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Quetiapine User Reviews & Ratings

Brand names: Seroquel, Seroquel XR

Quetiapine has an average rating of 7.2 out of 10 from a total of 2,114 reviews on Drugs.com. 63% of reviewers reported a positive experience, while 18% reported a negative experience.

Condition Avg. Rating Reviews Compare
Bipolar Disorder  
7.0
685 reviews for Bipolar Disorder 35 medications
Insomnia  Off-label
7.6
531 reviews for Insomnia 113 medications
Generalized Anxiety Disorder  Off-label
7.4
202 reviews for Generalized Anxiety Disorder 7 medications
Depression  
6.4
192 reviews for Depression 76 medications
Borderline Personality Disorder  Off-label
7.5
132 reviews for Borderline Personality Disorder 28 medications
Schizoaffective Disorder  
6.8
86 reviews for Schizoaffective Disorder 22 medications
Schizophrenia  
7.0
83 reviews for Schizophrenia 52 medications
Post Traumatic Stress Disorder  Off-label
7.8
72 reviews for Post Traumatic Stress Disorder 2 medications
Major Depressive Disorder  
6.4
60 reviews for Major Depressive Disorder 50 medications
Obsessive Compulsive Disorder  Off-label
8.5
48 reviews for Obsessive Compulsive Disorder 9 medications
Paranoid Disorder  Off-label
7.1
17 reviews for Paranoid Disorder 5 medications
Intermittent Explosive Disorder  Off-label
10.0
3 reviews for Intermittent Explosive Disorder 5 medications
Tourette's Syndrome  Off-label
7.0
3 reviews for Tourette's Syndrome 4 medications
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Reviews for Quetiapine

  • Baffled
  • January 19, 2021

For Insomnia "I have been prescribed 25mg quetiapine for sleep and am baffled as to how the people who are prescribed 100mg a day could remain conscious?? After being on this for 2 years I am still totally knocked out by one 25mg tablet. Most nights I take half a tab or less. I haven’t noticed any increased tolerance in the time I have been on it. Anyway can someone tell me, is my reaction abnormal? If not how do any of you on doses of 50,100, up to 800 stay awake.. once I take 25 mg, that’s it, I AM gonna sleep, like it or not. I have read that it is prescribed in doses up to 800mg for bi polar and thought omg if someone with bi polar was prescribed it at the doses I read (around 250mg) and they reacted like me.... they would literally be incapable of functioning... at all So I was just curious... if you have bi polar, does bi polar, by its nature, mean you have a much higher tolerance or different reaction? Or is my reaction to 25mg abnormal?"

10 / 10
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  • Marty
  • Taken for 2 to 5 years
  • July 9, 2021

For Insomnia "I would like to share the fact that this drug is prescribed for sleep at 25-50 mg maximum because the lower strength it acts like antihistamine similar to sleep ease or other sleep meds that cause drowsiness. If used at stronger doses it can engage not sleep favourable conditions, such as why it is used for depression and psychosis on label. I am a male weighing 210 lbs, and take between 12.5-max 25 mg. 25 knocks me out for 12-14 hours, 12.5 mg for more like 8 hours. I have studied this drug extensively and in most people(not all) it does not help sleep at higher doses. It can cause increased blood glucose at doses higher than 50 mg. Other negative effects are also shown in doses over 50 mg. I refer to a large study done recently in 2021."

10 / 10
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515 Report
  • anon
  • Taken for less than 1 month
  • February 6, 2021

Seroquel (quetiapine) for Bipolar Disorder "I thought writing this was important as there is so many negative reviews on here. I was so close to giving up and every single medication I put in my body would send me into a borderline psychosis. I had the prescription for Seroquel for awhile before I could convince myself to take it. I am so glad I did. Still adjusting the dosage so I am not 100% where I need to be, but a low dose of this has given me a sense of hope that I haven't felt in 7 months. I was so broken from Anxiety/adhd and I can finally see a light at the end of the tunnel from Seroquel. Felt effects within the first few days and still improving with dosage adjustments. Don't give up!!!!! xxx"

10 / 10
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556 Report

Frequently asked questions

  • Bjorn
  • Taken for 2 to 5 years
  • March 4, 2021

For Insomnia "I've been taking 50mg seroquel to sleep for a couple years now. It works every night for me. Within 1/2hr of taking it I am asleep for 6 hours. I tried quitting and got no sleep for days before giving up and taking it again. It felt like without it I would never sleep again. Apparently I'm dependent on it to sleep. Oh well, a good night's sleep is worth it. It's a 10 rating for me (minus 1 because I can't get off it)."

