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Septra User Reviews & Ratings

Septra has an average rating of 5.4 out of 10 from a total of 19 reviews on Drugs.com. 42% of reviewers reported a positive experience, while 42% reported a negative experience.

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Reviews for Septra

Commonly mentioned side effects
  • Jen...
  • January 12, 2013

For Urinary Tract Infection "This medication makes me extremely tired and causes headaches, but it seems to be working where other antibiotic treatments have failed to cure my infection. If you are able to tolerate the side effects, it's been a pretty good therapy for me."

6 / 10
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26 Report
  • Anonymous
  • August 5, 2011

For Acne "This medicine has done only good things for me. I have taken it for about 3 weeks now. It cleared up my moderately severe acne very quickly, no negative side effects. The only side effect I had was decreased appetite, which I was not opposed to, as I usually eat too much anyway!"

10 / 10
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23 Report
  • bos...
  • June 12, 2014

For Bacterial Infection "I was prescribed Septra for a bacterial infection. The prescription was for ten days, and about the fifth day, I had a headache that started with severe lower back pain also. On the seventh day, I broke out from head to toe with severe hives."

1 / 10
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18 Report

Frequently asked questions

  • lov...
  • January 25, 2010

For Bacterial Infection "I am taking Septra for an infection on the tip of my nose. Day one was horrible. Nausea, fatigue, and vertigo (felt like a flu). That lasted one day. Days 2-7 have been without issues. I take it with a meal and a good 12-16 ounces of fluid. Three days to go, and I expect that will be fine. My infection appeared much better by the 4th day."

9 / 10
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21 Report
  • cri...
  • August 19, 2015

For Urinary Tract Infection "Cleared infection right away, but had to stop medicine early because of all of the side effects I had from this. 4 days later, still having some of the effects. Not sure how long the effects will last, but I never want to feel this bad again."

9 / 10
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15 Report

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  • Jly...
  • Taken for less than 1 month
  • September 9, 2014

For Urinary Tract Infection "I've taken Septra DS before (with no side effects), but for some reason this time it is different! It has given me severe insomnia! Very odd and super frustrating. Also has caused me a lot of nausea, but the doctor prescribed Zofran (also known as the miracle medicine for nausea), so that's better. Also feel a bit 'out of it' and lethargic. One last strange symptom it's causing me is 'urinary hesitancy.' Had no idea there was such a thing until I spoke to my doctor about it. Hoping these symptoms resolve, or I may need to switch medicines, as I'm only halfway through this 10-day treatment."

8 / 10
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10 Report
  • Now...
  • Taken for less than 1 month
  • February 7, 2020

For Urinary Tract Infection "Septra was prescribed for a UTI, 2 tabs daily for 5 days. Since I started 2 days ago, I’ve been unable to fall asleep until the early morning hours! Very frustrating. I will stop taking this drug due to the terrible insomnia. The UTI seems to be cleared up, though."

5 / 10
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3 Report
  • Pep...
  • Taken for less than 1 month
  • March 23, 2019

For Kidney Infections "Has got to be the worst antibiotics I've ever been on, no pain relief at all on the third day in, I keep getting weird sensations in my body, and the constipation is horrible. I've also been told (by people around me) I've been really aggressive and depressed and lashing out ever since it built up in my system."

1 / 10
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2 Report
  • Anonymous
  • November 21, 2009

For Acne "Septra has worked wonders on my skin, within a week of taking it, my skin has gotten less oily, and my cystic acne is going away."

10 / 10
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29 Report
  • MtL...
  • August 23, 2015

For Urinary Tract Infection "Makes me extremely nauseated. Cannot tolerate it. Have had multiple UTIs, and Septra sometimes doesn't get rid of the infection all the way. Causes insomnia and almost confusion."

2 / 10
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16 Report
  • Anonymous
  • November 11, 2008

For Bacterial Skin Infection "This has cured my MRSA five times now. It is the only thing that works for me."

10 / 10
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24 Report
  • Anonymous
  • March 18, 2012

For Urinary Tract Infection "I'm pretty sensitive to antibiotics, and this one really makes me feel sick and tired, and now I have an itchy rash. Have finished day 2, still 5 days of this to go."

5 / 10
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15 Report
  • Anonymous
  • October 15, 2009

For Urinary Tract Infection "This medicine caused vomiting for me, whether my stomach was empty or not. I wish I could tolerate it, because it's a good treatment, but for those who are sensitive, this is not a good medicine."

1 / 10
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17 Report
  • Jos...
  • Taken for less than 1 month
  • January 26, 2021

For Bacterial Skin Infection "Worked within 12 hours to clear my mastitis. Side effects are: cold sweats, headaches. Worth it. Very pleased."

10 / 10
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5 Report
  • Anonymous
  • December 24, 2009

For Urinary Tract Infection "Caused nausea... but worked."

8 / 10
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14 Report
  • Jo1...
  • November 4, 2015

For Kidney Infections "I have frequent kidney infections, and this antibiotic didn't help at all. I've been doubled over in pain."

2 / 10
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8 Report
  • Izn...
  • Taken for less than 1 month
  • February 26, 2018

For Bacterial Skin Infection "I cannot tolerate this drug! It makes me depersonalized, dizzy, confused, and just very spacey! I don't understand why they make medications that have worse side effects than the actual disease!"

2 / 10
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8 Report
  • Gre...
  • February 23, 2018

For Urinary Tract Infection "No relief at all after 4 days of prescribed use. Got headaches, fever with chills, nausea, depression, constipation, among other negatives."

1 / 10
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4 Report
  • Anonymous
  • Taken for less than 1 month
  • January 19, 2023

For Bacterial Skin Infection "Septra caused an allergic reaction that I have never had to sulfa drugs before. I have developed a body rash that is itchy, have an itchy throat, and have difficulty swallowing."

2 / 10
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0 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.