Lunesta Side Effects
Generic name: eszopiclone
Medically reviewed by Drugs.com. Last updated on June 5, 2020.
Note: This document contains side effect information about eszopiclone. Some of the dosage forms listed on this page may not apply to the brand name Lunesta.
Common side effects of Lunesta include: infection, drowsiness, and unpleasant taste. Other side effects include: nausea, dizziness, and xerostomia. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to eszopiclone: oral tablet
Oral route (Tablet)
Complex sleep behaviors including sleep-walking, sleep-driving, and engaging in other activities while not fully awake may occur following use of eszopiclone. Some of these events may result in serious injuries, including death. Discontinue eszopiclone immediately if a patient experiences a complex sleep behavior.
Side effects requiring immediate medical attention
Along with its needed effects, eszopiclone (the active ingredient contained in Lunesta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking eszopiclone:
- lower back or side pain
- painful or difficult urination
- sleepiness or unusual drowsiness
- Bladder pain
- bloody or cloudy urine
- fear or nervousness
- feeling sad or empty
- frequent urge to urinate
- general feeling of discomfort or illness
- joint pain
- lack of appetite
- loss of interest or pleasure
- muscle aches and pains
- nerve pain
- runny nose
- seeing, hearing, or feeling things that are not there
- sore throat
- trouble concentrating
- trouble sleeping
- unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur while taking eszopiclone:
Symptoms of overdose
- Change or loss of consciousness
- difficult or troubled breathing
- irregular, fast or slow, or shallow breathing
- pale or blue lips, fingernails, or skin
- sleepiness or unusual drowsiness
Side effects not requiring immediate medical attention
Some side effects of eszopiclone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Bad, unusual, or unpleasant (after) taste
- change in taste
- dry mouth
- stomach discomfort, upset, or pain
- Abnormal dreams
- accidental injury
- decreased interest in sexual intercourse
- inability to have or keep an erection
- pain, cramps, or heavy bleeding (females)
- swelling of the breasts or breast soreness (in both males and females)
Incidence not known
- Change in sense of smell
- loss of memory
- problems with memory
For Healthcare Professionals
Applies to eszopiclone: oral tablet
The most commonly reported side effects included unpleasant taste, headache, somnolence, and infection.[Ref]
A dose-response relationship appears to exist for dizziness and unpleasant taste.
Headache was reported in 21% of non-elderly patients given 2 mg orally for 6 weeks, and in 17% of non-elderly adults given 3 mg orally for 6 weeks.
In patients 65 to 86 years of age, headache occurred in up to 15% of patients given 1 mg, and unpleasant taste occurred in up to 12% of patients given 2 mg orally for 2 weeks.
Very common (10% or more): Unpleasant taste (up to 34%), headache (up to 21%)
Common (1% to 10%): Dizziness, migraine, neuralgia, somnolence
Uncommon (0.1% to 1%): Ataxia, decreased reflexes, difficulty concentrating, hypertonia, hypesthesia, incoordination, memory impairment, nystagmus, paresthesia, vertigo, vestibular disorder
Rare (less than 0.1%): Abnormal gait, hyperesthesia, hypokinesia, neuritis, neuropathy, stupor, tremor
Postmarketing reports: Dysosmia[Ref]
A dose-response relationship appears to exist for confusion, decreased libido, and hallucinations.
Abnormal dreams and nervousness commonly occurred in patients aged 65 years of age or older.[Ref]
Uncommon (0.1% to 1%): Abnormal thinking, agitation, apathy, emotional lability, hostility, insomnia, neurosis,
Rare (less than 0.1%): Euphoria[Ref]
A dose-response relationship appears to exist for dry mouth.
Common (1% to 10%): Diarrhea, dry mouth, dyspepsia, nausea, vomiting
Uncommon (0.1% to 1%): Halitosis, melena, mouth ulceration, ulcerative stomatitis
Frequency not reported: Abdominal pain[Ref]
Common (1% to 10%): Dysmenorrhea, urinary tract infection
Uncommon (0.1% to 1%): Amenorrhea, breast engorgement, breast enlargement, breast pain, cystitis, dysuria, female lactation, hematuria, mastitis, menorrhagia, metrorrhagia, urinary frequency, urinary incontinence, uterine hemorrhage, vaginal hemorrhage, vaginitis
Rare (less than 0.1%): Urethritis[Ref]
Urinary tract infections commonly occurred in patients aged 65 years of age or older.[Ref]
A dose-response relationship appears to exist for rash.
Common (1% to 10%): Pruritus, rash
A dose-response relationship appears to exist for accidental injury and pain.
Accidental injury and pain commonly occurred in patients aged 65 years of age or older. Asthenia and pain have also been reported in this patient population.[Ref]
Common (1% to 10%): Accidental injury, pain
Rare (less than 0.1%): Hyperacusis
Frequency not reported: Asthenia[Ref]
Common (1% to 10%): Chest pain, peripheral edema
Uncommon (0.1% to 1%): Heat stroke, hypertension
Rare (less than 0.1%): Thrombophlebitis[Ref]
A dose-response relationship appears to exist for infection.[Ref]
Common (1% to 10%): Infection, viral infection
Rare (less than 0.1%): Herpes zoster
Frequency not reported: Flu syndrome[Ref]
Uncommon (0.1% to 1%): Allergic reaction[Ref]
Common (1% to 10%): Gynecomastia[Ref]
Uncommon (0.1% to 1%): Arthritis, bursitis, joint disorder, joint pain, joint swelling, joint stiffness, leg cramps, myasthenia, neck rigidity, twitching
Rare (less than 0.1%): Arthrosis, myopathy
Uncommon (0.1% to 1%): Anorexia, hypercholesterolemia, increased appetite, thirst, weight gain, weight loss
Uncommon (0.1% to 1%): Conjunctivitis, dry eyes
Uncommon (0.1% to 1%): Kidney calculus, kidney pain
Rare (less than 0.1%): Oliguria, pyelonephritis[Ref]
Uncommon (0.1% to 1%): Cholelithiasis
Rare (less than 0.1%): Hepatitis, hepatomegaly, liver damage[Ref]
Uncommon (0.1% to 1%): Breast neoplasm[Ref]
1. "Product Information. Lunesta (eszopiclone)." Sepracor Inc, Marlborough, MA.
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Some side effects may not be reported. You may report them to the FDA.