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Doxycycline User Reviews & Ratings (Page 5)

Brand names: Vibramycin, Monodox, Adoxa, Doryx, Oracea, Doxy 100, Morgidox, Doryx MPC, Avidoxy, Targadox, Uracil, Doxy-Caps, LymePak, Mondoxyne NL, Okebo, Acticlate, Doxy-D, Oraxyl, Alodox, Adoxa Pak, Adoxa TT Adoxa CK Doxy 200 …show all brand names

Doxycycline has an average rating of 6.4 out of 10 from a total of 1,638 reviews on Drugs.com. 50% of reviewers reported a positive experience, while 27% reported a negative experience.

Reviews for Doxycycline

Commonly mentioned side effects
  • bus...
  • December 24, 2019

For Pneumonia "Thought I had a bad cold with cough and shortness of breath. After about 7 days, when I got the pain going clear through the lung (front to back), I knew it was pneumonia (had it before). Started doxy 2 x a day, also using a nebulizer with albuterol solution 3 x a day and an emergency albuterol inhaler for nighttime breathing help. Better on day 3 but no further improvement until I began doxy 3 x a day. Always eat 30 minutes before taking doxy or you will have stomach issues. Drink a bottle of water every two hours to help flush the crud out of your system. You will be tired for 8-10 days after stopping doxy, but it has done its job."

7 / 10
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  • Pen...
  • Taken for less than 1 month
  • January 3, 2017

For Chlamydia Infection "I got a wonderful text from an ex-partner telling me he had tested positive for Chlamydia. I bought 1g of Azithromycin online as I didn't have time to go to the clinic and I had had 2 irregular periods. By the end of the week, I didn't feel right, had burning urine, which was new, so I ordered 7 days of Doxycycline 100 mg. These are brilliant as long as you strictly follow the instructions! Don't eat dairy with them, no multivitamins or indigestion remedies. Don't take less than an hour before bed, and make sure you eat something with them! Side effects for me were nausea if I didn't eat, a headache (manageable), and heartburn if I didn't drink enough water throughout the day. Burning pee cleared by day 2, and discharge by day 4."

10 / 10
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  • So...
  • Taken for 1 to 6 months
  • June 9, 2020

For Skin or Soft Tissue Infection "I was on a dose of 200 mg a day of doxycycline for two months, 100 mg/day for one month, and now on 40 mg/day for another month for a bad case of perioral dermatitis (40-year-old female). Tried elimination diet, herbs, and everything - and it didn’t work, but this (with some creams, elimination diet like 80% of the time, and tons of emotional processing) cleared my skin up!! I am totally sun sensitive, so I try to stay inside (yay quarantine). I take it with a FULL stomach, and I have no side effects. Also, I take the BEST probiotic from the vitamin shoppe. The doctor is weaning me off gradually to avoid rebound... Wish everyone the best!!!"

9 / 10
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Frequently asked questions

  • Fri...
  • June 17, 2019

For Lyme Disease "I had two tick bites on my hip by my belt line. Then, not a couple weeks later, I got bit again on my left arm. About three weeks later, I developed, almost out of nowhere, extreme joint pain and stiffness, a complete loss of energy, a headache, a very stiff neck, and sensitivity to light. I went to the doctor about two days into this. They did blood work for Lyme disease, and it came back negative. Symptoms persisted terribly. The doctor did a different panel, which came back negative, but the doctor, due to my symptoms, got me on this antibiotic. The first three days were the worst I've ever felt body-wise in my life. The doctor did instruct me that that would happen during the bacterial die-off (Herxheimer reaction). By day five, all symptoms but the extreme fatigue faded. I did experience weird light aberrations. The continued extreme fatigue is the only real problem now. The doctor did mention that the treatment can take 14 days up to a month before you are 100%."

