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User Reviews for Quetiapine to treat Bipolar Disorder

Also known as: Seroquel, Seroquel XR

Quetiapine has an average rating of 6.9 out of 10 from a total of 568 ratings for the treatment of Bipolar Disorder. 60% of users who reviewed this medication reported a positive effect, while 21% reported a negative effect.

Quetiapine Rating Summary

6.9/10 average rating

568 ratings from 597 user reviews.

Compare all 79 medications used in the treatment of Bipolar Disorder.

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Reviews for Quetiapine

anon · Taken for less than 1 month February 6, 2021

Seroquel (quetiapine): “I thought writing this was important as there is so many negative reviews on here. I was so close to giving up and every single medication I put in my body would send me into a borderline psychosis. I had the prescription for Seroquel for awhile before I could convince myself to take it. I am so glad I did. Still adjusting the dosage so I am not 100% where I need to be, but a low dose of this has given me a sense of hope that I haven't felt in 7 months. I was so broken from Anxiety/adhd and I can finally see a light at the end of the tunnel from Seroquel. Felt effects within the first few days and still improving with dosage adjustments. Don't give up!!!!! xxx”

10 / 10
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Molly · Taken for less than 1 month August 28, 2019

Seroquel (quetiapine): “This medication has saved my life. I was having the worst episodes ever high low high low, no sleep, totally impulsive on the downward spiral to self destruction. Spending money running around town all hours, telling off people at work... then the crash. Sobbing in my doctor's office, she wrote the script for Seroquel. I had zero faith, because all the anti-depressants etc. she'd tried me on never worked to calm the chaos/PTSD reactivity in my head. I was ready to end it all. Thank goodness I filled the script and took it. I slept! That in itself is a miracle. I kept my job, and I'm hopefully on a journey to wellness. My mind is calmer. I can think one thing after another in a logical order instead of a cloud of white noise and traumatic memories flashing. I think with this med and some good PTSD therapy I might have a second chance... at life. I don't care if I gain a little weight... I want to live without constant chaos. So grateful.”

8 / 10
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rhetthammond · Taken for 1 to 6 months June 23, 2021

Seroquel (quetiapine): “I have Chronic Insomnia, Mania from Bipolar Disorder Seroquel is effective for my insomnia and mania/mood swings. I take my 100mg dose of Seroquel at night at 9pm. I find that taking my dose at this time significantly reduces the groggy side effects in the morning allowing me to wake up feeling refreshed and well ready and with the energy I need to start my day. I also do not experience the Seroquel “munchies” that many report to experience. I am not a doctor or a practicer of health and medicine, therefore it is not my place to recommend others to take this. It is also not my place to tell others not to take it. For me it had a very beneficial effect on my life and functionality. My experience has been positive but it may not be for you. Also everyone take your meds as prescribed. If you don’t feel a benefit don’t stop it on your own terms. Express this to your doctor. They know more than you. Set alarms to make sure you take it consistently daily.”

9 / 10
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A-nonny-mouse · Taken for 2 to 5 years October 13, 2019

Seroquel (quetiapine): “If you have Bipolar Disorder type II, please learn as much as you can about this condition from professional, reputable sources so you can make informed decisions about treatment and management options. This is a treatable, manageable illness, take hope in that. After 20+ years struggling to "cure" myself "naturally" & being miserable, dangerously depressed & dysfunctional, I finally decided to try psych medication. I found a doctor who SPECIALISES in this disorder and is up to date with the latest research findings in this specific condition. If you don't like your current GP or Psych's attitude, find someone else! I started a combo of Lamictal (AM & PM) & Seroquel (Only PM - makes you drowsy). I kept a daily mood diary & it took 3 months for my mood to fully stabilise. To help the bipolar depression, we added bupropion & N-Acetyl Cysteine, a supplement (all based on clinical research!). For 5 years now, I’ve had my life back. Deciding to take this medication saved my life.”

7 / 10
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Chuck · Taken for less than 1 month November 28, 2019

Seroquel (quetiapine): “Seroquel is an excellent choice for stabilizing the mood and improving sleep in the context of a Bipolar disorder. I have Bipolar II mood disorder and recently experienced chronic sleeplessness and angry-agitated moods. The day of my medical appointment I became overtly angry in two separate social circumstances. These angry reactions are very hurtful to those who experience the triggered anger. Seroquel (an antipsychotic and mood stabilizer) calms down the CNS agitation, reduces negative thoughts and improves quality of sleep: very important for our overall health and well-being!”

