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User Reviews for Quetiapine

Also known as: Seroquel, Seroquel XR

Quetiapine has an average rating of 7.2 out of 10 from a total of 1,784 ratings on Drugs.com. 62% of those users who reviewed Quetiapine reported a positive effect, while 18% reported a negative effect.

Condition Avg. Rating Reviews Compare
Bipolar Disorder  
7.0
591 reviews 31 medications
Insomnia  Off-label
7.7
448 reviews 106 medications
Depression  
6.6
176 reviews 78 medications
Generalized Anxiety Disorder  Off-label
7.2
160 reviews 7 medications
Borderline Personality Disorder  Off-label
7.4
112 reviews 28 medications
Schizoaffective Disorder  
6.7
68 reviews 27 medications
Schizophrenia  
6.6
62 reviews 48 medications
Post Traumatic Stress Disorder  Off-label
8.0
57 reviews 5 medications
Major Depressive Disorder  
6.4
54 reviews 47 medications
Obsessive Compulsive Disorder  Off-label
8.7
38 reviews 11 medications
Paranoid Disorder  Off-label
6.7
14 reviews 5 medications
Intermittent Explosive Disorder  Off-label
10.0
2 reviews 5 medications
Tourette's Syndrome  Off-label
6.0
2 reviews 7 medications
Summary of Quetiapine reviews 7.2 1,784 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Quetiapine

RedWax · Taken for 1 to 6 months June 6, 2021

For Bipolar Disorder: “Took this to help with mania-related insomnia. Oh, it knocked me out alright--and kept me in a daze through the next day! Even when I took a low dose. I have no idea how people on doses >100 can function! In hindsight I don't think I should have even been driving on this drug. On the plus side, I did get PLENTY of shuteye whenever I'd take one. Unfortunately, I couldn't even take these during the week because I would make tons of mistakes at work. Plus, it didn't even really help my mania. It just made me manic and tired! Didn't work for me!”

6 / 10
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Sadness1972 · Taken for 1 to 6 months June 6, 2021

For Insomnia: “I have been taken the generic Seroquel for 3 months. I am up to a 50mg dose at night. It does make you have very vivid dreams, some scary life like, and I am a zombie most of the day. I get up maybe once and try to eat everything in the house too. Gaining weight!! I wonder if that will go away? Any thoughts on that? I do also take Klonopin, and Effexor for panic attacks and depression. My doctor put me on the Seroquel for a mood stabilizer and sleep too. My Mother took Seroquel XR for years. Her doctor took her off it because it made her a diabetic. She had a lot of trouble sleeping for months. I take the tablets only. Good luck to everyone.”

10 / 10
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Crod8309 · Taken for 1 to 6 months June 1, 2021

For Depression: “So I take for BPD and bipolar. Best med I've ever taken and tolerate it very well. It takes a few weeks to work like it should but you will feel some relief in about 5 days. you will sleep soundly and wake up rested it is a strong sedative. I feel that sleep relates to depression and anxiety. I have experienced zero weight gain I'm lucky I guess. You will wake up sedated but it goes away in about 30 min but I also take a stimulant, so that might be part of it, but I also wake up happy and ready for the day. The things that used to bother me no longer do with this med. It gave me my life back.”

10 / 10
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Baffled January 19, 2021

For Insomnia: “I have been prescribed 25mg quetiapine for sleep and am baffled as to how the people who are prescribed 100mg a day could remain conscious?? After being on this for 2 years I am still totally knocked out by one 25mg tablet. Most nights I take half a tab or less. I haven’t noticed any increased tolerance in the time I have been on it. Anyway can someone tell me, is my reaction abnormal? If not how do any of you on doses of 50,100, up to 800 stay awake.. once I take 25 mg, that’s it, I AM gonna sleep, like it or not. I have read that it is prescribed in doses up to 800mg for bi polar and thought omg if someone with bi polar was prescribed it at the doses I read (around 250mg) and they reacted like me.... they would literally be incapable of functioning... at all So I was just curious... if you have bi polar, does bi polar, by its nature, mean you have a much higher tolerance or different reaction? Or is my reaction to 25mg abnormal?”

10 / 10
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Bjorn · Taken for 2 to 5 years March 4, 2021

For Insomnia: “I've been taking 50mg seroquel to sleep for a couple years now. It works every night for me. Within 1/2hr of taking it I am asleep for 6 hours. I tried quitting and got no sleep for days before giving up and taking it again. It felt like without it I would never sleep again. Apparently I'm dependent on it to sleep. Oh well, a good night's sleep is worth it. It's a 10 rating for me (minus 1 because I can't get off it).”

