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Doxylamine Drug Interactions

A total of 670 drugs are known to interact with doxylamine.

  • 37 major drug interactions
  • 632 moderate drug interactions
  • 1 minor drug interaction

Show all medications in the database that may interact with doxylamine.

Check for interactions with doxylamine

Type in a drug name and select a drug from the list.

Common medications checked in combination with doxylamine

  • Adderall (amphetamine / dextroamphetamine)
  • Ambien (zolpidem)
  • Aspirin Low Strength (aspirin)
  • azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
  • Benadryl (diphenhydramine)
  • Claritin (loratadine)
  • codeine
  • CoQ10 (ubiquinone)
  • Cymbalta (duloxetine)
  • Dextromethorphan HBr Adult Formula (dextromethorphan)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Diphenhist, Diphen, Unisom SleepGels, Sleep, Diphen Cough, Hydramine, Benadryl Children's Allergy, Sominex, Diphenadryl, Dicopanol, Diphedryl, Diphenydramine Quick Melt, Nytol, Buckley's Bedtime, 40 Winks, DPH, Q-Dryl, Sleep-Eze-3, Valu-Dryl, Diphenyl, Beldin, Vicks QlearQuil Nighttime Allergy Relief, Sleep-ettes, Allermax, Diphendryl, Q-Dryl A/F, Histaprin, Tranquil Nighttime Sleep Aid, Dormin, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen AF, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Aller-G-Time, Sleep Tab II, Sleep Tabs, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Belix, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Quenalin, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Pharbedryl, Z-Sleep, Unisom SleepMelts, PediaCare Children's Allergy, Truxadryl, Simply Sleep, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • guaifenesin (Mucinex, Tussin, Robafen, Robitussin Chest Congestion, Humibid, Guaifenesin LA, Guaiatussin, Guiatuss, Siltussin, Guaifenex LA, Tussin Expectorant, Fenesin, Guaifenex G, Mucus Relief, Organ-1 NR, Liquibid, Breonesin, GG 200 NR, Glytuss, Mytussin, Q-Tussin, Sorbutuss, Robitussin Mucus + Chest Congestion, Diabetic Tuss, Balminil Expectorant, Xpect, Strepsils Chesty Cough, Kenkay Chesty Cough Eexpectorant, Liquituss GG, Siltussin DAS, Organidin NR, Benadryl Chesty Forte, G Bid, Touro EX, Pneumomist, Ganidin NR, Iofen-NF, Humibid Pediatric, Iodrol NR, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Q-Bid LA, Amibid LA, Mucobid-LA, Fenex-LA, Muco-Fen LA, Muco-Fen 800, Scot-Tussin Expectorant, Humavent LA, Guiacough, Lotussin, Altarussin, Anti-Tuss, Diabetic Expectorant, Allfen Jr, Genatuss, Halotussin, Mastussin, Ri-Tussin, Robichem, Siltuss DAS, T-Tussin, Tusscidin, Gua-SR, Humigen LA, Sinumist, Altorant, Duratuss G, Naldecon-EX Senior, Phanasin, Iophen NR, GG-Cen, Muco-Fen 1200, Liquidbid LA, Liquidbid 1200, Benylin E, Calmylin Expectorant, Guiadrine G-1200, Siltussin DAS-NA, Iofen, Muco-Fen, Drituss G, Beechams Veno's for Kids Chesty Cough, Junior Meltus Colour and Sugar Free Expectorant, Help I Have Chest Congestion, Tixylix Chesty Cough, Bidex-400, Humibid E, Fenesin IR, Hill's Balsam Chesty Cough, Jackson's Extra Strength All Fours, Junior Meltus Chesty Coughs with Catarrh, Liqufruta Garlic Cough Medicine, Family Meltus Chesty Coughs, Jackson's The Original All Fours, Beechams Veno's Expectorant, Lemsip Cough Chesty, Respa-GF, Nirolex Chesty Cough, Dristan Chesty Cough, Nyal Chesty Cough, Pharmacist Expectorant, Dristan Chesty Cough Guaiphenesin, Mucinex for Kids, Guaifen NR, Buckley's Chest Congestion, Lloydspharmacy Expectorant Adult Cough, Lloydspharmacy Expectorant Junior Cough, TabTussin 400, Diabetic Tussin Mucus Relief, Refenesen Chest Congestion Relief, Bronchoril, Hytuss, Actifed CC Chesty Cough, Mucaplex, Tussin Mucus + Chest Congestion, Air Power, Mucinex Maximum Strength)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Advil Infant's Concentrated Drops, Children's Motrin, Advil Children's, Ibu-8, Ibuprofen PMR, Caldolor, Motrin Childrens, Motrin Migraine Pain, Addaprin, Ibu-4, Ibu-Tab, Rufen, Midol IB, A-G Profen, Childrens Ibuprofen Berry, Advil Migraine, Ibu-6, Motrin Infant Drops, NeoProfen, Genpril, Haltran, Menadol, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Lexapro (escitalopram)
  • Lyrica (pregabalin)
  • melatonin (Melatonin Time Release, Bio-Melatonin, Health Aid Melatonin, SGard, VesPro Melatonin)
  • mirtazapine (Remeron, Remeron SolTab)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, Flanax Pain Reliever, EC-Naprosyn, Leader Naproxen Sodium, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • Nexium (esomeprazole)
  • Paracetamol (acetaminophen)
  • paroxetine (Paxil, Paxil CR, Brisdelle, Pexeva)
  • prednisone (Deltasone, Rayos, Sterapred DS, Sterapred, Prednicot, Meticorten, Liquid Pred, Orasone, Prednicen-M)
  • pseudoephedrine (Sudafed Congestion, SudoGest, Sudafed 12-Hour, Entex, Efidac, Silfedrine, Suphedrine, Chlor-Trimeton Nasal Decongestant, Nexafed Nasal Decongestant, nasofed, Suphedrin, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Sudafed Children's Nasal Decongestant, Decofed Liquid, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Sudafed 24-Hour, Contac Cold, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • pyridoxine (Vitamin B6, Aminoxin, Nestrex, Vitelle Nestrex)
  • sertraline (Zoloft)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramedo, GenRx Tramadol, ConZip, Zydol, Ryzolt, Larapam SR, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Rybix, Ultram ODT)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin B6 (pyridoxine)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zoloft (sertraline)
  • zolpidem (Ambien, Ambien CR, Zolpimist, Intermezzo, Edluar)
  • Zyrtec (cetirizine)

doxylamine alcohol/food Interactions

There is 1 alcohol/food interaction with doxylamine

doxylamine disease Interactions

There are 8 disease interactions with doxylamine which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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