Skip to Content

User Reviews for Quetiapine to treat Insomnia

Also known as: Seroquel, Seroquel XR

Quetiapine has an average rating of 7.7 out of 10 from a total of 423 ratings for the treatment of Insomnia. 68% of those users who reviewed Quetiapine reported a positive effect, while 14% reported a negative effect.

Quetiapine Rating Summary

7.7/10 average rating

423 ratings from 445 user reviews.

Compare all 81 medications used in the treatment of Insomnia.

10
36%
9
20%
8
12%
7
7%
6
4%
5
6%
4
2%
3
2%
2
3%
1
8%

Reviews for Quetiapine

Sadness1972 · Taken for 1 to 6 months June 6, 2021

“I have been taken the generic Seroquel for 3 months. I am up to a 50mg dose at night. It does make you have very vivid dreams, some scary life like, and I am a zombie most of the day. I get up maybe once and try to eat everything in the house too. Gaining weight!! I wonder if that will go away? Any thoughts on that? I do also take Klonopin, and Effexor for panic attacks and depression. My doctor put me on the Seroquel for a mood stabilizer and sleep too. My Mother took Seroquel XR for years. Her doctor took her off it because it made her a diabetic. She had a lot of trouble sleeping for months. I take the tablets only. Good luck to everyone.”

10 / 10
Was this helpful?YesNo
Lilith · Taken for less than 1 month May 10, 2021

“Quetiapine 25mg has literally changed my life. I’ve been a poor sleeper all my life but in the midst of menopause I’m lucky to get 3 hours a night and developed anxiety, depression and felt utterly lost. I have friends who are on large doses for bipolar features and tried 25 mgs for sleep and it worked. No daytime grogginess just sleep. I could only use it for sleep and happily my doc had no problem scripting off label for me. It’s only been a few days but I could cry with relief that I won’t spend 20 hours awake anymore. I’ve tried everything and this medication at this dose has changed my life.”

10 / 10
Was this helpful?YesNo
Bandit · Taken for 6 months to 1 year May 3, 2021

“Superb. 25mg dose nightly. Helps me sleep. It literally fixed my life long issue with insomnia. I also have Parkinson's, so sleep is difficult. No negative affects so far. It is very mild at 25mg.”

10 / 10
Was this helpful?YesNo
Baffled January 19, 2021

“I have been prescribed 25mg quetiapine for sleep and am baffled as to how the people who are prescribed 100mg a day could remain conscious?? After being on this for 2 years I am still totally knocked out by one 25mg tablet. Most nights I take half a tab or less. I haven’t noticed any increased tolerance in the time I have been on it. Anyway can someone tell me, is my reaction abnormal? If not how do any of you on doses of 50,100, up to 800 stay awake.. once I take 25 mg, that’s it, I AM gonna sleep, like it or not. I have read that it is prescribed in doses up to 800mg for bi polar and thought omg if someone with bi polar was prescribed it at the doses I read (around 250mg) and they reacted like me.... they would literally be incapable of functioning... at all So I was just curious... if you have bi polar, does bi polar, by its nature, mean you have a much higher tolerance or different reaction? Or is my reaction to 25mg abnormal?”

10 / 10
Was this helpful?YesNo
Bjorn · Taken for 2 to 5 years March 4, 2021

“I've been taking 50mg seroquel to sleep for a couple years now. It works every night for me. Within 1/2hr of taking it I am asleep for 6 hours. I tried quitting and got no sleep for days before giving up and taking it again. It felt like without it I would never sleep again. Apparently I'm dependent on it to sleep. Oh well, a good night's sleep is worth it. It's a 10 rating for me (minus 1 because I can't get off it).”

9 / 10
Was this helpful?YesNo
The Gid · Taken for 2 to 5 years January 15, 2021

“I read in various places that Seroquel is not a sleep med; apparent doctors and the like claim that that is not its purpose. Yeah, we know that, but I can assure you it is a very effective sleeping pill at 100mg. I have been taking it for four years and it has failed me not once. I've taken Trazadone and Ambien in the past and I will say Seroquel is the best by far. I wake up completely refreshed, I have gained zero pounds and it helps tremendously with helping one fall asleep and stay asleep. Give it a try, that would be my recommendation. Best of luck to you.”

