Skip to main content

Loperamide Dosage

Medically reviewed by Drugs.com. Last updated on Mar 18, 2022.

Applies to the following strengths: 2 mg; 1 mg/5 mL; 1 mg/7.5 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Diarrhea - Acute

4 mg orally after the first loose stool, then 2 mg orally after each unformed stool
Maximum dose: 16 mg per day

Comments:

  • Clinical improvement is usually seen within 48 hours.

Use(s): Control and symptomatic relief of acute nonspecific diarrhea

Usual Adult Dose for Diarrhea - Chronic

4 mg orally after the first loose stool, then 2 mg orally after each unformed stool until diarrhea is controlled
Maximum dose: 16 mg per day

Comments:

  • Clinical improvement is usually seen within 48 hours.
  • After diarrhea is controlled, reduce dose to meet individual requirements
  • When optimal daily dose has been established, this dose may be given as a single dose or in divided doses.
  • The average maintenance dose in clinical trials was 4 to 8 mg daily.
  • If no clinical improvement is seen with 16 mg per day after at least 10 days, symptoms are unlikely to be controlled by further administration.
  • Administration may be continued if diarrhea cannot be adequately controlled with diet or specific treatment.

Use(s): Control and symptomatic relief of chronic diarrhea associated with inflammatory bowel disease.

Usual Pediatric Dose for Diarrhea - Acute

2 to 5 years (13 to 20 kg):
First day dosage schedule: 1 mg orally 3 times a day (3 mg total daily dose)
Subsequent daily dosage: 1 mg only after a loose stool, not to exceed 3 mg/day

6 to 8 years (20 to 30 kg):
First day dosage schedule: 2 mg orally twice a day 2 (4 mg total daily dose)
Subsequent daily dosage: 2 mg only after a loose stool, not to exceed 4 mg/day

9 to 12 years (over 30 kg):
First day dosage schedule: 2 mg orally 3 times a day (6 mg total daily dose)
Subsequent daily dosage: 2 mg only after a loose stool, not to exceed 6 mg/day

13 years and older:
4 mg orally after the first loose stool, then 2 mg orally after each unformed stool
Maximum dose: 16 mg per day

Comments:

  • Do not use in patients less than 2 years old due to the risks of respiratory depression and serious cardiac adverse reactions.
  • Clinical improvement is usually seen within 48 hours.

Use(s): Control and symptomatic relief of acute nonspecific diarrhea

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Use with caution.

  • Systemic exposure may be increased due to reduced metabolism.

Precautions

US BOXED WARNING(S):

  • Cases of Torsades de Pointes, cardiac arrest, and death have been reported with use of higher than recommended doses.
  • Contraindicated in pediatric patients less than 2 years of age.
  • Avoid doses higher than recommended due to the risk of serious cardiac adverse reactions.

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

  • Avoid doses higher than recommended due to the risk of serious cardiac reactions.
  • Use the non-prescription liquid formulation for patients 2 to 5 years old.
  • For patients 6 years and older, either the liquid formulation or tablets/capsules may be used.

General:
  • Patients should receive fluid and electrolyte replacement as needed.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.