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Eszopiclone Side Effects

For the Consumer

Applies to eszopiclone: oral tablet

Along with its needed effects, eszopiclone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eszopiclone:

More common
  • Cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • sleepiness or unusual drowsiness
Less common
  • Bladder pain
  • bloody or cloudy urine
  • cold flu-like symptoms
  • confusion
  • difficult, burning, or painful urination
  • discouragement
  • fear or nervousness
  • feeling sad or empty
  • frequent urge to urinate
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • nerve pain
  • seeing, hearing, or feeling things that are not there
  • tiredness
  • trouble concentrating
  • trouble sleeping

Some side effects of eszopiclone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • bad, unusual, or unpleasant (after) taste
  • belching
  • change in taste
  • dizziness
  • dry mouth
  • headache
  • heartburn
  • indigestion
  • nausea
  • pain
  • stomach discomfort, upset, or pain
Less common
  • Abnormal dreams
  • accidental injury
  • decreased interest in sexual intercourse
  • diarrhea
  • inability to have or keep an erection
  • pain, cramps, or heavy bleeding (females)
  • rash
  • swelling of the breasts or breast soreness (in both males and females)
  • vomiting
Incidence not known
  • Loss of memory
  • problems with memory

For Healthcare Professionals

Applies to eszopiclone: oral tablet

Nervous system

Very common (10% or more): Headache
Common (1% to 10%): Dizziness, migraine, somnolence
Uncommon (0.1% to 1%): Ataxia, decreased reflexes, hypesthesia, hypertonia, incoordination, memory impairment, neurosis, nystagmus, paresthesia
Rare (less than 0.1%): Abnormal gait, hyperesthesia, hypokinesia, neuritis, neuropathy, stupor, tremor
Postmarketing reports: Dysosmia[Ref]

A dose-response relationship appears to exist for the side effects of dizziness and unpleasant taste. In patients aged 65 years or older, headache and unpleasant taste have been very commonly reported and dizziness, nervousness, and neuralgia have been commonly reported. Somnolence has also been reported in this patient population.[Ref]


A dose-response relationship appears to exist for the side effect of hallucinations. Abnormal dreams have been a commonly reported side effect in patients aged 65 years or older.[Ref]

Common (1% to 10%): Anxiety, confusion, depression, hallucinations, nervousness
Uncommon (0.1% to 1%): Abnormal thinking (mainly difficulty concentrating), agitation, apathy, emotional lability, hostility, insomnia
Rare (less than 0.1%): Euphoria
Frequency not reported: Abnormal dreams[Ref]


Rare cases of angioedema involving the tongue, glottis, or larynx have been reported in patients after taking the first or subsequent does of eszopiclone and that required medical therapy in the emergency department. Some patients have had additional symptoms such as dyspnea, throat closing, or nausea and vomiting that suggest anaphylaxis. If angioedema involves the tongue, glottis or larynx, airway obstruction may occur and be fatal. Patients who develop angioedema after treatment with eszopiclone should not be rechallenged with the drug.[Ref]

Uncommon (0.1% to 1%): Allergic reaction, photosensitivity[Ref]


Common (1% to 10%): Peripheral edema
Uncommon (0.1% to 1%): Hypertension
Rare (less than 0.1%): Thrombophlebitis[Ref]


Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Acne, alopecia, cellulitis, contact dermatitis, dry skin, eczema, skin discoloration, sweating, urticaria
Rare (less than 0.1%): Erythema multiforme, furunculosis, hirsutism, maculopapular rash, vesiculobullous rash
Frequency not reported: Angioedema[Ref]

A dose-response relationship appears to exist for the side effect of rash. Pruritus has been commonly reported in patients aged 65 years or older; rash has also been reported.[Ref]


A dose-response relationship appears to exist for the side effect of dry mouth. In patients aged 65 years of age or older diarrhea, dry mouth, and dyspepsia have been commonly reported. Abdominal pain and nausea have also been reported in these patients.[Ref]

Very common (10% or more): Unpleasant taste
Common (1% to 10%): Dry mouth, dyspepsia, nausea, vomiting
Uncommon (0.1% to 1%): Cholelithiasis, halitosis, melena, mouth ulceration, thirst, ulcerative stomatitis
Rare (less than 0.1%): Colitis, dysphagia, gastritis, rectal hemorrhage, stomach ulcer, stomatitis, tongue edema
Frequency not reported: Diarrhea[Ref]


Urinary tract infection has been commonly reported in patients aged 65 years or older.[Ref]

Common (1% to 10%): Dysmenorrhea, gynecomastia, decreased libido
Uncommon (0.1% to 1%): Amenorrhea, breast engorgement, breast enlargement, breast neoplasm, breast pain, cystitis, dysuria, female lactation, hematuria, kidney calculus, kidney pain, mastitis, menorrhagia, metrorrhagia, urinary frequency, uterine hemorrhage, urinary incontinence, vaginal hemorrhage, vaginitis
Rare (less than 0.1%): Oliguria, pyelonephritis, urethritis[Ref]


Uncommon (0.1% to 1%): Anemia, lymphadenopathy[Ref]


Rare (less than 0.1%): Hepatitis, hepatomegaly, liver damage[Ref]


A dose-response relationship appears to exist for the side effect of viral infection.[Ref]

Uncommon (0.1% to 1%): Viral infection
Rare (less than 0.1%): Herpes zoster
Frequency not reported: Flu syndrome[Ref]


Uncommon (0.1% to 1%): Anorexia, hypercholesterolemia, increased appetite, weight gain, weight loss
Rare (less than 0.1%): Dehydration, gout, hyperlipemia, hypokalemia[Ref]


Uncommon (0.1% to 1%): Arthritis, bursitis, joint disorder (mainly swelling, stiffness, and pain), leg cramps, myasthenia, neck rigidity, twitching
Rare (less than 0.1%): Arthrosis, myopathy
Frequency not reported: Back pain, myalgia[Ref]


Uncommon (0.1% to 1%): Conjunctivitis, dry eyes
Rare (less than 0.1%): Iritis, mydriasis, photophobia, ptosis[Ref]


Common (1% to 10%): Chest pain
Uncommon (0.1% to 1%): Ear pain, face edema, fever, heat stroke, hernia, malaise, otitis externa, otitis media, tinnitus, vertigo, vestibular disorder
Rare (less than 0.1%): Hyperacusis
Frequency not reported: Accidental injury, pain[Ref]

In patients aged 65 years or older, pain and accidental injury have been commonly reported. Asthenia has also been reported in these patients.[Ref]


Common (1% to 10%): Respiratory infection
Uncommon (0.1% to 1%): Asthma, bronchitis, dyspnea, epistaxis, hiccup, laryngitis
Frequency not reported: Pharyngitis, rhinitis[Ref]


1. "Product Information. Lunesta (eszopiclone)." Sepracor Inc, Marlborough, MA.

Some side effects of eszopiclone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.