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Doxycycline User Reviews & Ratings

Brand names: Vibramycin, Monodox, Oracea, Adoxa, Doryx, Doxy 100, Acticlate, Doryx MPC, Avidoxy, Uracil, Mondoxyne NL, Okebo, Doxy-D, Oraxyl, Doxy-Caps, Alodox, Morgidox, Adoxa Pak, Adoxa TT, Adoxa CK, Targadox LymePak Doxy 200 …show all brand names

Doxycycline has an average rating of 6.5 out of 10 from a total of 1,621 reviews on Drugs.com. 50% of reviewers reported a positive experience, while 26% reported a negative experience.

Condition Avg. Rating Reviews Compare
Acne  
6.8
771 reviews for Acne 515 medications
Bacterial Infection  
4.8
209 reviews for Bacterial Infection 176 medications
Rosacea  
7.9
117 reviews for Rosacea 109 medications
Chlamydia Infection  
6.7
98 reviews for Chlamydia Infection 59 medications
Lyme Disease  
6.9
71 reviews for Lyme Disease 36 medications
Upper Respiratory Tract Infection  
6.0
67 reviews for Upper Respiratory Tract Infection 113 medications
Pneumonia  
6.7
63 reviews for Pneumonia 190 medications
Skin or Soft Tissue Infection  
6.0
54 reviews for Skin or Soft Tissue Infection 164 medications
Bronchitis  
5.1
50 reviews for Bronchitis 290 medications
Urinary Tract Infection  
6.5
41 reviews for Urinary Tract Infection 197 medications
Prostatitis  
5.6
17 reviews for Prostatitis 49 medications
Lyme Disease, Neurologic  
7.2
9 reviews for Lyme Disease, Neurologic 34 medications
Pelvic Inflammatory Disease  
5.7
8 reviews for Pelvic Inflammatory Disease 67 medications
Malaria Prevention  
3.9
7 reviews for Malaria Prevention 25 medications
Malaria  
8.0
5 reviews for Malaria 44 medications
Rheumatoid Arthritis  Off-label
8.0
5 reviews for Rheumatoid Arthritis 371 medications
Ocular Rosacea  
3.2
5 reviews for Ocular Rosacea 44 medications
Ehrlichiosis  
8.3
3 reviews for Ehrlichiosis 23 medications
Bartonellosis  
5.5
2 reviews for Bartonellosis 36 medications
Gastroenteritis  
5.0
2 reviews for Gastroenteritis 20 medications
Gonococcal Infection, Uncomplicated  
5.0
2 reviews for Gonococcal Infection, Uncomplicated 62 medications
Lyme Disease, Arthritis  
7.5
2 reviews for Lyme Disease, Arthritis 36 medications
Rickettsial Infection  
5.5
2 reviews for Rickettsial Infection 26 medications
Syphilis, Early  
9.0
2 reviews for Syphilis, Early 44 medications
Bullous Pemphigoid  
9.0
1 reviews for Bullous Pemphigoid 77 medications
Brucellosis  
10.0
1 reviews for Brucellosis 30 medications
Q Fever  
9.0
1 reviews for Q Fever 1 medications
Pemphigoid  
7.0
1 reviews for Pemphigoid 77 medications
Cervicitis  
6.0
1 reviews for Cervicitis 33 medications
Mycoplasma Pneumonia  
10.0
1 reviews for Mycoplasma Pneumonia 37 medications
Anthrax  
10.0
1 reviews for Anthrax 28 medications
Bronchiectasis  
9.0
1 reviews for Bronchiectasis 154 medications
Pleural Effusion  
1 reviews for Pleural Effusion 15 medications
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Reviews for Doxycycline

  • User
  • Taken for 1 to 6 months
  • January 27, 2020

For Acne "I was prescribed doxycycline 100mg x 1 a day for three months which was for my acne. Please persevere!! After two months my skin had made no improvement at all, I was getting new spots everyday and these were now causing scarring. I felt so down at the fact that it had done absolutely nothing for me! I started exploring other options and considered coming off this antibiotic but thought I’d stick it out for the final month. I’m so glad I did, as I’m now on my final week of the third month and my skin is practically clear! The only thing I now worry is whether my acne will come back after finishing the course... but we will see."

9 / 10
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342 Report
  • Dolly
  • Taken for less than 1 month
  • January 5, 2020

For Bacterial Infection "I was terrified of taking this medication due to the reviews here which are so scary but had to take the medication for chronic sinusitis that was the worst for me. DO NOT let these reviews deter you as I had no side effects only that I had to eat before taking the meds..just a cracker will do even, to stop nausea. I was feeling so much better in just two days but kept taking my 14 day course to complete. I am allergic to penicillin and usually get many side effects listed on medications BUT NONE FROM THIS. I had headache anyhow from the sinusitis so just took a paracetamol as well as the doxy which is allowed and this sorted me right out. Should you be prescribed doxycycline then take it and do not worry about all the bad reviews just get better."

