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Epiduo Side Effects

Generic Name: adapalene / benzoyl peroxide topical

Note: This page contains information about the side effects of adapalene / benzoyl peroxide topical. Some of the dosage forms included on this document may not apply to the brand name Epiduo.

In Summary

Common side effects of Epiduo include: burning sensation of skin, desquamation, stinging of the skin, erythema, and xeroderma. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to adapalene / benzoyl peroxide topical: topical application gel/jelly

In addition to its needed effects, some unwanted effects may be caused by adapalene / benzoyl peroxide topical. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking adapalene / benzoyl peroxide topical:

More common:
  • Dryness and peeling of the skin
  • flushing or redness of the skin
  • unusually warm skin
Less common:
  • Blistering, burning, crusting, or flaking of the skin
  • burning, itching, redness, skin rash, swelling, or soreness at the application site
  • scaling, severe redness, or swelling of the skin
Incidence not known:
  • Skin pain
  • sunburn

Minor Side Effects

Some of the side effects that can occur with adapalene / benzoyl peroxide topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Burning, dry, or itching eyes
  • change in the color of the treated skin
  • discharge or excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • skin rash, encrusted, scaly, and oozing
  • swelling of the face

For Healthcare Professionals

Applies to adapalene / benzoyl peroxide topical: topical gel


The most commonly reported side effects include irritative contact dermatitis, burning sensation, and dry skin.[Ref]


Common (1% to 10%): Irritative contact dermatitis, dry skin/dryness, skin irritation, erythema, skin exfoliation/scaling
Uncommon (0.1% to 1%): Sunburn, pruritus, atopic dermatitis, eczema
Frequency not reported: Skin pain/stinging pain
Postmarketing reports: Allergic contract dermatitis, blisters/vesicles, skin discoloration, rash[Ref]


Common (1% to 10%): Application site burning, application site irritation[Ref]

Nervous system

Common (1% to 10%): Burning sensation/skin burning sensation[Ref]


Postmarketing reports: Eyelid edema, conjunctivitis[Ref]


Postmarketing reports: Throat tightness[Ref]


Postmarketing reports: Swelling face[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Epiduo (adapalene-benzoyl peroxide topical)." Galderma Laboratories Inc, Cranbury, NJ.

Not all side effects for Epiduo may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.