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Nortriptyline User Reviews & Ratings

Brand names: Pamelor

Nortriptyline has an average rating of 7.3 out of 10 from a total of 542 reviews on Drugs.com. 68% of reviewers reported a positive experience, while 20% reported a negative experience.

Condition Avg. Rating Reviews Compare
Migraine Prevention  Off-label
7.7
207 reviews for Migraine Prevention 18 medications
Pain  Off-label
6.6
125 reviews for Pain 1138 medications
Depression  
6.4
64 reviews for Depression 76 medications
Irritable Bowel Syndrome  Off-label
8.2
60 reviews for Irritable Bowel Syndrome 153 medications
Neuralgia  Off-label
8.1
28 reviews for Neuralgia 27 medications
Vulvodynia  Off-label
7.1
10 reviews for Vulvodynia 1 medications
Panic Disorder  Off-label
7.8
10 reviews for Panic Disorder 18 medications
Cyclic Vomiting Syndrome  Off-label
8.0
9 reviews for Cyclic Vomiting Syndrome 4 medications
Smoking Cessation  Off-label
9.4
7 reviews for Smoking Cessation 15 medications
Reflex Sympathetic Dystrophy Syndrome  Off-label
4.6
6 reviews for Reflex Sympathetic Dystrophy Syndrome 2 medications
Diabetic Peripheral Neuropathy  Off-label
5.8
6 reviews for Diabetic Peripheral Neuropathy 39 medications
Tinnitus  Off-label
3.3
4 reviews for Tinnitus 2 medications
Neurosis  Off-label
6.0
2 reviews for Neurosis 1 medications
Dysautonomia  Off-label
1.0
2 reviews for Dysautonomia 53 medications
Primary Nocturnal Enuresis  Off-label
8.0
1 reviews for Primary Nocturnal Enuresis 3 medications
Postherpetic Neuralgia  Off-label
10.0
1 reviews for Postherpetic Neuralgia 47 medications
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Reviews for Nortriptyline

  • Skier...
  • May 20, 2013

For Pain "I suffered lower back pain for 15 years and finally my 'Pain Specialist' gave me a prescription for a starter of Nortriptyline. 1 week 10mg, 1 week 20mg, 1 week 30mg, 1 week of 40mg and 1 week of 50 mg and the pain was gone. It made me very hyper, but I was out of pain and happy. I was on it for 6 months and a change in insurance forced me to taper back off. Basically the starter in reverse. As each week ended I kept wondering when the pain would come back. It was amazing because it never did come back. I had lost some weight and built up my core muscles, so that helped. After 15 years of daily pain, the kind that makes you think oh no when someone invites you anywhere, I have been pain free for over a year."

10 / 10
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506 Report
  • Patsy...
  • December 23, 2014

For Pain "I have unexplained nerve pain for about two years... After trying so many pills, I was at the end of my hope. All the pills either made me feel like a zombie or I gained weight. I tried 10 mg of Nortriptyline, and it has given me back my life! I have been on them for around 3 months now and hardly any pain."

10 / 10
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374 Report
  • Heath...
  • Taken for 6 months to 1 year
  • September 24, 2019

For Migraine Prevention "I started taking this nortriptyline medication back in February for chronic migraine with daily chronic headaches. I feel like I have tried just about everything to get rid of these headaches that just never went away. I finally had a referral to Neurology, where they suggested taking nortriptyline. I was so skeptical as everything else I had tried had failed. After the first night of 30 mg, I saw an improvement in my headaches and continue to have great relief still today. No more daily headaches, and migraines are pretty rare now. The main side effect I have is the dry mouth. The effect this has had on my life has been shocking. Because my head doesn't hurt all the time, I finally have energy, and I actually want to participate in other activities. Because of this, I am down 15 lbs! Haven't been able to lose weight in over ten years! This has been a lifesaver for me!"

9 / 10
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220 Report

Frequently asked questions

  • Fibro...
  • Taken for 1 to 2 years
  • June 20, 2014

For Pain "I am a 40-year-old woman, and I was diagnosed with fibromyalgia and myofascial pain syndrome around 2 years ago and had symptoms for about 3 years before that. This medication was my doctor's first choice. I am a member of one of the leading healthcare providers in CA, and she said that they have had much success prescribing this medication to patients with nerve pain disorders. This medicine made a considerable difference in my quality of life, improving my sleep, pain, stiffness, and tenderness. I take 30mg every evening before bed and make sure that I get about 8-9 hours of sleep. I can always tell the next day if I've forgotten my dose. I plan on taking it for as long as it helps."