9 / 10
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The Gid · Taken for 2 to 5 years January 15, 2021

For Insomnia: “I read in various places that Seroquel is not a sleep med; apparent doctors and the like claim that that is not its purpose. Yeah, we know that, but I can assure you it is a very effective sleeping pill at 100mg. I have been taking it for four years and it has failed me not once. I've taken Trazadone and Ambien in the past and I will say Seroquel is the best by far. I wake up completely refreshed, I have gained zero pounds and it helps tremendously with helping one fall asleep and stay asleep. Give it a try, that would be my recommendation. Best of luck to you.”

9 / 10
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Sleepy January 2, 2021

For Insomnia: “I was prescribed Quetiapine 25 mg for insomnia however I found out that it is really not a sleeping pill because it’s for depression, schizophrenia and anxiety. It have sedative side effects so I guess that’s why it was prescribed to me for sleep. This pill causes me to sleep half the day and feel like a zombie the other half of the day. I don’t know how anyone can take this and work or take care of any responsibilities. I told my dr. that I can’t take this, very disappointing that she prescribed this for me.”

1 / 10
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InsomniaLady · Taken for 5 to 10 years January 29, 2021

For Insomnia: “I went on Seroquel 6 years ago because I mentioned to my psychiatrist on a visit that I wasn’t sleeping well. She prescribed 150 ER and it knocked me out at night. And reading the other reviews, I get what they are saying about the next day drowsiness. I’m now up to 300 mg ER but I have to take it 3 hours before I go to sleep so it times it out right. HOWEVER, even though I says it’s not addictive, I cannot sleep without it. I don’t want to be on sleeping medications forever. I’ve gone 5 days with no sleep when trying to quit. DO NOT TAKE! they are lying about it’s dependency!!”

1 / 10
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anon · Taken for less than 1 month February 6, 2021

Seroquel (quetiapine) for Bipolar Disorder: “I thought writing this was important as there is so many negative reviews on here. I was so close to giving up and every single medication I put in my body would send me into a borderline psychosis. I had the prescription for Seroquel for awhile before I could convince myself to take it. I am so glad I did. Still adjusting the dosage so I am not 100% where I need to be, but a low dose of this has given me a sense of hope that I haven't felt in 7 months. I was so broken from Anxiety/adhd and I can finally see a light at the end of the tunnel from Seroquel. Felt effects within the first few days and still improving with dosage adjustments. Don't give up!!!!! xxx”

10 / 10
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Lilith · Taken for less than 1 month May 10, 2021

For Insomnia: “Quetiapine 25mg has literally changed my life. I’ve been a poor sleeper all my life but in the midst of menopause I’m lucky to get 3 hours a night and developed anxiety, depression and felt utterly lost. I have friends who are on large doses for bipolar features and tried 25 mgs for sleep and it worked. No daytime grogginess just sleep. I could only use it for sleep and happily my doc had no problem scripting off label for me. It’s only been a few days but I could cry with relief that I won’t spend 20 hours awake anymore. I’ve tried everything and this medication at this dose has changed my life.”

10 / 10
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YourFavoriteHeadache · Taken for 1 to 2 years February 10, 2021

For Insomnia: “This medication was prescribed after I tapered off of Klonopin and could not sleep. I had weight gain at first but only because the doctor had me taking 200mg. I tapered down to 25mg and lost all the weight and still slept great. In fact I felt much better on the lower dose and slept deeper. I had nightmares and sleep paralysis at the higher dose. It also helped my anxiety without feeling groggy the day after. I even take a half of the 25mg to help soothe my anxiety. It’s been a game changer for me.”

9 / 10
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Kpsan February 21, 2020

For Insomnia: “I have to start by stating every drug effects everyone differently and some respond positively to certain meds and others had horrible reviews. For me, this drug quetiapine literally saved my life. I was going on 3 weeks of no sleep from chronic stress. I was manic and could not sleep no matter what I tried. I took Xanax, over the counter antihistamines, downloaded meditation apps, etc. I was literally on the verge of the end of my life until my parents forced me to go to behavioral health hospital. At intake, I was in the worst shape of my life, lost so much weight and looked like a complete paranoid schizophrenic out of his mind. The psychiatrist told me that they were going to give me something to knock me out and I asked what. She said seroquel and I asked what kind of drug is that and she said an antipsychotic. I took 100 mg and sure enough, I finally got rest. It did take a while to get back to normal again, about a month but I really believe if I hadn’t been given this drug, it would have been the end of me”

10 / 10
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Ed · Taken for 10 years or more February 25, 2020

For Insomnia: “I have been taking quitiapine for more than 15 years for bipolar but especially for insomnia. Lately my brain feels sick and tired and sometimes anxious all too often. I tried stop taking the quetiapine but it is absolutely impossible to sleep without it. I am taking 200mg which is necessary. I understand that l can go insane without adequate sleep. My doctor up till now has not given me a solution. Do you have any suggestions l could try as l am caught between a rock and a hard place.”

