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Medications for Nasal Congestion

Other names: Blocked Nose

Nasal congestion refers to a stuffy nose. In most cases, the nose becomes congested when the tissues lining it become swollen. The swelling is due to inflamed blood vessels.

Drugs used to treat Nasal Congestion

The following list of medications are in some way related to or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
pseudoephedrine 6.5 77 reviews
Rx/OTC N N

Generic name: pseudoephedrine systemic

Brand names:  Sudafed Congestion, Sudafed 12-Hour, SudoGest, Sudafed 24-Hour, Suphedrine, Chlor-Trimeton Nasal Decongestant, Cenafed, Children's Dimetapp Decongestant Infant, Contac Cold, Drixoral Decongestant Non-Drowsy, Genaphed, Nexafed Nasal Decongestant, Silfedrine, SudoGest 12 Hour, Suphedrin, Zephrex-D …show all

Drug class: decongestants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph

phenylephrine 6.3 18 reviews
Rx/OTC C N

Generic name: phenylephrine systemic

Brand names:  Sudafed PE Congestion, Neo-Synephrine, Contac-D, Nasop, Sudogest PE …show all

Drug class: vasopressors, decongestants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Sudafed Congestion 7.5 12 reviews
Rx/OTC N N

Generic name: pseudoephedrine systemic

Drug class: decongestants

For consumers: dosage, interactions, side effects

Afrin 3.1 124 reviews
OTC C N

Generic name: oxymetazoline nasal

Drug class: nasal antihistamines and decongestants

For consumers: dosage, interactions, side effects

Sudafed 12-Hour 6.5 4 reviews
Rx/OTC N N

Generic name: pseudoephedrine systemic

Drug class: decongestants

For consumers: dosage, interactions, side effects

oxymetazoline 4.5 210 reviews
OTC C N

Generic name: oxymetazoline nasal

Brand names:  Afrin, Afrin Original, Mucinex Sinus-Max Full Force, Zicam Extreme Congestion Relief, Zicam Sinus Relief, Afrin NoDrip Sinus, Afrin Severe Congestion, Afrin Sinus, Vicks Sinex 12-Hour Decongestant Nasal Spray, 12 Hour Nasal, 12 Hour Nasal Decongestant Spray, Allerest 12 Hour Nasal Spray, Dristan 12 Hour Nasal Spray, Duramist Plus, Duration, Four-Way Nasal Spray, Genasal, Mucinex Sinus-Max Clear & Cool, Mucinex Sinus-Max Moisture Smart, Nostrilla, Vicks QlearQuil 12 Hour Nasal Decongestant Moisturizing Spray, Vicks Sinex Moisturizing 12-Hour Decongestant UltraFine Mist, Vicks Sinex Severe Nasal Spray …show all

Drug class: nasal antihistamines and decongestants

For consumers: dosage, interactions, side effects

Claritin-D 6.4 50 reviews
OTC B N

Generic name: loratadine / pseudoephedrine systemic

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

Sudafed PE Congestion 10 1 review
OTC C N

Generic name: phenylephrine systemic

Drug class: decongestants

For consumers: dosage, interactions, side effects

Saline Nasal Mist 1.0 2 reviews
OTC C N

Generic name: sodium chloride nasal

Drug class: nasal lubricants and irrigations

For consumers: dosage, side effects

Loratadine-D 24 Hour 10 1 review
OTC B N

Generic name: loratadine / pseudoephedrine systemic

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

SudoGest 0.0 2 reviews
Rx/OTC N N

Generic name: pseudoephedrine systemic

Drug class: decongestants

For consumers: dosage, interactions, side effects

Claritin-D 24 Hour 6.0 6 reviews
OTC B N

Generic name: loratadine / pseudoephedrine systemic

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

Sudafed 24-Hour 5.0 6 reviews
Rx/OTC N N

Generic name: pseudoephedrine systemic

Drug class: decongestants

For consumers: dosage, interactions, side effects

Ayr Saline Nasal 4.0 23 reviews
OTC C N

Generic name: sodium chloride nasal

Drug class: nasal lubricants and irrigations

For consumers: dosage, side effects

loratadine / pseudoephedrine 6.6 70 reviews
OTC B N

Generic name: loratadine / pseudoephedrine systemic

Brand names:  Claritin-D, Loratadine-D 24 Hour, Claritin-D 24 Hour, Claritin-D 12 Hour, Alavert D-12 Hour Allergy and Sinus, Loratadine-D 12 Hour, Allergy & Congestion Relief, Clear-Atadine-D, Leader Allergy Relief D-24 …show all

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

phenylephrine 6.8 28 reviews
OTC C N

Generic name: phenylephrine nasal

Brand names:  4 Way Fast Acting Nasal Spray, Afrin 4 Hour Extra Moisturizing, Little Noses Decongestant, Nasal Four, Neo-Synephrine Nasal, Rhinall, Vicks Sinex Nasal Spray (old formulation) …show all

Drug class: nasal antihistamines and decongestants

For consumers: dosage, interactions, side effects

sodium chloride 4.3 70 reviews
OTC C N

Generic name: sodium chloride nasal

Brand names:  Saline Nasal Mist, Ayr Saline Nasal, Deep Sea Nasal Spray, Ocean, NeilMed Sinus Rinse Kit, Ayr Saline Nasal No-Drip Spray, 4 Way Saline, Afrin Saline, Altamist, Ayr Baby Saline, Ayr Sinus Rinse Kit, ENTsol, Little Noses, Neilmed Nasogel, Ocean Complete, Ocean Kids, Sea Soft …show all

Drug class: nasal lubricants and irrigations

For consumers: dosage, side effects

Neo-Synephrine Rate Add review
Rx/OTC C N

Generic name: phenylephrine systemic

Drug class: vasopressors, decongestants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Deep Sea Nasal Spray 8.0 1 review
OTC C N

Generic name: sodium chloride nasal

Drug class: nasal lubricants and irrigations

For consumers: dosage, side effects

epinephrine Rate Add review
Rx/OTC C N

Generic name: epinephrine topical

Drug class: miscellaneous topical agents, mouth and throat products

For consumers: dosage, interactions, side effects

Claritin-D 12 Hour 7.7 6 reviews
OTC B N

Generic name: loratadine / pseudoephedrine systemic

Drug class: upper respiratory combinations

For consumers: dosage, interactions, side effects

doxylamine 1.0 1 review
Rx/OTC B N X

Generic name: doxylamine systemic

Brand names:  Equaline Sleep Aid, Equate Sleep Aid

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph

Ocean 1.0 2 reviews
OTC C N

Generic name: sodium chloride nasal

Drug class: nasal lubricants and irrigations

For consumers: dosage, side effects

Suphedrine Rate Add review
Rx/OTC N N

Generic name: pseudoephedrine systemic

Drug class: decongestants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

xylometazoline 5.4 65 reviews
OTC C N

Generic name: xylometazoline nasal

Drug class: nasal antihistamines and decongestants

For consumers: dosage, interactions,

Alternative treatments for Nasal Congestion

The following products are considered to be alternative treatments or natural remedies for Nasal Congestion. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Nasal Congestion.

Learn more about Nasal Congestion

Care guides

Symptoms and treatments

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.