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Hyoscyamine Dosage

Medically reviewed on March 12, 2018.

Applies to the following strengths: 0.5 mg/mL; 0.125 mg; 0.375 mg; 0.125 mg/5 mL; 0.125 mg/mL; 0.15 mg; 0.375 mg dual-release; sulfate; hydrobromide

Usual Adult Dose for Anticholinesterase Poisoning

0.125 mg Orally Disintegrating/Sublingual Tablets:
1 to 2 tablets orally 3 to 4 times a day
-May increase to every 4 hours, as needed
Maximum dose: 12 tablets per 24 hours


0.375 mg Extended Release Tablets:
1 to 2 tablets orally every 12 hours
OR
1 tablet orally every 8 hours
Maximum dose: 4 tablets per 24 hours


Oral Solution/Drops/Elixir: 1 to 2 mL orally every 4 hours as needed
Maximum dose: 12 mL per 24 hours


Use(s):
-Adjunctive peptic ulcer therapy
-Control gastric secretion, visceral spasm and hypermotility in spastic colon or bladder, cystitis, pylorospasm, and associated abdominal cramps
-Functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis
-Adjunctive therapy for neurogenic bladder and bowel disturbances, including splenic flexure syndrome and neurogenic colon
-Symptomatic relief of biliary and renal colic (with morphine or other narcotics)
-As a "drying agent" for acute rhinitis symptoms
-Parkinsonism, to reduce rigidity and tremors and control sialorrhea and hyperhidrosis
-Anticholinesterase poisoning

Usual Adult Dose for Parkinsonian Tremor

0.125 mg Orally Disintegrating/Sublingual Tablets:
1 to 2 tablets orally 3 to 4 times a day
-May increase to every 4 hours, as needed
Maximum dose: 12 tablets per 24 hours


0.375 mg Extended Release Tablets:
1 to 2 tablets orally every 12 hours
OR
1 tablet orally every 8 hours
Maximum dose: 4 tablets per 24 hours


Oral Solution/Drops/Elixir: 1 to 2 mL orally every 4 hours as needed
Maximum dose: 12 mL per 24 hours


Use(s):
-Adjunctive peptic ulcer therapy
-Control gastric secretion, visceral spasm and hypermotility in spastic colon or bladder, cystitis, pylorospasm, and associated abdominal cramps
-Functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis
-Adjunctive therapy for neurogenic bladder and bowel disturbances, including splenic flexure syndrome and neurogenic colon
-Symptomatic relief of biliary and renal colic (with morphine or other narcotics)
-As a "drying agent" for acute rhinitis symptoms
-Parkinsonism, to reduce rigidity and tremors and control sialorrhea and hyperhidrosis
-Anticholinesterase poisoning

Usual Adult Dose for Peptic Ulcer

0.125 mg Orally Disintegrating/Sublingual Tablets:
1 to 2 tablets orally 3 to 4 times a day
-May increase to every 4 hours, as needed
Maximum dose: 12 tablets per 24 hours


0.375 mg Extended Release Tablets:
1 to 2 tablets orally every 12 hours
OR
1 tablet orally every 8 hours
Maximum dose: 4 tablets per 24 hours


Oral Solution/Drops/Elixir: 1 to 2 mL orally every 4 hours as needed
Maximum dose: 12 mL per 24 hours


Use(s):
-Adjunctive peptic ulcer therapy
-Control gastric secretion, visceral spasm and hypermotility in spastic colon or bladder, cystitis, pylorospasm, and associated abdominal cramps
-Functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis
-Adjunctive therapy for neurogenic bladder and bowel disturbances, including splenic flexure syndrome and neurogenic colon
-Symptomatic relief of biliary and renal colic (with morphine or other narcotics)
-As a "drying agent" for acute rhinitis symptoms
-Parkinsonism, to reduce rigidity and tremors and control sialorrhea and hyperhidrosis
-Anticholinesterase poisoning

Usual Adult Dose for Irritable Bowel Syndrome

0.125 mg Orally Disintegrating/Sublingual Tablets:
1 to 2 tablets orally 3 to 4 times a day
-May increase to every 4 hours, as needed
Maximum dose: 12 tablets per 24 hours


0.375 mg Extended Release Tablets:
1 to 2 tablets orally every 12 hours
OR
1 tablet orally every 8 hours
Maximum dose: 4 tablets per 24 hours


Oral Solution/Drops/Elixir: 1 to 2 mL orally every 4 hours as needed
Maximum dose: 12 mL per 24 hours


Use(s):
-Adjunctive peptic ulcer therapy
-Control gastric secretion, visceral spasm and hypermotility in spastic colon or bladder, cystitis, pylorospasm, and associated abdominal cramps
-Functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis
-Adjunctive therapy for neurogenic bladder and bowel disturbances, including splenic flexure syndrome and neurogenic colon
-Symptomatic relief of biliary and renal colic (with morphine or other narcotics)
-As a "drying agent" for acute rhinitis symptoms
-Parkinsonism, to reduce rigidity and tremors and control sialorrhea and hyperhidrosis
-Anticholinesterase poisoning

