Spironolactone Drug Interactions
Currently displaying a list of 382 drugs known to interact with spironolactone.
- 51 major drug interactions
- 311 moderate drug interactions
- 20 minor drug interactions
Medications known to interact with spironolactone
Note: Showing generic names only.
A
- abiraterone
- acebutolol
- afatinib
- aldesleukin
- alfentanil
- aliskiren
- alprazolam
- amifostine
- amiloride
- amisulpride
- amitriptyline
- amobarbital
- amoxapine
- anisindione
- apixaban
- apomorphine
- apraclonidine ophthalmic
- ardeparin
- aripiprazole
- asenapine
- ashwaganda
- aspirin
- atenolol
- avanafil
- azilsartan medoxomil
B
- baclofen
- benazepril
- betamethasone
- betaxolol
- betaxolol ophthalmic
- betrixaban
- bexagliflozin
- binimetinib
- bisacodyl
- bismuth subsalicylate
- bisoprolol
- bosutinib
- brentuximab
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- bromfenac
- budesonide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butorphanol
C
- cabergoline
- canagliflozin
- candesartan
- cannabis
- captopril
- carbamazepine
- cariprazine
- carisoprodol
- carteolol ophthalmic
- carvedilol
- casanthranol
- cascara sagrada
- castor oil
- celecoxib
- chloral hydrate
- chlordiazepoxide
- chlorphenesin
- chlorpromazine
- chlorzoxazone
- cholestyramine
- choline salicylate
- citalopram
- clobazam
- clomipramine
- clonazepam
- clorazepate
- clozapine
- cobimetinib
- codeine
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- cyclobenzaprine
- cyclosporine
D
- dabigatran
- dalteparin
- danaparoid
- dapagliflozin
- daunorubicin
- daunorubicin liposomal
- deflazacort
- demeclocycline
- desipramine
- desvenlafaxine
- dexamethasone
- dexmedetomidine
- dexmethylphenidate
- diatrizoate
- diazepam
- diclofenac
- dicumarol
- diflunisal
- digitoxin
- digoxin
- dimenhydrinate
- diphenhydramine
- docetaxel
- doxepin
- doxepin topical
- doxycycline
- dronabinol
- drospirenone
- duloxetine
E
- edoxaban
- empagliflozin
- enalapril
- enalaprilat
- enoxaparin
- eplerenone
- epoprostenol
- eprosartan
- eravacycline
- ertugliflozin
- escitalopram
- eslicarbazepine
- ethanol
- etodolac
- exenatide
F
- fenoldopam
- fenoprofen
- fentanyl
- fidaxomicin
- finerenone
- fludrocortisone
- fluoxetine
- fluphenazine
- flurazepam
- flurbiprofen
- fluvoxamine
- fosinopril
- fostemsavir
- furazolidone
G
H
- halazepam
- haloperidol
- heparin
- heroin
- hydralazine
- hydrocodone
- hydrocortisone
- hydromorphone
- hydroxyzine
I
- ibuprofen
- idarubicin
- iloperidone
- iloprost
- imipramine
- indomethacin
- iodamide
- iodipamide
- iodixanol
- iohexol
- iomeprol
- iopamidol
- iopromide
- iothalamate
- ioversol
- ioxaglate
- ioxilan
- irbesartan
- irinotecan
- irinotecan liposomal
- isocarboxazid
K
L
- labetalol
- lactitol
- lactulose
- larotrectinib
- lefamulin
- levobunolol ophthalmic
- levodopa
- levomilnacipran
- licorice
- linezolid
- lisinopril
- lithium
- lofexidine
- loperamide
- lorazepam
- losartan
- loxapine
- lumateperone
- lurasidone
- lusutrombopag
- lvp solution with potassium
M
- magnesium citrate
- magnesium hydroxide
- magnesium salicylate
- maprotiline
- maraviroc
- meclofenamate
- mefenamic acid
- meloxicam
- meperidine
- meprobamate
- mesoridazine
- metformin
- methadone
- methdilazine
- methocarbamol
- methotrimeprazine
- methylphenidate
- methylprednisolone
- metipranolol ophthalmic
- metoprolol
- metrizamide
- midazolam
- milnacipran
- mineral oil
- minocycline
- mirtazapine
- mitotane
- mitoxantrone
- moexipril
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nabumetone
- nadolol
- nalbuphine
- naldemedine
- naloxegol
- naproxen
- nebivolol
- nefazodone
- niraparib
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- omadacycline
- opium
- orphenadrine
- oxaprozin
- oxazepam
- oxycodone
- oxytetracycline
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- paliperidone
- paraldehyde
- parenteral nutrition solution w/electrolytes
- paroxetine
- pazopanib
- pentazocine
- pentosan polysulfate sodium
- pentoxifylline
- perindopril
- perphenazine
- phenelzine
- phenobarbital
- phenolphthalein
- phenylbutazone
- pimozide
- pindolol
- piroxicam
- polyethylene glycol 3350
- polyethylene glycol 3350 with electrolytes
- pomalidomide
- potassium acetate
- potassium acid phosphate
- potassium bicarbonate
- potassium chloride
- potassium citrate
- potassium gluconate
- potassium guaiacolsulfonate
- potassium perchlorate
- potassium phosphate
- prednisolone
- prednisone
- procarbazine
- prochlorperazine
- promazine
- promethazine
- propiomazine
- propoxyphene
- propranolol
- protriptyline
- prucalopride
- pyrilamine
Q
R
- ramipril
- ranolazine
- rasagiline
- relugolix
- remifentanil
- remimazolam
- repotrectinib
- rimegepant
- riociguat
- ripretinib
- risperidone
- rofecoxib
- romidepsin
- rucaparib
S
- safinamide
- salsalate
- secobarbital
- selegiline
- selexipag
- senna
- sertraline
- sibutramine
- sildenafil
- silodosin
- sodium nitrite
- sodium oxybate
- sodium salicylate
- sodium thiosalicylate
- sotagliflozin
- sotalol
- sparsentan
- sufentanil
- sulindac
T
- tacrolimus
- tadalafil
- talazoparib
- taurine
- telmisartan
- temazepam
- tetrabenazine
- tetracycline
- thiethylperazine
- thioridazine
- thiothixene
- ticagrelor
- tigecycline
- timolol
- timolol ophthalmic
- tinzaparin
- tizanidine
- tolmetin
- tolvaptan
- trandolapril
- tranylcypromine
- trazodone
- treprostinil
- triamcinolone
- triamterene
- triazolam
- trifluoperazine
- triflupromazine
- trimeprazine
- trimethoprim
- trimipramine
U
V
- valdecoxib
- valsartan
- vamorolone
- vardenafil
- venetoclax
- venlafaxine
- vericiguat
- vilazodone
- vismodegib
- voclosporin
- vortioxetine
- vosoritide
W
Z
Spironolactone alcohol/food interactions
There is 1 alcohol/food interaction with spironolactone.
Spironolactone disease interactions
There are 7 disease interactions with spironolactone which include:
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