10 / 10
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286 Report
  • Emua
  • Taken for less than 1 month
  • September 1, 2018

For Urinary Tract Infection "I was prescribed this medicine for UTI. So far (day 3) my UTI pain has gone down a lot. If you’re like me and you research every detail of a medicine before you take it, please listen to me. I have extremely bad anxiety and I’ll think I have tons of symptoms after I take my medicine but it’s just my anxiety. Take a deep breath. Take some probiotics, eat (if it is with food) and then take your antibiotics and you’ll be fine. Get some rest and drink water. This medicine gave me no symptoms. Stop researching! Everyone’s different, just because someone had a bad experience doesn’t mean you do!"

9 / 10
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331 Report

Frequently asked questions

  • Griff
  • October 2, 2020

For Acne "I have been taking doxycycline for about a month and a half now and finally see improvement in my acne. I have been taking pictures every week and the first month was horrific. My acne got way worse and I started to get a little depressed. I still have acne and white heads but I can see a difference in my skin, although I have acne scares all over my cheeks. I will update next month."

7 / 10
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183 Report
  • Marley...
  • Taken for less than 1 month
  • August 14, 2021

For Bacterial Infection "I suffer from severe health anxiety and a medication phobia. When I'm prescribed a drug, I come onto these sites and scour the reviews, usually terrified from all the negative ones I see. I'm not sure why people leave these extremely negative reviews. I guess they just want to share their experience. But what happens is those experiences frighten people like me who don't really have a choice in taking a prescribed drug. Let me now tell you my experience. I took this drug for 10 days and had no side effects except a little sleepiness. I am extremely thankful we have antibiotics like this in today's times."

10 / 10
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116 Report

Are you taking this medicine?

  • Taylor
  • Taken for 1 to 6 months
  • May 25, 2020

For Acne "I started doxycycline in late July 2019 for acne. At the end of the 1st week my acne looked as if it dried up (meaning there wasn’t any pimples only acne scars). If you never use to wear sunscreen well you would need to especially during the first months, your skin is soooo sensitive. Waxing is a no no and exfoliating is a big no (learned the hard way lol). It also causes nausea, it is very important to take it whilst eating or right after a meal to not get nausea. The scaring eventually go away in 2 months or so after use (my experience), for quicker results my Dr. prescribed a skin lightening cream for spot treatment. After 6 months I was off Doxycycline and I just use Retin A and Deriva C alternatively. I don’t have any “active” acne well except the occasional 1 or 2 pimples that appear during menstruation."

9 / 10
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139 Report
  • Reinh...
  • Taken for less than 1 month
  • January 19, 2021

For Urinary Tract Infection "The two side effects that always got me while taking doxy were the feeling of nausea and having diarrhea shortly after taking the medicine. For the nausea, I would just eat and it would pretty much immediately go away. Anyways... I did a 10 day course because I noticed burning in my urethra while peeing and the need to go to the restroom very often, and after about the 3rd or 4th day, the burning was gone but it took until about the 7th or 8th day for the urgency to pee to go away. I’m an adult male 6’1, 230lbish, and I took a 100mg dose twice a day, usually 12 hours apart. Hope this helps!"

9 / 10
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120 Report

More FAQ

  • ktano
  • Taken for less than 1 month
  • August 23, 2019

For Acne "This stuff is a gift. After struggling with acne for years without response to topical medications. I was prescribed this by my dermatologist. At first I was a little hesitant because of the reviews (people talking about the purging phase, side effects, etc) but after being on it for about 2 weeks, my skin is almost completely cleared up. Better yet, I haven’t had any of the side effects and I didn’t experience a purging period. The reviews are worrying but don’t knock it till you try it, seriously."

10 / 10
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146 Report
  • richy...
  • Taken for less than 1 month
  • August 28, 2013

For Urinary Tract Infection "I had a severe urinary tract infection and walking pneumonia and doxycycline saved my life. I had 8 seizures back to back due to the serious infections and they tried keflex 1st but it did not work. Doxycycline is awesome and I'm alive today because of it!"

10 / 10
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267 Report
  • Patty
  • February 18, 2020

For Acne "I used this drug for annoying moderate acne. It started off weird. After 2-3 weeks my skin looked like it was starting to clear up. It stayed like that for about a month. Then at the end of the 2nd month my skin was the worst it’s ever been. Now, I thing that was the purging stage because I stuck to taking it everyday, twice and now I’m in the middle of my third and last month taking it. My skin looks amazing and it’s the best it’s ever been. I would recommend this drug, but make sure u ride with it and trust it because it does take a while to see results."

