Skip to Content

User Reviews for Doxycycline to treat Skin or Soft Tissue Infection

Also known as: Vibramycin, Oracea, Monodox, Doxy 100, Adoxa, Avidoxy, Doryx, Acticlate, Targadox, Oraxyl, Alodox, Morgidox, Uracil, Doxy 200, Doxy-D, Doxy-Caps, Adoxa Pak, Adoxa TT, Adoxa CK, LymePak Mondoxyne NL Okebo Doryx MPC …show all brand names

Doxycycline has an average rating of 5.9 out of 10 from a total of 38 ratings for the treatment of Skin or Soft Tissue Infection. 45% of users who reviewed this medication reported a positive effect, while 32% reported a negative effect.

Doxycycline Rating Summary

5.9/10 average rating

38 ratings from 40 user reviews.

Compare all 136 medications used in the treatment of Skin or Soft Tissue Infection.

10
18%
9
21%
8
5%
7
5%
6
5%
5
11%
4
3%
3
3%
2
11%
1
18%

Reviews for Doxycycline

MLA · Taken for 1 to 6 months March 27, 2019

“Doxycycline was the only thing that worked for my perioral dermatitis (which I got from using triamcinolone on my face - huge mistake!). I tried metrolotion at first as it's a more conservative treatment, but it did nothing for me. Doxy cleared it up in about 11 days, but I continued to take it for a month to make sure it didn't come back. It hasn't come back and it's been about a year.”

10 / 10
Was this helpful?YesNo
So far, so good · Taken for 1 to 6 months June 9, 2020

“I was on a dose of 200mg a day of doxycycline for two months, 100mg/ day for one month and now on 40 mg/ day for another month for a bad case of perioral dermatitis (40 year old female). Tried elimination diet, herbs and everything - and it didn’t work but this (with some creams, elimination diet like 80% of the time and tons of emotional processing) cleared my skin up!! I am totally sun sensitive so I try to stay inside (yay quarantine). I take it with a FULL stomach and I have no side effects. Also - I take the BEST probiotic from the vitamin shoppe. Dr is weaning me off gradually to avoid rebound... Wish everyone the best!!!”

9 / 10
Was this helpful?YesNo
bbrann November 27, 2016

“Had a serious case of cellulitis and didn't go in until suffering 7 days of intense swelling/pain in my right calf. Prescribed doxycycline 100 mg twice daily. Didn't pay attention to no calcium or the option of taking with or without food. First pill taken with food, no upset tummy. Second pill taken with food and a cup of coffee loaded with cream, so I reduced its effectiveness considerably until I read up on it. Third pill took without food, felt urpy for about half an hour but I wanted the full dose and suffered it out by hydrating with lots of hot tea and water. It's the third day of usage and I finally feel some relief. Pain in leg is less intense. Swelling is nearly gone! I can finally stand! Happy I got it!”

9 / 10
Was this helpful?YesNo
Poz · Taken for less than 1 month August 8, 2020

“I was prescribed this drug doxycycline for a sinus infection I’d had for weeks. Having read all the reviews I was dreading taking it. However despite everything I read I did proceed with the initial weeks course. Apart from suppressing my appetite, not such a bad thing, I feel fine on this medication. My infection started to feel so much better 48 hours in and although I had to take a second course to completely clear it up I would recommend this medication. I honestly feel it’s like most drugs, some people are more sensitive than others. I often struggle to find medication that agrees with me, but do not be put off by all the negative reviews.”

9 / 10
Was this helpful?YesNo
San April 8, 2020

“I developed cellulitis on my right calf. Based on my medical history and a previous cellulitis case that required two courses of cephalexin, my doctor suspected that it was caused by MRSA and I given doxycycline hyclate prescription. I was rather hesitant to take this, since I'd heard that doxycycline isn't the best for cellulitis and due to side effects from other antibiotic classes (Azithromycin made me too dizzy to walk; Cipro made me have unrelenting diarrhea). But lo and behold, I developed only minor side effects on this drug (gas, occasional dizziness) and my infection started to look significantly better about six hours after my first dose. Avoiding calcium and iron was a bit of a pain, but I'm just glad that my infection was vanquished.”

10 / 10
Was this helpful?YesNo
Steve · Taken for less than 1 month April 3, 2020

“30-year-old male prescribed 100mg doxycycline hyclate (daily) for perioral dermatitis. Received a four week supply from the dermatologist. Dermatologist and pharmacist both echoed the recommendations available online (take with food and water, do not lie down after ingesting, watch out for sunburn). Four days into treatment with no adverse effects, visible improvement to dermatitis evident. Seems to be working.”

9 / 10
Was this helpful?YesNo
Anonymous June 25, 2016

“I was prescribed this for periol dermatitis and skin infection. My whole head feels so much clearer and inflammation in my body that I didn't know I had ( due to a shoulder injury) I have lost all inflammation and I've gone down a pant size. I use to have to take omeprazole for stomach acid. After 3 days my insides opened up and no more omeprazole OR MY ANXIETY meds. I believe in this medication. It helps with everything.”

