Skip to Content

User Reviews for Nortriptyline

Also known as: Pamelor, Aventyl Hydrochloride

Nortriptyline has an average rating of 7.3 out of 10 from a total of 463 ratings on Drugs.com. 70% of those users who reviewed Nortriptyline reported a positive effect, while 19% reported a negative effect.

Condition Avg. Rating Reviews Compare
Migraine Prevention  Off-label
7.8
185 reviews 32 medications
Pain  Off-label
6.8
108 reviews 1123 medications
Depression  
6.4
58 reviews 78 medications
Irritable Bowel Syndrome  Off-label
8.3
42 reviews 137 medications
Neuralgia  Off-label
8.0
21 reviews 28 medications
Vulvodynia  
7.1
9 reviews 9 medications
Cyclic Vomiting Syndrome  Off-label
8.0
9 reviews 4 medications
Panic Disorder  Off-label
8.5
6 reviews 19 medications
Smoking Cessation  Off-label
9.5
6 reviews 18 medications
Reflex Sympathetic Dystrophy Syndrome  Off-label
3.8
5 reviews 2 medications
Diabetic Peripheral Neuropathy  Off-label
5.0
5 reviews 42 medications
Tinnitus  Off-label
1.0
3 reviews 2 medications
Neurosis  Off-label
6.0
2 reviews 1 medications
Dysautonomia  Off-label
1.0
2 reviews 53 medications
Primary Nocturnal Enuresis  
8.0
1 reviews 5 medications
Postherpetic Neuralgia  Off-label
10.0
1 reviews 41 medications
Summary of Nortriptyline reviews 7.3 463 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Nortriptyline

rosa1617 · Taken for 1 to 6 months June 21, 2021

For Migraine Prevention: “Lots of drowsiness, feeling sick after taking the medicine, headaches didn't stop, for a lot of people here with migraines, head pressure, neck pain, nausea, weakness, please check with your doctor to see if you have TMJ disorder, occipital neuralgia that can be the cause of all your problems. It's awful, I feel sick constantly because the TMJ and occipital neuralgia. Hope this helps.”

3 / 10
Was this helpful?YesNo
Grace April 17, 2021

For Cyclic Vomiting Syndrome: “I tried a number of different anti-nausea medications and was misdiagnosed about 5 times over the course of a year. I went through cycles of vomiting so bad that I couldn’t eat drink anything for 2 weeks and ended up in the hospital for dehydration. IV fluids helped for about a week or so and then I started getting sick again. Finally my gastroenterologist decided we were going to try 25mg of nortriptyline and within 6 weeks the vomiting nearly completely stopped. I still get sick about once a month give or take but tend to just vomit once and then feel fine. Much better than daily vomiting and gastroparesis brought on due to it. I had been on SSRI’s before but the vomiting occurred on and off of those because they work differently. I also have no side effects unlike other antidepressants. Highly recommend giving nortriptyline a try if you’re having gastrointestinal distress with no known cause.”

10 / 10
Was this helpful?YesNo
Lucky · Taken for less than 1 month April 15, 2021

For Migraine Prevention: “The basic problem that I started having was, every time I talk my right side of the head used to pain a lot , scalp, back of the head etc. It also aggravates upon work tension, watching computer, colds etc, but worst is when I am tense. My neurologist thought this problem was a migraine and prescribed nortryptiline which I am taking for the last 6 weeks(10mg daily). I saw some improvements some days but the pain still persists. Initially I have ignored that because it was so weird that how can some headache come when someone talks? Did anyone had this kind of experience, I felt I am alone although my neurologist does not think so. Please share your thoughts. Thank you”

Was this helpful?YesNo

Frequently asked questions

Skierick May 20, 2013

For Pain: “I suffered lower back pain for 15 years and finally my "Pain Specialist" gave me a prescription for a starter of Nortriptyline. 1 week 10mg, 1 week 20mg, 1 week 30mg, 1 week of 40mg and 1 week of 50 mg and the pain was gone. It made me very hyper, but I was out of pain and happy. I was on it for 6 months and a change in insurance forced me to taper back off. Basically the starter in reverse. As each week ended I kept wondering when the pain would come back. It was amazing because it never did come back. I had lost some weight and built up my core muscles, so that helped. After 15 years of daily pain, the kind that makes you think oh no when someone invites you anywhere, I have been pain free for over a year.”

