Skip to Content

Medications for Insomnia

Other names: Difficulty sleeping; Dyssomnia; Inability to sleep; Sleeplessness; Wakefulness

About Insomnia

Inability to sleep, abnormal wakefulness.

Drugs used for Insomnia

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
trazodone Off-label 6.3 785 reviews
Rx C N X

Generic name: trazodone systemic

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Ambien 7.1 513 reviews
Rx C 4 X

Generic name: zolpidem systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

zolpidem 7.0 921 reviews
Rx C 4 X

Generic name: zolpidem systemic

Brand names:  Ambien, Ambien CR, Edluar, Zolpimist …show all

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

temazepam 6.6 376 reviews
Rx X 4 X

Generic name: temazepam systemic

Brand name:  Restoril

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Lunesta 6.0 278 reviews
Rx C 4 X

Generic name: eszopiclone systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

amitriptyline 7.0 235 reviews
Rx C N X

Generic name: amitriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Restoril 7.3 90 reviews
Rx X 4 X

Generic name: temazepam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Ativan 7.4 31 reviews
Rx D 4 X

Generic name: lorazepam systemic

Drug class: benzodiazepines, miscellaneous antiemetics, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

lorazepam 7.6 103 reviews
Rx D 4 X

Generic name: lorazepam systemic

Brand name:  Ativan

Drug class: benzodiazepines, miscellaneous antiemetics, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

clonazepam Off-label 7.4 163 reviews
Rx D 4 X

Generic name: clonazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

mirtazapine Off-label 7.1 374 reviews
Rx C N X

Generic name: mirtazapine systemic

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

quetiapine Off-label 7.6 437 reviews
Rx C N X

Generic name: quetiapine systemic

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Ambien CR 6.5 85 reviews
Rx C 4 X

Generic name: zolpidem systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Belsomra 3.6 480 reviews
Rx C 4 X

Generic name: suvorexant systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

doxepin 5.9 271 reviews
Rx N N X

Generic name: doxepin systemic

Brand name:  Silenor

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

gabapentin Off-label 7.7 114 reviews
Rx C N X

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

diphenhydramine 5.0 246 reviews
Rx/OTC B N X

Generic name: diphenhydramine systemic

Brand names:  Compoz Nighttime Sleep Aid, Sominex, Unisom SleepGels, ZzzQuil, Nytol QuickCaps, Simply Sleep, Sleepinal, Twilite, Z-Sleep …show all

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, antihistamines, anticholinergic antiemetics, anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

eszopiclone 5.7 359 reviews
Rx C 4 X

Generic name: eszopiclone systemic

Brand name:  Lunesta

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Halcion 8.4 28 reviews
Rx X 4 X

Generic name: triazolam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

flurazepam 8.5 79 reviews
Rx N 4 X

Generic name: flurazepam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Rozerem 4.5 93 reviews
Rx C N X

Generic name: ramelteon systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

estazolam 8.8 22 reviews
Rx X 4 X

Generic name: estazolam systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Sonata 5.7 68 reviews
Rx C 4 X

Generic name: zaleplon systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Silenor 6.4 122 reviews
Rx N N X

Generic name: doxepin systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Advil PM 7.3 8 reviews
OTC N N X

Generic name: diphenhydramine / ibuprofen systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Topics under Insomnia

Alternative treatments for Insomnia

The following products are considered to be alternative treatments or natural remedies for Insomnia. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Insomnia.

Learn more about Insomnia

IBM Watson Micromedex

Symptoms and treatments

Drugs.com Health Center

Mayo Clinic Reference

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Browse Treatment Options

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.