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User Reviews for Quetiapine

Also known as: Seroquel, Seroquel XR

Quetiapine has an average rating of 7.2 out of 10 from a total of 1,984 ratings on Drugs.com. 63% of reviewers reported a positive experience, while 19% reported a negative experience.

Condition Avg. Rating Reviews Compare
Bipolar Disorder  
6.9
647 reviews 32 medications
Insomnia  Off-label
7.6
501 reviews 109 medications
Depression  
6.4
189 reviews 78 medications
Generalized Anxiety Disorder  Off-label
7.4
183 reviews 7 medications
Borderline Personality Disorder  Off-label
7.5
121 reviews 28 medications
Schizoaffective Disorder  
6.7
80 reviews 27 medications
Schizophrenia  
6.9
76 reviews 49 medications
Post Traumatic Stress Disorder  Off-label
7.9
65 reviews 5 medications
Major Depressive Disorder  
6.3
57 reviews 47 medications
Obsessive Compulsive Disorder  Off-label
8.6
43 reviews 9 medications
Paranoid Disorder  Off-label
7.0
16 reviews 5 medications
Intermittent Explosive Disorder  Off-label
10.0
3 reviews 5 medications
Tourette's Syndrome  Off-label
7.0
3 reviews 7 medications
Summary of Quetiapine reviews 7.2 1,984 reviews

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Quetiapine

Baffled · January 19, 2021

For Insomnia: “I have been prescribed 25mg quetiapine for sleep and am baffled as to how the people who are prescribed 100mg a day could remain conscious?? After being on this for 2 years I am still totally knocked out by one 25mg tablet. Most nights I take half a tab or less. I haven’t noticed any increased tolerance in the time I have been on it. Anyway can someone tell me, is my reaction abnormal? If not how do any of you on doses of 50,100, up to 800 stay awake.. once I take 25 mg, that’s it, I AM gonna sleep, like it or not. I have read that it is prescribed in doses up to 800mg for bi polar and thought omg if someone with bi polar was prescribed it at the doses I read (around 250mg) and they reacted like me.... they would literally be incapable of functioning... at all So I was just curious... if you have bi polar, does bi polar, by its nature, mean you have a much higher tolerance or different reaction? Or is my reaction to 25mg abnormal?”

10 / 10
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anon · Taken for less than 1 month · February 6, 2021

Seroquel (quetiapine) for Bipolar Disorder: “I thought writing this was important as there is so many negative reviews on here. I was so close to giving up and every single medication I put in my body would send me into a borderline psychosis. I had the prescription for Seroquel for awhile before I could convince myself to take it. I am so glad I did. Still adjusting the dosage so I am not 100% where I need to be, but a low dose of this has given me a sense of hope that I haven't felt in 7 months. I was so broken from Anxiety/adhd and I can finally see a light at the end of the tunnel from Seroquel. Felt effects within the first few days and still improving with dosage adjustments. Don't give up!!!!! xxx”

10 / 10
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Marty · Taken for 2 to 5 years · July 9, 2021

For Insomnia: “I would like to share the fact that this drug is prescribed for sleep at 25-50 mg maximum because the lower strength it acts like antihistamine similar to sleep ease or other sleep meds that cause drowsiness. If used at stronger doses it can engage not sleep favourable conditions, such as why it is used for depression and psychosis on label. I am a male weighing 210 lbs, and take between 12.5-max 25 mg. 25 knocks me out for 12-14 hours, 12.5 mg for more like 8 hours. I have studied this drug extensively and in most people(not all) it does not help sleep at higher doses. It can cause increased blood glucose at doses higher than 50 mg. Other negative effects are also shown in doses over 50 mg. I refer to a large study done recently in 2021.”

10 / 10
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Bjorn · Taken for 2 to 5 years · March 4, 2021

For Insomnia: “I've been taking 50mg seroquel to sleep for a couple years now. It works every night for me. Within 1/2hr of taking it I am asleep for 6 hours. I tried quitting and got no sleep for days before giving up and taking it again. It felt like without it I would never sleep again. Apparently I'm dependent on it to sleep. Oh well, a good night's sleep is worth it. It's a 10 rating for me (minus 1 because I can't get off it).”