10 / 10
Was this helpful?YesNo
HeatherJ · Taken for 6 months to 1 year September 24, 2019

For Migraine Prevention: “I started taking this nortriptyline medication back in February for chronic migraine with daily chronic headaches. I feel like I have tried just about everything to get rid of these headaches that just never went away. I finally had a referral to Neurology, where they suggested taking Nortriptyline. I was so skeptical as everything else I had tried, failed. After the first night of 30 mg, I saw an improvement in my headaches and continue to have great relief still today. No more daily headaches and migraines are pretty rare now. The main side effect I have is the dry mouth. The effect this has had on my life has been shocking. Because my head doesn't hurt all the time, I finally have energy and I actually want to participate in other activities. Because of this, I am down 15 lbs! Haven't been able to lose weight in over ten years! This has been a life saver for me!”

9 / 10
Was this helpful?YesNo
Patsy 7 December 23, 2014

For Pain: “I have unexplained nerve pain for about two years..after trying so many pills I was at the end of my hope. All the pills either made me feel like a zombie or I gained weight. I tried 10 mg of Nortriptyline and it has given me back my life! I have been on them for around 3 months now and hardly any pain.”

10 / 10
Was this helpful?YesNo
grateful_heart June 10, 2020

For Irritable Bowel Syndrome: “Honestly, this medication saved my life - it is a miracle. I have suffered with IBS for 10 years (am now 20) and it caused me to miss so much school. I started on 10mg of Amitrityptline in Dec 2019 and within a few weeks I had really terrible mental side effects. I became apathetic & had sustained low moods which were uncharacteristic. I switched to 10mg of Nortriptyline after 3 weeks and have been on the same dose since (it is now June 2020). It took exactly 3 weeks for me to start feeling a difference - but then after that, the improvement just got better and better. I now have almost no IBS issues! This medication won't, however, erase your food intolerances. If I go near dairy or fried chips, or have loads of large meals then I might still have a bit of trouble. But I went from having such a limited diet to now being able to eat almost anything, and it has made life so much easier. Alhamdullilah for this miracle drug, I seriously cannot recommend it highly enough :,)”

10 / 10
Was this helpful?YesNo

More FAQ

Fibro/Myofascial pain · Taken for 1 to 2 years June 20, 2014

For Pain: “I am 40 year old woman and I was diagnosed with Fibromyalgia and Myofascial pain syndrome around 2 years ago and had symptoms for about 3 years before that. This medication was my doctor's first choice. I am a member of one of leading health care providers in CA, and she said that they have had much success prescribing this medication to patients with nerve pain disorders. This medicine made a considerable difference in my quality of life, improving my sleep, pain, stiffness, and tenderness. I take 30mg every evening before bed and make sure that I get about 8-9 hours sleep. I can always tell the next day if I've forgotten my dose. I plan on taking it for as long as it helps.”

10 / 10
Was this helpful?YesNo
Tasha · Taken for less than 1 month June 29, 2020

For Pain: “8 months of right-sided facial pain - burning, searing, shooting in the ear, cheek, temples and jaw due to possible never damage. Paracetamol and ibuprofen did absolutely nothing for the pain, after being prescribed a raft of antibiotics and other drugs like prednisone my doctor prescribed me amitriptyline which I noticed no difference in pain levels when taking. I then was prescribed nortriptyline 20mg and my pain level went to almost zero. I have been taking it for two weeks now and it feels so good at wake up in the morning pain-free and not like I have been hit by a truck. I don't notice any side effects as of yet.”

9 / 10
Was this helpful?YesNo
Karla K December 9, 2014

For Pain: “You name it I have every back problem known to man. I have been on this medicine for only a month. And I live a pain free life. I do have hyper activities but that's disappearing dry mouth and no appetite, and without eating as much my blood sugar level have been wonderful, (hypoglycemia). I love the way I feel , I have told many people, this is a miracle. ”

Was this helpful?YesNo
Skaz December 9, 2019

For Pain: “I’ve been dealing with chronic pain in my back for about 6 or 7 years. I’m 22 years old and I’ve been to lots of drs and specialist to find out what’s going on. Let’s just say nobody knows what’s causing it. I’m 22 years old and feel like I’m in my 60s can hardly get out of bed some days or even weeks. Two drs recommended this med for me and I refused to take it. My mindset is it is mainly used for depression. But at the low does they gave me it was for pain. After some research and being stuck in bed hardly able to move I reached a point of I have nothing to lose In my life. I’ve taken nortriptyline for a few days now and it has helped wonders. I stopped for a day to see if what’s happen and yep pain returned. Hope now I can just take the meds and go to the gym to lose the weight and hopefully that’ll help too. My grandma was prescribed this and it didn’t help her. But for me it has. So everyone’s body is different just remember that.”

8 / 10
Was this helpful?YesNo
Anonymous · Taken for 1 to 6 months December 20, 2014

For Pain: “I have been living with chronic back and hip pain for 12 years. I have had many surgeries with little to no relief of pain. After being in the pain management program at Kaiser for 2 months the doctor prescribed nortriptyline and within days I felt like a new person. Even just sitting doing nothing was painful and now I can do my daily household chores with little pain. Some things are still difficult but my daily life has improved substantially.”

