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Drug interactions between metformin and spironolactone

Results for the following 2 drugs:
metformin
spironolactone

Interactions between your drugs

Moderate

spironolactone metFORMIN

Applies to: spironolactone and metformin

Talk to your doctor before using spironolactone together with metFORMIN. Spironolactone can increase blood sugar levels and interfere with diabetic control. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. Due to its effects on the kidneys, spironolactone can also increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis that may occasionally occur during treatment with metformin-containing products. Lactic acidosis is caused by a buildup of lactic acid in the blood, and is more likely to occur if you have kidney or liver disease, acute or unstable congestive heart failure, dehydration, or an excess intake of alcohol. You should seek immediate medical attention if you develop potential signs and symptoms of lactic acidosis such as fatigue, weakness, muscle pain, increasing drowsiness, abdominal pain or discomfort, fast or irregular heartbeat, difficult or rapid breathing, chills, and other unusual symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

No results found in our database - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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