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Nortriptyline Side Effects

Medically reviewed by Last updated on Apr 10, 2024.

Applies to nortriptyline: oral capsule, oral solution.


Oral route (Capsule; Solution)

Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder and other psychiatric disorders. This risk must be balanced with the clinical need, as nortriptyline is not approved for use in pediatric patients. Closely monitor patients of all ages for clinical worsening, suicidality, or unusual changes in behavior; not approved for use in pediatric patients.

Serious side effects of Nortriptyline

Along with its needed effects, nortriptyline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nortriptyline:

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking nortriptyline:

Symptoms of overdose

Other side effects of Nortriptyline

Some side effects of nortriptyline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to nortriptyline: compounding powder, oral capsule, oral solution.

Nervous system

Frequency not reported: Alteration in electroencephalogram (EEG) patterns, ataxia, dizziness, drowsiness, extrapyramidal symptoms, extremity paresthesia, headache, incoordination, mydriasis, numbness, peculiar taste, peripheral neuropathy, seizures, stroke, tingling, tremors[Ref]


Frequency not reported: Agitation, anxiety, confusional states with hallucinations, delusions, disorientation, exacerbation of psychosis, hypomania, increased/decreased libido, insomnia, nightmares, panic, restlessness, suicidal behaviors, suicidal ideation[Ref]


Frequency not reported: Abdominal cramps, black tongue, constipation, diarrhea, dry mouth, epigastric distress, gingivitis, nausea, paralytic ileus, parotid swelling, stomatitis, sublingual adenitis, tongue edema, vomiting[Ref]


Frequency not reported: Arrhythmias, edema, flushing, general edema, heart block, hypertension, hypotension, myocardial infarction, palpitation, tachycardia

Postmarketing reports: Brugada syndrome[Ref]


Frequency not reported: Breast enlargement, delayed micturition, dilation of the urinary tract, galactorrhea, impotence, nocturia, urinary frequency, urinary retention, testicular swelling[Ref]


Frequency not reported: Alopecia, face edema, itching, perspiration, petechia, photosensitization, skin rash, urticaria[Ref]


Frequency not reported: Agranulocytosis, aplastic anemia, bone marrow depression, eosinophilia, purpura, thrombocytopenia[Ref]


Frequency not reported: Drug fever, fatigue, malaise, tinnitus, weakness[Ref]


Frequency not reported: Altered liver function, hepatitis, jaundice (simulating obstructive), liver necrosis[Ref]


Frequency not reported: Anorexia, elevation/depression of blood sugar levels, weight gain/loss[Ref]


Frequency not reported: Blurred vision, disturbance of accommodation

Postmarketing reports: Angle-closure glaucoma[Ref]


Frequency not reported: Gynecomastia, syndrome of inappropriate antidiuretic hormone (SIADH) secretion[Ref]


Frequency not reported: Cross sensitivity (with other tricyclic drugs)[Ref]


Frequency not reported: Increased risk of bone fractures[Ref]

Frequently asked questions


1. (2002) "Product Information. Pamelor (nortriptyline)." Sandoz Pharmaceuticals Corporation

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.