10 / 10
Was this helpful?YesNo
Anonymous · Taken for 1 to 2 years July 7, 2014

For Pain: “I'm 21 years old and have been suffering from chronic abdominal pain and Irritable Bowel Syndrome for almost two years now. I started the nortriptyline about a year ago after countless trips to the hospital to get a grip on my pain. Since last summer, I've noticed a HUGE difference since being on the nortriptyline. There is still some pain, but the medicine really calmed everything down. The only thing that I frown upon is the fact that it makes me very tired. Even though I take it at bedtime. I take 75mg every night and I wake up feeling groggy every day. I'm not sure if anyone else has had this experience and side effect. But I'd rather be tired than in pain, good luck to everyone!”

8 / 10
Was this helpful?YesNo
Flutter · Taken for 1 to 2 years May 16, 2020

For Depression: “I had literally tried every SSRI and SNRI out there... 7 years of going through my nightmare of a life and nothing worked for my Treatment Resistant Depression. I was honestly considering ECT... I asked my psychiatrist if we could try a tricyclic in a last ditch effort... he put me on Nortriptyline a year ago. I'm now up to 100mg at bedtime, but this antidepressant has helped me more than anything had in 7 years, and no weight gain or bad side effects for me.”

10 / 10
Was this helpful?YesNo
Anonymous February 2, 2011

Pamelor (nortriptyline) for Pain: “For several years I have lived with spine and disc-damage. I have been on a controlled narcotics program for quite a while. It saved my life. Chronic pain scrambles the brain. I was already on fluoxetine, but felt I was losing ground. Then my docor put me on nortriptyline. GREAT results. I feel better mentally, and the medicine somehow "soothes" inflamed spinal-cord areas. NOT my imagination-over the years, doctors tried several medicines for this, none worked. This one helped both the depression AND nerve-impulses at the discs/spinal-cord.”

9 / 10
Was this helpful?YesNo
Pain free pleasure December 17, 2013

For Pain: “12 years of severe facial pain and misdiagnosed on numerous occasions with sinus infections. Multiple trips to the dentist, root canals, extractions, teeth fillings removed and replaced with porcelain ones. Septoplasty by ENT specialist. Numerous doses of Antibiotics and tramadol for pain. I told all this to a doctor that listened and he turned to my and said "You have trigeminal neuralgia". I was given Gabapentin, which didn't work. Went back and was put on Nortriptyline. After 12 years I am pain free.”

10 / 10
Was this helpful?YesNo
Joe Mizz January 4, 2013

For Pain: “So I read some of these experiences and was doubtful it could help my lower back pain, tried pain killers and months of physical therapy to no avail, my primary finally sent me to a neurologist (already had x-rays, and went through that tube, in agony I may add because I could not lay flat) they quickly put me on the Nortriptyline at 10mg dose, one week I did not feel any relief, they upped my dose to 25mg and same thing not much relief at all, went to 50mg and felt better really dulled the shooting pains down my left leg and foot, went to 100mg with better results. Now I'm at 125mg and life is much better, I can walk in a mall, drive my car and get back to a normal life again. This is supposed to break my pain cycle and so far so good.”

9 / 10
Was this helpful?YesNo
Gramma M · Taken for 1 to 6 months August 1, 2014

For Pain: “I have been taking nortriptyline 10mg capsules (6 capsules for 60 mg) every night before I go to bed for over 3 months now. I was involved in a MVA collision by a drunk driver and I now suffer constant head pain. I now have Post Concussive Head Syndrome. I was taking narcotics constantly because of the head pain, I do not have migraines. I was able to be seen by a neurologist and because of the frustration and anger I had against the drunk driver, well the nortriptyline has help considerably in my head pain and also feeling depressed. The only side effect I am experiencing is dry mouth and sleeplessness. I am now taking it 2 to 3 hours before I go to sleep. There was a couple of times I missed the doses and the pain was there again.”

9 / 10
Was this helpful?YesNo
Pain is Gone! · Taken for 2 to 5 years June 9, 2014

For Pain: “When I was 47 I was diagnosed with arthritis in my neck which was triggering migraines and shoulder pain. Even 800 mg of Motrin didn't help. Nortriptyline was a miracle and I am migraine free. I tried going off of it about 4 times, and every time I had headaches and shoulder pain the next day. I am so thankful for Nortriptyline because I can go to work and think clearly without a headache clouding my thoughts.”

