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Medications for Acne

Other names: Acne Vulgaris; Blackheads; Breakouts; Cystic acne; Pimples; Whiteheads; Zits

About Acne:  An inflammatory skin condition characterized by superficial skin eruptions around hair follicles.

Drugs Used to Treat Acne

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
doxycycline D N X 609 reviews
7.0

Generic name: doxycycline systemic

Brand names:  Doryx, Vibramycin, Acticlate, Doxy 100, Monodox, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Avidoxy, Doryx MPC, Mondoxyne NL, Morgidox, Ocudox, Oraxyl, Targadox, Vibra-Tabs …show all

Drug class: tetracyclines, miscellaneous antimalarials

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

spironolactone Off Label C N X 267 reviews
7.0

Generic name: spironolactone systemic

Brand name:  Aldactone

Drug class: potassium-sparing diuretics, aldosterone receptor antagonists

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

minocycline D N 394 reviews
6.0

Generic name: minocycline systemic

Brand names:  Solodyn, Minocin, Cleeravue-M, Dynacin, Minolira, Myrac, Ximino …show all

Drug class: tetracyclines

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Aldactone Off Label C N X 7 reviews
8.0

Generic name: spironolactone systemic

Drug class: potassium-sparing diuretics, aldosterone receptor antagonists

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

clindamycin B N 96 reviews
7.0

Generic name: clindamycin topical

Brand names:  Clindagel, Cleocin T, Clinda-Derm, Evoclin, Clindacin ETZ, Clindacin P, Clindacin PAC, ClindaReach Pledget, Clindets …show all

Drug class: topical acne agents, vaginal anti-infectives

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

tretinoin C N 355 reviews
7.0

Generic name: tretinoin topical

Brand names:  Retin-A, Atralin, Altreno, Avita, Stieva-A, Stieva-A Forte …show all

Drug class: topical acne agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Bactrim Off Label D N X 73 reviews
8.0

Generic name: sulfamethoxazole / trimethoprim systemic

Drug class: sulfonamides

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

Retin-A C N 53 reviews
8.0

Generic name: tretinoin topical

Drug class: topical acne agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

isotretinoin X N X 778 reviews
8.0

Generic name: isotretinoin systemic

Brand names:  Claravis, Absorica, Amnesteem, Myorisan, Zenatane, Sotret …show all

Drug class: miscellaneous antineoplastics, miscellaneous uncategorized agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Aczone C N 190 reviews
7.0

Generic name: dapsone topical

Drug class: topical acne agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Epiduo C N 543 reviews
7.0

Generic name: adapalene / benzoyl peroxide topical

Drug class: topical acne agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Differin C N 188 reviews
7.0

Generic name: adapalene topical

Drug class: topical acne agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Solodyn D N 96 reviews
6.0

Generic name: minocycline systemic

Drug class: tetracyclines

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

benzoyl peroxide C N 32 reviews
8.0

Generic name: benzoyl peroxide topical

Brand names:  Acne Treatment, BenzEFoam, PanOxyl, Acetoxyl, Acne-10, Acne-Clear, Acnomel BP 5, Alquam-X Acne Therapy Gel, Benprox, Benzac, Benzac AC, Benzac AC Wash, Benzac W, Benzagel, Benzagel Wash, Benzashave, BenzEFoam Ultra, BenzePro, Benziq, Benziq Wash, Binora, BP Foaming Wash, BPO-5 Wash, BPO-10 Wash, BPO 3 Foaming Cloths, BPO 6 Foaming Cloths, BPO 9 Foaming Cloths, BPO Gel, BP Wash, Brevoxyl, Brevoxyl Acne Wash Kit, Brevoxyl Creamy Wash, Clearskin, Clinac BPO, Delos, Desquam-X Wash, Fostex Wash 10%, Inova, NeoBenz Micro, NeoBenz Micro SD, NeoBenz Micro Wash Plus Pack, Neutrogena Clear Pore Cleanser / Mask, Neutrogena Rapid Clear Stubborn Acne, Oscion, Oxy-10, Oxy Daily Wash, Pacnex, PanOxyl 4% Acne Creamy Wash, PanOxyl 10% Acne Foaming Wash, Peroderm 7 Wash, Persa-Gel, PR Benzoyl Peroxide Wash, Riax, SE BPO, SoluCLENZ Rx, Triaz …show all

Drug class: topical acne agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

Doryx D N X 56 reviews
7.0

Generic name: doxycycline systemic

Drug class: tetracyclines, miscellaneous antimalarials

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

SMZ-TMP DS Off Label D N X 4 reviews
7.0

Generic name: sulfamethoxazole / trimethoprim systemic

Drug class: sulfonamides

For consumers: dosage, interactions, side effects

Off Label: Yes

tetracycline D N 21 reviews
7.0

Generic name: tetracycline systemic

Brand names:  Achromycin V, Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap, Tetracon …show all

Drug class: tetracyclines

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

adapalene C N 318 reviews
7.0

Generic name: adapalene topical

Brand name:  Differin

Drug class: topical acne agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Tazorac X N 14 reviews
7.0

Generic name: tazarotene topical

Drug class: topical antipsoriatics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

cephalexin Off Label B N 3 reviews
6.0

Generic name: cephalexin systemic

Brand names:  Keflex, Biocef, Daxbia, Panixine …show all

Drug class: first generation cephalosporins

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Septra Off Label D N X 2 reviews
9.0

Generic name: sulfamethoxazole / trimethoprim systemic

Drug class: sulfonamides

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

sulfamethoxazole / trimethoprim Off Label D N X 143 reviews
8.0

Generic name: sulfamethoxazole / trimethoprim systemic

Brand names:  Bactrim, SMZ-TMP DS, Septra, Bactrim DS, Septra DS, Co-trimoxazole, Sulfatrim …show all

Drug class: sulfonamides

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

Off Label: Yes

Vibramycin D N X 3 reviews
8.0

Generic name: doxycycline systemic

Drug class: tetracyclines, miscellaneous antimalarials

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Bactrim DS Off Label D N X 21 reviews
7.0

Generic name: sulfamethoxazole / trimethoprim systemic

Drug class: sulfonamides

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

Benzaclin C N 81 reviews
8.0

Generic name: benzoyl peroxide / clindamycin topical

Drug class: topical acne agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

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Topics under Acne

Alternative treatments for Acne

The following products are considered to be alternative treatments or natural remedies for Acne. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Acne.

Learn more about Acne

Micromedex® Care Notes

Symptoms and treatments

Drugs.com Health Center

Mayo Clinic Reference

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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