9 / 10
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  • Hea...
  • Taken for less than 1 month
  • July 16, 2014

For Bacterial Infection "Prescribed 100mg 2x a day for 14 days for a skin infection. It is so important that you drink lots of water and do not lie down within 30 minutes of taking this medicine to prevent ulcers in the esophagus. I followed this and had no issues whatsoever. On the 7th day, I had slight nausea, take with food. Also, I wanted to mention I did experience chest tightness/shortness of breath from days 3 to 12. It stopped 24 hours after my last dose...Prilosec helped. Recommend taking a probiotic once a day to prevent any stomach issues, including diarrhea. Works great for me."

8 / 10
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  • Sus...
  • Taken for less than 1 month
  • May 27, 2023

For Skin or Soft Tissue Infection "I had terrible side effects from doxycycline. Slowly recovering since going off it 2 weeks ago. After 4 days of 100 mg daily for my dermatitis staph infection, I almost passed out. All of a sudden, my head got so heavy and exhausted, and pressure all over my head and behind my eyes. I went to sleep, but my mind felt like it was racing and all confused, like you’d feel if you had a concussion and fever. I woke up in the morning, and my brain felt like it had not slept at all. Brain extremely fatigued. I also had chronic nausea, tinnitus, dizziness, foggy head, confusion, and high anxiety and irritability. It honestly felt like I had suffered a traumatic head injury. I will never take doxycycline again."

1 / 10
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  • son...
  • Taken for less than 1 month
  • September 20, 2016

For Upper Respiratory Tract Infection "I started taking this and am now three days in. I was first given a course of amoxicillin. It didn't clear my chest or my sinuses. I then phoned 111 (UK) and their out-of-hours doctor prescribed me doxycycline. Immediately, the tension in my head was alleviated and the pain in my sinuses was gone. Stupidly, this morning I took my tablet on time and went back to sleep, please don't do this. I wish I had seen these testimonies, but now I have and won't make the same mistake. Other than that, the medicine is good, and I believe I should have been prescribed this first and not any other wishy-washy antibiotics."

5 / 10
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More FAQ

  • Joh...
  • Taken for less than 1 month
  • August 18, 2019

For Bacterial Infection "My doctor prescribed me this doxycycline antibiotic orally, 100 mg for MRSA after the first two antibiotics failed (some sort of penicillins). The doxycycline has managed to fade the MRSA boils but not completely eradicate the infection. The side effects are by far the worst I’ve ever experienced from any other drug I’ve taken. From dizziness, nausea, and the worst of all, the pressure it causes in your head. My whole 10 days on this drug have consisted of being in bed or lying on my couch with anxiety from side effects. I wouldn’t recommend this drug to my worst enemy."

3 / 10
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  • Dea...
  • Taken for less than 1 month
  • March 11, 2020

For Bacterial Infection "Doctor prescribed doxy for sinus infection. After 3 days, I am experiencing huge headaches, stomach pain, and muscle pains. Am stopping this medication now. The pain it is causing me isn’t worth taking any more."

1 / 10
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  • jul...
  • Taken for less than 1 month
  • February 10, 2018

For Upper Respiratory Tract Infection "Reading most of these user reviews, it seems I'm the only one not suffering from side effects. I've taken doxy after tick bites about 4 times in my 52 years on Earth. 2 of those times were preventative, the other 2 times I already was infected (erythema migrans was clearly visible). I can't say enough good about this antibiotic. You just have to not take it on an empty stomach. The negative reviews, to me, seem like whining and blaming doxy for something it is not even responsible for. I've decided to take it this week (in 2018) when I was coughing for 2 weeks and had flu-like symptoms, even after having been vaccinated against the flu. This worked wonders. I had only taken 2 x 100 mg doxy, and the entire thing was over the next day. This is an absolute killer antibiotic. Try to avoid direct sunlight up to a week after you've taken it, or your skin will burn. Highly recommend this drug for lots of bacterial infections."

10 / 10
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  • cor...
  • October 23, 2008

For Pneumonia "Used twice for Atypical Pneumonia and when all other drugs failed, this one always works. I've had pneumonia twice in the last year, the first time for 3 months. A pulmonary specialist was called in from within the hospital, and he prescribed the doxycycline, and it instantly worked - in about 24 hours, I felt almost normal. This time around, the same experience - first we tried my new doctor's way, and then doxycycline, and it worked."

