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Diphenhydramine for Allergic Reactions User Reviews (Page 2)

Brand names: Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Diphen, Benadryl Children's Allergy, Unisom SleepGels, Sleep Tablets, DPH, Diphenyl, Sominex, Calm-Aid, Nytol, Hyrexin, Valu-Dryl, Altaryl, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, ConRx Allergy, Dicopanol, Buckley's Bedtime, Hydramine Cough Syrup, Diphenhist, Bydramine, Diphedryl, Diphen AF, Diphen Cough, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Diphenadryl, Genahist, Aller-G-Time, Sleep Tab II, Nytol QuickCaps, Trux-adryl, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Hydramine, Silphen Cough, Diphenylin, Hydramine Compound, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy Sleep-ettes D Diphenydramine Quick Melt Diphenmax Ben-Tann Dytan Vanamine PD Pharbedryl Histaprin Z-Sleep Aurodryl Children's Allergy Unisom SleepMelts Simply Sleep Complete Allergy Relief Dytuss Dormin Miles Nervine Scot-Tussin Allergy Sleepwell 2-nite …show all brand names

Reviews for Diphenhydramine

Commonly mentioned side effects
  • Pk3...
  • Taken for 10 years or more
  • February 28, 2020

Diphenhydramine "I suffer from severe sinusitis, but I am a person who suffers from multiple other ailments. Especially, a really bad heart. (5 heart attacks and a mini-stroke) This is the only over-the-counter med that helps me without affecting my heart in any way. I find it safe and it has helped me when I had anaphylaxis along with prednisone."

10 / 10
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4 Report
  • The...
  • September 4, 2020

Diphenhydramine "Benadryl is the gold standard for allergies, anxiolysis, and sleep aid. It works like a charm! It is not particularly fast-acting, though. I usually take a half a tablet (12.5 mg) at a time, and it can take up to an hour to really kick in."

10 / 10
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4 Report
  • cup...
  • Taken for 6 months to 1 year
  • May 3, 2013

"My doctor gave me this in 2010 when I first began having seasonal allergies. I thought it was the best allergy medication out there, like top-notch stuff. Turns out it's just a basic type of medication. No superpowers involved, but it works great you would think there are superpowers in them!"

10 / 10
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6 Report

Frequently asked questions

  • Bri...
  • November 25, 2016

Diphenhydramine "I have had allergies all my life, pretty severe, and I live in allergy heaven in TX. I have tried everything, and for me, Benadryl is still the best. I work, and it does not affect me, I often take it several times a day."

10 / 10
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7 Report
  • Sch...
  • Taken for less than 1 month
  • January 7, 2017

Diphenhydramine "Takes 4 hours to work, and by then you need another dose. Since they took the other ingredient out, Benadryl and Wal-Dryl no longer work for me. Back to experimenting. No side effects, but not effective either."

1 / 10
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7 Report

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  • Rob...
  • February 1, 2024

Diphenhydramine "I had a headache attack in June of 2023 and a seizure and had to be put in the hospital. They gave me Ativan, Benadryl, and IV Tylenol as a headache cocktail and it worked like a dream! After 5 days in the hospital, I was all better after that nasty headache."

9 / 10
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1 Report
  • Kas...
  • Taken for 1 to 2 years
  • January 7, 2023

"I am extremely sensitive to histamine. As a result, I get extreme inflammation, acne sores, and muscle pain. I take a small dose of 12.5 mg of Benadryl twice a day (if needed), and it helps significantly. It especially helps when my face swells up, I notice an immediate change. I get it OTC and get the dye-free version (25 mg white pill) at Walgreens."

9 / 10
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More FAQ

  • Efn...
  • Taken for less than 1 month
  • November 28, 2017

Diphenhydramine "I’m a 24 healthy female athlete. I never get sick, however, I today have the flu. When I take this med, it helps the pain and aches, but my eye swells completely shut 30 mins after taking this every time - the left eye in particular, lower lid, and my eye waters and gets pus."

5 / 10
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1 Report
  • Ski...
  • Taken for less than 1 month
  • May 27, 2020

Diphenhydramine "Benadryl works great to help with the chronic itching this infestation has caused - I got bit by chigger bugs. Only side effect is sleepiness, so I spread the dosage of 2 out. It’s too bad the packaging is so difficult to open. My heart goes out to anyone with arthritis or trembling that would have to open this product."

