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Lunesta Side Effects

Generic Name: eszopiclone

Note: This document contains side effect information about eszopiclone. Some of the dosage forms listed on this page may not apply to the brand name Lunesta.

In Summary

Common side effects of Lunesta include: infection, drowsiness, and unpleasant taste. Other side effects include: nausea, dizziness, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eszopiclone: oral tablet

Along with its needed effects, eszopiclone (the active ingredient contained in Lunesta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eszopiclone:

More Common

  • Cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • sleepiness or unusual drowsiness

Less Common

  • Bladder pain
  • bloody or cloudy urine
  • cold flu-like symptoms
  • confusion
  • difficult, burning, or painful urination
  • discouragement
  • fear or nervousness
  • feeling sad or empty
  • frequent urge to urinate
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • nerve pain
  • seeing, hearing, or feeling things that are not there
  • tiredness
  • trouble concentrating
  • trouble sleeping

Some side effects of eszopiclone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Abnormal dreams
  • accidental injury
  • decreased interest in sexual intercourse
  • diarrhea
  • inability to have or keep an erection
  • pain, cramps, or heavy bleeding (females)
  • rash
  • swelling of the breasts or breast soreness (in both males and females)
  • vomiting

Incidence Not Known

  • Loss of memory
  • problems with memory

For Healthcare Professionals

Applies to eszopiclone: oral tablet

Nervous system

Very common (10% or more): Headache

Common (1% to 10%): Dizziness, migraine, somnolence

Uncommon (0.1% to 1%): Ataxia, decreased reflexes, hypesthesia, hypertonia, incoordination, memory impairment, neurosis, nystagmus, paresthesia

Rare (less than 0.1%): Abnormal gait, hyperesthesia, hypokinesia, neuritis, neuropathy, stupor, tremor

Postmarketing reports: Dysosmia[Ref]

A dose-response relationship appears to exist for the side effects of dizziness and unpleasant taste. In patients aged 65 years or older, headache and unpleasant taste have been very commonly reported and dizziness, nervousness, and neuralgia have been commonly reported. Somnolence has also been reported in this patient population.[Ref]

Psychiatric

A dose-response relationship appears to exist for the side effect of hallucinations. Abnormal dreams have been a commonly reported side effect in patients aged 65 years or older.[Ref]

Common (1% to 10%): Anxiety, confusion, depression, hallucinations, nervousness

Uncommon (0.1% to 1%): Abnormal thinking (mainly difficulty concentrating), agitation, apathy, emotional lability, hostility, insomnia

Rare (less than 0.1%): Euphoria

Frequency not reported: Abnormal dreams[Ref]

Hypersensitivity

Rare cases of angioedema involving the tongue, glottis, or larynx have been reported in patients after taking the first or subsequent does of eszopiclone (the active ingredient contained in Lunesta) and that required medical therapy in the emergency department. Some patients have had additional symptoms such as dyspnea, throat closing, or nausea and vomiting that suggest anaphylaxis. If angioedema involves the tongue, glottis or larynx, airway obstruction may occur and be fatal. Patients who develop angioedema after treatment with eszopiclone should not be rechallenged with the drug.[Ref]

Uncommon (0.1% to 1%): Allergic reaction, photosensitivity[Ref]

Cardiovascular

Common (1% to 10%): Peripheral edema

Uncommon (0.1% to 1%): Hypertension

Rare (less than 0.1%): Thrombophlebitis[Ref]

Dermatologic

Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Acne, alopecia, cellulitis, contact dermatitis, dry skin, eczema, skin discoloration, sweating, urticaria

Rare (less than 0.1%): Erythema multiforme, furunculosis, hirsutism, maculopapular rash, vesiculobullous rash

Frequency not reported: Angioedema[Ref]

A dose-response relationship appears to exist for the side effect of rash. Pruritus has been commonly reported in patients aged 65 years or older; rash has also been reported.[Ref]

Gastrointestinal

A dose-response relationship appears to exist for the side effect of dry mouth. In patients aged 65 years of age or older diarrhea, dry mouth, and dyspepsia have been commonly reported. Abdominal pain and nausea have also been reported in these patients.[Ref]

Very common (10% or more): Unpleasant taste

Common (1% to 10%): Dry mouth, dyspepsia, nausea, vomiting

Uncommon (0.1% to 1%): Cholelithiasis, halitosis, melena, mouth ulceration, thirst, ulcerative stomatitis

Rare (less than 0.1%): Colitis, dysphagia, gastritis, rectal hemorrhage, stomach ulcer, stomatitis, tongue edema

Frequency not reported: Diarrhea[Ref]

Genitourinary

Common (1% to 10%): Dysmenorrhea, gynecomastia, decreased libido

Uncommon (0.1% to 1%): Amenorrhea, breast engorgement, breast enlargement, breast neoplasm, breast pain, cystitis, dysuria, female lactation, hematuria, kidney calculus, kidney pain, mastitis, menorrhagia, metrorrhagia, urinary frequency, uterine hemorrhage, urinary incontinence, vaginal hemorrhage, vaginitis

Rare (less than 0.1%): Oliguria, pyelonephritis, urethritis[Ref]

Urinary tract infection has been commonly reported in patients aged 65 years or older.[Ref]

Hematologic

Uncommon (0.1% to 1%): Anemia, lymphadenopathy[Ref]

Hepatic

Rare (less than 0.1%): Hepatitis, hepatomegaly, liver damage[Ref]

Immunologic

A dose-response relationship appears to exist for the side effect of viral infection.[Ref]

Uncommon (0.1% to 1%): Viral infection

Rare (less than 0.1%): Herpes zoster

Frequency not reported: Flu syndrome[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia, hypercholesterolemia, increased appetite, weight gain, weight loss

Rare (less than 0.1%): Dehydration, gout, hyperlipemia, hypokalemia[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Arthritis, bursitis, joint disorder (mainly swelling, stiffness, and pain), leg cramps, myasthenia, neck rigidity, twitching

Rare (less than 0.1%): Arthrosis, myopathy

Frequency not reported: Back pain, myalgia[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis, dry eyes

Rare (less than 0.1%): Iritis, mydriasis, photophobia, ptosis[Ref]

Other

Common (1% to 10%): Chest pain

Uncommon (0.1% to 1%): Ear pain, face edema, fever, heat stroke, hernia, malaise, otitis externa, otitis media, tinnitus, vertigo, vestibular disorder

Rare (less than 0.1%): Hyperacusis

Frequency not reported: Accidental injury, pain[Ref]

In patients aged 65 years or older, pain and accidental injury have been commonly reported. Asthenia has also been reported in these patients.[Ref]

Respiratory

Common (1% to 10%): Respiratory infection

Uncommon (0.1% to 1%): Asthma, bronchitis, dyspnea, epistaxis, hiccup, laryngitis

Frequency not reported: Pharyngitis, rhinitis[Ref]

References

1. "Product Information. Lunesta (eszopiclone)." Sepracor Inc, Marlborough, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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