Skip to Content
Print Share
Diagnosed with Prostate Cancer? Learn about your treatment options >>

Septra (sulfamethoxazole / trimethoprim) Drug Interactions

A total of 512 drugs are known to interact with Septra (sulfamethoxazole / trimethoprim).

  • 114 major drug interactions
  • 169 moderate drug interactions
  • 229 minor drug interactions

Show all medications in the database that may interact with Septra (sulfamethoxazole / trimethoprim).

Check for interactions

Type in a drug name to check for interactions with Septra (sulfamethoxazole / trimethoprim).

Most frequently checked interactions

View interaction reports for Septra (sulfamethoxazole / trimethoprim) and the medicines listed below.

  • acetaminophen (Tylenol, Paracetamol, Panadol, Mapap, Tylenol Arthritis Pain, Tylenol Extra Strength, Ofirmev, Aceta, Perfalgan, Children's Tylenol, Tactinal, Arthritis Pain Relief, Doliprane, Altenol, Efferalgan, Panamax, Acephen, Paracetamol Almus, Panadol ActiFast, Mapap Arthritis Pain, Panadol Extend, Cipla Genpharm Paracetamol, Alvedon, Anadin Paracetamol, Panadol Osteo, RP Scherer Paracetamol, Setamol, Feverall, Tempra, Pharbetol, Dolono, Actamin, Paracetamol Ranbaxy, Paracetamol Teva, Q-Pap, Infant's Tylenol, Calpol Infant, Paralgin, Tylophen, Pain Clear Paracetamol, Tylenol 8 Hour, Abenol, Bydol, Mapap Rapid Release Gelcaps, Zee Unaspirin ES, Panadol Childrens, Dafalgan, Doliprane Adultes, Paracetamol Arrow, Paracetamol Sandoz Conseil, Lloydspharmacy Paracetamol Infant, Atasol, Triaminic Infant Drops, Disprol Soluble Paracetamol, Disprol Paracetamol, Calpol Paediatric, Cetafen, Aminofen, Orajel Maximum Strength Toothache, RP Scherer Paracetamol Liquid-Filled Capsules, Promax, Terry White Chemists Paracetamol, Pharmacist Advice Paracetamol, Terry White Chemists Paracetamol Colourfree Children 5-12 Years, Paracare, Tylenol Childrens Paracetamol, Conney Aspirin-Free, Priceline Paracetamol, Panadol Gel Caps, Pacimol Caplets, Pharmore Paracetamol, Basics Paracetamol, Genapap, Sigma Pain Relief, Paraspen Drops, Panadol Colourfree Drops, Pharmacist Paracetamol Infant Drops, Pharmacist Paracetamol Infant Drops Colour Free, Bi-Lo Paracetamol, Pain-Eze Paracetamol Infant Drops Colour Free, Pharmaction Paracetamol, Biochemie Paracetamol, Healthsense Pain Relief Drops Children 1 Month to 2 Years, Black And Gold Paraceatmol, Pharmacist Advice Paracetamol Infant Drops, Black and Gold Paracetamol, Hexal Comfarol, Blooms the Chemist Paracetamol, Paracetamol Soluble, Vitapap, Bristol Pharma Paracetamol, Sigma Paracetamol, Actimol Infant, ConRx Extra Strength, PediaCare Infants' Acetaminophen Fever Reducer/Pain Reliever, PediaCare Children's Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Childrens, PediaCare Smooth Melts Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Infants and Childrens Drops 1 Month-4 Years, Mapap Children's, Capital Chemist Paracetamol, Lemsip Cold and Flu Liquid Capsule, Children's Silapap, Febrol Solution, Pharmacy Health Own Name Paracetamol for Children, Febridol Infant Drops, Accidental Rapatabs, Chem Mart Chemadol Children 1 to 5 Years, Chem Mart Chemadol Colourfree, Chem Mart Chemadol Colourfree Children 5-12 Years, Chemists Own Chiildrens Paracetamol 5-12 Years, Lemsip Headcold, Chemists Own Childrens Paracetamol 1-5 Years, Lemsip Max, Chemists Own Paracetamol, Lemsip Original, Chemists Own Paracetamol Capseals, Chemists Own Paracetamol Pain & Fever 1 Month to 2 Years, Chemists Own Paracetamol Pain & Fever 1 to 5 Years, Chemists Own Paracetamol Pain and Fever 5 to 12 Years, A-Pak Laboratories Paediatric Analgesic Paracetamol, Chemplus Paracetamol, Chemworld Colourfree Childrens Paracetamol Double Strength 5-12 Years, Chemworld Colourfree Childrens Paracetamol Junior 1-5 