10 / 10
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327 Report
  • Karla...
  • December 9, 2014

For Pain "You name it, I have every back problem known to man. I have been on this medicine for only a month. And I live a pain-free life. I do have hyperactivities, but that's disappearing. Dry mouth and no appetite, and without eating as much, my blood sugar levels have been wonderful (hypoglycemia). I love the way I feel, I have told many people, this is a miracle."

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291 Report

Are you taking this medicine?

  • Flutter
  • Taken for 1 to 2 years
  • May 16, 2020

For Depression "I had literally tried every SSRI and SNRI out there... 7 years of going through my nightmare of a life and nothing worked for my Treatment Resistant Depression. I was honestly considering ECT... I asked my psychiatrist if we could try a tricyclic in a last-ditch effort... he put me on Nortriptyline a year ago. I'm now up to 100mg at bedtime, but this antidepressant has helped me more than anything had in 7 years, and no weight gain or bad side effects for me."

10 / 10
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152 Report
  • grate...
  • June 10, 2020

For Irritable Bowel Syndrome "Honestly, this medication saved my life - it is a miracle. I have suffered with IBS for 10 years (am now 20) and it caused me to miss so much school. I started on 10mg of Amitriptyline in Dec 2019 and within a few weeks I had really terrible mental side effects. I became apathetic & had sustained low moods which were uncharacteristic. I switched to 10mg of Nortriptyline after 3 weeks and have been on the same dose since (it is now June 2020). It took exactly 3 weeks for me to start feeling a difference - but then after that, the improvement just got better and better. I now have almost no IBS issues! This medication won't, however, erase your food intolerances. If I go near dairy or fried chips, or have loads of large meals then I might still have a bit of trouble. But I went from having such a limited diet to now being able to eat almost anything, and it has made life so much easier. Alhamdulillah for this miracle drug, I seriously cannot recommend it highly enough :)"

10 / 10
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150 Report
  • Pain...
  • December 17, 2013

For Pain "12 years of severe facial pain and misdiagnosed on numerous occasions with sinus infections. Multiple trips to the dentist, root canals, extractions, teeth fillings removed and replaced with porcelain ones. Septoplasty by ENT specialist. Numerous doses of antibiotics and tramadol for pain. I told all this to a doctor that listened and he turned to me and said 'You have trigeminal neuralgia'. I was given Gabapentin, which didn't work. Went back and was put on nortriptyline. After 12 years, I am pain-free."

10 / 10
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290 Report
  • Anonymous
  • Taken for 1 to 6 months
  • December 20, 2014

For Pain "I have been living with chronic back and hip pain for 12 years. I have had many surgeries with little to no relief of pain. After being in the pain management program at Kaiser for 2 months, the doctor prescribed nortriptyline, and within days, I felt like a new person. Even just sitting doing nothing was painful, and now I can do my daily household chores with little pain. Some things are still difficult, but my daily life has improved substantially."

10 / 10
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255 Report
  • Anonymous
  • February 2, 2011

Pamelor (nortriptyline) for Pain "For several years I have lived with spine and disc damage. I have been on a controlled narcotics program for quite a while. It saved my life. Chronic pain scrambles the brain. I was already on fluoxetine, but felt I was losing ground. Then my doctor put me on nortriptyline. GREAT results. I feel better mentally, and the medicine somehow 'soothes' inflamed spinal cord areas. NOT my imagination - over the years, doctors tried several medicines for this, none worked. This one helped both the depression AND nerve impulses at the discs/spinal cord."

9 / 10
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326 Report
  • Anonymous
  • Taken for 1 to 2 years
  • July 7, 2014

For Pain "I'm 21 years old and have been suffering from chronic abdominal pain and Irritable Bowel Syndrome for almost two years now. I started the nortriptyline about a year ago after countless trips to the hospital to get a grip on my pain. Since last summer, I've noticed a HUGE difference since being on the nortriptyline. There is still some pain, but the medicine really calmed everything down. The only thing that I frown upon is the fact that it makes me very tired. Even though I take it at bedtime. I take 75mg every night and I wake up feeling groggy every day. I'm not sure if anyone else has had this experience and side effect. But I'd rather be tired than in pain, good luck to everyone!"