10 / 10
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  • bbr...
  • November 27, 2016

For Skin or Soft Tissue Infection "Had a serious case of cellulitis and didn't go in until suffering 7 days of intense swelling/pain in my right calf. Prescribed doxycycline 100 mg twice daily. Didn't pay attention to no calcium or the option of taking with or without food. First pill taken with food, no upset tummy. Second pill taken with food and a cup of coffee loaded with cream, so I reduced its effectiveness considerably until I read up on it. Third pill took without food, felt urpy for about half an hour but I wanted the full dose and suffered it out by hydrating with lots of hot tea and water. It's the third day of usage and I finally feel some relief. Pain in leg is less intense. Swelling is nearly gone! I can finally stand! Happy I got it!"

9 / 10
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  • Ant...
  • Taken for 1 to 2 years
  • May 24, 2019

For Rosacea "Had a really good experience with this doxycycline. Developed rosacea at age 36. Small white pimples and red lesions covered my cheeks and parts of my neck and jawline. Saw a dermatologist, and he put me on this drug, one tablet per day. Within two weeks, my rosacea basically disappeared, and my skin looks normal now. I will say that you need to take this with food. A simple glass of water is not enough, and I developed nausea the first week when I took this pill and skipped breakfast. I'm off the drug completely now, but occasionally get small rosacea flare-ups during stressful times, but they go away quickly."

10 / 10
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  • ano...
  • Taken for less than 1 month
  • January 31, 2020

Doxycycline for Acne "I got off minocycline a month and a half ago after 6 months of successful treatment with it for my acne, and no side effects (mild to moderate inflamed acne here). Acne started coming back, so my derm put me on doxycycline (I use azelaic acid 15% once a day topically too). I've been only 4 days on doxy 100 mg twice daily, and my skin is completely clear again. Zero side effects with this as well. The inflammation subsided in just 2 days. It has saved my skin once again. Tetracyclines work so well for me, it's hard to get off of them."

10 / 10
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  • Kar...
  • Taken for 1 to 6 months
  • October 27, 2023

For Pneumonia "Had COVID, then developed pneumonia. Started on amoxicillin, didn’t do much. Really went back to doctors, was given doxycycline and steroids. Within a couple of hours, started to feel better. Had no side effects. I’ll be asking for this medication first from now on, it’s magic."

9 / 10
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  • Duk...
  • Taken for less than 1 month
  • March 24, 2019

For Bacterial Infection "I have been on doxycycline for 4 days, in conjunction with an expectorant, for a sinus infection. The script is for 10 days. I have followed 'how to use this medication' received from the pharmacy, including drinking non-caffeinated drinks, and have had no negative interaction with this medication. As a matter of fact, my symptoms broke today, but as with any medication, even though I am feeling better, I will complete the 10-day round of this antibiotic. I am allergic to penicillin and diagnosed with epilepsy, and find this antibiotic one of the best I have taken, and have not had any medication interactions. In addition to medication, rest and plenty of fluid assist in recovery."

10 / 10
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  • Yup...
  • Taken for less than 1 month
  • October 15, 2019

For Lyme Disease "On doxycycline for Lyme disease. 21 days. No side effects at all. I have one more week taking it. I was worried about the stomach problems and did my research before taking it. I drink a whole glass of water before and after. I think that’s the key to taking this antibiotic. I also make sure I am taking a probiotic every day."

10 / 10
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  • GiG...
  • Taken for 6 months to 1 year
  • November 5, 2019

For Rosacea "I had been on doxycycline (rosacea) for months, it did not work. I was given methotrexate 2x, it did not work. I was on Ivermectin 2x, it also did not work, and I have used gels, nothing. My face is still red, pimples, and itchy. Also taking spironolactone 50 mg. NEED HELP!!"