9 / 10
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130 Report
  • Anonymous
  • February 15, 2014

For Bacterial Infection "This is the only medicine that helps get rid of my sinus infections and it looks like that goes for a lot of other people too. This is the only antibiotic that I can take because I am allergic to so many others."

10 / 10
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237 Report
  • phishon
  • Taken for less than 1 month
  • January 15, 2020

For Bacterial Infection "No side effects at all. I am not sure what all the negative reviews are about. If you're having an allergic reaction that is different. Allergic reactions are not the drugs fault, the reaction of your body to the doxycycline, but you should definitely stop if you are showing signs of allergy. It worked great for me. Started to feel better in a couple of days and was completely better in about 4 days. I took the full course as directed."

9 / 10
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122 Report
  • Andy
  • Taken for less than 1 month
  • October 31, 2019

For Upper Respiratory Tract Infection "Had a chesty, wheezy cough for nearly 4 weeks and during that time brought up a lot of green/yellow mucus. Snotty nose. No other symptoms like muscle aches and thought I'd soldier on. After 6 weeks decided to visit Dr. who said my right lung was crackly, and prescribed amoxicillin. Taken for 1 week, only started to feel better on last day of course. Mucus reduced, cough still niggly. Cough became really wet and mucus restarted. Felt like a cup full every time I expelled some. So 10 days later and back to Dr. and it Doxycycline prescribed this time twice a day on day 1, then 1 a day til blister pack completed. Snotty nose disappeared 1st night and on day 3 wheeze disappeared and I still have 4 days of meds to take. No side effects as taken with food and a pint of water at ingestion. If I have anything like this again, I'll press for immediate prescribing of doxy."

10 / 10
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125 Report
  • Unknown
  • Taken for less than 1 month
  • January 18, 2021

For Chlamydia Infection "I got tested positive for Chlamydia and was prescribed Doxycyline for a week and Ciprofloxiane for 10 days (for some reason) by my doctor. All symptoms have seemed to go within time but the penile discharge hasn't gone away. It's been about 5 days since I stopped doxycycline and a couple of days since I stopped the other one. Is it normal to still be discharging?!"

3 / 10
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95 Report
  • Celina
  • Taken for 1 to 6 months
  • August 2, 2020

For Acne "So I'm almost 29. Ive had acne for nearly 5 years. I thought I could cure my acne by just trying new creams, washes, scrubs but finally gave up and went to the doctor. She recommended doxycyline (3 months) and adapalene gel after telling me it looked like severe acne. I was a bit hesitant to take medication as I was afraid it'd come back. She told me the only the option was to see a dermatologist which was about $200-$300. I finally decided to take the meds and use the gel and honestly that was the best decision ever! I started to see a difference on the first day. 2 months in and I feel so confident with my skin. She said if I wanted to repeat it I could. But I'll try and attempt to get off it after my 3rd month. My scarring is still a work in progress but there is a considerable improvement"

9 / 10
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89 Report
  • BigDawg
  • Taken for 1 to 6 months
  • January 16, 2020

For Acne "I posted my review on my 8th week of doxycycline a while back ago under Bigdawg- December 20, 2019. YOUR ACNE WILL GET BAD!!!! February 2nd will be my 3 month mark and so far my acne is clearing up. Just be patient all these side effects are normal. You're not going to magically wake up and have clear skin or any side effects so bring your self to reality. YOUR DR SAID 3 MONTHS for a reason not no 1 month or 2 months. Stick to it and be patient it works!"

10 / 10
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97 Report
  • Penny...
  • Taken for less than 1 month
  • May 29, 2020

For Bacterial Infection "Had extreemly painful sinusitis. Had been given 2 lots of Amoxcillin which didn’t work . Given a 7 day course of Doxy .2 capsules to take on the first day ,then one a day This worked and I did not suffer any side effects at all . Would definitely take this again ."

10 / 10
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90 Report
  • Anonymous
  • December 7, 2019

For Chlamydia Infection "DON’T let these reviews scare you! I was terrified to take these meds after testing positive for Chlamydia because these reviews are so scary. I have a massive phobia of vomit/vomiting and had a huge panic attack before taking my first dose. I awaited the inevitable side effects. 1 week later and I can say that I have had ZERO side effects from this drug. No nausea, no bowl issues, no heart burn. After day 4 all symptoms of Chlamydia were gone and I was feeling very healthy. Here’s hoping my retest comes back negative and I’ll be very happy with the experience and result. All I can say is, don’t worry, Remember that everyone experiences side effects differently and most of these reviews are horror stories. I had a full glass of water with every dose and then another full glass over the next 10-20 minutes after taking it. Hope this helps someone out there! Good luck."