9 / 10
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  • The...
  • Taken for 2 to 5 years
  • January 15, 2021

For Insomnia "I read in various places that Seroquel is not a sleep med; apparent doctors and the like claim that that is not its purpose. Yeah, we know that, but I can assure you it is a very effective sleeping pill at 100mg. I have been taking it for four years and it has failed me not once. I've taken Trazadone and Ambien in the past and I will say Seroquel is the best by far. I wake up completely refreshed, I have gained zero pounds and it helps tremendously with helping one fall asleep and stay asleep. Give it a try, that would be my recommendation. Best of luck to you."

9 / 10
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472 Report

Are you taking this medicine?

  • NRano
  • Taken for 6 months to 1 year
  • November 27, 2018

For Generalized Anxiety Disorder "I am so thankful for this medication. After trying multiple SSRI and SNRIs with limited success, Seroquel bridged the gap. I have GAD and some depression; this medication took me from a place where I had taken a 3 month leave of absence from a successful career as an executive, to a place where I can function again in what remains a highly intense corporate environment. While Seroquel is a miracle drug for me, I am very thankful to Jesus for carrying me through this period - He's my true miracle."

10 / 10
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671 Report
  • Lilith
  • Taken for less than 1 month
  • May 10, 2021

For Insomnia "Quetiapine 25mg has literally changed my life. I’ve been a poor sleeper all my life but in the midst of menopause I’m lucky to get 3 hours a night and developed anxiety, depression and felt utterly lost. I have friends who are on large doses for bipolar features and tried 25 mgs for sleep and it worked. No daytime grogginess just sleep. I could only use it for sleep and happily my doc had no problem scripting off label for me. It’s only been a few days but I could cry with relief that I won’t spend 20 hours awake anymore. I’ve tried everything and this medication at this dose has changed my life."

10 / 10
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352 Report
  • Sleepy
  • January 2, 2021

For Insomnia "I was prescribed Quetiapine 25 mg for insomnia however I found out that it is really not a sleeping pill because it’s for depression, schizophrenia and anxiety. It have sedative side effects so I guess that’s why it was prescribed to me for sleep. This pill causes me to sleep half the day and feel like a zombie the other half of the day. I don’t know how anyone can take this and work or take care of any responsibilities. I told my dr. that I can’t take this, very disappointing that she prescribed this for me."

1 / 10
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  • Kpsan
  • February 21, 2020

For Insomnia "I have to start by stating every drug effects everyone differently and some respond positively to certain meds and others had horrible reviews. For me, this drug quetiapine literally saved my life. I was going on 3 weeks of no sleep from chronic stress. I was manic and could not sleep no matter what I tried. I took Xanax, over the counter antihistamines, downloaded meditation apps, etc. I was literally on the verge of the end of my life until my parents forced me to go to behavioral health hospital. At intake, I was in the worst shape of my life, lost so much weight and looked like a complete paranoid schizophrenic out of his mind. The psychiatrist told me that they were going to give me something to knock me out and I asked what. She said seroquel and I asked what kind of drug is that and she said an antipsychotic. I took 100 mg and sure enough, I finally got rest. It did take a while to get back to normal again, about a month but I really believe if I hadn’t been given this drug, it would have been the end of me"

10 / 10
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425 Report
  • Molly
  • Taken for less than 1 month
  • August 28, 2019

Seroquel (quetiapine) for Bipolar Disorder "This medication has saved my life. I was having the worst episodes ever high low high low, no sleep, totally impulsive on the downward spiral to self destruction. Spending money running around town all hours, telling off people at work... then the crash. Sobbing in my doctor's office, she wrote the script for Seroquel. I had zero faith, because all the anti-depressants etc. she'd tried me on never worked to calm the chaos/PTSD reactivity in my head. I was ready to end it all. Thank goodness I filled the script and took it. I slept! That in itself is a miracle. I kept my job, and I'm hopefully on a journey to wellness. My mind is calmer. I can think one thing after another in a logical order instead of a cloud of white noise and traumatic memories flashing. I think with this med and some good PTSD therapy I might have a second chance... at life. I don't care if I gain a little weight... I want to live without constant chaos. So grateful."

