Doxycycline Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Doxycycline	Humira (adalimumab)	Methotrexate	Enter another drug to compare

Doxycycline

Humira (adalimumab)

Methotrexate

Prescription only

Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more

Prescription only

Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more

Prescription only

Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more

More about Doxycycline

More about Humira (adalimumab)

More about Methotrexate

Ratings & Reviews

Doxycycline has an average rating of 6.4 out of 10 from a total of 1641 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 27% reported a negative effect.

Humira has an average rating of 6.4 out of 10 from a total of 703 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 30% reported a negative effect.

Methotrexate has an average rating of 6.5 out of 10 from a total of 338 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 1641 reviews

View all 703 reviews

View all 338 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (19.9%)
Headaches (9.6%)
Acne (7.9%)
Vomiting (7.7%)
Upset stomach (5.4%)
Diarrhea (3.2%)
Dizziness (3.2%)

View all Doxycycline side effects

Pain (10.7%)
Headaches (4.7%)
Fatigue (4.4%)
Psoriasis (4.4%)
Rash (4.3%)
Tiredness (3.6%)
Itching (3.3%)

View all Humira side effects

Nausea (14.8%)
Tiredness (13.9%)
Fatigue (11.5%)
Hair loss (8.6%)
Pain (6.8%)
Headaches (5.6%)
Loss of appetite (5.0%)

View all Methotrexate side effects

Drug Class

Generic Availability

Lower cost generic

N/A

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	2 tablet
Strength	hyclate 100 mg
Per unit^*	$6.62
Cost^*	$13.23

View all Doxycycline prices

Quantity	2 kit
Strength	40 mg/0.8 mL
Per unit^*	$3,700.02
Cost^*	$7,400.03

View all Humira prices

Quantity	20 each
Strength	2.5 mg
Per unit^*	$1.52
Cost^*	$30.31

View all Methotrexate prices

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Dosage Forms

Injectable powder for injection
Oral capsule
Oral delayed release capsule
Oral delayed release tablet
Oral powder for reconstitution
Oral tablet

Subcutaneous kit

Injectable powder for injection
Injectable solution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

23 hours

480 hours

15 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 237 drugs are known to interact with Doxycycline:

22 major drug interactions (60 brand and generic names)
210 moderate drug interactions (2248 brand and generic names)
5 minor drug interactions (21 brand and generic names)

A total of 555 drugs are known to interact with Humira:

300 major drug interactions (871 brand and generic names)
245 moderate drug interactions (944 brand and generic names)
9 minor drug interactions (37 brand and generic names)

A total of 728 drugs are known to interact with Methotrexate:

145 major drug interactions (668 brand and generic names)
567 moderate drug interactions (2745 brand and generic names)
15 minor drug interactions (47 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more

Disease Interactions

First Approval Date

December 05, 1967

December 31, 2002

December 07, 1953

WADA Class View classifications

N/A

More Information

Patient Resources

Doxycycline uses

Humira uses

Methotrexate uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Doxycycline Alternatives Compared

See also:

Amoxil

Vibramycin

Stelara

Monodox

Minocin

Doryx

Moxatag

Penicillin g potassium

Minocycline

Amoxicillin

Further information

Doxycycline Alternatives Compared

See also:

Further information

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