Sulfamethoxazole/trimethoprim Interactions
There are 452 drugs known to interact with sulfamethoxazole/trimethoprim, along with 12 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 63 are major, 177 are moderate, and 212 are minor.
- View all 452 medications that may interact with sulfamethoxazole/trimethoprim
- View sulfamethoxazole/trimethoprim alcohol/food interactions (1)
- View sulfamethoxazole/trimethoprim disease interactions (12)
Most frequently checked interactions
View interaction reports for sulfamethoxazole / trimethoprim and the medicines listed below.
- Aspirin Low Strength (aspirin)
- Augmentin (amoxicillin / clavulanate)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flonase (fluticasone nasal)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- MiraLAX (polyethylene glycol 3350)
- Mucinex (guaifenesin)
- Norco (acetaminophen / hydrocodone)
- ProAir HFA (albuterol)
- Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
- Symbicort (budesonide / formoterol)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Tylenol Extra Strength (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Sulfamethoxazole/trimethoprim alcohol/food interactions
There is 1 alcohol/food interaction with sulfamethoxazole / trimethoprim.
Sulfamethoxazole/trimethoprim disease interactions
There are 12 disease interactions with sulfamethoxazole / trimethoprim which include:
- colitis
- hematologic toxicity
- hypersensitivity reactions
- liver disease
- porphyria
- renal dysfunction
- folate deficiency
- crystalluria
- hemodialysis
- urinary obstruction
- dialysis
- renal dysfunction
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