8 / 10
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452 Report
  • YourF...
  • Taken for 1 to 2 years
  • February 10, 2021

For Insomnia "This medication was prescribed after I tapered off of Klonopin and could not sleep. I had weight gain at first but only because the doctor had me taking 200mg. I tapered down to 25mg and lost all the weight and still slept great. In fact I felt much better on the lower dose and slept deeper. I had nightmares and sleep paralysis at the higher dose. It also helped my anxiety without feeling groggy the day after. I even take a half of the 25mg to help soothe my anxiety. It’s been a game changer for me."

9 / 10
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318 Report
  • Insom...
  • Taken for 5 to 10 years
  • January 29, 2021

For Insomnia "I went on Seroquel 6 years ago because I mentioned to my psychiatrist on a visit that I wasn’t sleeping well. She prescribed 150 ER and it knocked me out at night. And reading the other reviews, I get what they are saying about the next day drowsiness. I’m now up to 300 mg ER but I have to take it 3 hours before I go to sleep so it times it out right. HOWEVER, even though I says it’s not addictive, I cannot sleep without it. I don’t want to be on sleeping medications forever. I’ve gone 5 days with no sleep when trying to quit. DO NOT TAKE! they are lying about it’s dependency!!"

1 / 10
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316 Report
  • Edano
  • Taken for 10 years or more
  • February 25, 2020

For Insomnia "I have been taking quitiapine for more than 15 years for bipolar but especially for insomnia. Lately my brain feels sick and tired and sometimes anxious all too often. I tried stop taking the quetiapine but it is absolutely impossible to sleep without it. I am taking 200mg which is necessary. I understand that l can go insane without adequate sleep. My doctor up till now has not given me a solution. Do you have any suggestions l could try as l am caught between a rock and a hard place."

10 / 10
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334 Report
  • Mrmeds
  • August 29, 2019

Seroquel (quetiapine) for Schizophrenia "This drug has really helped me with the voices and the paranoia. I have been on it for nearly 3 years. I have been on pretty much every antipsychotic there is and have been dealing with this illness for a long, long time. The downside is that you will gain weight. I have lost some of it by reducing calories and taking metformin. Walking seems to help too. If you do take this one, stay as active as you can to avoid diabetes because as my psychiatrist told me "It will happen eventually" Also, I adopted a vegatarian diet to help lower other risks with this one. The other downside is that it can make you very tired. I take 400mg at night and 75mg in the morning and another 75mg in the afternoon. I still hear voices and don't want to be around other people but it is much more manageable and I can at least have some kind of life. To be honest, I probably would have killed myself if it were not for this drug. I am surprised I even wrote this as I am a very paranoid person."

10 / 10
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363 Report
  • North...
  • Taken for 5 to 10 years
  • October 22, 2012

Seroquel (quetiapine) for Generalized Anxiety Disorder "This medicine is great for daytime anxiety or anxiety with insomnia. Doctors give way too much of this 300mg, 500mg, etc. to non-manic patients when much smaller dosages will work. I used a HALF TABLET (12.5mg) for sleep. Lately I used 1/4 tablet (one in morning and one in afternoon) to lower base anxiety level. You don't need to be knocked out to get relief from anxiety!"

8 / 10
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712 Report
  • Allis...
  • Taken for 5 to 10 years
  • February 2, 2021

For Insomnia "5 years on Trazodone, and quetiapine for sleep. 50mg-75...A month ago I decided to start the process, with my doctors approval, to decrease my dosage. 37.5mg 3 wks, 4 wks later 12mg 4wks later I'm done. Last night was the first night. Woke up early 1.5 hours earlier. And a little out of sort. But I know this will pass. The traz, I'm in 1/2 tab soon I'll be off of that. It can be done. Put tabs of melatonin in the pill holder or bottle instead. You have to get off this stuff. And you will."

1 / 10
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241 Report
  • Jacina
  • Taken for 2 to 5 years
  • February 14, 2021

For Insomnia "I’ve been taking quetiapine for over 3 years and it absolutely has helped me sleep. I began on a 25mg dosage, but self- reduced the pills to quarter dosage to ween myself off of these about 3 months into my prescription. What worries me is that if I forget to take my little 6.25mg portion of pill, then I wake up after 2 hours sleep each and every time, and after trying 3 or 4 days I become so tired I start using again. These work good, just too good."

