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Restoril Side Effects

Generic name: temazepam

Medically reviewed by Last updated on Sep 27, 2022.

Note: This document contains side effect information about temazepam. Some dosage forms listed on this page may not apply to the brand name Restoril.

Applies to temazepam: oral capsule.


Oral route (Capsule)

Risks From Concomitant Use With Opioids; Abuse, Misuse, and Addiction; and Dependence and Withdrawal ReactionsConcomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.The use of benzodiazepines, including temazepam, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing temazepam and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction.The continued use of benzodiazepines, including temazepam, may lead to clinically significant physical dependence. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose. Abrupt discontinuation or rapid dosage reduction of temazepam after continued use may precipitate acute withdrawal reactions, which can be life-threatening. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue temazepam or reduce the dosage.

Serious side effects of Restoril

Along with its needed effects, temazepam (the active ingredient contained in Restoril) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking temazepam:

Less common


Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking temazepam:

Symptoms of overdose

Other side effects of Restoril

Some side effects of temazepam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common


For Healthcare Professionals

Applies to temazepam: oral capsule.


The most commonly reported side effects included drowsiness, headache, and fatigue.[Ref]

Nervous system

Lightheadedness, slurred speech, and unsteadiness usually occur at the start of treatment and disappear with repeated doses.[Ref]

Common (1% to 10%): Dizziness, drowsiness, hangover, headache, lethargy, sedation, vertigo

Uncommon (0.1% to 1%): Ataxia, equilibrium loss, faintness, muzziness, sciatica, taste loss, tremor

Rare (0.01% to 0.1%): Dysarthria

Frequency not reported: Amnesia, anterograde amnesia, coma, convulsions, daytime drowsiness, epileptic seizures, extrapyramidal symptoms, extremity tingling, horizontal nystagmus, hypersensitivity to light/noise/physical contact, impaired concentration, lightheadedness, numbness, oversedation, perceptual disturbances, reduced alertness, seizures, slurred speech, unsteadiness[Ref]


Common (1% to 10%): Anxiety, confusion, depression, euphoria, nervousness, nightmares

Uncommon (0.1% to 1%): Decreased orgasm, disorientation, increased dreaming, irritability, libido changes, unmasking of depression, vivid dreams

Rare (0.01% to 0.1%): Restless sleep

Frequency not reported: Abuse, aggressiveness/aggression, agitation, broken sleep (with vivid dreams), confusional states, delusion, depersonalization, dependence, derealization, disinhibition, excitement, extreme anxiety, hallucinations, hostility, inappropriate behavior, insomnia, mood changes, numbed emotions, other adverse behavioral effects, overstimulation, physical dependence, psychological dependence, psychoses, psychotic manifestations, rage, rebound insomnia, restlessness, sexual arousal, sleep disturbance, stimulation, suicidal attempt, suicidal ideation, tension, withdrawal effects/symptoms[Ref]

Dependence and numbed emotions usually occur at the start of treatment and disappear with repeated doses.[Ref]


Common (1% to 10%): Abdominal discomfort, diarrhea, dry mouth, nausea

Uncommon (0.1% to 1%): Gastrointestinal upset, vomiting

Rare (0.01% to 0.1%): Salivation changes

Frequency not reported: Abdominal cramps, constipation, gastrointestinal disturbances[Ref]


Common (1% to 10%): Fatigue, weakness

Uncommon (0.1% to 1%): Asthenia

Frequency not reported: Falls, hyperacusis, hypothermia, paradoxical reactions, rebound phenomenon, tinnitus[Ref]


Common (1% to 10%): Blurred vision

Uncommon (0.1% to 1%): Burning eyes

Rare (0.01% to 0.1%): Visual disturbances

Frequency not reported: Diplopia/double vision, photophobia[Ref]

Double vision usually occurs at the start of treatment and disappears with repeated doses.[Ref]


Uncommon (0.1% to 1%): Allergic skin reactions, hyperhidrosis, macular rash, pruritus

Rare (0.01% to 0.1%): Skin reactions

Frequency not reported: Alopecia, sweating[Ref]


Uncommon (0.1% to 1%): Increased neutrophils, leukocytosis

Rare (0.01% to 0.1%): Blood disorders, blood dyscrasias

Frequency not reported: Agranulocytosis, pancytopenia, thrombocytopenia[Ref]


Uncommon (0.1% to 1%): Increased AST, increased bilirubin

Rare (0.01% to 0.1%): Abnormal liver function, jaundice

Frequency not reported: Increased liver enzymes[Ref]


Uncommon (0.1% to 1%): Impotence, proteinuria

Rare (0.01% to 0.1%): Incontinence, urinary retention[Ref]


Uncommon (0.1% to 1%): Palpitations, tachycardia

Rare (0.01% to 0.1%): Hypotension

Frequency not reported: Lowering in blood pressure, mild systolic hypertension, orthostatic hypotension[Ref]


Uncommon (0.1% to 1%): Backache, leg cramps

Rare (0.01% to 0.1%): Impaired muscular function

Frequency not reported: Muscle pain, muscle weakness[Ref]

Muscle weakness usually occurs at the start of treatment and disappears with repeated doses.[Ref]


Respiratory depression usually occurs at the start of treatment and disappears with repeated doses.[Ref]

Uncommon (0.1% to 1%): Breathlessness, dyspnea

Frequency not reported: Apnea, respiratory depression, worsening of obstructive pulmonary disease, worsening of sleep apnea[Ref]


Uncommon (0.1% to 1%): Anorexia, increased serum alkaline phosphatase

Frequency not reported: Hyponatremia, loss of appetite[Ref]


Uncommon (0.1% to 1%): Increased blood urea nitrogen[Ref]


Rare (0.01% to 0.1%): Fatal anaphylaxis

Frequency not reported: Hypersensitivity reactions, severe anaphylactic reaction, severe anaphylactoid reaction[Ref]


Frequency not reported: Syndrome of inappropriate antidiuretic hormone secretion (SIADH)[Ref]


1. Product Information. Restoril (temazepam). Sandoz Pharmaceuticals Corporation. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.