Years, Chemworld Paracetamol, Chemworld Paracetamol Infant Colour Free, HyVee Health 8 Hour Pain Relief, Chem Mart Chemadol, Leader 8 Hour Pain Reliever, Children's ElixSure, Little Fevers, Benylin Sore Throat, Fawns & McAllan Paracetamol, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Midol Long Lasting Relief, Childrens Panadol 1 - 5 Years Colourfree, Childrens Panadol 1 - 5 Years, Childrens Panadol 5 - 12 Years Colourfree, Childrens Panadol 5 - 12 Years, Equaline Pain Relief, Help I Have A Headache, Febridol Clear Effervescent, Herron Paracetamol Tabsules, Panadol Rapid Handipak, Panadol Soluble, Paralgin Paracetamol Tabsules, Pharmacist Childrens Paracetamol Colourfree 1-5 Years, Pharmacist Childrens Paracetamol Colourfree 5-12 Years, Pharmacy Health Colour Free Childrens Paracetamol, Gold Cross Paracetamol, Tylenol Cold Sore Throat, Alpha First Aid Supplies Paracetamol, Guardian Childrens Paracetamol 5-12 Years, Guardian Paracetamol, Guardian Paracetamol Tabsules, Rex Paracetamol, Topcare Arthritis Pain Relief, Accidental First Aid Supplies Paracetamol, Panadol Jr, Flu Strength Hot Lemon Powders, Paineze Paracetamol, Health Care Chemist Paracetamol Infant Drops Colour Free, Genebs, Buckley's Complete, Herron Gold Paracetamol Tabsules, Tylenol Regular Strength, Panamol, Herron Paracetamol, Tempra 2, Tempol, Herron Paracetamol Capseals, Tempra 3, Taminol, Herron Paracetamol Capseals Handy Pack, Herron Paracetamol Handy Pack, Apra, Q-Nol, Claradol, Anacin Aspirin Free, Conacetol, Coles Paracetamol, Genapap Extra Strength, Doliprane Sans Sucre, Dolitabs, Home Brand Paracetamol, Q-Pap Extra Strength, Dolko, ICN Paracetamol, Redutemp, Dolko Enfants, Dolotec, Vicks Formula 44 Custom Care Body Aches, James Dean Pharmacy Paracetamol, Pain-Eze, Efferalgan Pediatrique, Uniserts, Efferalganodis, Silapap Childrens, Expandox, Dolono Infant, Geluprane, Paracetamol Biogaran, Ed-APAP, Paracetamol EG, St. Joseph Aspirin-Free, Country Chemists Paracetamol, Paracetamol Ivax, Paracetamol Merck, Liquiprin, Paracetamol Qualimed, Adprin B, BF-Paradac, Paracetamol RPG, DG Health Pain Reliever, Tempra Quicklets, Paracetamol Sandoz, Tycolene, Lloydspharmacy Paracetamol Six Plus, Paracetamol Winthrop, Triaminic Fever Reducer Pain Reliever, Paracetamol Zydus, Atasol Forte, Paralyoc, Tylenol Cool Caplet Extra Strength, Perfalgan Nourrissons Et Enfants, Acetaminophen-odan, Mapap Rapid Tabs, Jr. Tylenol, Mapap Extra Strength Rapid Burst, Elixsure Fever/Pain, Infadrops, Galpamol, Paldesic, Medinol Paediatric, Medinol Under 6, Infantaire Drops, Lemsip Pharmacy Non-Decongestant Formula, Calpol Fastmelts, Calpol Six Plus, Masophen, Medinol Over 6, Nortemp Children's, Paracets, Hedex, UN-Aspirin Extra Strength, Mandanol, Valorin, Actimol Children's, Dakota Paracetamol, Miradol, Umphamol, Remedol, Panamax 240, Parahexal, Febridol, Mid West Products Numol Paracetamol, Parmol, Silapap Infants, Cuprofen for Children, Mapap Infant Drops, Mandanol Infant, Cetafen Extra, Mandanol 6+, Lemsip Childrens Cold & Flu, Fennings Childrens Cooling, Duatrol SR, Aldi Hedanol Paracetamol, Under Ten Care Infant, Alphapharm Paracetamol, Amadol Paracetamol, No Frills Paracetamol, Tylenol Sore Throat Daytime, Nova Paracetamol, Mapap Meltaway, Numark Paracetamol, Amcal Childrens Paracetamol 1-5 Years, Nyal Paracetamol, Medi-Tabs, Amcal Childrens Paracetamol 5-12 Years, Amcal Paracetamol Pain Relief, Ordov Febrigesic Paracetamol, Topcare 8 Hour Pain Relief, Amcal Paracetamol Infant Drops 1 Month to 2 Years, Pain-Eze Paracetamol Infant Drops, Febridol Syrup for Children, Amcal Paracetamol Tabsules, Pharmacist Advice Colourfree Childrens Paracetamol Double Strength, Guardian Childrens Paracetamol, Pharmacist Formula Paracetamol, Pharmacist Formula