8 / 10
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1 Report
  • Ray...
  • Taken for 2 to 5 years
  • March 14, 2025

"33 years old male living in central Texas. Diphenhydramine is my go-to allergy medicine, it is effective in eliminating hay fever and allergic symptoms, no noticeable side effects for me, didn't notice any drowsiness. The only complaint I have is I had to take it once every few hours, and I didn't want to depend on my life on a drug. It's not as powerful and long-lasting as fexofenadine or loratadine, but it works."

8 / 10
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  • Bit...
  • Taken for less than 1 month
  • June 24, 2021

Diphenhydramine "I had been to the doctor for hives from an insect bite, and they told me to use Benadryl cream and medicine, but it didn't help. I used calamine lotion and everything else I could think of, even Cortisone 10 extra strength, it didn't help. I went to the doctor for the 2nd time, and they told me to use the same thing, no help at all. I was itching so badly, the hives were spreading, even the itching and burning sensations to my arm, ankles, burning feeling in my fingers, and hives spreading to my chest. I couldn't help but scratch them sometimes, that probably caused them to spread, but I couldn't help it. I went to see another doctor for the 3rd time, and he prescribed Prednisone and Hydroxyzine, and this is my 2nd day taking them, and I see a great difference. My arms and everything are clearing up, and I finally could rest. I recommend Prednisone. I give it a 10."

10 / 10
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  • Swi...
  • July 1, 2021

Diphenhydramine "Cinnamon flavor alcohol base diphenhydramine is a med that truly helps with rapid onset allergic responses. It’s hard to obtain in the U.S. Regular children’s Benadryl doesn’t deliver the quick relief of symptoms. Can you make it more available? Prescription is okay if that’s what it takes to get it during summer and fall months. Please."

10 / 10
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  • Anonymous
  • Taken for 10 years or more
  • February 6, 2018

Diphenhydramine "If you have problems with Benadryl, try the dye-free one. I'm wildly allergic to FD&C Red #40 and must use dye-free. Dye-free works well for me."

9 / 10
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23 Report
  • Mia...
  • April 5, 2008

Diphenhydramine "It's the only one I trust with my allergies..."

10 / 10
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39 Report
  • bru...
  • Taken for less than 1 month
  • October 4, 2021

Diphenhydramine "It's making my heart race and making me feel so weird, and my sore throat didn't go away, and I still feel bad."

4 / 10
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8 Report
  • Anonymous
  • January 27, 2009

Diphenhydramine "I'm allergic to pollen. Took a dose, felt a million times better. Slept for 16 hours straight."

6 / 10
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25 Report
  • Anonymous
  • Taken for less than 1 month
  • September 22, 2012

Diphenhydramine "Stopped the infernal itching (from poison ivy) within 15 minutes and dramatically reduced the swelling of the blisters."

9 / 10
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15 Report
  • All...
  • Taken for 5 to 10 years
  • April 20, 2016

Diphenhydramine "Best drug for me to wake up with good sleep and not have a headache. I have used it for 8 years for allergies (itchy eyes, bug reactions), and my house always has it in stock. Love the drug!"

10 / 10
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10 Report
  • Anonymous
  • April 16, 2010

Diphenhydramine "Made me fall asleep. Makes me way too tired."

4 / 10
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14 Report
  • ben...
  • Taken for 10 years or more
  • May 22, 2012

Diphenhydramine "Relieves most allergy symptoms."

10 / 10
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11 Report
  • Anonymous
  • August 4, 2008

"I use this medicine before going to bed when I have allergies, and it helps me a lot."

10 / 10
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8 Report
  • Anonymous
  • Taken for 1 to 2 years
  • October 19, 2015

"Drowsiness is a recurring problem for me. I have difficulty focusing and end up passing out. The effect of the drug comes a little slowly, depending on how severe my allergy attack is."

7 / 10
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4 Report
  • Mam...
  • Taken for less than 1 month
  • June 23, 2012

"It's a great medication, except for the drowsy and sluggish effects."

7 / 10
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4 Report
  • How...
  • Taken for less than 1 month
  • September 16, 2021

Diphenhydramine "Stops the itch by making you sleepy. After half an hour, I end up falling asleep and not having any itching needs."

10 / 10
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1 Report
  • Ano...
  • January 23, 2025

Diphenhydramine "I love Benadryl. I have always had a positive experience with it, and I never feel ill after usage."

10 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.