Skip to Content

Aczone Side Effects

Generic Name: dapsone topical

Note: This document contains side effect information about dapsone topical. Some of the dosage forms listed on this page may not apply to the brand name Aczone.

For the Consumer

Applies to dapsone topical: topical gel/jelly

Along with its needed effects, dapsone topical (the active ingredient contained in Aczone) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dapsone topical:

Incidence not known
  • Bluish-colored lips, fingernails, or palms
  • dark urine
  • difficult breathing
  • dizziness or lightheadedness
  • fever
  • headache
  • pale skin
  • rapid heart rate
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of dapsone topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dryness, redness, oiliness, or peeling at the application site

For Healthcare Professionals

Applies to dapsone topical: topical gel

General

The most commonly reported side effects were application site reaction not otherwise specified, application site dryness, application site erythema, and oiliness/peeling.[Ref]

Hematologic

Frequency not reported: Agranulocytosis, hemolytic anemia
Postmarketing reports: Methemoglobinemia[Ref]

Dermatologic

Frequency not reported: Toxic epidermal necrolysis, erythema multiforme, morbilliform and scarlatiniform reactions, bullous and exfoliative dermatitis, erythema nodosum, urticaria[Ref]

Local

Very common (10% or more): Application site reaction not otherwise specified (18%), application site dryness (16%), application site erythema (13%), oiliness/peeling (up to 13%)
Common (1% to 10%): Application site pruritus[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection not otherwise specified, sinusitis not otherwise specified, influenza, pharyngitis, cough[Ref]

Other

Common (1% to 10%): Pyrexia
Very rare (less than 0.01%): Facial swelling[Ref]

Musculoskeletal

Common (1% to 10%): Joint sprain[Ref]

Nervous system

Common (1% to 10%): Headache not otherwise specified
Frequency not reported: Tonic clonic movements, peripheral neuropathy (motor loss and muscle weakness)[Ref]

Psychiatric

Very rare (less than 0.01%): Depression, psychosis
Frequency not reported: Suicide attempt[Ref]

Gastrointestinal

Frequency not reported: Abdominal pain, severe vomiting, pancreatitis[Ref]

References

1. "Product Information. Aczone (dapsone topical)." QLT USA, Inc, Fort Collins, CO.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Hide