9 / 10
Was this helpful?YesNo
watts52 · Taken for 2 to 5 years November 30, 2013

For Pain: “I've been on Nortriptyline for about a year. I was having problems falling and staying asleep. After a week or so I realized that it helped with my nerve pain in my back and neck. It was amazing, I was able to wean myself off of prescription Motrin (600-800 Mg) several times a day for 24 years. I take 30 mg nortriptyline before bed. For those of you who feel out of it, you must take it with the intent of getting a full nights sleep, 8 hours and more if you're taking a high dose otherwise you will not feel right.”

10 / 10
Was this helpful?YesNo
Relieved June 9, 2019

For Migraine Prevention: “I’ve had migraines on and off since high school. Around my 50th birthday I started getting them every 3 to 4 weeks for over a year and a half. Over the counter meds didn’t work. The only thing that worked was an IV at the hospital. My doctor prescribed 10 mg of nortriptyline, which did nothing. It was increased to 25 mg, then finally 50 mg. It’s now been about 12 weeks since I’ve had a migraine. I had a mild headache last week due to a cold, but Tylenol took care of it. My doctor thinks my migraines are hormonal, caused by peri menopause, and plans to keep me on it for another year or two until I go through menopause. Without wanting to sound sappy, this medication in this dosage has changed my quality of life as I can make plans without fear of having to cancel them.”

10 / 10
Was this helpful?YesNo
Anonymous · Taken for 1 to 6 months March 26, 2014

For Pain: “I have been taking nortriptline for a little over a month now and have found it has helped in several areas of my life. I have been suffering from headaches for over 10 years due to nerve trauma from a wisdom tooth extraction. I have been on every medication under the sun and then some. Usually strong narcotics and several at a time with no real results at all. I have also suffered from chronic depression, anxiety and panic attacks. I happened to see a doctor not my own who asked if I would be willing to try it. Why not can't hurt was my thought. I am so grateful for his suggestion, I have stopped taking the narcotics and anxiety/depression medicines. I am currently at 50mg going to start 60mg with no side effects other than dry mouth.”

10 / 10
Was this helpful?YesNo
Maedie February 20, 2014

For Pain: “Three years ago, after a hospitalization for a severe ischemic colitis episode, I had severe and unremitting nerve pain. I tried gabapentin which did work initially. After about 6 months, the pain gradually returned. I then was put on 10 mg of nortriptyline, which was like a miracle, no more pain. I take it at night and have no residual effects the next day. I wish I had tried it sooner!”

10 / 10
Was this helpful?YesNo
cover April 22, 2014

For Pain: “Who knew that a popular non surgical procedure involving the banding of my hemorrhoids would result in neuropathic pain. The pain in my rectum was relentless and unbearable, their was no doubt that nerves were affected. Nortriptyline was prescribed and while not perfect it has taken away a majority of my pain. I would recommend to anyone suffering from nerve pain to consider taking this medication, but you have to be patient it may take a few months to work. Don't let pain run your life! Suffering is optional, you do have a choice.”

9 / 10
Was this helpful?YesNo
Harlow · Taken for 6 months to 1 year February 6, 2020

For Migraine Prevention: “I have been taking nortriptyline to help stop getting migraines, been on it for about 6 months now and it has completely changed my life. I used to get migraines 3-5 times a week and they were unbearable. I do still get migraines but maybe only a handful of times a month. I also take it for anxiety and it has seemed to help quite a bit with that too.”

9 / 10
Was this helpful?YesNo
Mad anger & Major Depression! · Taken for less than 1 month February 13, 2016

For Pain: “I've never felt so angry in my life than on this drug! Terrible!!!! Frustrating because doctors won't prescribe my OxyContin I've been on for 9 years ( that completely helped my back after 3 failed surgeries) anymore because of all the irresponsible people abusing it! HOW IS THAT FAIR!? So annoyed that people who really need it have to pay the price! So I've been trying all this junk that has terrible side effects.”

1 / 10
Was this helpful?YesNo
brndtrftn April 28, 2011

Pamelor (nortriptyline) for Panic Disorder: “Pamelor works great for anxiety panic attacks. It calms you down and helps you to be able to think clearly to calm yourself down. You need to make sure that your doctor is giving you the proper mg amount for your panic attack disorder. I will not stop taking this. I highly recommend this for people to try.”

10 / 10
Was this helpful?YesNo
Rdoh November 10, 2013

For Migraine Prevention: “52 year old female. I had recurring mid range to severe headaches which became migraines for several years. I had them so often, I was taking tons of over the counter headache pills, which then damaged my stomach after long term excessive use. After finally telling my doctor about them, he put me on Nortiptyline, (2) 10mg pills every night, so 20mg total daily. It was like a miracle for me! Within a very short time, I was 95% migraine free. It has no side effects for me and I have eliminated my excessively large intake of over the counter pills almost entirely. What a huge impact this medication has made for me.”

10 / 10
Was this helpful?YesNo

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.