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User Reviews for SMZ-TMP DS

SMZ-TMP DS has an average rating of 4.3 out of 10 from a total of 46 ratings on Drugs.com. 23% of those users who reviewed SMZ-TMP DS reported a positive effect, while 51% reported a negative effect.

Condition Avg. Rating Reviews Compare
Urinary Tract Infection  
3.5
24 reviews 189 medications
Prostatitis  
7.0
4 reviews 49 medications
Acne  Off-label
7.3
4 reviews 524 medications
Bacterial Skin Infection  
2.7
4 reviews 50 medications
Kidney Infections  
1.0
3 reviews 94 medications
Bacterial Infection  
6.0
3 reviews 171 medications
Sinusitis  
5.0
2 reviews 248 medications
Prevention of Bladder infection  
1.0
1 reviews 29 medications
Upper Respiratory Tract Infection  
8.0
1 reviews 120 medications
Summary of SMZ-TMP DS reviews 4.3 46 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for SMZ-TMP DS

DJ22 · Taken for less than 1 month February 14, 2021

For Urinary Tract Infection: “This medication (Bactrim) works as prescribed for me and with no side effects. Actually cleared up 3 out 4 UTI’s. One UTI was so severe no oral antibiotic would work. I ended up with daily antibiotic infusions over a 10 day span via a PICC line. Chances are Bactrim will work for you as side effects are typically rare - so my doctors tell me. Good luck!”

9 / 10
AM · Taken for 1 to 6 months December 17, 2020

For Prostatitis: “24 yo Male, No side effect symptoms on this, while I had moderate symptoms with Doxy. While it did not completely clear up the main issue (yet, still have about 5 days left on it out of a 45 day supply), it did help”

7 / 10
LotusFlower · Taken for less than 1 month June 16, 2020

For Urinary Tract Infection: “I took this medicine for a UTI because I was told it kills the bacteria that showed up on my labs and other antibiotics may be resistant to it. The medicine made me go to the bathroom even more, especially at night and caused headaches and muscle cramps. I've been switched now to Cipro. We will see how this goes.”

1 / 10

Frequently asked questions

c · Taken for less than 1 month September 9, 2018

For Urinary Tract Infection: “I had smelly urine but not the usual symptoms of UTI, but doc put me on this and by 4th day still had problem and felt sick - listless, not able to eat, stomach felt like it was FULL and heavy. By day 8 of taking it my son convinced me to stop med. I did and felt a bit better but it is now a month later and I have lost 14 lbs and barely able to stomach any food. Almost throw up when even thinking about eating! Have to force myself to eat--not at all happy!!!!!”

1 / 10
Sick chick March 25, 2020

For Kidney Infections: “Wow I should have looked at reviews prior to taking this SMZ-TMP DS medication. I had this prescribed for a UTI/possible kidney infection. I only had a 3 day course, day 2 I woke up extremely sick horrid headache that turned into nausea and vomiting. That caused the headache to be even worse. I felt so weak and dehydrated like the worst hangover of my life except there was no alcohol involved!! :( i had to drink water all day or else I felt I was gonna pass out and did nothing but lay on the couch under the blankets. Moving in any way made me out of breath. I finished the dose as I was scared to not finish since internet says it’s bad to not complete antibiotics. On the night of day 2 I was finally recuperating but surely after taking morning dose of day 3 I went back to feeling super crappy!!! I’m hoping my infection is gone, but my back is still hurting so I guess we’ll have to wait and see. Anyone taking this beware!! Make sure to eat a lot and drink a lot a lot of fluids.”

1 / 10
Anonymous · Taken for less than 1 month April 10, 2019

For Urinary Tract Infection: “I was prescribed sulfamethoxazole and trimethoprim (SMZ/TMP) twice a day for 7 days for a UTI. I have one pill left, almost all the symptoms are gone. The first day I took the pill I was extremely sleepy. Every day after that I had a horrible headache in the back of my head and a stiff neck that came and went every few hours, also brought on by light sensitivity. Nausea, out of breathe at times, cold sweat on exertion & jittery.”

2 / 10
Anonymous May 26, 2010

For Urinary Tract Infection: “I would get a urinary tract infection when I had sex. To control the situation my doctor prescribed SMZ-TMP DS. I took one or 2 a day for years. As long as I took the pills I was not bothered with a UTI. Miss a day or 2, and UTI. Worked wonderful. ”

10 / 10

More FAQ

Anonymous · Taken for less than 1 month September 26, 2018

For Urinary Tract Infection: “I was prescribed this for a UTI. Worst experience ever! got up to day 4 of taking it and started to feel weak, confused, had really bad back and neck pain, pain when I walked. I also had watery, itchy, burning eyes, massive headache, sleepy and fatigue and like tight chest. At night I couldn't sleep, had the chills and a cold sweat. I have lost my appetite and have lost 6 pounds in just 4 days! I have stopped taking them but now I am developing a rash on my body that really itches. Please people beware of this. My advise is to ask for something else, or at the first sign of a symptom stop taking.”