Usual Adult Dose for Neurogenic Bladder

0.125 mg Orally Disintegrating/Sublingual Tablets:
1 to 2 tablets orally 3 to 4 times a day
-May increase to every 4 hours, as needed
Maximum dose: 12 tablets per 24 hours


0.375 mg Extended Release Tablets:
1 to 2 tablets orally every 12 hours
OR
1 tablet orally every 8 hours
Maximum dose: 4 tablets per 24 hours


Oral Solution/Drops/Elixir: 1 to 2 mL orally every 4 hours as needed
Maximum dose: 12 mL per 24 hours


Use(s):
-Adjunctive peptic ulcer therapy
-Control gastric secretion, visceral spasm and hypermotility in spastic colon or bladder, cystitis, pylorospasm, and associated abdominal cramps
-Functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis
-Adjunctive therapy for neurogenic bladder and bowel disturbances, including splenic flexure syndrome and neurogenic colon
-Symptomatic relief of biliary and renal colic (with morphine or other narcotics)
-As a "drying agent" for acute rhinitis symptoms
-Parkinsonism, to reduce rigidity and tremors and control sialorrhea and hyperhidrosis
-Anticholinesterase poisoning

Usual Pediatric Dose for Anticholinesterase Poisoning

Oral solution/drops:
12 years and older: 1 to 2 mL orally every 4 hours as needed
Maximum dose: 12 mL per 24 hours

2 to 11 years: 1/4 to 1 mL orally every 4 hours as needed
Maximum dose: 6 mL per 24 hours

Under 2 years, dosed by body weight:
3.4 kg: 4 drops every 4 hours as needed; maximum 24 drops per 24 hours
5 kg: 5 drops every 4 hours as needed; maximum 30 drops per 24 hours
7 kg: 6 drops every 4 hours as needed; maximum 36 drops per 24 hours
10 kg: 8 drops every 4 hours as needed; maximum 48 drops per 24 hours


0.125 mg Orally Disintegrating/Sublingual Tablets:
12 and older: 1 or 2 tablets orally 3 or 4 times a day; maximum 12 tablets per 24 hours
-May increase dose to every 4 hours, as needed
2 to 12 years: 1/2 to 1 tablet orally every 4 hours as needed; maximum 6 tablets per 24 hours


0.375 mg Extended release tablets:
12 and older: 1 or 2 tablets orally every 12 hours; maximum 4 tablets per 24 hours
Under 12 years: Use is not recommended

Use(s):
-Treatment of infant colic (elixir and drops)
-Adjunctive peptic ulcer therapy
-Control gastric secretion, visceral spasm and hypermotility in spastic colon or bladder, cystitis, pylorospasm, and associated abdominal cramps
-Functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis
-Adjunctive therapy for neurogenic bladder and bowel disturbances, including splenic flexure syndrome and neurogenic colon
-Symptomatic relief of biliary and renal colic (with morphine or other narcotics)
-As a "drying agent" for acute rhinitis symptoms
-Parkinsonism, to reduce rigidity and tremors and control sialorrhea and hyperhidrosis
-Anticholinesterase poisoning

Usual Pediatric Dose for Peptic Ulcer

Oral solution/drops:
12 years and older: 1 to 2 mL orally every 4 hours as needed
Maximum dose: 12 mL per 24 hours

2 to 11 years: 1/4 to 1 mL orally every 4 hours as needed
Maximum dose: 6 mL per 24 hours

Under 2 years, dosed by body weight:
3.4 kg: 4 drops every 4 hours as needed; maximum 24 drops per 24 hours
5 kg: 5 drops every 4 hours as needed; maximum 30 drops per 24 hours
7 kg: 6 drops every 4 hours as needed; maximum 36 drops per 24 hours
10 kg: 8 drops every 4 hours as needed; maximum 48 drops per 24 hours


0.125 mg Orally Disintegrating/Sublingual Tablets:
12 and older: 1 or 2 tablets orally 3 or 4 times a day; maximum 12 tablets per 24 hours
-May increase dose to every 4 hours, as needed
2 to 12 years: 1/2 to 1 tablet orally every 4 hours as needed; maximum 6 tablets per 24 hours


0.375 mg Extended release tablets:
12 and older: 1 or 2 tablets orally every 12 hours; maximum 4 tablets per 24 hours
Under 12 years: Use is not recommended

Use(s):
-Treatment of infant colic (elixir and drops)
-Adjunctive peptic ulcer therapy
-Control gastric secretion, visceral spasm and hypermotility in spastic colon or bladder, cystitis, pylorospasm, and associated abdominal cramps
-Functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis
-Adjunctive therapy for neurogenic bladder and bowel disturbances, including splenic flexure syndrome and neurogenic colon
-Symptomatic relief of biliary and renal colic (with morphine or other narcotics)
-As a "drying agent" for acute rhinitis symptoms
-Parkinsonism, to reduce rigidity and tremors and control sialorrhea and hyperhidrosis
-Anticholinesterase poisoning

Usual Pediatric Dose for Urinary Incontinence

Oral solution/drops:
12 years and older: 1 to 2 mL orally every 4 hours as needed
Maximum dose: 12 mL per 24 hours

2 to 11 years: 1/4 to 1 mL orally every 4 hours as needed
Maximum dose: 6 mL per 24 hours

Under 2 years, dosed by body weight:
3.4 kg: 4 drops every 4 hours as needed; maximum 24 drops per 24 hours
5 kg: 5 drops every 4 hours as needed; maximum 30 drops per 24 hours
7 kg: 6 drops every 4 hours as needed; maximum 36 drops per 24 hours
10 kg: 8 drops every 4 hours as needed; maximum 48 drops per 24 hours


0.125 mg Orally Disintegrating/Sublingual Tablets:
12 and older: 1 or 2 tablets orally 3 or 4 times a day; maximum 12 tablets per 24 hours
-May increase dose to every 4 hours, as needed
2 to 12 years: 1/2 to 1 tablet orally every 4 hours as needed; maximum 6 tablets per 24 hours


0.375 mg Extended release tablets:
12 and older: 1 or 2 tablets orally every 12 hours; maximum 4 tablets per 24 hours
Under 12 years: Use is not recommended

Use(s):
-Treatment of infant colic (elixir and drops)
-Adjunctive peptic ulcer therapy
-Control gastric secretion, visceral spasm and hypermotility in spastic colon or bladder, cystitis, pylorospasm, and associated abdominal cramps
-Functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis
-Adjunctive therapy for neurogenic bladder and bowel disturbances, including splenic flexure syndrome and neurogenic colon
-Symptomatic relief of biliary and renal colic (with morphine or other narcotics)
-As a "drying agent" for acute rhinitis symptoms
-Parkinsonism, to reduce rigidity and tremors and control sialorrhea and hyperhidrosis
-Anticholinesterase poisoning

Usual Pediatric Dose for Neurogenic Bladder

Oral solution/drops:
12 years and older: 1 to 2 mL orally every 4 hours as needed
Maximum dose: 12 mL per 24 hours

2 to 11 years: 1/4 to 1 mL orally every 4 hours as needed
Maximum dose: 6 mL per 24 hours

Under 2 years, dosed by body weight:
3.4 kg: 4 drops every 4 hours as needed; maximum 24 drops per 24 hours
5 kg: 5 drops every 4 hours as needed; maximum 30 drops per 24 hours
7 kg: 6 drops every 4 hours as needed; maximum 36 drops per 24 hours
10 kg: 8 drops every 4 hours as needed; maximum 48 drops per 24 hours


0.125 mg Orally Disintegrating/Sublingual Tablets:
12 and older: 1 or 2 tablets orally 3 or 4 times a day; maximum 12 tablets per 24 hours
-May increase dose to every 4 hours, as needed
2 to 12 years: 1/2 to 1 tablet orally every 4 hours as needed; maximum 6 tablets per 24 hours


0.375 mg Extended release tablets:
12 and older: 1 or 2 tablets orally every 12 hours; maximum 4 tablets per 24 hours
Under 12 years: Use is not recommended

Use(s):
-Treatment of infant colic (elixir and drops)
-Adjunctive peptic ulcer therapy
-Control gastric secretion, visceral spasm and hypermotility in spastic colon or bladder, cystitis, pylorospasm, and associated abdominal cramps
-Functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis
-Adjunctive therapy for neurogenic bladder and bowel disturbances, including splenic flexure syndrome and neurogenic colon
-Symptomatic relief of biliary and renal colic (with morphine or other narcotics)
-As a "drying agent" for acute rhinitis symptoms
-Parkinsonism, to reduce rigidity and tremors and control sialorrhea and hyperhidrosis
-Anticholinesterase poisoning

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Glaucoma
-Obstructive uropathy (e.g. bladder neck obstruction from prostatic hypertrophy)
-Obstructive disease of the gastrointestinal tract (e.g. achalasia, pyloroduodenal stenosis)
-Paralytic ileus, intestinal atony of elderly or debilitated patients
-Unstable cardiovascular status in acute hemorrhage
-Severe ulcerative colitis
-Toxic megacolon complicating ulcerative colitis
-Myasthenia gravis

Safety and efficacy of extended release products have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available
-This drug is dialyzable.

Other Comments

Administration advice:
-Tablets (including extended release, orally disintegrating) should be taken 30 to 60 minutes before meals.
-Extended release tablets should be swallowed whole.

Patient advice:
-Use with caution during exercise or hot weather; overheating may cause heat stroke.
-This drug may cause drowsiness, dizziness, or blurred vision; use caution when driving or performing other tasks requiring mental alertness.
-Extended release tablets may appear in the stool, but the medication will have been released.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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