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Eszopiclone Dosage

Medically reviewed by Drugs.com. Last updated on May 15, 2019.

Applies to the following strengths: 1 mg; 2 mg; 3 mg

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Insomnia

Initial dose: 1 mg orally once a day immediately before bedtime
Maintenance dose: 1 to 3 mg orally once a day immediately before bedtime
Maximum dose: 3 mg/day

Comments:
-The lowest effective dose should be used.
-Patients should be monitored for cognitive and/or motor impairments, especially if this drug is used repeatedly.
-Patients should be reevaluated if insomnia persists after 7 to 10 days of treatment.

Use: Treatment of insomnia

Usual Geriatric Dose for Insomnia

Initial dose: 1 mg orally once a day immediately before bedtime
Maintenance dose: 1 to 2 mg orally once a day immediately before bedtime
Maximum dose: 2 mg/day

Comments:
-The lowest effective dose should be used.
-Patients should be monitored for cognitive and/or motor impairments, especially if this drug is used repeatedly.
-Patients should be reevaluated if insomnia persists after 7 to 10 days of treatment.

Use: Treatment of insomnia

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild to moderate liver dysfunction: No adjustment recommended; use with caution.
Severe liver dysfunction: Up to 2 mg orally once a day immediately prior to bedtime
-Maximum dose: 2 mg/day

Dose Adjustments

CONCOMITANT USE WITH CENTRAL NERVOUS SYSTEM (CNS) DEPRESSANTS: Dose adjustment may be required; however, no specific guidelines have been suggested. Caution is recommended.

DEBILITATED PATIENTS AND/OR THOSE TAKING POTENT CYP450 3A4 INHIBITORS: Up to 2 mg orally once a day immediately prior to bedtime
-Maximum dose: 2 mg/day

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or to any of the ingredients
-Patients who have previously experienced an episode of complex sleep behaviors after taking this drug

US BOXED WARNINGS:
COMPLEX SLEEP BEHAVIORS:
-Complex sleep behaviors including sleepwalking, sleep-driving, and engaging in other activities while not fully awake may occur following the use of this drug.
-Some of these events may result in serious injuries, including death.
Recommendation:
-Discontinue this drug immediately is a patient experiences a complex sleep behavior.

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration advice:
-Doses should be administered immediately before bedtime.
-The effects of eszopiclone on sleep onset may be reduced if it is taken with or immediately after a high-fat/heavy meal.

General:
-This drug decreased sleep latency and improved sleep maintenance when administered at bedtime in clinical trials.
-Taking a sedative/hypnotic while still up and about may result in short-term memory impairment, hallucinations, impaired coordination, dizziness, and lightheadedness.
-The risk of next day impairment of driving and other activities that require full alertness is increased following use of 2 mg or 3 mg doses.
-Withdrawal effects may occur if the dose is rapidly reduced or treatment discontinued.

Monitoring:
-NERVOUS SYSTEM: Changes in cognitive function, including complex behaviors
-PSYCHIATRIC: New/worsening depression

Patient advice:
-Patients should be instructed to immediately report "sleep driving," other complex behaviors, and any new/worsening signs/symptoms of depression.
-Inform patients that this drug may cause somnolence and/or transient amnesia, and they should remain in bed and avoid driving or operating machinery for a full 7 to 8 hours after administration of this drug.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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