8 / 10
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238 Report
  • SRano
  • Taken for 1 to 6 months
  • December 2, 2020

For Insomnia "After trying MANY sleep remedies (Natural and prescription) I tried seroquel as a last resort. This is the only thing that has worked for me!! I only take 12.5 mg and have no ill side effects. I am so very thankful my doctor suggested this. It helps turn off all the worry during the night so I can sleep 8-9 hours. A true miracle!"

10 / 10
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240 Report
  • Mere
  • Taken for 2 to 5 years
  • November 12, 2020

For Insomnia "I have been on Quetiapine for sleep for about 3 years. Started at a low dose but increased up to 200mg, which I have been on for about 2 years. I get sleepy about 20 minutes after my dose and can sleep a full 8 hours. It has been a complete game changer for me."

10 / 10
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235 Report
  • Rach
  • Taken for less than 1 month
  • August 25, 2020

For Insomnia "After quitting my 20 year marijuana habit, I developed insomnia and then I developed anxiety about the insomnia. 50 mg of Seroquel works for my insomnia every single night. I am so thankful for it. It usually takes 30 minutes to kick in. Been on it for 3 weeks."

10 / 10
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239 Report
  • A-non...
  • Taken for 2 to 5 years
  • October 13, 2019

Seroquel (quetiapine) for Bipolar Disorder "If you have Bipolar Disorder type II, please learn as much as you can about this condition from professional, reputable sources so you can make informed decisions about treatment and management options. This is a treatable, manageable illness, take hope in that. After 20+ years struggling to "cure" myself "naturally" & being miserable, dangerously depressed & dysfunctional, I finally decided to try psych medication. I found a doctor who SPECIALISES in this disorder and is up to date with the latest research findings in this specific condition. If you don't like your current GP or Psych's attitude, find someone else! I started a combo of Lamictal (AM & PM) & Seroquel (Only PM - makes you drowsy). I kept a daily mood diary & it took 3 months for my mood to fully stabilise. To help the bipolar depression, we added bupropion & N-Acetyl Cysteine, a supplement (all based on clinical research!). For 5 years now, I’ve had my life back. Deciding to take this medication saved my life."

7 / 10
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276 Report
  • Princ...
  • Taken for 2 to 5 years
  • October 15, 2019

For Generalized Anxiety Disorder "I have been diagnosed with GAD for 20 yrs. I have tried most antidepressants but I got more anxiety. Until 3 years ago my doctor prescribed quetiapine it helped me control my anxiety and panic disorder. I love this medication."

10 / 10
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271 Report
  • Devin
  • January 24, 2021

For Insomnia "I've been on it for a week and a half for insomnia. Taking 75 mg per night and helps with sleep but can often wake and not get back to sleep after only an hour. Have felt increased anxiety the next day which is worse than when I don't sleep at all. I haven't been diagnosed with any particular mental illness but would consider myself to have some form of PTSD. My thoughts are not normal and have increasingly intrusive thoughts and ruminations. Will be getting off this from today and hopefully on something that levels me out and helps me sleep. Strange how we all react so differently"

2 / 10
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207 Report
  • Sunfl...
  • November 19, 2019

For Generalized Anxiety Disorder "I first started this medication (quetiapine) about a week or so ago. The first two days on it I felt like a complete zombie - I didn't leave my bed for two days and did not eat a single thing. I started this medication on the weekend so I didn't feel weird while I was at work. Fast forward to Monday - I get into work and I could not concentrate as my brain felt foggy and reading my emails felt like the biggest struggle. After the day had passed I had noticed that I wasn't as anxious as I normally am. During the first full week on this I felt great. I wasn't anxious (if I was it was very minimal) and I wasn't angry for no apparent reason anymore. Now two weeks later - all of my symptoms are back and feel way worse. I wake up wit terrible anxiety - so bad that I contemplate calling into work because I'm not able to control my breathing. My mood swings are terrible, the smallest things trigger me and i just overall am feeling bad again. Has this happened to anyone else?"

5 / 10
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254 Report
  • Dad
  • Taken for 6 months to 1 year
  • January 17, 2021

For Insomnia "Got prescribed this for sleep after trazodone failed to help. It is VERY powerful at the 25mg dose for me. Please let your psych know if you have frequent or strong side effects to medicine before using. It knocks me out and keeps me asleep, but makes me VERY groggy in the morning, like I am hungover, and make me hungry while I'm getting drowsy. Be sure to go straight to bed after you take it to combat eating and risks of dizziness."

7 / 10
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194 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.