Phenylephrine Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 6, 2025.

Applies to phenylephrine: intravenous solution.

Precautions

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

This medicine may cause a permanent depression (necrosis) under the skin at the injection site. Tell your doctor right away if you notice any of these side effects at the injection site: depressed or indented skin, blue-green to black skin discoloration, or pain, redness, or sloughing (peeling) of the skin.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of phenylephrine

Along with its needed effects, phenylephrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking phenylephrine:

Get emergency help immediately if any of the following symptoms of overdose occur while taking phenylephrine:

Symptoms of overdose

• feeling of fullness in the head
• pounding or rapid pulse
• tingling in the arms or legs
• vomiting

Other side effects of phenylephrine

Some side effects of phenylephrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to phenylephrine: compounding powder, injectable solution, intravenous solution, oral disintegrating strip, oral liquid, oral suspension extended release, oral tablet, oral tablet chewable, oral tablet chewable extended release, oral tablet disintegrating.

Cardiovascular adverse events

• Frequency not reported: Bradycardia, AV block, ventricular extrasystoles, myocardial ischemia, hypertensive crisis^[Ref]

Nervous system

• Frequency not reported: Headache, paresthesia, tremor^[Ref]

Respiratory

• Frequency not reported: Pulmonary edema, rales^[Ref]

Psychiatric

• Frequency not reported: Nervousness, excitability^[Ref]

Gastrointestinal

• Frequency not reported: Nausea, vomiting^[Ref]

Local

• Frequency not reported: Extravasation^[Ref]

Hypersensitivity

• Frequency not reported: Sulfite sensitivity^[Ref]

Other

• Frequency not reported: Chest pain^[Ref]

Dermatologic

• Frequency not reported: Diaphoresis, pallor, piloerection, skin blanching, skin necrosis with extravasation^[Ref]

See also:

Frequently asked questions

• Phenylephrine vs Pseudoephedrine - How do they compare?
• Does Mucinex help with Covid?

Further information

Phenylephrine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer