Spironolactone Interactions
There are 382 drugs known to interact with spironolactone, along with 7 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 51 are major, 311 are moderate, and 20 are minor.
- View all 382 medications that may interact with spironolactone
- View spironolactone alcohol/food interactions (1)
- View spironolactone disease interactions (7)
Most frequently checked interactions
View interaction reports for spironolactone and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Aspir 81 (aspirin)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- CoQ10 (ubiquinone)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Entresto (sacubitril / valsartan)
- Farxiga (dapagliflozin)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Jardiance (empagliflozin)
- Lasix (furosemide)
- Lexapro (escitalopram)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- Ozempic (semaglutide)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xarelto (rivaroxaban)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Spironolactone alcohol/food interactions
There is 1 alcohol/food interaction with spironolactone.
Spironolactone disease interactions
There are 7 disease interactions with spironolactone which include:
Report options
More about spironolactone
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- Reviews (703)
- Drug images
- Latest FDA alerts (2)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: aldosterone receptor antagonists
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Jardiance
Jardiance (empagliflozin) is used to treat type 2 diabetes, chronic kidney disease and reduce the ...
Farxiga
Farxiga (dapagliflozin) is an oral prescription medication that may be given to certain adults with ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Lasix
Lasix is a loop diuretic used to treat fluid retention from heart, liver, or kidney conditions, and ...
Atenolol
Atenolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about ...
Carvedilol
Carvedilol (Coreg) is used to treat heart failure and hypertension (high blood pressure). Includes ...
Hydrochlorothiazide
HCTZ (hydrochlorothiazide) used to treat high blood pressure (hypertension) and edema. Includes ...
Furosemide
Furosemide is a loop diuretic used to treat fluid retention and high blood pressure by increasing ...
Metoprolol
Metoprolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
