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Medications for Insomnia

Other names: Difficulty sleeping; Dyssomnia; Inability to sleep; Sleeplessness; Wakefulness

About Insomnia:  Inability to sleep, abnormal wakefulness.

Drugs Used for Insomnia

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
trazodone Off Label C N X 605 reviews
6.0

Generic name: trazodone systemic

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Ambien C 4 X 447 reviews
7.0

Generic name: zolpidem systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

zolpidem C 4 X 748 reviews
7.0

Generic name: zolpidem systemic

Brand names:  Ambien, Ambien CR, Intermezzo, Edluar, Zolpimist …show all

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Lunesta C 4 X 215 reviews
6.0

Generic name: eszopiclone systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

temazepam X 4 X 276 reviews
6.0

Generic name: temazepam systemic

Brand name:  Restoril

Drug class: benzodiazepines

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Ativan D 4 X 23 reviews
7.0

Generic name: lorazepam systemic

Drug class: benzodiazepines, miscellaneous antiemetics, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Restoril X 4 X 69 reviews
7.0

Generic name: temazepam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

amitriptyline C N X 190 reviews
7.0

Generic name: amitriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Ambien CR C 4 X 73 reviews
6.0

Generic name: zolpidem systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

lorazepam D 4 X 74 reviews
8.0

Generic name: lorazepam systemic

Brand name:  Ativan

Drug class: benzodiazepines, miscellaneous antiemetics, benzodiazepine anticonvulsants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Prosom X 4 X 2 reviews
9.0

Generic name: estazolam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Belsomra C 4 X 383 reviews
3.0

Generic name: suvorexant systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

clonazepam Off Label D 4 X 115 reviews
7.0

Generic name: clonazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

eszopiclone C 4 X 267 reviews
6.0

Generic name: eszopiclone systemic

Brand name:  Lunesta

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Halcion X 4 X 21 reviews
8.0

Generic name: triazolam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Rozerem C N X 69 reviews
4.0

Generic name: ramelteon systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

diphenhydramine B N X 111 reviews
6.0

Generic name: diphenhydramine systemic

Brand names:  Compoz Nighttime Sleep Aid, Nytol, Sominex, Unisom SleepGels, Unisom SleepMelts, ZzzQuil, Nytol QuickCaps, Simply Sleep, Sleepinal, Tranquil Nighttime Sleep Aid, Twilite, Z-Sleep …show all

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

doxepin N N X 206 reviews
6.0

Generic name: doxepin systemic

Brand name:  Silenor

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Advil PM N N X 1 review
6.0

Generic name: diphenhydramine / ibuprofen systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

mirtazapine Off Label C N X 225 reviews
7.0

Generic name: mirtazapine systemic

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Silenor N N X 110 reviews
6.0

Generic name: doxepin systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Sonata C 4 X 49 reviews
5.0

Generic name: zaleplon systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

flurazepam N 4 X 24 reviews
8.0

Generic name: flurazepam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

gabapentin Off Label C N X 84 reviews
7.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

quetiapine Off Label C N X 299 reviews
8.0

Generic name: quetiapine systemic

Drug class: atypical antipsychotics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

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Topics under Insomnia

Alternative treatments for Insomnia

The following products are considered to be alternative treatments or natural remedies for Insomnia. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Insomnia.

Learn more about Insomnia

Micromedex® Care Notes

Symptoms and treatments

Drugs.com Health Center

Mayo Clinic Reference

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

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