3 / 10
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  • Sus...
  • Taken for 6 months to 1 year
  • January 20, 2019

For Rosacea "This medication has been life-changing. I had been battling constant pustules and papules for over a decade, getting much worse the last four years. I had tried a range of over-the-counter creams and treatments, and on Rozex cream for a year - which helped a bit. A new doctor put me on this, and in six months I have virtually no “pimples” or skin thickening at all. Miraculous. I did find I needed to combine it with a pill to settle my stomach, the main symptom being burping and a little discomfort. My skin is now clear, and I can happily go makeup-free. Results began after two weeks, but it took about five months for the full impact to be seen. Highly commended for p/p rosacea. I am in Australia, and the price is very reasonable."

10 / 10
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  • Mom...
  • Taken for less than 1 month
  • May 29, 2019

For Bronchitis "I had what I thought was allergies that actually developed into bronchitis and sinusitis. Was prescribed 100 mg doxy 2x a day. I'm on day 2 and feel like myself again! I've only taken it with a semi-full tummy and have had zero gastro issues. I was told to be sure to sit up for about 30 mins after taking it and stay away from dairy since it binds to the doxy and makes it ineffective. I've got 5 more days to go and I'm looking forward to feeling 100% again!"

9 / 10
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  • jam...
  • September 3, 2014

For Acne "I could say that I would recommend this to people with mild to severe acne. I have been on doxycycline for about 1 month and a couple of weeks, close to 2 months, and my acne has improved so, so much. I'm supposed to be on this for three months, and I'm already close to flawless, acne-free skin, but of course, with a combination of Epiduo, chemical peels, and a gentle cleanser. Overall, doxycycline has been great, and with no doubt, I would suggest it."

10 / 10
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  • Mar...
  • February 16, 2014

For Bacterial Infection "I had minor surgery and developed cellulitis, and was put on doxycycline. It made some immediate improvement in the pain and swelling. The culture came back as MRSA. Ten days of doxycycline was extended for two more weeks, but after five days, with the infection not completely gone, I switched to vancomycin infusions for twenty-five days until I was considered healed. The problem wasn't the medication, rather, it was the lousy suturing with internal stitches that started emerging through the wound for weeks, keeping the infection deep in my thigh. Then I got a bad cold or flu with a terrible sinus infection, so I started taking the remaining doxycycline. I don't think I've taken it for sinus before, but I felt better right away and had no real side effects. Great!"

8 / 10
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  • cbr...
  • May 13, 2017

For Lyme Disease "Even though it says it is absorbed better without food, I would definitely advise taking it with food (as my pharmacist suggested to me). I tried to take the first dose without food, big mistake. Within an hour, I started getting really shaky and nauseous, felt like throwing up big time. I had to hurry up and down some food quickly to stop it. As long as I take it right after a meal, and with plenty of water, I am fine. Occasional headaches with this medicine. You can definitely tell it is a strong medication (for an antibiotic), so be careful. I was prescribed two weeks of doxycycline to prevent possible Lyme disease from being bit by a tick a few days ago. As long as you can stick through the side effects, this medicine is effective."

7 / 10
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  • Sup...
  • Taken for less than 1 month
  • January 16, 2020

For Bacterial Infection "I had a bacterial infection, Ureaplasma Urealyticum, and was definitely hesitant to take this doxycycline pill due to the nasty reviews. The first time I took this medication, it was terrible, but that was because I took it on an empty stomach. It takes about 30 minutes to kick in, and if you haven't eaten, it will be miserable, but once I ate 30 minutes prior to taking each pill, I didn't experience any nausea or vomiting."

7 / 10
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  • Tap...
  • Taken for 1 to 6 months
  • April 16, 2015

For Lyme Disease "Works miracles to keep Lyme in check, does not necessarily eradicate it. Took about 4 years since infection for Lyme to get a foothold before I was able to get proper medical attention. On badly spread Lyme, expect severe side effects -- much of it, so I have been told -- have to do with chemicals resulting from the bacteria dying rather than the doxycycline itself: severe depression and suicidal thoughts that disappeared as soon as I finished the medication (discomfort, but at least I was able to put up with it knowing it would pass once the six-week 500mg/day was up). Also, take with proper meals -- I've woken up to throw up blood when taken on an empty stomach. Also, stay out of direct sunlight, or, if possible, take during winter months."

8 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.