8 / 10
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Maxed · Taken for 2 to 5 years September 4, 2019

Seroquel (quetiapine): “I have bipolar mania with stages of depression. It has been like this since I was very young. It comes along with episodes of mood swings. I am on 25 mg of Seroquel now and have been on both 50mg and 100 mg. 25 mg does great things for me. No more sleepless nights. No more intense spending sprees. No more major anxiety most of the time. A lot less depression and a lot less irritability I experienced as well. I get tired and a little unmotivated in the morning, but I have coffee and breakfast and I'm good. Weight gain is the other concerns but I have controlled it with walking good amounts each day. Well worth a try and definitely something to consider for a bipolar patient.”

8 / 10
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Debbie · Taken for 5 to 10 years July 8, 2021

Seroquel (quetiapine): “I was prescribed Seroquel for sleep and I was diagnosed with Bipolar II. At first I was prescribed a low dose, but still couldn't sleep, so now the dose is 200 mg at night. I also have ADHD, so take Adderall, along with the Seroquel. What I notice is this. If I go off Adderall, I get very depressed. I did some research on this phenomenon, and found out that Seroquel is a dopamine antagonist, which means that it actually suppresses dopamine in your brain. I also take 100 mg of Topamax twice daily as a mood stabilizer, and the combination of medications seem to work like magic. I don't gain weight at all. However, when I had some blood work done, my thyroid hormones were low, and also my blood sugars were very high, even though I am not overweight. I believe these are side effects from the Seroquel. I do not recommend Seroquel, unless absolutely necessary for sleep, because there are too many metabolic side effects.”

2 / 10
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Tayson · Taken for 1 to 6 months April 27, 2019

Seroquel (quetiapine): “I was put on Seroquel 4 months ago as before I was on it I had really bad, uncontrollable mood swings throughout the day. After about 3 months of really struggling I had a really bad depressive episode where I was convinced people at work were out to get me. My mind was racing extremely fast, I had a huge amount of anxiety, and was extremely stressed out combined with really low sinking depression. I had to spend 24 hours in a hospital and they put me on Seroquel and a few other medications. The Serooquel has completely saved my life, along with my support system. I had low sinking moods occasionally for about 2 months and had my dosage upped. Now I'm at 200mg every night and am about 90% stable. I was diagnosed Major Depression W/ Psychotic Features but since have been diagnosed with Bipolar II. If you're having mood swings or intense anxiety with an out of control racing mind please don't force yourself to push through it. Try seroquel and it might give you your life back like it did me.”

9 / 10
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k · Taken for 1 to 6 months July 26, 2019

Seroquel (quetiapine): “I have struggled with depression and anxiety for about 14 years (I am 27). The past 2 years have been the hardest, I have been suicidal every day and I had lost all hope. For about 10 months I have been on: lexapro for 3 months, then effexor for 3 months, and now pristiq for 4 months. I have also had regular talk therapy with a psychologist. About a month ago a psychiatrist prescribed seroquel 25mg as an add on to my pristiq. The past 4 weeks have been the best I have felt in many years. I feel much lighter (as in, the heaviness of depression has lifted), much more positive, I haven't been ruminating about the past. Seroquel has truly made a world of difference. I truly think its very possible I could have ended up a suicide eventually without it. It's only been 4 weeks, but hopefully the effects continue. It's worth a try if nothing else has worked.”

10 / 10
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Jenny · Taken for less than 1 month September 5, 2020

Seroquel (quetiapine): “I got very sick, and was put into the ICU for a very long time which caused ICU Delirium and Depression. I had been on Cymbalta, but they changed it to Seroquel. My friends who are nurses make jokes about how awesome Seroquel is for shutting patients up and making them comply. I felt awful on this drug. Leg spasms, drooling, worsened diabetes, etc. They didn't tell me that they'd put me on it. When someone finally told me, I demanded they take me off of it, and the drooling and spasms stopped almost immediately. And I was able to stay awake, and think more clearly. And able to participate in physical therapy. I didn't notice any mood improvements and in fact I was incredibly depressed, but being in the ICU is traumatic, and I had a machine breathing for me, and I was trying to process having almost died. I would recommend trying just about everything else first. I've told my doctors they're never putting me on it again.”