8 / 10
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255 Report
  • Pheonix...
  • July 21, 2016

For Depression "I've suffered with depression for most of my life. I'd taken Prozac for almost 20 years and decided to try something else because of the sexual side effects. That started a 5-year nightmare of drugs and severe side effects. So I quit taking pills and tried to go it alone. After a year without medication, I lost contact with my friends and most of my family, no longer went out for enjoyment, stopped writing, and generally just comforted myself with TV. I finally went back to my doctor a week ago and he put me on Nortriptyline 10mg. The first two days were a painful introduction of lethargy and dizzy spells. On the third day, my world had changed. I'm talking to people, making plans, cleaning. After a week, the sadness and death fantasies are gone."

10 / 10
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206 Report
  • Joe...
  • January 4, 2013

For Pain "So I read some of these experiences and was doubtful it could help my lower back pain. I tried painkillers and months of physical therapy to no avail. My primary finally sent me to a neurologist. I already had x-rays and went through that tube, in agony I may add because I could not lay flat. They quickly put me on Nortriptyline at a 10mg dose. One week, I did not feel any relief. They upped my dose to 25mg and the same thing, not much relief at all. I went to 50mg and felt better; it really dulled the shooting pains down my left leg and foot. I went to 100mg with better results. Now I'm at 125mg and life is much better. I can walk in a mall, drive my car, and get back to a normal life again. This is supposed to break my pain cycle and so far so good."

9 / 10
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268 Report
  • watts
  • Taken for 2 to 5 years
  • November 30, 2013

For Pain "I've been on Nortriptyline for about a year. I was having problems falling and staying asleep. After a week or so, I realized that it helped with my nerve pain in my back and neck. It was amazing, I was able to wean myself off of prescription Motrin (600-800 mg) several times a day for 24 years. I take 30 mg of nortriptyline before bed. For those of you who feel out of it, you must take it with the intent of getting a full night's sleep, 8 hours, and more if you're taking a high dose; otherwise, you will not feel right."

10 / 10
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243 Report
  • Pain...
  • Taken for 2 to 5 years
  • June 9, 2014

For Pain "When I was 47, I was diagnosed with arthritis in my neck, which was triggering migraines and shoulder pain. Even 800 mg of Motrin didn't help. Nortriptyline was a miracle, and I am migraine-free. I tried going off of it about 4 times, and every time, I had headaches and shoulder pain the next day. I am so thankful for Nortriptyline because I can go to work and think clearly without a headache clouding my thoughts."

9 / 10
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232 Report
  • Gramma...
  • Taken for 1 to 6 months
  • August 1, 2014

For Pain "I have been taking nortriptyline 10mg capsules (6 capsules for 60 mg) every night before I go to bed for over 3 months now. I was involved in a MVA collision by a drunk driver and I now suffer constant head pain. I now have Post Concussive Head Syndrome. I was taking narcotics constantly because of the head pain, I do not have migraines. I was able to be seen by a neurologist and because of the frustration and anger I had against the drunk driver, well the nortriptyline has helped considerably in my head pain and also feeling depressed. The only side effect I am experiencing is dry mouth and sleeplessness. I am now taking it 2 to 3 hours before I go to sleep. There were a couple of times I missed the doses and the pain was there again."

9 / 10
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225 Report
  • Tasha
  • Taken for less than 1 month
  • June 29, 2020

For Pain "8 months of right-sided facial pain - burning, searing, shooting in the ear, cheek, temples, and jaw due to possible nerve damage. Paracetamol and ibuprofen did absolutely nothing for the pain. After being prescribed a raft of antibiotics and other drugs like prednisone, my doctor prescribed me amitriptyline, which I noticed no difference in pain levels when taking. I was then prescribed nortriptyline 20mg, and my pain level went to almost zero. I have been taking it for two weeks now, and it feels so good to wake up in the morning pain-free and not like I have been hit by a truck. I haven't noticed any side effects as of yet."

9 / 10
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108 Report
  • Skaz
  • December 9, 2019

For Pain "I’ve been dealing with chronic pain in my back for about 6 or 7 years. I’m 22 years old and I’ve been to lots of doctors and specialists to find out what’s going on. Let’s just say nobody knows what’s causing it. I’m 22 years old and feel like I’m in my 60s; can hardly get out of bed some days or even weeks. Two doctors recommended this med for me and I refused to take it. My mindset is it is mainly used for depression. But at the low dose they gave me, it was for pain. After some research and being stuck in bed, hardly able to move, I reached a point of I have nothing to lose in my life. I’ve taken nortriptyline for a few days now and it has helped wonders. I stopped for a day to see what would happen and yep, pain returned. Hope now I can just take the meds and go to the gym to lose the weight and hopefully that’ll help too. My grandma was prescribed this and it didn’t help her. But for me, it has. So everyone’s body is different; just remember that."

