Skip to main content

Epiduo Side Effects

Generic name: adapalene / benzoyl peroxide topical

Medically reviewed by Last updated on Feb 3, 2024.

Note: This document contains side effect information about adapalene / benzoyl peroxide topical. Some dosage forms listed on this page may not apply to the brand name Epiduo.

Applies to adapalene/benzoyl peroxide topical: topical application gel/jelly, topical application pad.

Serious side effects of Epiduo

Along with its needed effects, adapalene/benzoyl peroxide topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking adapalene / benzoyl peroxide topical:

More common

Less common

Incidence not known

Other side effects of Epiduo

Some side effects of adapalene / benzoyl peroxide topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to adapalene / benzoyl peroxide topical: topical gel.


The most commonly reported side effects include irritative contact dermatitis, burning sensation, and dry skin.[Ref]


Common (1% to 10%): Irritative contact dermatitis, dry skin/dryness, skin irritation, erythema, skin exfoliation/scaling

Uncommon (0.1% to 1%): Sunburn, pruritus, atopic dermatitis, eczema

Frequency not reported: Skin pain/stinging pain

Postmarketing reports: Allergic contract dermatitis, blisters/vesicles, skin discoloration, rash[Ref]


Common (1% to 10%): Application site burning, application site irritation[Ref]

Nervous system

Common (1% to 10%): Burning sensation/skin burning sensation[Ref]


Postmarketing reports: Eyelid edema, conjunctivitis[Ref]


Postmarketing reports: Throat tightness[Ref]


Postmarketing reports: Swelling face[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. Cerner Multum, Inc. "Australian Product Information."

3. (2009) "Product Information. Epiduo (adapalene-benzoyl peroxide topical)." Galderma Laboratories Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.