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User Reviews for Sulfamethoxazole / trimethoprim

Also known as: Bactrim, Bactrim DS, Septra, SMZ-TMP DS, Co-trimoxazole, Septra DS, Bactrim Pediatric, Sulfatrim Pediatric, Bactrim IV Bethaprim Bethaprim Pediatric …show all brand names

Sulfamethoxazole / trimethoprim has an average rating of 4.9 out of 10 from a total of 1,652 ratings on Drugs.com. 34% of reviewers reported a positive experience, while 47% reported a negative experience.

Condition Avg. Rating Reviews Compare
Urinary Tract Infection  
4.3
739 reviews 189 medications
Bacterial Skin Infection  
5.0
253 reviews 53 medications
Bacterial Infection  
3.8
194 reviews 171 medications
Acne  Off-label
7.7
193 reviews 524 medications
Sinusitis  
5.1
75 reviews 250 medications
Kidney Infections  
4.4
72 reviews 94 medications
Prostatitis  
4.6
50 reviews 49 medications
Upper Respiratory Tract Infection  
4.1
16 reviews 120 medications
Bronchitis  
6.9
15 reviews 290 medications
Infection Prophylaxis  
5.0
10 reviews 24 medications
Diverticulitis  
5.6
9 reviews 32 medications
Otitis Media  
5.2
9 reviews 137 medications
Prevention of Bladder infection  
4.7
8 reviews 29 medications
Traveler's Diarrhea  
7.7
3 reviews 76 medications
Nocardiosis  
8.5
2 reviews 21 medications
Pneumocystis Pneumonia  
7.0
1 reviews 32 medications
Pneumonia  
3.0
1 reviews 188 medications
Meningitis  
1.0
1 reviews 70 medications
Shigellosis  
10.0
1 reviews 30 medications
Summary of Sulfamethoxazole / trimethoprim reviews 4.9 1,652 reviews

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Sulfamethoxazole / trimethoprim

It’ll be okay · August 17, 2019

Bactrim (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “I prayed long and hard, I want to pay it forward so someone else didn’t experience the anxiety that came with looking at these reviews. Know that you’re taking this because you have an infection, and that in itself can make you feel miserable. A lot of these side effects mentioned are parallel with symptoms of a significant infection. So there’s that. Take AFTER you eat. Not a “bite of banana. Eat a good meal- Take with a full bottle of water- I took mine with benedryl due to the fact my skin gets itchy ( not a rash) I also took a GOOD probiotic to counter any gut microbiome disruption. Eat bananas- simple foods- not greasy meals. Avoid extra sun exposure or anything that will zap you. Yes, it can make your stomach a little off, but it was tolerable and I was on it twice a day for 5 days 800mg. I was scared- and I will add have FAITH. Let it go. You’re taking it to heal- it’s not always a happy walk in the park process. Every single person reacts different Hope this helps someone.”

8 / 10
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Sadie · April 21, 2021

Bactrim (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “Let me tell you, I was so nervous to start Bactrim after reading these reviews. I thought for sure I was going to have terrible side effects. Turns out, I’m completely fine. The most I’ve had is some nausea/lack of appetite but I get that with almost all antibiotics. Make sure you eat a meal ahead of taking each pill and drink lots of water. As long as you’re not allergic to sulfa drugs, I can almost guarantee that you’re going to be ok :). Remember, temporary side effects are better than a kidney infection!!”

9 / 10
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Anonymous · Taken for less than 1 month · May 14, 2019

Bactrim DS (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “I promised that if I had a decent experience with this antibiotic I would write about it. You will not have any of these scary reactions if you are not allergic or are taking a medication that will interact with this. I have anxiety so I know how it feels to read horrible reviews about meds, but the bactrim worked great for my UTI.”

8 / 10
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C · Taken for less than 1 month · July 8, 2021

Bactrim (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “Gave me severe anxiety, I felt like I was psychotic. Panic attack where I could barely even talk, eyes were bugging out. I am not a mentally ill person in any way and I have never felt this way before in my life the way this pill made me feel. I almost didn’t know it was the drug until I checked this website and read that everyone and their mothers have experienced severe anxiety caused by this pill. Doctor told me it doesn’t cause anxiety to continue taking it today so it looks like I won’t be listening to them after reading a web page full of people with complaints of severe anxiety and panic. I also definitely felt like I was losing myself/my mind without knowing why as someone has mentioned on here before. It’s tricky because physically I have not had issues with this pill I was not sick from it so I thought everything was going well, but it really messed with my brain. Do not take this.”

