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Phenylephrine Drug Interactions

A total of 339 drugs are known to interact with phenylephrine.

  • 57 major drug interactions
  • 279 moderate drug interactions
  • 3 minor drug interactions

Show all medications in the database that may interact with phenylephrine.

Check for interactions

Type in a drug name to check for interactions with phenylephrine.

Most frequently checked interactions

View interaction reports for phenylephrine and the medicines listed below.

  • Adderall (amphetamine / dextroamphetamine)
  • Advil (ibuprofen)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Amoxicot, Moxatag, DisperMox, Biomox, Wymox, Moxilin)
  • Aspirin Low Strength (aspirin)
  • Benadryl (diphenhydramine)
  • chlorpheniramine (Chlor-Trimeton, Chlorpheniramine (Allergy), Allergy Relief, Aller-Chlor, Pharbechlor, C.P.M., Wal-finate, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Teldrin HBP Allergy, Chlor-Mal, Chlo-Amine, Chlorphen, Chlor-Trimeton Allergy SR, PediaTan, ChlorTan, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit)
  • Claritin (loratadine)
  • codeine
  • Concerta (methylphenidate)
  • CoQ10 (ubiquinone)
  • Cymbalta (duloxetine)
  • Dextromethorphan HBr Adult Formula (dextromethorphan)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Benadryl Children's Allergy, Diphen, Sominex, Unisom SleepGels, Nytol, Simply Sleep, Diphedryl, Dicopanol, Diphenhist, Diphenadryl, Quenalin, 40 Winks, Hydramine, Diphenydramine Quick Melt, Dormin, Hydramine Cough Syrup, Diphen Cough, Calm-Aid, Sleep Tabs, Diphenyl, Pharbedryl, Histaprin, Tranquil Nighttime Sleep Aid, Unisom SleepMelts, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, Bydramine, Diphen AF, DPH, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep Tab II, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Z-Sleep, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • fexofenadine (Allegra, Allegra Allergy, Mucinex Allergy, Aller-Ease, Allegra ODT, Allegra Hives)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Motrin IB, Proprinal, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Motrin Childrens, Rufen, Ibuprofen PMR, Ibu-8, Motrin Pediatric, Menadol, Nuprin, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, NeoProfen, Ibu-Tab, Genpril, Haltran, IBU-200, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Claritin Reditabs, Wal-itin, Loratadine Reditab, Allergy Relief Tablets, Children's Claritin Allergy, Allergy Relief 24 Hour, Help I Have Allergies, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND)
  • Lyrica (pregabalin)
  • Mucinex (guaifenesin)
  • Paracetamol (acetaminophen)
  • pseudoephedrine (Sudafed Congestion, Sudafed 12-Hour, SudoGest, Entex, Sudafed 24-Hour, Sudafed Children's Nasal Decongestant, Contac Cold, Silfedrine, Children's Dimetapp Decongestant Infant, Chlor-Trimeton Nasal Decongestant, Nexafed Nasal Decongestant, nasofed, Suphedrin, Suphedrine, ElixSure Congestion, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • Singulair (montelukast)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zofran (ondansetron)
  • Zoloft (sertraline)
  • Zyrtec (cetirizine)

Phenylephrine disease interactions

There are 4 disease interactions with phenylephrine which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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