Skip to main content

Lunesta Side Effects

Generic name: eszopiclone

Medically reviewed by Drugs.com. Last updated on Oct 11, 2021.

Note: This document contains side effect information about eszopiclone. Some of the dosage forms listed on this page may not apply to the brand name Lunesta.

Summary

Common side effects of Lunesta include: infection, drowsiness, and unpleasant taste. Other side effects include: nausea, dizziness, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eszopiclone: oral tablets

Warning

    Risk of Serious Injury and Death Resulting From Complex Sleep Behaviors
  • Serious injuries and/or death resulting from complex sleep behaviors (e.g., sleepwalking, sleep driving, and engaging in other activities while not fully awake) can occur following use of eszopiclone, zaleplon, and zolpidem.200

  • Complex sleep behaviors have occurred in patients with and without a history of such behaviors and can occur even at the lowest recommended doses and after just one dose of these drugs.200

  • Discontinue drug if a complex sleep behavior occurs.200 (See Risk of Serious Injury and Death Resulting From Complex Sleep Behaviors under Cautions.)

Side effects include:

Headache, dry mouth, dizziness, somnolence, nervousness, dyspepsia, nausea, infection, unpleasant taste.

For Healthcare Professionals

Applies to eszopiclone: oral tablet

General

The most commonly reported side effects included unpleasant taste, headache, somnolence, and infection.[Ref]

Nervous system

A dose-response relationship appears to exist for dizziness and unpleasant taste.

Headache was reported in 21% of non-elderly patients given 2 mg orally for 6 weeks, and in 17% of non-elderly adults given 3 mg orally for 6 weeks.

In patients 65 to 86 years of age, headache occurred in up to 15% of patients given 1 mg, and unpleasant taste occurred in up to 12% of patients given 2 mg orally for 2 weeks.

Dizziness and neuralgia commonly occurred in patients aged 65 years of age or older. Somnolence has also been reported in this patient population.[Ref]

Very common (10% or more): Unpleasant taste (up to 34%), headache (up to 21%)

Common (1% to 10%): Dizziness, migraine, neuralgia, somnolence

Uncommon (0.1% to 1%): Ataxia, decreased reflexes, difficulty concentrating, hypertonia, hypesthesia, incoordination, memory impairment, nystagmus, paresthesia, vertigo, vestibular disorder

Rare (less than 0.1%): Abnormal gait, hyperesthesia, hypokinesia, neuritis, neuropathy, stupor, tremor

Postmarketing reports: Dysosmia[Ref]

Psychiatric

A dose-response relationship appears to exist for confusion, decreased libido, and hallucinations.

Abnormal dreams and nervousness commonly occurred in patients aged 65 years of age or older.[Ref]

Common (1% to 10%): Abnormal dreams, anxiety, confusion, decreased libido, depression, hallucinations, nervousness

Uncommon (0.1% to 1%): Abnormal thinking, agitation, apathy, emotional lability, hostility, insomnia, neurosis,

Rare (less than 0.1%): Euphoria[Ref]

Gastrointestinal

A dose-response relationship appears to exist for dry mouth.

Diarrhea, dry mouth, and dyspepsia commonly occurred in patients aged 65 years of age or older. Abdominal pain and nausea have also been reported in this patient population.[Ref]

Common (1% to 10%): Diarrhea, dry mouth, dyspepsia, nausea, vomiting

Uncommon (0.1% to 1%): Halitosis, melena, mouth ulceration, ulcerative stomatitis

Rare (less than 0.1%): Colitis, dysphagia, gastritis, rectal hemorrhage, stomach ulcer, stomatitis, tongue edema

Frequency not reported: Abdominal pain[Ref]

Genitourinary

Common (1% to 10%): Dysmenorrhea, urinary tract infection

Uncommon (0.1% to 1%): Amenorrhea, breast engorgement, breast enlargement, breast pain, cystitis, dysuria, female lactation, hematuria, mastitis, menorrhagia, metrorrhagia, urinary frequency, urinary incontinence, uterine hemorrhage, vaginal hemorrhage, vaginitis

Rare (less than 0.1%): Urethritis[Ref]

Urinary tract infections commonly occurred in patients aged 65 years of age or older.[Ref]

Dermatologic

A dose-response relationship appears to exist for rash.

Pruritus commonly occurred in patients aged 65 years of age or older. Abdominal pain has also been reported in this patient population.[Ref]

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Acne, alopecia, cellulitis, contact dermatitis, dry skin, eczema, photosensitivity, skin discoloration, sweating, urticaria

Rare (less than 0.1%): Erythema multiforme, furunculosis, hirsutism, maculopapular rash, vesiculobullous rash[Ref]

Other

A dose-response relationship appears to exist for accidental injury and pain.

Accidental injury and pain commonly occurred in patients aged 65 years of age or older. Asthenia and pain have also been reported in this patient population.[Ref]

Common (1% to 10%): Accidental injury, pain

Uncommon (0.1% to 1%): Ear pain, face edema, fever, hernia, malaise, otitis externa, otitis media, tinnitus

Rare (less than 0.1%): Hyperacusis

Frequency not reported: Asthenia[Ref]

Cardiovascular

Common (1% to 10%): Chest pain, peripheral edema

Uncommon (0.1% to 1%): Heat stroke, hypertension

Rare (less than 0.1%): Thrombophlebitis[Ref]

Immunologic

A dose-response relationship appears to exist for infection.[Ref]

Common (1% to 10%): Infection, viral infection

Rare (less than 0.1%): Herpes zoster

Frequency not reported: Flu syndrome[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Allergic reaction[Ref]

Endocrine

Common (1% to 10%): Gynecomastia[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Arthritis, bursitis, joint disorder, joint pain, joint swelling, joint stiffness, leg cramps, myasthenia, neck rigidity, twitching

Rare (less than 0.1%): Arthrosis, myopathy

Frequency not reported: Back pain, myalgia[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia, hypercholesterolemia, increased appetite, thirst, weight gain, weight loss

Rare (less than 0.1%): Dehydration, gout, hyperlipemia, hypokalemia[Ref]

Respiratory

Uncommon (0.1% to 1%): Asthma, bronchitis, dyspnea, epistaxis, hiccup, laryngitis

Frequency not reported: Pharyngitis, rhinitis[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis, dry eyes

Rare (less than 0.1%): Iritis, mydriasis, photophobia, ptosis[Ref]

Renal

Uncommon (0.1% to 1%): Kidney calculus, kidney pain

Rare (less than 0.1%): Oliguria, pyelonephritis[Ref]

Hematologic

Uncommon (0.1% to 1%): Anemia, lymphadenopathy[Ref]

Hepatic

Uncommon (0.1% to 1%): Cholelithiasis

Rare (less than 0.1%): Hepatitis, hepatomegaly, liver damage[Ref]

Oncologic

Uncommon (0.1% to 1%): Breast neoplasm[Ref]

Frequently asked questions

References

1. "Product Information. Lunesta (eszopiclone)." Sepracor Inc (2004):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.