8 / 10
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118 Report
  • Anonymous
  • Taken for 1 to 6 months
  • March 26, 2014

For Pain "I have been taking nortriptyline for a little over a month now and have found it has helped in several areas of my life. I have been suffering from headaches for over 10 years due to nerve trauma from a wisdom tooth extraction. I have been on every medication under the sun and then some. Usually strong narcotics and several at a time with no real results at all. I have also suffered from chronic depression, anxiety, and panic attacks. I happened to see a doctor not my own who asked if I would be willing to try it. Why not can't hurt was my thought. I am so grateful for his suggestion. I have stopped taking the narcotics and anxiety/depression medicines. I am currently at 50mg, going to start 60mg with no side effects other than dry mouth."

10 / 10
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217 Report
  • Maedie
  • February 20, 2014

For Pain "Three years ago, after a hospitalization for a severe ischemic colitis episode, I had severe and unremitting nerve pain. I tried gabapentin, which did work initially. After about 6 months, the pain gradually returned. I was then put on 10 mg of nortriptyline, which was like a miracle, no more pain. I take it at night and have no residual effects the next day. I wish I had tried it sooner!"

10 / 10
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214 Report
  • cover
  • April 22, 2014

For Pain "Who knew that a popular non-surgical procedure involving the banding of my hemorrhoids would result in neuropathic pain. The pain in my rectum was relentless and unbearable; there was no doubt that nerves were affected. Nortriptyline was prescribed, and while not perfect, it has taken away a majority of my pain. I would recommend to anyone suffering from nerve pain to consider taking this medication, but you have to be patient; it may take a few months to work. Don't let pain run your life! Suffering is optional; you do have a choice."

9 / 10
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206 Report
  • Relie...
  • June 9, 2019

For Migraine Prevention "I’ve had migraines on and off since high school. Around my 50th birthday, I started getting them every 3 to 4 weeks for over a year and a half. Over-the-counter meds didn’t work. The only thing that worked was an IV at the hospital. My doctor prescribed 10 mg of nortriptyline, which did nothing. It was increased to 25 mg, and finally 50 mg. It’s now been about 12 weeks since I’ve had a migraine. I had a mild headache last week due to a cold, but Tylenol took care of it. My doctor thinks my migraines are hormonal, caused by perimenopause, and plans to keep me on it for another year or two until I go through menopause. Without wanting to sound sappy, this medication in this dosage has changed my quality of life as I can make plans without fear of having to cancel them."

10 / 10
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118 Report
  • Rdoh
  • November 10, 2013

For Migraine Prevention "52-year-old female. I had recurring mid-range to severe headaches, which became migraines for several years. I had them so often that I was taking tons of over-the-counter headache pills, which then damaged my stomach after long-term excessive use. After finally telling my doctor about them, he put me on Nortriptyline, (2) 10mg pills every night, so 20mg total daily. It was like a miracle for me! Within a very short time, I was 95% migraine-free. It has no side effects for me, and I have eliminated my excessively large intake of over-the-counter pills almost entirely. What a huge impact this medication has made for me."

10 / 10
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203 Report
  • brndt...
  • April 28, 2011

Pamelor (nortriptyline) for Panic Disorder "Pamelor works great for anxiety panic attacks. It calms you down and helps you to be able to think clearly to calm yourself down. You need to make sure that your doctor is giving you the proper mg amount for your panic attack disorder. I will not stop taking this. I highly recommend this for people to try."

10 / 10
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237 Report
  • Mad...
  • Taken for less than 1 month
  • February 13, 2016

For Pain "I've never felt so angry in my life than on this drug! Terrible! Frustrating because doctors won't prescribe my OxyContin I've been on for 9 years (that completely helped my back after 3 failed surgeries) anymore because of all the irresponsible people abusing it! HOW IS THAT FAIR!? So annoyed that people who really need it have to pay the price! So I've been trying all this junk that has terrible side effects."

1 / 10
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164 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.