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Doxylamine use while Breastfeeding

Medically reviewed by Last updated on Sep 21, 2023.

Drugs containing Doxylamine: Vicks NyQuil Cold & Flu Nighttime Relief, Sleep Aid, Diclegis, Unisom SleepTabs, Vicks NyQuil Severe Cold & Flu, Bonjesta, Robitussin Nighttime Cough DM, Vicks Nyquil Cough, Alka-Seltzer Plus Severe Cold & Flu Day & Night (Night Formula), Vicks Nyquil D Cold and Flu Nighttime Relief, Show all 70 »Vicks Nyquil Cough DM + Congestion, Night Time Cold & Flu, Equate Sleep Aid, Coricidin HBP Nighttime Multi-Symptom Cold, Tylenol Sinus NightTime, Poly Hist Forte, Tylenol Cold Multi-Symptom Nighttime Liquid, Tylenol Severe Cold & Flu Night Time, Alka-Seltzer Plus Severe Cold Powerfast Fizz Day and Night, Robitussin Nighttime Cough DM Maximum Strength, Nighttime Sleepaid, Robitussin Peak Cold Nighttime Cold + Flu, Contac Cold + Flu (Night) Cooling Relief Liquid, Delsym Night Time Cough & Cold, Robitussin Cold + Flu (Nighttime), Vicks Nature Fusion Cold & Flu Nighttime Relief, Tylenol Cold & Cough Nighttime, Multi Symptom NiteTime, Night Time Multi Symptom Cold/Flu Relief, Alka-Seltzer Plus Severe Cold+Cough Night Liquid, Tylenol Cough & Sore Throat Nightime, Vicks NyQuil HBP Cold & Flu, Clear Cough PM Multi-Symptom, Mucinex Fast-Max Day & Night, Mucinex Sinus-Max Day & Night, DayQuil/NyQuil Severe Cold and Flu, Mucinex Fast-Max Day Severe Cold and Night Cold & Flu, Delsym Night Time Multi-Symptom, Alka-Seltzer Plus Night Cold Formula Liquid, Alka-Seltzer Plus Multi-Symptom Cold & Flu (Night Formula), Alka-Seltzer Plus Severe Sinus Congestion & Cough (Night Formula), Mucinex Fast-Max Night Time Cold & Flu Liquid Gels, Alka-Seltzer Plus Severe Sinus Congestion, Allergy & Cough Liquid Gels, Alka-Seltzer Plus Maximum Strength Night Cold & Flu Liquid Gels, Alka-Seltzer Plus Maximum Strength Day & Night Cold & Flu Liquid Gels (Night Formula), Alka-Seltzer Plus Multi-Symptom Cold & Flu Day & Night Liquid Gels (Night Formula), Alka-Seltzer Plus Night Severe Cold+Flu Hot Drink Mix, All-Nite Cold, Multi-Symptom Nighttime, NyCair, All-Nite Multi-Symptom Cold/Flu Relief, Vicks QlearQuil Nighttime Sinus & Congestion, Alka-Seltzer Plus Severe Allergy Sinus Congestion & Headache, Vicks Sinex Nighttime, Tylenol Sinus Day/Night Convenience Pack, Alka-Seltzer Plus Day & Night Cold Formula (Night Cold), Alka-Seltzer Plus Cold Powerfast Fizz Night, Alka-Seltzer Plus Night Cold Formula Effervescent Tablets, Nighttime Cough, Safetussin PM, Lortuss DM, Fast Sleep, Care One Sleep Aid, Doxytex, Aldex AN Chewable, Aldex AN, Nytol Maximum Strength, Equaline Sleep Aid, Medi-Sleep, Lortuss LQ

Doxylamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small occasional doses of doxylamine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information on doxylamine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2,3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.


Ito S, Blajchman A, Stephenson M, et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393–9. [PubMed: 8498418]
Messinis IE, Souvatzoglou A, Fais N, et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143–6. [PubMed: 3928731]
Pontiroli AE, De Castro e Silva E, Mazzoleni F, et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: Sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924–8. [PubMed: 7228996]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding




Gastrointestinal Agents

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Further information

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