9 / 10
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The Gid · Taken for 2 to 5 years · January 15, 2021

For Insomnia: “I read in various places that Seroquel is not a sleep med; apparent doctors and the like claim that that is not its purpose. Yeah, we know that, but I can assure you it is a very effective sleeping pill at 100mg. I have been taking it for four years and it has failed me not once. I've taken Trazadone and Ambien in the past and I will say Seroquel is the best by far. I wake up completely refreshed, I have gained zero pounds and it helps tremendously with helping one fall asleep and stay asleep. Give it a try, that would be my recommendation. Best of luck to you.”

9 / 10
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NR · Taken for 6 months to 1 year · November 27, 2018

For Generalized Anxiety Disorder: “I am so thankful for this medication. After trying multiple SSRI and SNRIs with limited success, Seroquel bridged the gap. I have GAD and some depression; this medication took me from a place where I had taken a 3 month leave of absence from a successful career as an executive, to a place where I can function again in what remains a highly intense corporate environment. While Seroquel is a miracle drug for me, I am very thankful to Jesus for carrying me through this period - He's my true miracle.”

10 / 10
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Sleepy · January 2, 2021

For Insomnia: “I was prescribed Quetiapine 25 mg for insomnia however I found out that it is really not a sleeping pill because it’s for depression, schizophrenia and anxiety. It have sedative side effects so I guess that’s why it was prescribed to me for sleep. This pill causes me to sleep half the day and feel like a zombie the other half of the day. I don’t know how anyone can take this and work or take care of any responsibilities. I told my dr. that I can’t take this, very disappointing that she prescribed this for me.”

1 / 10
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InsomniaLady · Taken for 5 to 10 years · January 29, 2021

For Insomnia: “I went on Seroquel 6 years ago because I mentioned to my psychiatrist on a visit that I wasn’t sleeping well. She prescribed 150 ER and it knocked me out at night. And reading the other reviews, I get what they are saying about the next day drowsiness. I’m now up to 300 mg ER but I have to take it 3 hours before I go to sleep so it times it out right. HOWEVER, even though I says it’s not addictive, I cannot sleep without it. I don’t want to be on sleeping medications forever. I’ve gone 5 days with no sleep when trying to quit. DO NOT TAKE! they are lying about it’s dependency!!”

1 / 10
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Molly · Taken for less than 1 month · August 28, 2019

Seroquel (quetiapine) for Bipolar Disorder: “This medication has saved my life. I was having the worst episodes ever high low high low, no sleep, totally impulsive on the downward spiral to self destruction. Spending money running around town all hours, telling off people at work... then the crash. Sobbing in my doctor's office, she wrote the script for Seroquel. I had zero faith, because all the anti-depressants etc. she'd tried me on never worked to calm the chaos/PTSD reactivity in my head. I was ready to end it all. Thank goodness I filled the script and took it. I slept! That in itself is a miracle. I kept my job, and I'm hopefully on a journey to wellness. My mind is calmer. I can think one thing after another in a logical order instead of a cloud of white noise and traumatic memories flashing. I think with this med and some good PTSD therapy I might have a second chance... at life. I don't care if I gain a little weight... I want to live without constant chaos. So grateful.”

8 / 10
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Lilith · Taken for less than 1 month · May 10, 2021

For Insomnia: “Quetiapine 25mg has literally changed my life. I’ve been a poor sleeper all my life but in the midst of menopause I’m lucky to get 3 hours a night and developed anxiety, depression and felt utterly lost. I have friends who are on large doses for bipolar features and tried 25 mgs for sleep and it worked. No daytime grogginess just sleep. I could only use it for sleep and happily my doc had no problem scripting off label for me. It’s only been a few days but I could cry with relief that I won’t spend 20 hours awake anymore. I’ve tried everything and this medication at this dose has changed my life.”

10 / 10
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Kpsan · February 21, 2020

For Insomnia: “I have to start by stating every drug effects everyone differently and some respond positively to certain meds and others had horrible reviews. For me, this drug quetiapine literally saved my life. I was going on 3 weeks of no sleep from chronic stress. I was manic and could not sleep no matter what I tried. I took Xanax, over the counter antihistamines, downloaded meditation apps, etc. I was literally on the verge of the end of my life until my parents forced me to go to behavioral health hospital. At intake, I was in the worst shape of my life, lost so much weight and looked like a complete paranoid schizophrenic out of his mind. The psychiatrist told me that they were going to give me something to knock me out and I asked what. She said seroquel and I asked what kind of drug is that and she said an antipsychotic. I took 100 mg and sure enough, I finally got rest. It did take a while to get back to normal again, about a month but I really believe if I hadn’t been given this drug, it would have been the end of me”