Infants, Paraspen, Savings Paracetamol, Signature Range Paracetamol, Dymadon, Soul Pattinson Childrens Paracetamol Elixir, Soul Pattinson Colour Free Paracetamol 1-5 Years, Soul Pattinson Colour Free Paracetamol Drops, Soul Pattinson Colourfree Childrens Paracetamol, Panadol Gel Tabs, API Healthcare Coloufree Childrens Paracetamol, Soul Pattinson Paracetamol, API Healthcare Colourfree Childrens Paracetamol Double Strength, Soul Pattinson Paracetamol Clear Effervescent, Panadol Mini Caps, API Healthcare Paracetamol, Pharmacy Health Paracetamol, Terry White Chemists Colour Free Paracetamol 1-5 Years, Pharmacist Paracetamol, Terry White Chemists Colour Free Paracetamol Infant Drops)
  • albuterol (Ventolin, Ventolin HFA, ProAir HFA, Proventil, Proventil HFA, ProAir RespiClick, AccuNeb, Respirol, ProAir Digihaler, Volmax, Airet, Vospire ER)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Moxatag, Amoxicot, DisperMox, Biomox, Moxilin, Wymox)
  • aspirin (Ecotrin, Acetylsalicylic Acid, Aspir 81, Bayer Aspirin, Aspirin Low Strength, Bufferin, Arthritis Pain, Easprin, Ascriptin, Fasprin, Low Dose ASA, Buffered Aspirin, Aspir-Low, Durlaza, Ascriptin Enteric, Acuprin 81, Halfprin, Aspergum, Empirin, Bayer Children's Aspirin, Aspirin Lite Coat, Aspi-Cor, Aspirtab, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Entercote, Minitabs, St. Joseph Aspirin, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Aspiritab, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Bayer Aspirin Regimen, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Ativan (lorazepam)
  • Augmentin (amoxicillin / clavulanate)
  • Bactrim (sulfamethoxazole / trimethoprim)
  • Benadryl (diphenhydramine)
  • Cipro (ciprofloxacin)
  • ciprofloxacin (Cipro, Cipro I.V., Cipro XR, Cipro Cystitis Pack, Proquin XR)
  • clindamycin (Cleocin, Cleocin Phosphate, Cleocin Pediatric, Cleocin HCl, Cleocin Phosphate ADD-Vantage)
  • doxycycline (Vibramycin, Monodox, Oracea, Doxy 100, Doryx, Adoxa, Acticlate, Targadox, Morgidox, Vibra-Tabs, Doxy-Caps, Uracil, Periostat, Avidoxy, Adoxa TT, Mondoxyne NL, Doxy 200, Doxy-D, Oraxyl, Alodox, Adoxa Pak, Adoxa CK, Ocudox, LymePak, NicAzel Doxy, Doxy-Lemmon, Doryx MPC)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Motrin IB, Advil Liqui-Gels, Motrin Childrens, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Ibuprofen PMR, Nuprin, NeoProfen, Proprinal, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Advil Infant's Concentrated Drops, Motrin Pediatric, Ibu-Tab, Rufen, Genpril, Haltran, IBU-200, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Motrin Migraine Pain, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Ibu-8, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Advil Film-Coated)
  • Lasix (furosemide)
  • Lipitor (atorvastatin)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • metformin (Glucophage, Glumetza, Fortamet, Glucophage XR, Riomet)
  • methadone (Dolophine, Methadose, Methadone Diskets, Methadose Sugar-Free)
  • Neurontin (gabapentin)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • pantoprazole (Protonix, Protonix IV)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Liquid Pred, Meticorten, Orasone, Prednicen-M)
  • Tylenol (acetaminophen)
  • Vitamin D3 (cholecalciferol)
  • warfarin (Coumadin, Jantoven)
  • Xanax (alprazolam)

Septra (sulfamethoxazole / trimethoprim) alcohol/food interactions

There is 1 alcohol/food interaction with Septra (sulfamethoxazole / trimethoprim)

Septra (sulfamethoxazole / trimethoprim) disease interactions

There are 12 disease interactions with Septra (sulfamethoxazole / trimethoprim) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Drugs.com Mobile Apps

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Explore Apps
Hide