Clonazepam Dosage

Usual Adult Dose for Seizure Prophylaxis

1.5 mg orally per day divided into 3 doses; this may be increased in increments of 0.5 mg to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase.
Maximum dose: 20 mg orally per day

Comments:
-The use of multiple anticonvulsants may result in an increase of depressant adverse effects.

Use:
-Alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures

Usual Adult Dose for Panic Disorder

Initial dose: 0.25 mg orally 2 times per day
Maintenance dose: 1 mg orally per day
Maximum dose: 4 mg orally per day

Comments:
-An increase to the target dose for most patients of 1 mg/day may be made after 3 days.
-The dose may be increased in increments of 0.125 mg to 0.25 mg 2 times per day every 3 days until panic disorder is controlled or until side effects make further increases undesired.
-Administration of one dose at bedtime may be desired, to reduce the inconvenience of somnolence.
-Treatment should be discontinued gradually, with a decrease of 0.125 mg 2 times per day every 3 days, until the drug is completely withdrawn.

Use:
-Treatment of panic disorder, with or without agoraphobia

Usual Pediatric Dose for Seizure Prophylaxis

Up to 10 years of age or 30 kg of body weight:
0.01 mg/kg/day to 0.05 mg/kg/day orally administered in 2 or 3 divided doses

10 years or older or 30 kg and over:
See adult dosing

Comments:
-Dosage should be increased by no more than 0.25 mg to 0.5 mg every third day until the daily maintenance dose has been reached, unless seizures are controlled or side effects preclude further increase.
-Whenever possible, the daily dose should be divided into three equal doses.
-If doses are not equally divided, the largest dose should be given before retiring.

Use:
-Alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures

Renal Dose Adjustments

-Impaired renal function: Use with caution

Liver Dose Adjustments

-Impaired hepatic function: Use with caution

Precautions

Safety and efficacy have not been established in patients with panic disorder younger than 18 years.

Safety and efficacy have not been established in patients with seizure disorder younger than 10 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-The tablets should be administered with water by swallowing the tablet whole.
-Orally disintegrating tablets: Immediately upon opening the blister, using dry hands, remove the tablet and place it in the mouth. Tablet disintegration occurs rapidly in saliva so it can be easily swallowed with or without water.

Storage requirements:
-Protect from light