10 / 10
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Mrmeds · August 29, 2019

Seroquel (quetiapine) for Schizophrenia: “This drug has really helped me with the voices and the paranoia. I have been on it for nearly 3 years. I have been on pretty much every antipsychotic there is and have been dealing with this illness for a long, long time. The downside is that you will gain weight. I have lost some of it by reducing calories and taking metformin. Walking seems to help too. If you do take this one, stay as active as you can to avoid diabetes because as my psychiatrist told me "It will happen eventually" Also, I adopted a vegatarian diet to help lower other risks with this one. The other downside is that it can make you very tired. I take 400mg at night and 75mg in the morning and another 75mg in the afternoon. I still hear voices and don't want to be around other people but it is much more manageable and I can at least have some kind of life. To be honest, I probably would have killed myself if it were not for this drug. I am surprised I even wrote this as I am a very paranoid person.”

10 / 10
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Ed · Taken for 10 years or more · February 25, 2020

For Insomnia: “I have been taking quitiapine for more than 15 years for bipolar but especially for insomnia. Lately my brain feels sick and tired and sometimes anxious all too often. I tried stop taking the quetiapine but it is absolutely impossible to sleep without it. I am taking 200mg which is necessary. I understand that l can go insane without adequate sleep. My doctor up till now has not given me a solution. Do you have any suggestions l could try as l am caught between a rock and a hard place.”

10 / 10
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YourFavoriteHeadache · Taken for 1 to 2 years · February 10, 2021

For Insomnia: “This medication was prescribed after I tapered off of Klonopin and could not sleep. I had weight gain at first but only because the doctor had me taking 200mg. I tapered down to 25mg and lost all the weight and still slept great. In fact I felt much better on the lower dose and slept deeper. I had nightmares and sleep paralysis at the higher dose. It also helped my anxiety without feeling groggy the day after. I even take a half of the 25mg to help soothe my anxiety. It’s been a game changer for me.”

9 / 10
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Princess · Taken for 2 to 5 years · October 15, 2019

For Generalized Anxiety Disorder: “I have been diagnosed with GAD for 20 yrs. I have tried most antidepressants but I got more anxiety. Until 3 years ago my doctor prescribed quetiapine it helped me control my anxiety and panic disorder. I love this medication.”

10 / 10
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Sunflower · November 19, 2019

For Generalized Anxiety Disorder: “I first started this medication (quetiapine) about a week or so ago. The first two days on it I felt like a complete zombie - I didn't leave my bed for two days and did not eat a single thing. I started this medication on the weekend so I didn't feel weird while I was at work. Fast forward to Monday - I get into work and I could not concentrate as my brain felt foggy and reading my emails felt like the biggest struggle. After the day had passed I had noticed that I wasn't as anxious as I normally am. During the first full week on this I felt great. I wasn't anxious (if I was it was very minimal) and I wasn't angry for no apparent reason anymore. Now two weeks later - all of my symptoms are back and feel way worse. I wake up wit terrible anxiety - so bad that I contemplate calling into work because I'm not able to control my breathing. My mood swings are terrible, the smallest things trigger me and i just overall am feeling bad again. Has this happened to anyone else?”

5 / 10
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A-nonny-mouse · Taken for 2 to 5 years · October 13, 2019

Seroquel (quetiapine) for Bipolar Disorder: “If you have Bipolar Disorder type II, please learn as much as you can about this condition from professional, reputable sources so you can make informed decisions about treatment and management options. This is a treatable, manageable illness, take hope in that. After 20+ years struggling to "cure" myself "naturally" & being miserable, dangerously depressed & dysfunctional, I finally decided to try psych medication. I found a doctor who SPECIALISES in this disorder and is up to date with the latest research findings in this specific condition. If you don't like your current GP or Psych's attitude, find someone else! I started a combo of Lamictal (AM & PM) & Seroquel (Only PM - makes you drowsy). I kept a daily mood diary & it took 3 months for my mood to fully stabilise. To help the bipolar depression, we added bupropion & N-Acetyl Cysteine, a supplement (all based on clinical research!). For 5 years now, I’ve had my life back. Deciding to take this medication saved my life.”