9 / 10
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95 Report
  • Eric
  • Taken for less than 1 month
  • December 8, 2018

For Urinary Tract Infection "I noticed my urine had a very strong, pungent odor to it, was a little darker than normal, but, no pain or problems urinating. I googled "why does my urine smell so pungent". The response was possible UTI (Urinary Tract Infection). I purchased AZO urinary tract infection home self testing Test Strips at my local pharmacy and the results were positive. My doctor prescribed Doxycycline Hyclate 100mg. Within 3 days, the color and odor of my urine returned to normal. I continued to take my RX as prescribed for the next 7 days, took another AZO self test, and the results were negative. This drug worked for me; no side effects."

10 / 10
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109 Report
  • Snm
  • Taken for less than 1 month
  • November 12, 2013

Vibramycin (doxycycline) for Bacterial Infection "I was diagnosed with a bacterial sinus infection and was prescribed this antibiotic, due to being allergic to amoxicillin. The pills are 100 mg each I am to take twice daily. At this time many of my sinus symptoms have dissipated which is an excellent sign that i'm finally on the mend. I haven't had any side effects with this, and have taken as directed. Avoiding dairy products, not laying down 30 minutes after ingesting, and making sure to take it with food and a large glass of water."

8 / 10
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165 Report
  • Jessie
  • Taken for less than 1 month
  • February 2, 2019

For Rosacea "I have been dealing with moderate Rosacea Subtype 2 for a few years. Manageable. This Christmas I had the worst flare I’ve ever had. My cheeks were covered in papules. My face was bright red and BURNED and stung horribly. It spread from cheek to cheek within weeks and nothing would calm it down. Derm prescribed Doxy 100mg 2xday and within 2 weeks the burning subsided and bumps started to go away. I’m so thankful it worked. My skin is not perfect but the painful part is gone. I plan on continuing on with the pills for another 3 months. Please try this medication if you’re suffering from this horrible skin condition. I’m sorry if you’re having to suffer with this painful skin. Good Luck and remember this is temporary and it can be managed with antibiotics."

9 / 10
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98 Report
  • Count...
  • September 6, 2019

For Lyme Disease "I woke up 4 weeks ago with a red blotchy rash and immediately went to see my doctor. I was diagnosed with Lyme and started taking doxycycline prescribed for 21 days. I had the symptoms of extreme fatigue and what I thought were flu symptoms. I did the research on the doxy before I took it, I am not a fan of taking any medication. I read that it should be taken with a lot of water. I would drink 8 ounces of water before the pill and the same after and the only time I got sick was when I drank less than 8 ounces, it was an awful experience. I am on my last day of the meds, In my opinion, drinking almost 40 ounces of water a day has helped this process. It prevents you from getting sick and it flushes the toxins out of your body, your stomach will reward you and you are helping your body detox. I am excited as today is my last day on doxy and looking forward to positive lab results in a few weeks. Wishing everyone that reads this a healthy and complete recovery!"

10 / 10
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88 Report
  • Steph
  • Taken for less than 1 month
  • February 18, 2020

For Urinary Tract Infection "I took doxycycline with food and a large glass of water both morning and night. I had no side effects whatsoever- no nausea, vomiting, headache, etc. I felt symptom relief after just 1 day. While I’m sure others may have had different experiences- don’t let that deter you from trying!"

10 / 10
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81 Report
  • Dave...
  • November 25, 2014

For Lyme Disease "Hopefully, this will help somebody. I was a chronic Lyme patient for 15 years. Doxy kept it in check, but I still had symptoms, even if I took up to 500 mg per day. The doc said it was then best to lower my intake to about 200 mg per day, the lowest amount that allowed me to still feel OK. After many years of this I had some strange symptoms regarding my heart. I guessed that Lyme disease had affected my heart, which was partly true, and asked if I could try to increase the doxy to combat it. The doc said yes we could try that again. I began taking 400 mg per day again and I never missed a dose. Six months later, I finally eradicated my Lyme disease. DO NOT miss a dose to beat this unique bacteria."

10 / 10
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148 Report
  • pinkl...
  • April 8, 2015

For Bacterial Infection "Every time I get a sinus infection I ask for Doxy it clears me up in a few days. I don't have any bad side effects, guess I'm lucky. I would recommend this medicine highly for sinus infections since it works so fast. I have to work and don't have time to be sick, I'm also a single mother and can't be down too long and this medicine never let's me down!"

10 / 10
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136 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.