1 / 10
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Andrea · Taken for 10 years or more September 2, 2020

Seroquel (quetiapine): “I have Affective bipolar disorder and took Seroquel for 12 years started at 100mg , last 8 years 300mg night. I had psychotic suicidal depression. Yes it made me sleep well except towards end restless legs. It never stopped the depressions from recurring nor could I sleep with it during the bouts. A year ago a psych stopped it cold turkey or over 5 days. Instantly I developed tardive dyskinesia TD a debilitating progressive neurological condition . Very uncomfortable, painful and no, I would not recommend it. I am 63 having to start a new life, homebound, super self conscious of my face, avoid meeting people”

3 / 10
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Mick · Taken for less than 1 month January 24, 2020

Seroquel (quetiapine): “Thank you everyone for sharing your views. For those that Seroquel has helped, how many weeks did it take to feel relief from the agitation? I have been on this for a week and don't feel less agitated yet, only too drowsy to yell as much after I take it for a period.”

6 / 10
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EpGuy February 13, 2021

Seroquel (quetiapine): “Seroquel has been nothing short of a miracle for my depression, anxiety, sleep, and mood. I take 800 mg at night around 10 pm and it has helped me in ways I couldn’t have imagined. The side effect of weight gain has been significant but I’ll gladly take the trade of being fat.”

10 / 10
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Polarizer · Taken for 1 to 6 months January 3, 2020

Seroquel (quetiapine): “This drug absolutely did not work for me. Well the sleeping part worked.... I never slept so much in my life. Instead of waking up from 12 hours of sleep feeling well rested, I woke up angry and wanting to punch someone in the face. Sure I can have anger outbursts but only while on Seroquel did I want to punch someone. Started low at 25mg and my doctor kept increasing my dosage to 100.mg At 100mg, I would sleep 18 hours straight and my days and nights were blurred. The anger caused me great urges to drink alcohol, which is ironic because I don't even like alcohol. Eventually just stopped cold turkey and to this day I have never woken up as miserable as I was on Seroquel. Also I gained 60 pounds in a little over 2 months and had severe impotence. So definitely not for me.”

2 / 10
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Travis · Taken for 1 to 6 months February 19, 2020

Seroquel (quetiapine): “I have been on Seroquel off and on for three years. I have tried other meds for my Bipolar Disorder but nothing has worked better for me. I feel the only drawback is waking up in the morning with a cloudy head and dry mouth.”

9 / 10
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Zully May 2, 2020

Seroquel (quetiapine): “I can, now, see my own sign of mania or depression (having had Dialectical Behavioral therapy for six months). With that said, the meds are not miracles and after some dialectical treatment to add to my “tool box”... seroquel really helps. When I am restless, racing thoughts and moody I feel well balance after about 48-72 hours after using “coping skills” plus adding seroquel to prevent lack of sleep which induces worsening of thoughts, moods, eating, etc. For me, it’s very helpful to have self-relaxation skills to level my reactions. I give this medication, after months of skill work, A++. My experience is not to say it is 100% fluent to all bipolar sufferers. Good thing DBT is not a medication so won’t hurt to try it as a “tool”. The side-effects are mild. It does make me drowsy and sometimes do get oily face... yet, I can accept that over extended episodes. I also have to keep drinking lots of water as dry mouth is mild and do feel thirsty.”

10 / 10
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veronikanchad · Taken for 1 to 6 months August 27, 2019

Seroquel (quetiapine): “Started at 25mg felt groggy in am but it passed after a week then increased to 50mg. My moods are stable but I don't feel drugged up. At least I'm sleeping well now. At this dose it still lets me express emotions. Doesn't interfere with my daily activities at all. Just wish I'd taken it years ago.”

10 / 10
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SnoSpeaks · Taken for 5 to 10 years May 18, 2021

Seroquel (quetiapine): “I started off taking 25 mg of seroquel with lamictal, 450 mg of buproprion xl, risperidone and 9 mg of melatonin to aid the sleep effect of the seroquel. I slept great and gained no weight on it. I began having trouble falling asleep. My pdoc upped the dosage to 50 mg without changing anything else. At first, I was a little groggy in the morning. That went away, and now I sleep well every night, and for a little over 8 hours, which is normal for me. So I've had a very good experience with it.”