10 / 10
Was this helpful?YesNo

Frequently asked questions

Bill · Taken for less than 1 month August 20, 2019

“3 days into taking doxycycline for skin infection and I have terrible heartburn and constantly feel nauseous. My Doctors directions said to try and take this on an empty stomach. DON’T...unless you enjoy vomiting. Even when I take it with food and drink plenty of fluids, the nausea and heartburn feel comes roaring in a few hours later. Trying to clear up a cyst that recently developed on my scalp. I am super self conscious about it and to be honest, I’d rather have the cyst stay there forever than to endure another day of this medication.”

1 / 10
Was this helpful?YesNo
C · Taken for 1 to 6 months May 10, 2020

“Very effective in treating perioral dermatitis, I had no side effects compared to minocycline which gave me chronic migraines and vertigo. However the dermatitis has returned again and it's been 5 months since I finished a 3 month treatment. Very frustrating.”

8 / 10
Was this helpful?YesNo
jtp_313 · Taken for less than 1 month December 4, 2012

“I took this medication for an infection I acquired after a cut in my finger. It basically works by "STOPPING" the growth of bacteria. You have to take it with a lot water to insure it is totally flushed through your esophagus and DO NOT lay down within 45 minuets of taking it - or it can work it's way back up into your esophagus and thus might cause a small ulcer there in time. As its effectiveness in curing the infection..it worked just fine.”

8 / 10
Was this helpful?YesNo
Anonymous · Taken for less than 1 month January 24, 2020

“If you suffer from migraines (especially with aura) proceed with CAUTION with doxycycline! I was prescribed this med as a preventative measure after a routine cyst excision. I wish I had never taken it. After just 2 doses I suffered my first migraine with aura in months. I was losing my vision and it was terrifying. Please avoid if you have neurological sensitivities such as migraines.”

2 / 10
Was this helpful?YesNo
Agde80 · Taken for 1 to 6 months October 17, 2019

“I was prescribed 40mg doxycycline once daily for 8 weeks to treat perioral dermatitis that would not clear despite months of trying everything else to clear it. On the positive side, it's been four weeks and other than a little redness, the dermatitis has cleared. There are many negatives though - I've basically felt under the weather every single day. I have no energy and no appetite. Despite eating less, I have gained 12 pounds in 4 weeks. Now I know that people often want to blame medication for weight gain when it's likely not the culprit...but I have weighed the same for about 12 years, give or take 1-2 lbs. This is crazy. I feel like I'm wearing a fat suit at all times and it's very uncomfortable. To the point where I don't know how to manage the next four weeks. I read a research paper online that stated 100mg doxy is given to malnourished children to cause weight gain so I guess this isn't a figment of my imagination.”

6 / 10
Was this helpful?YesNo
Fluffy · Taken for 2 to 5 years January 9, 2020

“I take this doxycycline on and off for various skin complaints. First time I took this I was vomiting within 20 minutes. So now I only take this with meals and have been fine. After a few days I do see a lot of improvement.”

9 / 10
Was this helpful?YesNo
ABee · Taken for 1 to 6 months September 20, 2020

“I was on Doxycycline 100mg twice a day for 2 months for perioral dermatitis. During this time, I had horrible burning skin on my face and scalp. I also was very sensitive to sunlight and had bad nausea after taking it for an hour. It did clear my perioral dermatitis though. 3 months later, my hair started coming out. I do not recommend this antibiotic if you can avoid it. It has caused many issues for me.”

1 / 10
Was this helpful?YesNo
msgta · Taken for 5 to 10 years May 10, 2018

“There are 2 types of Doxycycline: Doxycycline Monohydrate, & Doxycycline Hyclate, I have taken both for Perioral Dermatitis. The 1st time I took Doxycycline Monohydrate, with absolutely no side effects. The 2nd time I took Doxycycline Hyclate, because my Perioral Dermatitis, didn't go away. From the beginning with Doxycycline Hyclate I had side effects of severe fatigue, feeling shaky, headaches, achiness, tingly finger tips, painful carpel tunnel, pain in my neck, numbness, & tingling in my right arm elbow, & up to my armpit. This Medication gives you a feeling of being very ill. I will be putting this Medication of my RX List of "Do Not Prescribe to Patient."”

Was this helpful?YesNo
Boulder girl · Taken for 1 to 6 months August 31, 2013

“I've been taking this medicine for a form of dermatitis under my nose on my lip. It's working great - no problems with the nausea symptoms as I take it with a lot of water. I have been pounding probiotics to avoid the yeast infection which has totally worked! The only side effect I'm noticing is vaginal dryness which may be linked to the general "drying" out other folks have experienced with this medicine- frustrating for sure. Hate to take any medicines but this is working well.”

