Spironolactone Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 11, 2022.
Applies to spironolactone: oral suspension, oral tablets.
Side effects include:
Most common adverse effect (incidence >5%): Gynecomastia.
Other adverse effects: Hyperkalemia; hypotension; worsening renal function; hyponatremia; hypomagnesemia; hypocalcemia; hypochloremic alkalosis; hyperglycemia; impaired neurologic function/coma in patients with hepatic impairment, cirrhosis and ascites.
For Healthcare Professionals
Applies to spironolactone: compounding powder, oral suspension, oral tablet.
The most common adverse effect was gynecomastia.[Ref]
Very common (10% or more): Gynecomastia (13%)
Frequency not reported: Breast disorders in women, slight androgenic effects, breast tenderness in women, voice deepening in women, breast pain[Ref]
Common (1% to 10%): Hyperkalemia, hyponatremia
Uncommon (0.1% to 1%): Acidosis in patients with liver problems
Rare (less than 0.1%): Dehydration, porphyria, hyperuricemia
Common (1% to 10%): Changes in vaginal secretions, amenorrhea, postmenopausal bleeding
Common (1% to 10%): Lethargy in patients with cirrhosis, paresthesia
Rare (less than 0.1%): Paralysis, paraplegia of the limbs due to hyperkalemia
Very rare (less than 0.01%): Gastric inflammation, gastric ulcers, intestinal hemorrhage, cramps
Common (1% to 10%): Libido reduced in women
Uncommon (0.1% to 1%): Confusion
Frequency not reported: Libido reduced in men[Ref]
Common (1% to 10%): Malaise
Common (1% to 10%): Weakness
Rare (less than 0.1%): Eczema
Very rare (less than 0.01%): Alopecia, erythema annulare centrifugum, hypertrichosis
Frequency not reported: Hirsutism, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS), maculopapular or erythematous cutaneous eruptions[Ref]
Uncommon (0.1% to 1%): Muscle spasms, leg cramps
Uncommon (0.1% to 1%): Serum creatinine elevated
Rare (less than 0.1%): BUN increased
Very rare (less than 0.01%): Acute renal failure
Frequency not reported: Renal dysfunction[Ref]
Rare (less than 0.1%): Thrombocytopenia, eosinophilia, leukopenia
Rare (less than 0.1%): Hypersensitivity
Frequency not reported: Anaphylactic reactions[Ref]
Very rare (less than 0.01%): Vasculitis
Frequency not reported: Mild hypotension[Ref]
Very rare (less than 0.01%): Hepatitis
Frequency not reported: Mixed cholestatic/hepatocellular toxicity[Ref]
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- Drug class: aldosterone receptor antagonists
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Related treatment guides
1. Product Information. Aldactone (spironolactone). Searle. 2001.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
3. Cerner Multum, Inc. Australian Product Information.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.