1 / 10
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Leia · Taken for less than 1 month · November 8, 2019

Bactrim (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “I have an intense phobia of taking meds due to a life threatening experience with another antibiotic, so I've been tuned into any possible side effect forming within my body after reading all the warnings for this med. I was diagnosed with a severe UTI that was starting to effect my kidneys, so my doc said it was imperative I take medication and prescribed Bactrim DS for 7 days, twice a day. I have had 2 full doses, and 24 hours about 70% of my UTI symptoms have disappeared and I have had virtually no negative side effects. Within 48 hours almost completely gone. I do have some very mild itching with no rash or redness that comes and goes. And heartburn (potentially from a combo of taking the med plus cranberry juice that already gives me heartburn sometimes). That's it! Energy is fine, no weird pains, no tummy specific issues, etc. I am only on day 2, so if anything scary happens, I will update that info. So far, I have had a good experience with Bactrim!”

10 / 10
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Cwalk · Taken for 1 to 6 months · April 29, 2020

Bactrim DS (sulfamethoxazole / trimethoprim) for Prostatitis: “I’ve been on bactrim for almost three months for Prostatitis which is getting better slowly. Having some lower back pain. Has anyone else had to be on a bactrim for this long to cure this problem. During all this the pain started in my testicles and went up into pain behind my penis. So tired of this pain. Anyone else have the same issues?”

6 / 10
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Mel · Taken for less than 1 month · December 18, 2019

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Infection: “I just wanted to share my experience for people like me that are anxious about trying new drugs and see all these bad reviews. Only people who had a bad experience/are allergic tend to write reviews. Probably 90% of people who took Bactrim had no side effects. On that note, I was prescribed this for a moderate bacterial infection. It was probably 50% healed overnight after starting antibiotics, with only VERY minor side effects. It made me pretty tired and gave me a teeny bit of heartburn but that’s it. Don’t worry, major side effects are rare. :)”

8 / 10
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Frequently asked questions

Niki · Taken for less than 1 month · February 4, 2021

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Infection: “Noo!!! Do not take this medicine. I was at the hospital a week ago for a severe UTI they prescribed me Bactrim. They wanted me to take it twice daily for 10 days. I made it to day 6 and tonight I feel so bad. My legs are tingling my tongue feels tingly and my mouth is super dry. I’m having bad stomach cramps and my ears hurt. This is all from this medicine. I’ve been having severe headaches, nausea and my anxiety is so bad. Please be very aware with taking this medicine.”

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Maria · Taken for 1 to 2 years · November 8, 2019

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Skin Infection: “I started getting boils about a couple of years ago. And they are the worse! Took me along time to figure out what I could do to get some relief and make them go away. My dr prescribes me Bactrim and it starts to relieve the pressure and they start going down within 24 hours. I also like to put this boil salve on them with a bandaid, to keep it on there and without a mess. And the two work great! I see a lot of bad reviews. Well I have had bad anxiety/panic attacks for over 10 years now and Bactrim does not make it any worse. I don't have any side effects from this antibiotic. It works great for me. Some people may read reviews that are bad and they may think themselves into a panic attack. If you're allergic to it, that's another thing. Can't do anything for that. I'm just happy I have found an antibiotic that gets rid of these severe painful boils!”

10 / 10
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Wow · Taken for less than 1 month · June 9, 2020

Bactrim (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “I was on this drug for only 2 days until I had the worst stomach pains ever like it knocked the wind out of me. I had severe diarrhea with mucus and blood that lasted for weeks after discontinued use. It has been a month and I still have nausea with severe abdominal pains, headaches, anxiety, light sensitivity, white bumps on my gums. I’m scared that my organs are damaged which I am currently being tested for. I have never had any of these symptoms before and was perfectly healthy! I am young too. This drug RUINED my life. I would rate this drug in the negatives if I could. Should not be allowed to be prescribed!”

