Quazepam Side Effects
Medically reviewed by Drugs.com. Last updated on Apr 24, 2025.
Applies to quazepam: oral tablet.
Important warnings
This medicine can cause some serious health issues
Oral route (tablet)
Warning: Risks From Concomitant Use With Opioids; Abuse, Misuse, and Addiction; and Dependence and Withdrawal Reactions. Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.
Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate.
Limit dosages and durations to the minimum required.
Follow patients for signs and symptoms of respiratory depression and sedation.The use of benzodiazepines, including quazepam, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death.
Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes.
Before prescribing quazepam and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction.The continued use of benzodiazepines, including quazepam, may lead to clinically significant physical dependence.
The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose.
Abrupt discontinuation or rapid dosage reduction of quazepam after continued use may precipitate acute withdrawal reactions, which can be life-threatening.
To reduce the risk of withdrawal reactions, use a gradual taper to discontinue quazepam or reduce the dosage
Precautions
It is very important that your doctor check your progress at regular visits to see if the medicine is working properly and to check for any unwanted effects.
Tell your doctor if you are pregnant or planning to become pregnant. Using this medicine during the later pregnancy may cause problems in your newborn baby (eg, sedation or withdrawal symptoms). Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, feeding problems, a high-pitched cry, irritability, low muscle tone, restlessness, shakiness or tremors, sluggishness, trouble breathing, weight loss, vomiting, or fails to gain weight. If you think you have become pregnant while using the medicine, tell your doctor right away.
If your condition does not improve within 7 to 10 days, or if it becomes worse, check with your doctor.
Quazepam may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have itching, hives, hoarseness, nausea or vomiting, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth or throat while you are using this medicine.
This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, barbiturates or seizures medicine, muscle relaxants, or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you Stop taking quazepam. Check with your doctor before taking any of the above while you are using this medicine.
This medicine may cause some people, especially older persons, to become drowsy or less alert than they are normally, which may lead to falls. Even though quazepam is taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Do not stop using this medicine without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, including hallucinations, seizures, stomach or muscle cramps, tremors, or unusual behavior.
This medicine may cause you to do things while you are still asleep that you may not remember the next morning. It is possible you could drive a car, sleepwalk, have sex, make phone calls, or prepare and eat food while you are asleep or not fully awake. Tell your doctor right away if you learn that any of these has happened.
If you develop any unusual and strange thoughts or behavior while you are taking quazepam, be sure to discuss it with your doctor. Some changes that have occurred in people taking this medicine are like those seen in people who drink alcohol and then act in a manner that is not normal. Other changes may be more unusual and extreme, such as confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.
Symptoms of an overdose include: change in consciousness, changes in patterns and rhythms of speech, hallucinations, loss of consciousness, loss of strength or energy, mood or mental changes, muscle pain or weakness, nightmares, sleepiness or unusual drowsiness, shakiness and unsteady walk, slurred speech, trouble in speaking, trouble sleeping, unsteadiness, trembling, or other problems with muscle control or coordination, unusual drowsiness, dullness, tiredness, weakness or feeling of sluggishness, unusual excitement, nervousness, restlessness, or irritability, or unusual weak feeling. Call your doctor right away if you notice these symptoms.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of quazepam
Along with its needed effects, quazepam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking quazepam:
More common side effects
- drowsiness
Less common side effects
- dizziness
Rare side effects
- anxiety
- dry mouth
- hyperventilation
- increased muscle spasm
- irregular heartbeats
- irritability
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- nightmares
- restlessness
- shaking
- trouble breathing
- unusual excitement, nervousness, restlessness, or irritability
Incidence not known
- changes in patterns and rhythms of speech
- chills
- clay-colored stools
- dark urine
- decrease in frequency of urination
- decrease in urine volume
- difficulty in passing urine (dribbling)
- fever
- headache
- inability to move the eyes
- increased blinking or spasms of the eyelid
- itching or rash
- loss of appetite
- loss of bladder control
- nausea
- painful urination
- seizures
- shakiness in the legs, arms, hands, or feet
- slurred speech
- sticking out of the tongue
- stomach pain
- trembling or shaking of the hands or feet
- trouble in speaking or swallowing
- uncontrolled twisting movements of the neck, trunk, arms, or legs
- unpleasant breath odor
- unusual facial expressions
- unusual tiredness or weakness
- vomiting of blood
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking quazepam:
Symptoms of overdose
- agitation
- change in consciousness
- changes in patterns and rhythms of speech
- confusion
- loss of consciousness
- loss of strength or energy
- mood or mental changes
- nightmares
- shakiness and unsteady walk
- sleepiness or unusual drowsiness
- slurred speech
- talkativeness
- trouble speaking
- unsteadiness, trembling, or other problems with muscle control or coordination
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- unusual excitement, nervousness, restlessness, or irritability
- unusual weak feeling
Other side effects of quazepam
Some side effects of quazepam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- acid or sour stomach
- belching
- heartburn
- indigestion
- stomach discomfort or upset
Incidence not known
- decreased interest in sexual intercourse
- inability to have or keep an erection
- increase in sexual ability, desire, drive, or performance
- increased interest in sexual intercourse
- loss in sexual ability, desire, drive, or performance
- menstrual changes
- sweating
- vomiting
For healthcare professionals
Applies to quazepam: oral tablet.
General adverse events
The most frequently reported side effects included daytime drowsiness, headache, fatigue, dizziness, dry mouth, and dyspepsia.
Nervous system
- Very common (10% or more): Daytime drowsiness (up to 12%)
- Common (1% to 10%): Dizziness, fatigue, headache
- Frequency not reported: Central nervous system effects, next-day impairment[Ref]
Gastrointestinal
- Common (1% to 10%): Dry mouth, dyspepsia[Ref]
Psychiatric
- Frequency not reported: Abnormal thinking, behavior changes, benzodiazepine withdrawal syndrome, complex behaviors, worsening of depression
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References
1. (2001) "Product Information. Doral (quazepam)." Wallace Laboratories
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Further information
Quazepam side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.