1 / 10
Chris S · Taken for less than 1 month November 16, 2018

For Bacterial Infection: “Side effects I got on the first dose: very bad headache, dizziness, difficulty urinating, irritated eyes, joint and muscle pain, fever with chills. I am still recovering, it's been over 12 hours, I've gotten maybe 4 hours of sleep while I started this. I had to discontinue it, and I contacted my doctor. My advice: Do not take if you have High Blood Pressure or a Thyroid condition, this medication seems to Interact with medications for those conditions as well as interact with those conditions themselves.”

1 / 10
tducheneau July 3, 2017

For Kidney Infections: “I will not ever take this medication again (Generic form of Bactrim DS). I landed in the ER with a severe kidney infection... was given antibiotics, nausea medication, and pain medication through an IV. went home six hours later and started the Bactrim that night. I woke up at 2am absolutely drenched head to toe in sweat, with chills... couldn't fall back asleep. The next day I had the worst headache... terrible, terrible pain in the base of my skull, and a horribly stiff and sore neck. Any time I stood up I could feel my blood pressure in my head sore, just throbbing. I had zero appetite. I stopped the Rx after 2.5 days. I felt worse after I started the Rx than before it. Never, ever again.”

1 / 10
Ginny S · Taken for less than 1 month January 11, 2019

For Bacterial Skin Infection: “After reading all the precautions for this drug and the one review; I have decided I'll let the Brown Recluse bite resolve itself. It's on the mend now anyway I'm 75 years old and this does not seem to be something I need to be taking. Thanks for the reviews and the information on the internet for giving me some insight.”

Anonymous March 19, 2012

For Urinary Tract Infection: “After being on this for 5 days, my urianry tract infection was *almost* gone. I had to ask for another prescription. During the time I was on it on I noticed shortness of breath, almost twice a day I tasted metal and noticed I had small nosebleeds. I also couldn't really go out in the sunlight, as it hurt my eyes a lot and my skin felt like it was burning.”

5 / 10
Kathy Turner · Taken for less than 1 month October 3, 2014

For Urinary Tract Infection: “Based on results of a urine culture, I was put on this medication. I have taken 4 pills. While at work today, my tongue was feeling like I just took a big bite of piping hot pizza. The burning feeling was quite intense and I had not eaten anything that might have caused this. I also had numbness of my lips. The last pill I took was at 7:30 am and I still have intense burning and a bit of numbness. I was puzzled and decided to look up side effects of this new medication because it was the only thing newly exposed to my body. Since these problems were listed in your side effects listing, I will immediately discontinue using it.”

1 / 10
Reviewer99 · Taken for less than 1 month January 29, 2018

For Urinary Tract Infection: “It helped my simple UTI almost immediately and completely but I had side effects that I've never experienced with any other drug. My face was extremely red (like a bright, painful red that felt like a bad sunburn) all over for the entire time, plus a week after I stopped taking it. I felt extremely anxious and jittery and I didn't get a good night of sleep for a week after I stopped this med. I should add that I had all these side effects when I only took the drug for 3 days! I've never experienced side effects with other antibiotics. I believe this is a sulfa containing drug and I guess I must have a sulfa allergy.”

3 / 10
Side effect October 23, 2015

For Urinary Tract Infection: “After the 5th pill side effects were horrendous. Slight right side facial weekness, shaking, confused and nearly paralyzed from the right shoulder thru my neck. I asked the pharmacists if there was anything I should know before taking this drug, he told me no.”

1 / 10
Vinylville July 31, 2016

For Urinary Tract Infection: “I've just finished my treatment for a urinary tract infection. I no longer have any symptoms from the infection. First 8 days of a 15 day treatment was fine with no side effects. Beginning the 9th day, I began experiencing a mild rash and itching which seem to begin on my chest and neck and migrated to my back. A bit of a nuisance but tolerable. Around the 11th day, I began to experience mild joint and muscle ache and a tender scalp around the base of the skull. Acetaminophen and ibuprofen have helped to overcome this but by the 14th and 15th day, I felt like a had the flu with no nausea but a loss of appetite. I took the last pill this morning and by 1PM, had to lay down with chills, aches and pains, headache and a slight fever.”

6 / 10
LizG · Taken for less than 1 month August 6, 2019

For Urinary Tract Infection: “I have been prescribed this medication many times over the last 40 years for urinary tract infections and it always works for me with no side effects. Just into my second day of this round for the latest UTI and it is already working. The burning sensation when urinating and the blood in urine has almost stopped. I will take the remaining pills — two a day for seven days — and I’m sure I will be right as rain until I get the next UTI. I seem to get these once or twice a year, but this drug seems to work best for me...better than Macrobid.”

10 / 10
Lili · Taken for less than 1 month May 20, 2019

For Bacterial Infection: “I have Dysuria, Furuncle of groin, cellulitis at the same time , I was given sulfamethoxazole plus TMP/ Ds 800 every 12 hours. I also have hashimoto disease, and took my levothyroxine a while after taking bactrim (sulfamethoxazole plus TMP). The first day I started having cramps on left side of stomach , thinking it was normal, took the 2nd, pill after 12 hours I was worse than before , light headache, nausea, full and heavy stomach feeling. Then I took the 3rd, pill in the morning and soon I was having chest pain, nausea, tired irregular heartbeat, fatigue and tight chest , pain on teeth, lips and muscle pain. The symptoms are not improving I called pharmacy and they wanted me to call my doctor, but I will stop this medication, as per my primary doctor. I will have a long talk with them tomorrow as according to my medical records I shouldn’t have been on this medication”

10 / 10
Jrzgirl July 3, 2015

For Urinary Tract Infection: “I am on the 5th day of my UTI. The pressure and bearing down while urinating is similar to labor pains. I'm out of state and visited an Urgent Care Center. The NP prescribed the generic Bactrim. I went back to the Urgent Care Center after 4 days and she gave me 3 more days of the SMZ -TMP DS. I told her my symptoms were the same as my initial visit. Promised that infection would clear with the additional pills in addition to AZO , an over the counter pill to relieve the pressure. It's now day 5 and I feel like I'm on day 1. This medication is doing NOTHING for me. It's Friday and I'm sure I will be visiting another Dr. on Monday. I just want to feel like myself again. ”

1 / 10
Lucy · Taken for less than 1 month January 7, 2020

For Urinary Tract Infection: “I was prescribed this for UTI. I’ve had severe stomach pain, back pain and had to stop eating. Day 4 of 7 day prescription. It does not work for the UTI and instead I’m wondering if I have ulcer from this medication!”

5 / 10
Noel Prada May 28, 2012

For Acne: “When I had acne, I tried almost every medicine. I was in Boston in my house alone and my friend told me he had acne and he took SMZ-TMP DS. When I tried it, everything worked in a jiffy. So now when someone has acne I just tell them to try SMZ-TMP DS and you will never regret.”

10 / 10
Karna1962 May 11, 2017

For Urinary Tract Infection: “After taking the 2nd dose, I began having a very bad burning feeling in my stomach. Then my back muscles hurt. The was no getting comfortable. I also could only urinate once in 10 hours when I had been going about every 2 hours prior. About 10 hours after I took that dose, I finally and unexpectedly vomited. I fell asleep for a few hours and when I woke, my backache was gone and I wasn't doubled over in pain from my stomach. I immediately decided that I wasn't even going to try another dose and called to be put on something different. It's now been 5 days since I took this medicine and my stomach still feels like it has a hole eaten through it.”

1 / 10
Mrs no neck · Taken for less than 1 month October 26, 2019

For Urinary Tract Infection: “First time ever taking this medicine. I have had stomach pains and nausea. I did everything the Dr told me to and I still have the horrible side effects! I thought it was from the UTI. After reading all the other comments I see it’s from the medication. The dr only gave me 3 day supply. I have had a headache from day one of the pills and I have been constipated too. Calling the Dr tomorrow to see what we can do to get rid of the side effects. Will not take this ever again!”

1 / 10
Aaron · Taken for less than 1 month April 10, 2020

For Bacterial Skin Infection: “I have cellulitis. I took the first dose of sulfamethoxazole/trimethoprim and my chest tightened up in about 4 hours accompanied with shortness of breath if I move the slightest bit. This is how I found this blog thru a Google search. Yup one dose is all I'm taking.”

1 / 10
Anonymous October 4, 2011

For Acne: “I was prescribed this for my acne along with several other creams and within a month my mild acne problem was cleared up, but if I stopped taking the pills completely I would break out so instead I slowly went off the medicines and now I'm taking one every other day and have clear skin. This medicine works wonders.”

10 / 10
96yearoldman · Taken for less than 1 month October 4, 2019

For Urinary Tract Infection: “Experienced confusion, overal body weakness, could not sleep, extreme lower body weakness (resulting in repetitive falls), dizziness These symptoms occurred when my 96 year old father was prescribed this medication for a UTI, symptoms began after the first day of taking it. By the second day he fell once, the 3rd day he fell 2 seperate times and I finally realized the medicine was probably the cause and discontinued using it. Note: Dad is old, but it is worth mentioning that he slept A LOT prior to starting this medicine, and was able to get himself to the bathroom himself without falling. (He slept the large majority of daytime and nightime). At least by the 2nd day of taking this med, he didn't sleep more then an hour at a time and was awake and confused, and restless for the majority of the time. I stopped administering medicine after the 3rd day. It is only the first day of stopping the med, so I don't know yet how long these side effects will last!”

1 / 10
R.Jones · Taken for 2 to 5 years June 24, 2013

For Upper Respiratory Tract Infection: “Being that I have rheumatoid arthritis and take medication for that, finding antibiotics to treat infection isn't easy. I did not have many side effects from this medicine, as I took it how the doctor prescribed. I did have upset stomach though at first. Any infection I had, showed definite improvement within the first 36 hrs.”

8 / 10
No Keflex For Me! October 13, 2016

For Urinary Tract Infection: “Was prescribed this for a UTI. Spent 6 hours in the emergency room for dehydration after 3 1/2 hours of extreme abdominal pain, severe diarrhea, and vomiting. This, after only 1 pill. Worse than my experience with augmentin by far.”

1 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.