Tazorac Side Effects

Generic name: tazarotene topical

Medically reviewed by Philip Thornton, DipPharm. Last updated on Feb 17, 2024.

Note: This document provides detailed information about Tazorac Side Effects associated with tazarotene topical. Some dosage forms listed on this page may not apply specifically to the brand name Tazorac.

Applies to tazarotene topical: topical cream, topical foam, topical gel/jelly, topical lotion.

Serious side effects of Tazorac

Along with its needed effects, tazarotene topical (the active ingredient contained in Tazorac) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tazarotene topical:

More common

• burning or stinging of the skin (severe)
• changes in color of the treated skin
• deep grooves or lines in the skin
• dryness, itching, peeling, or redness of the skin (severe)
• pain or swelling of the treated skin
• skin rash (in patients with psoriasis only)

Incidence not known

• blistering, crusting, or irritation of the skin
• cracked, dry, scaly skin
• flaking and falling off of the skin
• swelling at or near the application site

Other side effects of Tazorac

Some side effects of tazarotene topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• burning or stinging after application
• dryness, itching, peeling, or redness of the skin (mild)

For healthcare professionals

Applies to tazarotene topical: topical cream, topical foam, topical gel, topical lotion.

Dermatologic

• Very common (10% or more): Desquamation (29%), dry skin (27%), erythema (21%), burning sensation (14%)
• Common (1% to 10%): Pruritus, irritation, nonspecific rash, irritant contact dermatitis, skin pain, worsening of psoriasis, stinging sensation, inflammation
• Uncommon (0.1% to 1%): Cheilitis, excoriated skin, eczema, erythema sun-induced, papules, skin tightness, worsened acne
• Postmarketing reports: Blister, dermatitis, urticaria, skin exfoliation, swelling at or near application sites, skin discoloration (including skin hyperpigmentation or skin hypopigmentation)^[Ref]

Metabolic

• Common (1% to 10%): Hypertriglyceridemia^[Ref]

Other

• Common (1% to 10%): Facial pain^[Ref]

Ocular

• Common (1% to 10%): Eyelid edema, eyelid irritation, eyelid inflammation^[Ref]

Immunologic

• Uncommon (0.1% to 1%): Infection^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Pharyngitis^[Ref]

Nervous system

• Uncommon (0.1% to 1%): Headache, hypesthesia^[Ref]

Frequently asked questions

• What are the most common skin conditions? (with photos)
• Is Tazorac better than Retin-A?
• Is Tazorac the same as Retin-A?
• Does it help with acne scars?
• How long does it take to work?
• Tazorac Cream vs Gel: What's the difference?
• What are the different brands of tazarotene?
• Does it cause purging?
• Can Tazorac and Differin be used together?

Further information

Tazorac side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer