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Phenylephrine Drug Interactions

A total of 338 drugs are known to interact with phenylephrine.

  • 57 major drug interactions
  • 278 moderate drug interactions
  • 3 minor drug interactions

Show all medications in the database that may interact with phenylephrine.

Check for interactions

Type in a drug name to check for interactions with phenylephrine.

Most frequently checked interactions

View interaction reports for phenylephrine and the medicines listed below.

  • Adderall (amphetamine / dextroamphetamine)
  • Advil (ibuprofen)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Amoxicot, Moxatag, DisperMox, Moxilin, Wymox, Biomox)
  • Aspirin Low Strength (aspirin)
  • Benadryl (diphenhydramine)
  • chlorpheniramine (Chlor-Trimeton, Chlorpheniramine (Allergy), Allergy Relief, Aller-Chlor, Chlorphen, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, C.P.M., Chlor-Mal, Chlo-Amine, Chlor-Trimeton Allergy SR, PediaTan, Wal-finate, ChlorTan, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit)
  • Claritin (loratadine)
  • codeine
  • Concerta (methylphenidate)
  • Cymbalta (duloxetine)
  • Dextromethorphan HBr Adult Formula (dextromethorphan)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Unisom SleepGels, Sominex, Sleep Tabs, Benadryl Children's Allergy, Dicopanol, Diphen, Nytol, Simply Sleep, Diphenhist, Hydramine, Diphenydramine Quick Melt, Sleepwell 2-nite, Hydramine Cough Syrup, Bydramine, Diphedryl, DPH, Calm-Aid, Diphenadryl, Sleep Tab II, Diphenyl, Altaryl, Quenalin, Diphendryl, Sleep-ettes D, Dytan, Vanamine PD, Unisom SleepMelts, Dormin, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, 40 Winks, Diphen AF, Diphen Cough, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Pharbedryl, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • fexofenadine (Allegra, Allegra Allergy, Mucinex Allergy, Allegra ODT, Allegra Hives, Aller-Ease)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Loratadine Reditab, Allergy Relief Tablets, Allergy Relief 24 Hour, Claritin Reditabs, Wal-itin, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, Help I Have Allergies, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND, Children's Claritin Allergy)
  • Lyrica (pregabalin)
  • Mucinex (guaifenesin)
  • Paracetamol (acetaminophen)
  • pseudoephedrine (Sudafed Congestion, Sudafed 12-Hour, SudoGest, Entex, Sudafed Children's Nasal Decongestant, Silfedrine, Sudafed 24-Hour, Suphedrin, Suphedrine, Chlor-Trimeton Nasal Decongestant, Contac Cold, Drixoral Decongestant Non-Drowsy, Nexafed Nasal Decongestant, nasofed, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zofran (ondansetron)
  • Zoloft (sertraline)
  • Zyrtec (cetirizine)

Phenylephrine disease interactions

There are 4 disease interactions with phenylephrine which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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