7 / 10
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Sadness1972 · Taken for 1 to 6 months · June 6, 2021

For Insomnia: “I have been taken the generic Seroquel for 3 months. I am up to a 50mg dose at night. It does make you have very vivid dreams, some scary life like, and I am a zombie most of the day. I get up maybe once and try to eat everything in the house too. Gaining weight!! I wonder if that will go away? Any thoughts on that? I do also take Klonopin, and Effexor for panic attacks and depression. My doctor put me on the Seroquel for a mood stabilizer and sleep too. My Mother took Seroquel XR for years. Her doctor took her off it because it made her a diabetic. She had a lot of trouble sleeping for months. I take the tablets only. Good luck to everyone.”

10 / 10
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Alliswell · Taken for 5 to 10 years · February 2, 2021

For Insomnia: “5 years on Trazodone, and quetiapine for sleep. 50mg-75...A month ago I decided to start the process, with my doctors approval, to decrease my dosage. 37.5mg 3 wks, 4 wks later 12mg 4wks later I'm done. Last night was the first night. Woke up early 1.5 hours earlier. And a little out of sort. But I know this will pass. The traz, I'm in 1/2 tab soon I'll be off of that. It can be done. Put tabs of melatonin in the pill holder or bottle instead. You have to get off this stuff. And you will.”

1 / 10
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Northern Guy · Taken for 5 to 10 years · October 22, 2012

Seroquel (quetiapine) for Generalized Anxiety Disorder: “This medicine is great for daytime anxiety or anxiety with insomnia. Doctors give way too much of this 300mg, 500mg, etc. to non-manic patients when much smaller dosages will work. I used a HALF TABLET (12.5mg) for sleep. Lately I used 1/4 tablet (one in morning and one in afternoon) to lower base anxiety level. You don't need to be knocked out to get relief from anxiety!”

8 / 10
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Rach · Taken for less than 1 month · August 25, 2020

For Insomnia: “After quitting my 20 year marijuana habit, I developed insomnia and then I developed anxiety about the insomnia. 50 mg of Seroquel works for my insomnia every single night. I am so thankful for it. It usually takes 30 minutes to kick in. Been on it for 3 weeks.”

10 / 10
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Pugglemama · Taken for less than 1 month · February 27, 2021

For Generalized Anxiety Disorder: “I noticed this pill started working for me within the first week. I've been on it now for 4 weeks and have noticed a big change. I was taking Ativan every day for a month before I started taking this medication as my anxiety and intrusive thoughts were out of control. I haven't had to take Ativan for 3 weeks now and am feel so much better, and back to my happy self. I'm on the lowest does you can be on. So happy I gave this a go! Looking forward to the future of feeling good and less anxiety.”

10 / 10
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Toiletboss · Taken for less than 1 month · January 2, 2021

For Insomnia: “I'm on a very small dose of seroquel. The side effects are really horrible, I need to use my glasses all day because I keep making spelling errors and it does not effect my pain medication (morphine sulphur).”

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josianne · May 25, 2021

Seroquel XR (quetiapine) for Depression: “I am diagnosed with BPD, severe anxiety and depression. I've tried multiple antidepressant before, and none of them worked for me. My doctor prescribed me 50 mg of Seroquel XR, and I take it before going to sleep. I have now been taking it for 3 months, and it literally saved my life. I've experienced some side effects at first, but now that my body is used to the medication, I feel so much better. I can go out, see friends, and do a lot of things I couldn't even think about doing 2 months ago. In contrary to a lot of people, I didn't gain weight yet, I even lost some. It also helps my mood swings and my dissociation. The only negative thing I can think of is the tiredness. But, if I get out of bed right away, I'm good for the day. I can recommend to not take it too late, because it can make it hard to wake up in the morning. In conclusion, I think it's a great medication and even if you're scared to take it, just give it a try and let it time to start working.”

10 / 10
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Anonymous · Taken for 10 years or more · June 5, 2020

For Generalized Anxiety Disorder: “Whatever your condition, from my experience do not start taking this drug quetiapine. I speak from experience with bipolar, major depression, and anxiety. The side effects are far worse than any benefits. The only benefit I have found is some help with sleep, but even that is inconsistent and sometimes my overall sleep is much worse (fewer hours). It causes massive weight gain over time and dependency. Once you take it, you feel like you won't be able to sleep without it. I have been on it for years and have been unable to get off it, even though at this point I am on a low dose of 25 mg when I used to be on a high dose.”

1 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.