9 / 10
Was this helpful?YesNo
sherriboberry September 9, 2011

“Worked very well for my skin infection however it did cause severe nausea about half way through my course of therapy. It would happen about half an hour after taking the medication. If I took it about 20 minutes after taking Dramamine (the meclizine kind), the nausea subsided. No other side-effects and very effective.”

9 / 10
Was this helpful?YesNo

More FAQ

ReneeChristian · Taken for less than 1 month December 16, 2014

“I took this medication for a skin infection. 100mg twice a day for 10 days. Towards the end I would get severe nausea after taking it but I never threw up. The medication worked great & cleared up my infection, however I am starting to get concerned it may be coming back on my arms this time. Before it was on my face and scalp. I have suffered from KP my whole life on my arms so I'm hoping the skin infection & medicine may have temporarily made it flare up worse than normal. I did get the beginning signs of a yeast infection on day 4-5 so I had my doctor call in a prescription to treat it. I took it immediately and continued the antibiotics. The yeast infection was gone within 24 hours. Overall no complaints.”

10 / 10
Was this helpful?YesNo
Jess · Taken for less than 1 month August 28, 2018

“I've been taking this drug for 5 days now for folliculitis, the 1st time I took it I was violently sick within 5 minutes. I've been suffering with headaches and nausea (feeling really drunk, room spinning) for these 5days. I've found my skin is so tender and feels really raw and very dry. Day 5 and I've woken up to vagina dryness which I'm guessing is due to this being a bacterial antibiotic so it's pretty uncomfortable... Haven't noticed any improvement but it's only day 5, I was prescribed a 60 day course. Hope it works as I've been struggling for nearly 10 years with this skin infection...”

5 / 10
Was this helpful?YesNo
AveMaria02 · Taken for less than 1 month December 9, 2016

“I will never ever take this medication again. When I took my very first pill, it caused me to throw up within a matter of minutes. I called the doctor and they told me to try it again in the morning and if I still threw up then to call them back. So I tried it again in the morning and this time I didn't throw up but I became extremely nauseous and nearly threw up so I called the doctor back. They ended up prescribing a different medicine for me. I also didn't like the fact that I had to wait 2 hours after taking vitamins and minerals and so many hours before taking certain kinds of stomach medicine. I am prescribed both vitamins and minerals as well as stomach medicines so this made taking the doxycycline quite a burden.”

1 / 10
Was this helpful?YesNo
Broken Hill · Taken for less than 1 month February 25, 2020

“Was given this doxycycline for Cellulitis in my leg, (4th time I've had Cellulitis in the same area). I had various side effects, ie headache, stomach cramps, metallic and bitter taste,= ( like radio therapy!) vertigo, and it didn't get rid of the cullulitis. Had to have a further course of another antibiotic. Side effects settled down after 5 days, course was for 7 days. There was some improvement after 5 days but no cure of the condition. One can only speak as one finds.”

2 / 10
Was this helpful?YesNo
Lisa · Taken for less than 1 month November 11, 2019

“I took the medicine doxycycline for 3 days and could not handle side effects of weight gain. The scale started moving upward immediately and I was not eating any differently. My digestive track slowed down. It reduced the boil I had on my skin but I stopped taking it and asked my doctor to switch my antibiotic. I now am prescribed cefuroxime.”

5 / 10
Was this helpful?YesNo
Brandon · Taken for less than 1 month September 26, 2018

“This medicine wasn't so effective for my staph which is why I can't give it a good rating. However, for those of you who are worried about side effects, I experienced absolutely none. I took with a big meal and 12 oz to 14 oz of water. I also was very careful to remain upright (didn't lean back or lay down) for at least 2 hours after ingesting. The doctor recommended that if I experienced nausea that I should take a pill called Gravol one hour before. Luckily I didn't need it. For reference, Amoxicillin slightly messed up my lower stomach after about the 3rd or 4th day (probiotics did help) and Azithromycin gave me slight nausea about 45 minutes after ingesting so it's not like I have a stomach of steel or anything. It seems people who post reviews are are mostly those who had a bad experience which is understandable. But for those who are worry like I do, it was absolutely fine.”

3 / 10
Was this helpful?YesNo
Glow-worm May 16, 2018

“I was prescribed this medicine for a skin infection caused by MRSA. Yesterday was my 4th day of taking the capsule and within minutes I was retching my guts out. I am a cancer survivor, and even with aggressive chemo I never threw up! I also experienced extreme loud ringing in my ears for several minutes. And I notice that I feel very tired on this drug.Well, that's enough for me...I'm Out!!!”

2 / 10
Was this helpful?YesNo
lisa in mass · Taken for less than 1 month June 4, 2014

“I took 2 doses. The first had no side effects. The second brought extreme nausea. It's the first time I vomited in 30+ years, including when I had food poisoning. This was followed by dizziness and headache, though those could have been from all the retching. I discontinued it.”

Was this helpful?YesNo

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Learn more about Skin or Soft Tissue Infection

Drugs.com Health Center