9 / 10
Was this helpful?YesNo
Sleepy January 2, 2021

“I was prescribed Quetiapine 25 mg for insomnia however I found out that it is really not a sleeping pill because it’s for depression, schizophrenia and anxiety. It have sedative side effects so I guess that’s why it was prescribed to me for sleep. This pill causes me to sleep half the day and feel like a zombie the other half of the day. I don’t know how anyone can take this and work or take care of any responsibilities. I told my dr. that I can’t take this, very disappointing that she prescribed this for me.”

1 / 10
Was this helpful?YesNo
InsomniaLady · Taken for 5 to 10 years January 29, 2021

“I went on Seroquel 6 years ago because I mentioned to my psychiatrist on a visit that I wasn’t sleeping well. She prescribed 150 ER and it knocked me out at night. And reading the other reviews, I get what they are saying about the next day drowsiness. I’m now up to 300 mg ER but I have to take it 3 hours before I go to sleep so it times it out right. HOWEVER, even though I says it’s not addictive, I cannot sleep without it. I don’t want to be on sleeping medications forever. I’ve gone 5 days with no sleep when trying to quit. DO NOT TAKE! they are lying about it’s dependency!!”

1 / 10
Was this helpful?YesNo
YourFavoriteHeadache · Taken for 1 to 2 years February 10, 2021

“This medication was prescribed after I tapered off of Klonopin and could not sleep. I had weight gain at first but only because the doctor had me taking 200mg. I tapered down to 25mg and lost all the weight and still slept great. In fact I felt much better on the lower dose and slept deeper. I had nightmares and sleep paralysis at the higher dose. It also helped my anxiety without feeling groggy the day after. I even take a half of the 25mg to help soothe my anxiety. It’s been a game changer for me.”

9 / 10
Was this helpful?YesNo
Kpsan February 21, 2020

“I have to start by stating every drug effects everyone differently and some respond positively to certain meds and others had horrible reviews. For me, this drug quetiapine literally saved my life. I was going on 3 weeks of no sleep from chronic stress. I was manic and could not sleep no matter what I tried. I took Xanax, over the counter antihistamines, downloaded meditation apps, etc. I was literally on the verge of the end of my life until my parents forced me to go to behavioral health hospital. At intake, I was in the worst shape of my life, lost so much weight and looked like a complete paranoid schizophrenic out of his mind. The psychiatrist told me that they were going to give me something to knock me out and I asked what. She said seroquel and I asked what kind of drug is that and she said an antipsychotic. I took 100 mg and sure enough, I finally got rest. It did take a while to get back to normal again, about a month but I really believe if I hadn’t been given this drug, it would have been the end of me”

10 / 10
Was this helpful?YesNo
Ed · Taken for 10 years or more February 25, 2020

“I have been taking quitiapine for more than 15 years for bipolar but especially for insomnia. Lately my brain feels sick and tired and sometimes anxious all too often. I tried stop taking the quetiapine but it is absolutely impossible to sleep without it. I am taking 200mg which is necessary. I understand that l can go insane without adequate sleep. My doctor up till now has not given me a solution. Do you have any suggestions l could try as l am caught between a rock and a hard place.”

10 / 10
Was this helpful?YesNo
Rach · Taken for less than 1 month August 25, 2020

“After quitting my 20 year marijuana habit, I developed insomnia and then I developed anxiety about the insomnia. 50 mg of Seroquel works for my insomnia every single night. I am so thankful for it. It usually takes 30 minutes to kick in. Been on it for 3 weeks.”

10 / 10
Was this helpful?YesNo
Mere · Taken for 2 to 5 years November 12, 2020

“I have been on Quetiapine for sleep for about 3 years. Started at a low dose but increased up to 200mg, which I have been on for about 2 years. I get sleepy about 20 minutes after my dose and can sleep a full 8 hours. It has been a complete game changer for me.”