1 / 10
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Anonymous · Taken for less than 1 month · February 9, 2021

For Bacterial Infection: “If you never have had a panic attack but would like to know what one feels like then this sulfamethoxazole with trimethoprim is for you. If you are lucky enough to not have any side effects consider yourself lucky. It had me convinced I was going to die. Not from self inflicted injuries but from my heart jumping out of my chest. I have tried it several times and it’s the same result. Never again!!!”

1 / 10
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Hilgy · September 16, 2014

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Skin Infection: “Contacted MRSA and received Bactrim for 14 days and cleared. Three years later contacted cellulitus from a wound not taken care of by me. Bactrim took care of it. Dangerous conditions cured with Bactrim.”

10 / 10
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TJ · Taken for less than 1 month · January 21, 2021

Bactrim DS (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “Found this site as I was taking my first Bactrim dose and was concerned about side affects. The first day didn't feel great but I didn't attribute that to the medication. I took med with food, before and after and felt key was to drink a lot of water to flush system. I cut back on coffee intake as well. Completed all meds with no side effects. It cleared the UTI up quickly.”

10 / 10
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Lirpa13 · October 30, 2013

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Skin Infection: “Can't live without having this in by medicine cabinet. At the onset of a suspected boil I take this and problem solved! I have been taking this for many years. Before Bactrim I had boil after boil, scars, and embarrassment. Miracle drug for boils, who cares about minor side effects!!!”

10 / 10
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Greenfox · Taken for less than 1 month · September 17, 2020

For Bacterial Infection: “I am on the last day of a seven day course of this combo antibiotic sulfamethoxazole with trimethoprim. The infection has cleared up yes (UTI) but my anxiety has been amplified 10 fold, as well as having hot flushes, a hard time concentrating, fatigue, and extreme depression. I would recommend that anyone who has a preexisting anxiety disorder or depression request a different antibiotic as sulfamethoxazole with trimethoprim seems to make anxiety a lot worse. I feel miserable right now.”

1 / 10
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Girl with a red ear · February 6, 2017

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Skin Infection: “First and foremost I want to let you all know, reading things on the internet, WILL NOT help, nor really be a good indicator of your personal reaction to any drug. There are many negative reviews here for Bactrim, and I'm on day 3 of a 10 day dose for a staph infection (cellulitis) on, of all places the right side of my face/right ear (its wonderful!). Here's my experience: Side Effects: Fatigue, headaches (though not consistent). I have a weaker stomach, and its doing just fine with my probiotic (get one with 30billion strands) and drinking lots of water/eating while taking it. The infection is clearing up. Day 3 was when I really noticed. Don't be anxious when taking this, its definitely a mind over matter thing sometimes too.”

8 / 10
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ParanoidForNothing · Taken for less than 1 month · January 1, 2019

Bactrim DS (sulfamethoxazole / trimethoprim) for Sinusitis: “Like many others, I read review after review on here of negative experiences, making myself terrified of taking this drug. As someone who is so worried about throwing up that I carry anti-nausea medication with me everywhere I go, I was very reluctant to begin 6 weeks of Bactrim after reading all of these reviews. Fortunately, I experienced no major side effects and it seems to be helping with the infection. Some very mild nausea at first that was likely anxiety-induced, and acid reflux which is common with all antibiotics. Yogurt and a probiotic daily helps with this. Anyway, I promised myself that I would write a positive review if I ended up having a positive experience, so here it is. If you're worried like I was, remember that people are way more inclined to post drug reviews online when they have negative experiences, than normal or positive ones. The vast majority of people taking Bactrim feel absolutely fine, and keeping this in mind may help ease your fears as well.”

8 / 10
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kdezzle · Taken for less than 1 month · May 13, 2019

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Skin Infection: “Posting my experience to hopefully put some minds at ease as reading these reviews really scared me! I am very sensitive to antibiotics and have had adverse reactions to the past three I have taken. I was prescribed Bactrim for a nasty spider bite to help it & prevent further infection. On day two I already experience immense relief from the pain and the bite started to shrink. I now am on day five and have had no side effects at all except some fatigue and minor nausea at night. Definitely bearable. Be sure to take a probiotic and remember everyone’s body is different! I am happy I finally found an antibiotic that agrees with me.”

