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Doxylamine Drug Interactions

A total of 675 drugs are known to interact with doxylamine.

  • 37 major drug interactions
  • 637 moderate drug interactions
  • 1 minor drug interaction

Show all medications in the database that may interact with doxylamine.

Check for interactions

Type in a drug name to check for interactions with doxylamine.

Most frequently checked interactions

View interaction reports for doxylamine and the medicines listed below.

  • Adderall (amphetamine / dextroamphetamine)
  • Ambien (zolpidem)
  • Aspirin Low Strength (aspirin)
  • azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
  • Benadryl (diphenhydramine)
  • Claritin (loratadine)
  • codeine
  • CoQ10 (ubiquinone)
  • Cymbalta (duloxetine)
  • Dextromethorphan HBr Adult Formula (dextromethorphan)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Benadryl Children's Allergy, Diphen, Sominex, Unisom SleepGels, Nytol, Simply Sleep, Diphedryl, Dicopanol, Diphenhist, Diphenadryl, Quenalin, 40 Winks, Hydramine, Diphenydramine Quick Melt, Dormin, Hydramine Cough Syrup, Diphen Cough, Calm-Aid, Sleep Tabs, Diphenyl, Pharbedryl, Histaprin, Tranquil Nighttime Sleep Aid, Unisom SleepMelts, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, Bydramine, Diphen AF, DPH, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep Tab II, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Z-Sleep, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flexeril (cyclobenzaprine)
  • Flonase (fluticasone nasal)
  • guaifenesin (Mucinex, Robafen, Robitussin Chest Congestion, Tussin, Humibid, Tussin Expectorant, Guiatuss, Guaiatussin, Q-Tussin, Sorbutuss, Mucus Relief, Dristan Chesty Cough Guaiphenesin, Diabetic Tussin Mucus Relief, Altarussin, Siltussin, Benylin E, Mucinex Maximum Strength, Scot-Tussin Expectorant, Guaifenesin LA, Lotussin, Robitussin Mucus + Chest Congestion, Guaifenex G, Balminil Expectorant, Mucinex for Kids, Liquituss GG, Refenesen Chest Congestion Relief, Organidin NR, Benadryl Chesty Forte, G Bid, Touro EX, Pneumomist, Ganidin NR, Iofen-NF, Humibid Pediatric, Organ-1 NR, Iodrol NR, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Q-Bid LA, Amibid LA, Mucobid-LA, Guaifenex LA, Fenex-LA, Fenesin, Muco-Fen LA, Liquibid, Muco-Fen 800, Breonesin, Humavent LA, Guiacough, GG 200 NR, Glytuss, Anti-Tuss, Diabetic Expectorant, Allfen Jr, Genatuss, Halotussin, Mastussin, Mytussin, Ri-Tussin, Robichem, Siltuss DAS, T-Tussin, Tusscidin, Gua-SR, Humigen LA, Sinumist, Altorant, Duratuss G, Diabetic Tuss, Naldecon-EX Senior, Phanasin, Iophen NR, GG-Cen, Muco-Fen 1200, Liquidbid LA, Liquidbid 1200, Calmylin Expectorant, Guiadrine G-1200, Siltussin DAS-NA, Iofen, Muco-Fen, Drituss G, Beechams Veno's for Kids Chesty Cough, Junior Meltus Colour and Sugar Free Expectorant, Help I Have Chest Congestion, Tixylix Chesty Cough, Xpect, Bidex-400, Humibid E, Fenesin IR, Hill's Balsam Chesty Cough, Jackson's Extra Strength All Fours, Junior Meltus Chesty Coughs with Catarrh, Liqufruta Garlic Cough Medicine, Family Meltus Chesty Coughs, Jackson's The Original All Fours, Beechams Veno's Expectorant, Lemsip Cough Chesty, Respa-GF, Nirolex Chesty Cough, Dristan Chesty Cough, Nyal Chesty Cough, Strepsils Chesty Cough, Kenkay Chesty Cough Eexpectorant, Pharmacist Expectorant, Guaifen NR, Buckley's Chest Congestion, Lloydspharmacy Expectorant Adult Cough, Lloydspharmacy Expectorant Junior Cough, TabTussin 400, Siltussin DAS, Bronchoril, Hytuss, Actifed CC Chesty Cough, Mucaplex, Tussin Mucus + Chest Congestion, Air Power)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Motrin IB, Proprinal, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Motrin Childrens, Rufen, Ibuprofen PMR, Ibu-8, Motrin Pediatric, Menadol, Nuprin, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, NeoProfen, Ibu-Tab, Genpril, Haltran, IBU-200, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lyrica (pregabalin)
  • melatonin (Melatonin Time Release, SGard, Bio-Melatonin, Health Aid Melatonin, VesPro Melatonin)
  • mirtazapine (Remeron, Remeron SolTab)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, EC-Naprosyn, Midol Extended Relief, Flanax Pain Reliever, Aflaxen, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • Nexium (esomeprazole)
  • Paracetamol (acetaminophen)
  • paroxetine (Paxil, Paxil CR, Brisdelle, Pexeva)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Meticorten, Sterapred DS, Liquid Pred, Orasone, Prednicen-M)
  • pseudoephedrine (Sudafed Congestion, Sudafed 12-Hour, SudoGest, Entex, Sudafed 24-Hour, Sudafed Children's Nasal Decongestant, Contac Cold, Silfedrine, Children's Dimetapp Decongestant Infant, Chlor-Trimeton Nasal Decongestant, Nexafed Nasal Decongestant, nasofed, Suphedrin, Suphedrine, ElixSure Congestion, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • pyridoxine (Vitamin B6, Aminoxin, Nestrex, Vitelle Nestrex)
  • sertraline (Zoloft)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Zydol, Tramahexal, Ryzolt, Tramal SR, ConZip, Larapam SR, GenRx Tramadol, Tramedo, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin B6 (pyridoxine)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zoloft (sertraline)
  • zolpidem (Ambien, Ambien CR, Zolpimist, Intermezzo, Edluar)
  • Zyrtec (cetirizine)

Doxylamine alcohol/food interactions

There is 1 alcohol/food interaction with doxylamine

Doxylamine disease interactions

There are 8 disease interactions with doxylamine which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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