10 / 10
Was this helpful?YesNo
Jacina · Taken for 2 to 5 years February 14, 2021

“I’ve been taking quetiapine for over 3 years and it absolutely has helped me sleep. I began on a 25mg dosage, but self- reduced the pills to quarter dosage to ween myself off of these about 3 months into my prescription. What worries me is that if I forget to take my little 6.25mg portion of pill, then I wake up after 2 hours sleep each and every time, and after trying 3 or 4 days I become so tired I start using again. These work good, just too good.”

8 / 10
Was this helpful?YesNo
Leathy · Taken for 1 to 6 months August 16, 2020

“After years of chronic insomnia my GP prescribed 25mg of Quetiapine. It's been a miracle drug for me. Still walking in the night, but able to go back to sleep and get a full 8 hours. Godsend is all I can say :) Only weird thing is that I have a lot more vivid dreams - weird!”

9 / 10
Was this helpful?YesNo
tiz4tggr · Taken for 1 to 6 months May 3, 2020

“Up until my gastric sleeve surgery in 2012, sleep was never an issue for me. If anything, I slept too much. Fast forward to 2020 and for the last 8 years I have suffered horrible to mild insomnia and even on a good night I may get 5 hours of sleep. I have tried all the common sleeping scripts out there along with some pretty serious anti anxiety drugs which ended with pretty bad results (a week in the hospital). In February of this year I went in for my normal physical except my normal doctor had left the practice and the new doc, filling in for her, was the one I got to see. I explained all that I wrote above and she reviewed my chart. She asked if anyone had ever suggested Quetiapine, which they hadn't. I'm currently on day 61 of taking 50mg a night with 7-9 hours a night being the new norm. I'm so thankful this wonderful doctor came into my life. I'm not sure if any other doctor would have even considered this drug. So far no adverse side effects or weight gain. :)”

9 / 10
Was this helpful?YesNo
alvey · Taken for less than 1 month August 21, 2020

“So I was prescribed seroquel for insomnia and I was so scared to try it. I had the best night sleep I have had in probably 5 years. Downside is the side effects the next day were hard on me. My anxiety and depression is worse. So do I keep taking it and the side effects will subside or is this drug just not for me. Ugh its the only thing that has helped with sleep. Help”

Was this helpful?YesNo
Devin January 24, 2021

“I've been on it for a week and a half for insomnia. Taking 75 mg per night and helps with sleep but can often wake and not get back to sleep after only an hour. Have felt increased anxiety the next day which is worse than when I don't sleep at all. I haven't been diagnosed with any particular mental illness but would consider myself to have some form of PTSD. My thoughts are not normal and have increasingly intrusive thoughts and ruminations. Will be getting off this from today and hopefully on something that levels me out and helps me sleep. Strange how we all react so differently”

2 / 10
Was this helpful?YesNo
Dad · Taken for 6 months to 1 year January 17, 2021

“Got prescribed this for sleep after trazodone failed to help. It is VERY powerful at the 25mg dose for me. Please let your psych know if you have frequent or strong side effects to medicine before using. It knocks me out and keeps me asleep, but makes me VERY groggy in the morning, like I am hungover, and make me hungry while I'm getting drowsy. Be sure to go straight to bed after you take it to combat eating and risks of dizziness.”

7 / 10
Was this helpful?YesNo
Coffeeaddict85 · Taken for 5 to 10 years January 14, 2021

“Seroquel saved my life, due to PTSD I have insomnia for over 7 years it was so bad I felt crazy and unstable, I contemplated suicide daily and I couldn't function. I was finally able to sleep with seroquel after trying everything else. Unfortunately it made me gain a lot of weight and I have very irregular periods. I don't want to continue long term but it does help me sleep at night. I could not function without it.”

Was this helpful?YesNo
kas · Taken for 1 to 2 years January 3, 2021

“I used to have really bad insomnia. I don't know the cause but it made me sleep 7 hours in the span of three days. My mind was like a radio, non stop playing and talking. When I took seroquel for my bipolar disorder I was super drowsy and I could not wake up during the day. I started 25mg but I noticed that I was getting sleep. Overtime I had to increase my dose to 300mg to get good sleep. My body always gets use to meds and I ended up increasing every-time. I found that 300mg was good to give me 8 or 9 hours of sleep at night. If I take it early I can wake up early and feel well rested for the next day. I noticed that if I need to wake up sooner I less my dose with 200mg. The only downside to this medication is the weight gain. I would wake up in the middle of the night hungry and thirsty. Spoke with my doc and tried Trazodone and Temazepam but none worked better compare to Seroquel. Still a life saver.”

