Quetiapine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Quetiapine	Vraylar (cariprazine)	Caplyta (lumateperone)	Enter another drug to compare

Quetiapine

Vraylar (cariprazine)

Caplyta (lumateperone)

Prescription only

Quetiapine is an antipsychotic that calms and sedates, helping to relieve psychotic thoughts and manic and depressive behavior. Sedation, low blood pressure, and weight gain are common side effects... View more

Prescription only

Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar I disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to... View more

Prescription only

Caplyta is an atypical antipsychotic that is used to treat adults with schizophrenia or depression associated with bipolar disorder. Sleepiness is the most common side effect and it should not be... View more

More about Quetiapine

More about Vraylar (cariprazine)

More about Caplyta (lumateperone)

Ratings & Reviews

Quetiapine has an average rating of 7.2 out of 10 from a total of 2266 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect.

Vraylar has an average rating of 6.1 out of 10 from a total of 533 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 32% reported a negative effect.

Caplyta has an average rating of 6.6 out of 10 from a total of 189 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 28% reported a negative effect.

View all 2266 reviews

View all 533 reviews

View all 189 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Weight gain (19.8%)
Drowsiness (17.2%)
Tiredness (6.5%)
Anxiety (5.7%)
Insomnia (5.6%)
Increased appetite (4.5%)
Depression (4.1%)

View all Quetiapine side effects

Restlessness (16.3%)
Insomnia (14.6%)
Weight gain (12.4%)
Nausea (9.8%)
Anxiety (8.8%)
Tiredness (5.8%)
Hallucinations (5.4%)

View all Vraylar side effects

Headaches (14.8%)
Nausea (10.6%)
Dizziness (10.1%)
Dry mouth (10.1%)
Drowsiness (9.5%)
Tiredness (9.0%)
Weight gain (6.9%)

View all Caplyta side effects

Drug Class

Atypical antipsychotics

Atypical antipsychotics

Atypical antipsychotics

Generic Availability

Lower cost generic

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	300 mg
Per unit^*	$0.38
Cost^*	$18.80

View all Quetiapine prices

Quantity	20 each
Strength	1.5 mg
Per unit^*	$49.85
Cost^*	$997.00

View all Vraylar prices

Quantity	30 each
Strength	42 mg
Per unit^*	$55.94
Cost^*	$1,678.17

View all Caplyta prices

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Dosage Forms

Oral tablet
Oral tablet, extended release

Oral capsule

Oral capsule

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

6 hours

504 hours

18 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 766 drugs are known to interact with Quetiapine:

148 major drug interactions (504 brand and generic names)
613 moderate drug interactions (2397 brand and generic names)
5 minor drug interactions (21 brand and generic names)

A total of 579 drugs are known to interact with Vraylar:

103 major drug interactions (407 brand and generic names)
474 moderate drug interactions (1819 brand and generic names)
2 minor drug interactions (5 brand and generic names)

A total of 606 drugs are known to interact with Caplyta:

167 major drug interactions (620 brand and generic names)
437 moderate drug interactions (1728 brand and generic names)
2 minor drug interactions (5 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Grapefruit juice can increase the blood levels of cariprazine. This may increase side effects such... View more
Using cariprazine together with alcohol may increase side effects such as dizziness, drowsiness... View more

Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this... View more
Using lumateperone together with alcohol may increase side effects such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

September 26, 1997

September 17, 2015

December 20, 2019

WADA Class View classifications

N/A

More Information

Patient Resources

Quetiapine uses

Vraylar uses

Caplyta uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Quetiapine Alternatives Compared

See also:

Lybalvi

Rexulti

Caplyta

Vraylar

Auvelity

Abilify

Seroquel

Lamictal

Depakote

Divalproex sodium

Further information

Quetiapine Alternatives Compared

See also:

Further information

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