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Drug Interactions between cosyntropin and spironolactone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

spironolactone cosyntropin

Applies to: spironolactone and cosyntropin

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: The accuracy of cosyntropin as a diagnostic agent in the screening of adrenocortical insufficiency may be impaired by the concomitant use of spironolactone. Spironolactone may falsely elevate plasma cortisol levels, which may lead to inaccurate results following the administration of cosyntropin.

MONITOR: Cosyntropin may antagonize the effects of spironolactone by inducing sodium and fluid retention.

MANAGEMENT: Clinicians should be aware of the potential for inaccurate results when administering a cosyntropin test to patients on concomitant therapy with spironolactone. Some authorities recommend withholding spironolactone on the day of testing. In addition, patients receiving spironolactone and prolonged cosyntropin therapy should have blood pressure, electrolyte levels, and body weight monitored regularly, and be observed for the development of edema and congestive heart failure. The dosage of spironolactone may require adjustment.

Drug and food interactions

Moderate

spironolactone food

Applies to: spironolactone

Spironolactone and ethanol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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