10 / 10
Was this helpful?YesNo
bobcat · Taken for 5 to 10 years February 15, 2020

“Seroquel at 25mg is a miracle sleep inducer. I took it for 10 years every night. One night I was away and without the pill. Guess what, horrible sleep! Lately I'm taking 50mg as 25mg seems to give now 6.5 vs 8 hours of sleep. Just like Tramadol fixed my depression, seroquel fixed my sleep. These two meds don't send your psychiatrist to conferences in Maui and Tahiti, hence the lack of interest.”

10 / 10
Was this helpful?YesNo
Toiletboss · Taken for less than 1 month January 2, 2021

“I'm on a very small dose of seroquel. The side effects are really horrible, I need to use my glasses all day because I keep making spelling errors and it does not effect my pain medication (morphine sulphur).”

Was this helpful?YesNo
Lauren · Taken for 1 to 6 months December 29, 2020

“I’ve had trouble sleeping for so long. My issue is that I can’t fall asleep but when I do, I sleep without it being disturbed. It has caused me so many issues when I have to go somewhere in the morning and I haven’t slept not even for a minute. And when I don’t get sleep, I have muscle spasms, i vomit etc. So it is very important I get my sleep every night. I also have anxiety and I was prescribed this medication to help calm down my anxiety and unfortunately like every other medication I have tried, it doesn’t calm down my anxiety. However, it makes me so sleepy and puts me to sleep. Not straight away. But it is so amazing. It has helped my insomnia so well and I love it.”

7 / 10
Was this helpful?YesNo
charlie m · Taken for 6 months to 1 year December 15, 2020

“I have been on quetiapine 50mg a night for almost a year it has helped me sleep which I am truly grateful for. I do think I rely on this drug now and feel like I won’t ever get off it. The only negative side effect is my memory is awful I have to write everything down.”

10 / 10
Was this helpful?YesNo
SR · Taken for 1 to 6 months December 2, 2020

“After trying MANY sleep remedies (Natural and prescription) I tried seroquel as a last resort. This is the only thing that has worked for me!! I only take 12.5 mg and have no ill side effects. I am so very thankful my doctor suggested this. It helps turn off all the worry during the night so I can sleep 8-9 hours. A true miracle!”

10 / 10
Was this helpful?YesNo
TC · Taken for 6 months to 1 year May 19, 2020

“I feel like taking Seroquel MUST be like getting roofied. I took the 100mg and it literally knocked me out for 12 hours straight. Then after waking up, you're groggy for at least another 6 hours and are grumpy to people around you. I also got restless leg syndrome or some kind of VERY weird involuntary leg movements. I would ALSO always wake up in some kind of pain and it might be due to the fact that you're so knocked out your contorting your body in unusual positions while you sleep. I then got reduced halfway to the 50mg which did the SAME thing but with half of the SAME effects!!! Seroquel seems like a dangerous drug to me and I've been on a few.”

1 / 10
Was this helpful?YesNo
Squeaky · Taken for 2 to 5 years November 25, 2019

“My insomnia is genetic as everyone in my family seems to have it, but have no other diagnosis as to why. We sleep very heavy 2 hours at a time with periods of being awake 1-3 hours in between. Which makes working hard as we often only get 2-4 hours sleep a night. After being tried on many different over the counter and prescription drugs which either did not work or had to have the dose increased every few weeks my Dr. suggested this . I have been taking this for insomnia for 3 years. Unlike other medicines I have never had to increase my dose and the only adverse side effect I noticed was some weight gain. I take less than the clinical dose for many depressed patients as I take only 25 mg a night an hour before bed. This was my miracle! After 2-3 years of 2-4 hours sleep a night I was beginning to literally loose my mind due to lack of sleep. I now sleep 6-8 hoours straight every night,( with occasional bathroom trips).”

9 / 10
Was this helpful?YesNo

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Learn more about Insomnia

IBM Watson Micromedex

Symptoms and treatments

Drugs.com Health Center

Mayo Clinic Reference