Spironolactone Alternatives Compared
| Spironolactone | Doxycycline | Accutane (isotretinoin) |
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| Spironolactone | Doxycycline | Accutane (isotretinoin) |
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Prescription only
Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however... View more |
Prescription only
Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more |
Prescription only
Prescribed for Rosacea, Acne, Granuloma Annulare, Acute Nonlymphocytic Leukemia. Accutane may also be used for purposes not listed in this medication guide. |
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| More about Spironolactone | More about Doxycycline | More about Accutane (isotretinoin) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Spironolactone has an average rating of 6.9 out of 10 from a total of 703 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 24% reported a negative effect. |
Doxycycline has an average rating of 6.4 out of 10 from a total of 1635 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 27% reported a negative effect. |
Accutane has an average rating of 7.9 out of 10 from a total of 657 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 14% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Spironolactone side effects |
View all Doxycycline side effects |
View all Accutane side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic approved | ||||||||||||||||||||||||
| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Spironolactone prices |
View all Doxycycline prices |
View all Accutane prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Aldactone, CaroSpir | Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more | Other isotretinoin brands include: Absorica, Absorica LD, Amnesteem, Claravis, Myorisan, Sotret, Zenatane | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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37 hours |
23 hours |
32 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 382 drugs are known to interact with Spironolactone:
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A total of 235 drugs are known to interact with Doxycycline:
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A total of 142 drugs are known to interact with Accutane:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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January 21, 1960 |
December 05, 1967 |
May 07, 1982 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.