10 / 10
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Rach · Taken for less than 1 month August 25, 2020

For Insomnia: “After quitting my 20 year marijuana habit, I developed insomnia and then I developed anxiety about the insomnia. 50 mg of Seroquel works for my insomnia every single night. I am so thankful for it. It usually takes 30 minutes to kick in. Been on it for 3 weeks.”

10 / 10
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josianne May 25, 2021

Seroquel XR (quetiapine) for Depression: “I am diagnosed with BPD, severe anxiety and depression. I've tried multiple antidepressant before, and none of them worked for me. My doctor prescribed me 50 mg of Seroquel XR, and I take it before going to sleep. I have now been taking it for 3 months, and it literally saved my life. I've experienced some side effects at first, but now that my body is used to the medication, I feel so much better. I can go out, see friends, and do a lot of things I couldn't even think about doing 2 months ago. In contrary to a lot of people, I didn't gain weight yet, I even lost some. It also helps my mood swings and my dissociation. The only negative thing I can think of is the tiredness. But, if I get out of bed right away, I'm good for the day. I can recommend to not take it too late, because it can make it hard to wake up in the morning. In conclusion, I think it's a great medication and even if you're scared to take it, just give it a try and let it time to start working.”

10 / 10
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Jacina · Taken for 2 to 5 years February 14, 2021

For Insomnia: “I’ve been taking quetiapine for over 3 years and it absolutely has helped me sleep. I began on a 25mg dosage, but self- reduced the pills to quarter dosage to ween myself off of these about 3 months into my prescription. What worries me is that if I forget to take my little 6.25mg portion of pill, then I wake up after 2 hours sleep each and every time, and after trying 3 or 4 days I become so tired I start using again. These work good, just too good.”

8 / 10
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Mere · Taken for 2 to 5 years November 12, 2020

For Insomnia: “I have been on Quetiapine for sleep for about 3 years. Started at a low dose but increased up to 200mg, which I have been on for about 2 years. I get sleepy about 20 minutes after my dose and can sleep a full 8 hours. It has been a complete game changer for me.”

10 / 10
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Princess · Taken for 2 to 5 years October 15, 2019

For Generalized Anxiety Disorder: “I have been diagnosed with GAD for 20 yrs. I have tried most antidepressants but I got more anxiety. Until 3 years ago my doctor prescribed quetiapine it helped me control my anxiety and panic disorder. I love this medication.”

10 / 10
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NR · Taken for 6 months to 1 year November 27, 2018

For Generalized Anxiety Disorder: “I am so thankful for this medication. After trying multiple SSRI and SNRIs with limited success, Seroquel bridged the gap. I have GAD and some depression; this medication took me from a place where I had taken a 3 month leave of absence from a successful career as an executive, to a place where I can function again in what remains a highly intense corporate environment. While Seroquel is a miracle drug for me, I am very thankful to Jesus for carrying me through this period - He's my true miracle.”

10 / 10
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Leathy · Taken for 1 to 6 months August 16, 2020

For Insomnia: “After years of chronic insomnia my GP prescribed 25mg of Quetiapine. It's been a miracle drug for me. Still walking in the night, but able to go back to sleep and get a full 8 hours. Godsend is all I can say :) Only weird thing is that I have a lot more vivid dreams - weird!”

9 / 10
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tiz4tggr · Taken for 1 to 6 months May 3, 2020

For Insomnia: “Up until my gastric sleeve surgery in 2012, sleep was never an issue for me. If anything, I slept too much. Fast forward to 2020 and for the last 8 years I have suffered horrible to mild insomnia and even on a good night I may get 5 hours of sleep. I have tried all the common sleeping scripts out there along with some pretty serious anti anxiety drugs which ended with pretty bad results (a week in the hospital). In February of this year I went in for my normal physical except my normal doctor had left the practice and the new doc, filling in for her, was the one I got to see. I explained all that I wrote above and she reviewed my chart. She asked if anyone had ever suggested Quetiapine, which they hadn't. I'm currently on day 61 of taking 50mg a night with 7-9 hours a night being the new norm. I'm so thankful this wonderful doctor came into my life. I'm not sure if any other doctor would have even considered this drug. So far no adverse side effects or weight gain. :)”

9 / 10
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Sarah · Taken for 1 to 6 months February 1, 2021

