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Spironolactone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Spironolactone Remove Spironolactone from your drug comparison Doxycycline Remove Doxycycline from your drug comparison Minocycline Remove Minocycline from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Spironolactone Remove Spironolactone from your drug comparison Doxycycline Remove Doxycycline from your drug comparison Minocycline Remove Minocycline from your drug comparison

Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however,... View more

Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight nor in pregnant women in the last half of... View more

Prescribed for Acne, Bacterial Infection, Bartonellosis, Actinomycosis, Bullous Pemphigoid, Plague, Skin or Soft Tissue Infection, Skin and Structure Infection, Rabbit Fever, Q Fever, Psittacosis,... View more

Prescription only

Prescription only

Prescription only

Ratings & Reviews

View all 555 reviews

View all 1444 reviews

View all 527 reviews

Drug Class

Side Effects

See the full spironolactone side effects document.

See the full doxycycline side effects document.

Commonly reported side effects include: headache.

See the full minocycline side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 50 each
Dosage 25 mg
Per Unit* $0.25
Cost* $12.52

View all spironolactone prices

Quantity 1 capsule
Dosage hyclate 100 mg
Per Unit* $10.66
Cost* $10.66

View all doxycycline prices

Quantity 7 capsule
Dosage 100 mg
Per Unit* $1.31
Cost* $9.15

View all minocycline prices

Get free Discount Card

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Generic Availability

Yes (this medicine)

Yes (this medicine)

Yes (this medicine)

Dosage Form(s) Available
  • Oral tablet
  • Injectable powder for injection
  • Oral capsule
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Oral powder for reconstitution
  • Oral tablet
  • Oral capsule
  • Oral tablet
  • Oral tablet, extended release

Brand Names
Aldactone, CaroSpir Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more Dynacin, Minocin, Minocin for Injection, Minolira, Solodyn, Ximino

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

37 hours

23 hours

17.9 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
D
Category D Positive evidence of risk

See the full Pregnancy Warnings document.
D
Category D Positive evidence of risk

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (1)

N/A

N/A

Drug Interactions

A total of 350 drugs are known to interact with spironolactone:

  • 46 major drug interactions (197 brand and generic names)
  • 281 moderate drug interactions (1352 brand and generic names)
  • 23 minor drug interactions (191 brand and generic names)

A total of 189 drugs are known to interact with doxycycline:

  • 13 major drug interactions (39 brand and generic names)
  • 146 moderate drug interactions (1806 brand and generic names)
  • 30 minor drug interactions (122 brand and generic names)

A total of 187 drugs are known to interact with minocycline:

  • 15 major drug interactions (43 brand and generic names)
  • 146 moderate drug interactions (1807 brand and generic names)
  • 26 minor drug interactions (105 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Spironolactone and alcohol may have additive effects in lowering your blood pressure. You may... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

January 21, 1960

December 05, 1967

June 30, 1971

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer