful?YesNo
27 Report
  • Rosie...
  • Taken for 2 to 5 years
  • November 24, 2021

Benadryl (diphenhydramine) "So I've been taking this going on 2 years now, and I regret taking it so long, I even ended up in the ER because my heart wouldn't stop racing it was over 170. I believe it was due to the Benadryl, I ignored the side effect before I noticed sometimes when I took it my heart would beat funny and it would be hard to catch my breathe but I kept taking it as it stopped my itchy throat, eyes, and mouth. Doctors at the ER found arrhythmia but said everything else looked fine. I stopped taking it, haven't take it in a week and I'm still having racing heart and palpations. Don't take this stuff long term. I'm in my early 20s and healthy if any one reading this was curious."

6 / 10
Was this helpful?YesNo
11 Report
  • squir...
  • July 18, 2009

Benadryl Allergy (diphenhydramine) "I have severe allergies and life has been miserable. I couldn't afford the time or money anymore for allergy shots. Claritan stopped working. So did a bunch of over the counter allergy medications. I took so many cough and zinc lozenges my tongue became sore. I coughed all the time, to the point of stomach pain and incontinence. My coworker just gave me a Benadryl. I was on the verge of going home sick, but now I'm 100% better. A stress rash that was erupting on the back of my neck just now went away. This is a marvelous product, and I didn't know it had so many uses."

10 / 10
Was this helpful?YesNo
42 Report
  • Anonymous
  • October 20, 2009

Benadryl (diphenhydramine) "A little known and rare side effect of this drug is a condition that would probably be called idiopathic thrombocytopenic purpura (ITP). This describes a serious depletion of platelets in the blood. The blood will not clot properly and an injury can be life threatening due to uncontrolled bleeding. It's rare but if it happens and the cause is not figured out by your physician(s) this is a big problem."

1 / 10
Was this helpful?YesNo
40 Report
  • Anonymous
  • June 4, 2010

Benadryl Allergy (diphenhydramine) "I have taken Benadryl or its generic equivalent for many years. It is very good for itchy throats and ears and all kinds of symptoms, and particularly good for sneezing. If the Benadryl doesn't work, then I know I'm coming down with something more than just seasonal allergies. I try to keep Benadryl with me all the time. There are so many food products that I am supposed to be allergic to that sometimes I take a Benadryl before I eat, especially peanut butter and bananas, two of my favorite foods."

7 / 10
Was this helpful?YesNo
38 Report
  • Anonymous
  • Taken for less than 1 month
  • April 11, 2015

Benadryl Allergy (diphenhydramine) "Experienced an allergic reaction during dinner at a new restaurant. Throat started itching terribly so we left and drove to the nearest pharmacy. Used Benadryl syrup because I thought it would work faster. Fixed my allergic reaction in a minute."

10 / 10
Was this helpful?YesNo
27 Report
  • Connert
  • April 26, 2017

Benadryl (diphenhydramine) "I have no rest every time I take benadryl. I feel I have a really bad reaction as I feel restless, my body feels like itchy, nauseous and it makes me feel angry feeling restless it really hurts my stomach am I allergic to it? or it a bad reaction"

Was this helpful?YesNo
21 Report
  • Anonymous
  • October 7, 2008

Benadryl Allergy (diphenhydramine) "I am severely allergic to all nuts and I always keep a few pills with me. If I eat something that has been in contact with nuts I take two pills or a gulp of the syrup and my itchy mouth and throat, swollen lips are instantly soothed. The syrup does work faster than the pills but pills are lighter to carry around. I once ate a huge piece of hazelnut chocolate and having benadryl on me really saved me. It won't work on severe reaction i.e. eating peanut butter but it is definitely a life saver for all other allergic reactions. I am never without benadryl and my epipen. Only thing to look out for is intense drowsiness, so make sure to be at home to take a long nap when it takes effect."