8 / 10
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Crazy · Taken for less than 1 month · June 26, 2020

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Infection: “I had a staph infection and I am also on paxil for depression. I used bactrim for eight days and became very sick. My depression was very severe with this drug. Cold sweats, very weak, mouth issues, nerve pain in legs, headache insomnia and what makes it worse is that you are on a roller coaster. ”

2 / 10
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Kd0520 · Taken for less than 1 month · June 27, 2020

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Infection: “I took Bactrim for 4 days. On the 4th day, I started having leg pain. The day after I quit the meds, I had all over body aches, a low grade temp off and on and just a feeling of being ick. The next day, my aches went away but held on to the low grade temp, headache and weakness for two more days. During the course of the medication, I also had a pounding heart and no appetite. It did clear the infection though. I think I had a bad reaction and only wanted to report these so that others might know if they have the same thing happening to them. It took about 5 days from my last pill that I feel better.”

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Julu · Taken for less than 1 month · October 26, 2019

Bactrim (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “After a week of experiencing painful, and uncomfortably annoying UTI symptoms, I went to the doctor, and was prescribed Bactrim for 7 days. I have no insurance, but I was able to get 14 pills for $7.00 with Good RX. 30 minutes after taking the first pill, the feeling of urgency left. When I went to the restroom, there was almost no pain. I am on my third day, and I am feeling close to normal. The urgency is gone, and the pain while urinating is gone. The only side effects I can say I am experiencing is a slight lost in appetite and a little neck pain and joint pain in my hands. But on a scale of 1 to 10, I would say that those symptoms are at a 3. I see that many of the reviews on this medicine are scary. But just know that everyone's body is different, even to the point of pain tolerance. So what might be okay for one person, might not be so for another. Either way, the benefit of being relieved of my UTI symptoms far outweigh the other risks of side effects.”

8 / 10
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Lauren2349 · January 8, 2020

Bactrim (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “I was prescribed Bactrim for a UTI. Felt fine the first day. By day 2, I experienced horrible symptoms or side effects. I was having severe anxiety, nausea, increased heart rate, and shaking in my body. Called my doctor and she said to continue taking it but after reading all of these reviews I’ve decided to stop taking the antibiotics. So scary to see so many other women going through the same thing!”

1 / 10
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A-Thorson · June 6, 2016

Bactrim DS (sulfamethoxazole / trimethoprim) for Urinary Tract Infection: “I was scared to take this because I read about people having horrifying side effects...I'm taking the generic form of Bactrim DS 2x a day for 7 days. On day 5 and the only side effects I've noticed are mild gas and a headache. If you're skimming these reviews looking for reasons to be scared, just remember that most of these bad reviews are from people who are probably: A) Allergic to the medicine. B) Not drinking enough water. C) Using alcohol and non-prescription drugs which you are NOT supposed to do while on Bactrim. D) Not taking it with food. Take the medicine with food and a good probiotic and it will help minimize your side effects. Drink LOTS of water and stay out of the sun while on this medicine! Not soda, not coffee, WATER.”

7 / 10
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Col · August 18, 2018

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Skin Infection: “I’m on a Day 4 of very high dose (2 tabls twice a day) and it’s about the same as when I took it years ago (so far). On second day felt queasy, tongue and lips a little irritable, gut uncomfortable, generally crummy. By end of third day better on all fronts and expect/hope to be ok (using for a MRSA boil; redness going away rapidly!). I (almost) eliminated refined sugar, drink lots of water, not too much sun. Why so many bad reviews? I guess people who do ok (vast majority) don’t visit the site or leave comments. Hope this helps.”

9 / 10
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LizzyC. · Taken for less than 1 month · February 12, 2017

Bactrim (sulfamethoxazole / trimethoprim) for Bacterial Skin Infection: “I broke out in blisters on face, scalp, and chest. These were oozing a clear sticky fluid that literally melted the skin it oozed over. Tried everything over the counter and homeopathic but this flesh eating infection would not clear. Finally went to urgent care and was prescribed Bactrim for an assumed MRSA skin infection. Within The first 24 hours I had noticeable improvement. Sores weren't burning red and swollen, by 3rd day some scabs are already falling off with healthy pink skin underneath, no ooze, no new blisters. Day 5 you would hardly know I had a skin problem. All clear. Only side effect I had was loss of appetite. Didn't want to eat, nothing sounded good. Lost 4 pounds. Not everyone reacts bad to Bactrim.”

8 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.