10 / 10
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AnnieFromAfrica August 30, 2013

Seroquel (quetiapine): “I too gained masses of weight taking Seroquel but lost it all (35lb) in 6 months by healthy eating & being AWARE of the pitfalls. Seroquel does not make you gain weight. Seroquel makes you crazy HUNGRY craving all the bad stuff - salt/sugar/fried food for me. The secret is to ANTICIPATE your munchies. Prepare a large but healthy snack in advance or save half your evening meal and have it at bedtime just before you take your meds. This really worked for me. Taking my meds on a full stomach took the cravings away.”

8 / 10
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El February 20, 2020

Seroquel (quetiapine): “I suffer from Bipolar II, take 200mg Lamictal daily, and was prescribed 25mg Seroquel to take at night to help me sleep during hypomanic episodes. My psychiatrist claimed it would calm the racing thoughts, help me fall asleep, and hopefully make me think more clearly during the day. After taking it, I would still be awake for a couple hours trying to sleep and still having racing thoughts. In the morning, I had the worst experiences trying to wake up. I wasn’t trying to wake up early or anything, like 11 on my free days so I could sleep in, and even then I could barely open my eyes enough to turn off my alarm and would immediately fall back asleep. After finally waking up, I felt groggy and disoriented throughout the day. I couldn’t think straight, and was unable to focus during my classes. Not a good experience. I only took it a few times, and decided it was only having negative effects so I stopped taking it.”

1 / 10
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Affinenine · Taken for less than 1 month January 14, 2020

Seroquel (quetiapine): “They don't call it the demon drug for nothing. I was prescribed 25 mg in the evening for extreme irritability and "insomnia" off label. I cut it in half because I'm relatively small at 115 pounds. Knocked me out like a light. Went up to 50 mg and became nauseous, saw stars, heart palpitations, and my body felt extremely heavy. Stopped taking immediately after. Please note that the mood stabilizing effect only kicks in at a minimum dosage of 100 mg. Anything under that is a sedative, like Benadryl on steroids with the added benefit of developing akinesia and metabolic syndrome. You WILL gain weight on this drug regardless of dosage. On the bright side, it'll get rid of your allergy sniffles.”

4 / 10
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iluzzion October 30, 2007

Seroquel (quetiapine): “After suffering all of my life with depression and then later in life (20-33) with severe anxiety, insomnia, and a general feeling of restlessness to the point I thought I was going to "crawl the walls", I was prescribed Seroquel. I quickly found out I had to take my dose at bedtime due to being so sleepy when I took it during the day. Seroquel has been the ONLY medicine that has worked for me to ease the symptoms of my Bipolar Disorder 1. A Big Thanks to Seroquel for making life easier for me!”

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Siri86 November 5, 2014

Seroquel (quetiapine): “Got diagnosed with bipolar disorder three months ago, and started on Seroquel 50 mg at night. It has helped me a lot, and I feel like a totally different person (in a good way - I've suffered for 10 years!). At first I just thought I was in a "normal" phase (not manic or depressive) - but the depressions usually sneaks up on me after a few weeks when I've felt normal before. Not had any side-effects, other than restless legs syndrome, but I've had that before, so it wasn't a biggie. This side-effect has also almost disappeared after a few months. Was so scared of weight gain, but I watched what I eat, and work out a lot, instead I've gotten skinnier and healthier. Thumbs up! I got my life back! ”

10 / 10
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Lindsay · Taken for 6 months to 1 year October 13, 2019

Seroquel (quetiapine): “I take a low dose of Seroquel and it is helpful as a sleeping pill. It can get rid of bad thoughts. I've experienced weight loss on it. It helps with increasing my appetite though. I can still drive well on this drug. Insurance covers this drug”

10 / 10
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ahtibat87 · Taken for 2 to 5 years November 5, 2013

Seroquel (quetiapine): “This is my 2nd time on seroquel and now that I actually know two shits about mental disorder, I really do like seroquel. I've always had a terrible time falling and staying asleep which it helps with greatly, and my ridiculous bipolar tendencies it puts to rest. I recommend seroquel if it works for you. I've never had a single negative side effect from it but some people do. Every brain is different :)”

10 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

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