10 / 10
Was this helpful?YesNo
36 Report
  • Power...
  • February 15, 2016

Benadryl Allergy (diphenhydramine) "I couldn't stop coughing for one week, I lost my voice and severe lung pain due to the coughing. Went to see a pulmonologyst and did xrays, the results, negative. My lungs were clear and no infection whatsoever . He recommended me to go to Walmart and buy claritin pills, but I was desperate last night to have a good sleep without coughing all night, I haven't been able to sleep with this horrible killing coughing , not mentioning dry nose, itchy ears, and itchy throat. Last night I took two regular benadryl pills and slept like a babe for 10 hrs straight, the only problem is that I make my living driving and can't take the pills during the day. Probably I will take clartin during the day, but I honestly prefer benadryl, way more effective"

Was this helpful?YesNo
22 Report
  • marlene
  • Taken for 10 years or more
  • June 14, 2018

Benadryl (diphenhydramine) "I've used this and given it to my children for over 20 years. My teenage son would take 1 before going to bed so he could sleep without allergic reactions. I've used it for unknown allergies like bee stings and sunless tanner. Works great and so does the topical cream. No adverse affects with us."

10 / 10
Was this helpful?YesNo
13 Report
  • Robert
  • February 1, 2024

Benadryl (diphenhydramine) "I had a headache attack in June of 2023 and a seizure and had to be put in the hospital. They gave me Ativan, Benadryl, and IV Tylenol as a headache cocktail and it worked like a dream! After 5 days in the hospital, I was all better after that nasty headache."

9 / 10
Was this helpful?YesNo
1 Report
  • Agnos...
  • February 20, 2009

Benadryl Allergy (diphenhydramine) "I have been using Benadryl for the past 4 years and I never leave home without it. I have sneezing fits both indoors and outdoors and Benardryl is the only allergy pill that works for me. It works fast and stops my runny nose immediately. Although I do feel sleepy (most of the time), I can't be without it. "

10 / 10
Was this helpful?YesNo
24 Report
  • Jen
  • Taken for 6 months to 1 year
  • May 12, 2012

Benadryl (diphenhydramine) "I use this medicine for weather allergies and allergies to medications when I need it. It does help greatly but does not last long and my burning sensation comes back into my body and the hives start to show. However a lot of people say that this medicine makes them feel sedated. I have the complete opposite I take 1 before bed and I will not sleep."

8 / 10
Was this helpful?YesNo
20 Report
  • EMME
  • Taken for less than 1 month
  • November 13, 2020

Benadryl Children's Allergy (diphenhydramine) "My dog was sprayed with something poisonous from a frog in the bushes and if I had not had this in the house my dog would have died. Her airway was closing up and wishing minutes she could breathe again."

10 / 10
Was this helpful?YesNo
6 Report
  • Talv
  • July 3, 2021

Benadryl (diphenhydramine) "I took over the counter Benadryl for some minor reason and hours later I started itching all over my body. The itch was deeply intense from my scalp to my feet - a full body reaction. I started getting visible large hives and my throat and face was swelling. I went to the ER and they said it was impossible that I was allergic to Benadryl. The ER doctor was certain I was having a reaction to the pink dye in the pill. He injected me with clear liquid Benadryl to prove this to me. I immediately had a second reaction. They had to treat me with alternative medications; an injection in my bottom, prednisone to help with breathing and another green pill of some sort to take home with me. I am allergic to Benadryl."

Was this helpful?YesNo
5 Report
  • Aller...
  • March 14, 2012

Benadryl (diphenhydramine) "Works well and is one of my to go-to antihistamines. However it is very sedating and is also not long-lasting. It would work great for someone with insomnia as a milder sleep-aid, but for my use I would say that it works, but makes you sedated."

7 / 10
Was this helpful?YesNo
14 Report
  • Madam
  • January 25, 2016

Benadryl (diphenhydramine) "Allergy reaction to nuts. Started feeling swelling around mouth, throat.... very scary, feel like I am stopping to breath. This instant relieve. Give it 10-15 minutes till kicks in. WORKS WONDERS. BUT.... you might need a good snooze after a good dose..."

10 / 10
Was this helpful?YesNo
10 Report
  • Banop...
  • Taken for less than 1 month
  • November 22, 2023

Banophen (diphenhydramine) "Reduced my itching and after a while, it disappeared. The red on my body started disappearing too. Did cause me to sleep, but that is no problem as I'm in an assisted living facility. I do sleep a lot with it, but I figure my body needs to sleep anyhow. I'm happy with it so far. I take 1 25mg capsule every 6 hours. I am allergic to generic detergent that most facilities use to wash clothes, sheets, etc. I supply my own, but someone did not use it and used the generic stuff, and my body went into an itching fit from head to toe. The Banophen has really helped me."

10 / 10
Was this helpful?YesNo
1 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.