For Borderline Personality Disorder: “I’ve been taking 25mg of Quetiapine at night for a month. Was wary of the weight gain, however have not gained any weight. I do watch what I eat and walk for around 30mins-1hr everyday. I think it’s best to take it at night as it does make you very sleepy and do feel some slight hunger, so best to take at night to avoid urges to eat/over eat. In terms of mental health, it’s completed changed my life, I went from crying for hours a days by torturing myself with overthinking, to just finally being able to feel grounded and live my life like a ‘normal’ person. I haven’t changed and I’m not ‘doped’ out all the time as some people may imagine when someone takes a drug like this. I actually feel positive about my life and it’s allowed me to have some hope for overcoming BPD, or manage my symptoms. I would definitely recommend this drug, however I am aware people have different reactions, but for me it’s been very beneficial and I hope my review can help someone else too”

10 / 10
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alvey · Taken for less than 1 month August 21, 2020

For Insomnia: “So I was prescribed seroquel for insomnia and I was so scared to try it. I had the best night sleep I have had in probably 5 years. Downside is the side effects the next day were hard on me. My anxiety and depression is worse. So do I keep taking it and the side effects will subside or is this drug just not for me. Ugh its the only thing that has helped with sleep. Help”

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Anonymous · Taken for 10 years or more June 5, 2020

For Generalized Anxiety Disorder: “Whatever your condition, from my experience do not start taking this drug quetiapine. I speak from experience with bipolar, major depression, and anxiety. The side effects are far worse than any benefits. The only benefit I have found is some help with sleep, but even that is inconsistent and sometimes my overall sleep is much worse (fewer hours). It causes massive weight gain over time and dependency. Once you take it, you feel like you won't be able to sleep without it. I have been on it for years and have been unable to get off it, even though at this point I am on a low dose of 25 mg when I used to be on a high dose.”

1 / 10
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Devin January 24, 2021

For Insomnia: “I've been on it for a week and a half for insomnia. Taking 75 mg per night and helps with sleep but can often wake and not get back to sleep after only an hour. Have felt increased anxiety the next day which is worse than when I don't sleep at all. I haven't been diagnosed with any particular mental illness but would consider myself to have some form of PTSD. My thoughts are not normal and have increasingly intrusive thoughts and ruminations. Will be getting off this from today and hopefully on something that levels me out and helps me sleep. Strange how we all react so differently”

2 / 10
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Mrmeds August 29, 2019

Seroquel (quetiapine) for Schizophrenia: “This drug has really helped me with the voices and the paranoia. I have been on it for nearly 3 years. I have been on pretty much every antipsychotic there is and have been dealing with this illness for a long, long time. The downside is that you will gain weight. I have lost some of it by reducing calories and taking metformin. Walking seems to help too. If you do take this one, stay as active as you can to avoid diabetes because as my psychiatrist told me "It will happen eventually" Also, I adopted a vegatarian diet to help lower other risks with this one. The other downside is that it can make you very tired. I take 400mg at night and 75mg in the morning and another 75mg in the afternoon. I still hear voices and don't want to be around other people but it is much more manageable and I can at least have some kind of life. To be honest, I probably would have killed myself if it were not for this drug. I am surprised I even wrote this as I am a very paranoid person.”

10 / 10
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Molly · Taken for less than 1 month August 28, 2019

Seroquel (quetiapine) for Bipolar Disorder: “This medication has saved my life. I was having the worst episodes ever high low high low, no sleep, totally impulsive on the downward spiral to self destruction. Spending money running around town all hours, telling off people at work... then the crash. Sobbing in my doctor's office, she wrote the script for Seroquel. I had zero faith, because all the anti-depressants etc. she'd tried me on never worked to calm the chaos/PTSD reactivity in my head. I was ready to end it all. Thank goodness I filled the script and took it. I slept! That in itself is a miracle. I kept my job, and I'm hopefully on a journey to wellness. My mind is calmer. I can think one thing after another in a logical order instead of a cloud of white noise and traumatic memories flashing. I think with this med and some good PTSD therapy I might have a second chance... at life. I don't care if I gain a little weight... I want to live without constant chaos. So grateful.”

8 / 10
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Dad · Taken for 6 months to 1 year January 17, 2021

For Insomnia: “Got prescribed this for sleep after trazodone failed to help. It is VERY powerful at the 25mg dose for me. Please let your psych know if you have frequent or strong side effects to medicine before using. It knocks me out and keeps me asleep, but makes me VERY groggy in the morning, like I am hungover, and make me hungry while I'm getting drowsy. Be sure to go straight to bed after you take it to combat eating and risks of dizziness.”

7 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.