Spironolactone Alternatives Compared
| Spironolactone | Doxycycline | Minocycline |
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| Spironolactone | Doxycycline | Minocycline |
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Prescription only
Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however... View more |
Prescription only
Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more |
Prescription only
Prescribed for Bacterial Infection, Acne, Bartonellosis, Actinomycosis, Bullous Pemphigoid, Brucellosis, Campylobacter Gastroenteritis, Cholera, Granuloma Inguinale, Meningitis - Meningococcal... View more |
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| More about Spironolactone | More about Doxycycline | More about Minocycline | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Spironolactone has an average rating of 6.9 out of 10 from a total of 688 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 25% reported a negative effect. |
Doxycycline has an average rating of 6.4 out of 10 from a total of 1624 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 27% reported a negative effect. |
Minocycline has an average rating of 5.9 out of 10 from a total of 562 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 33% reported a negative effect. |
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| Side Effects | ||||||||||||||||||||||||||
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See also: spironolactone side effects in more detail. |
See also: doxycycline side effects in more detail. |
See also: minocycline side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all spironolactone prices |
View all doxycycline prices |
View all minocycline prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Aldactone, CaroSpir | Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more | Dynacin, Minocin, Minocin for Injection, Minolira, Solodyn, Ximino | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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37 hours |
23 hours |
17.9 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 376 drugs are known to interact with spironolactone:
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A total of 203 drugs are known to interact with doxycycline:
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A total of 202 drugs are known to interact with minocycline:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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January 21, 1960 |
December 05, 1967 |
June 30, 1971 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.