Aczone Side Effects
Generic Name: dapsone topical
Medically reviewed by Drugs.com. Last updated on Nov 18, 2020.
Note: This document contains side effect information about dapsone topical. Some of the dosage forms listed on this page may not apply to the brand name Aczone.
For the Consumer
Applies to dapsone topical: topical gel/jelly
Side effects requiring immediate medical attention
Along with its needed effects, dapsone topical (the active ingredient contained in Aczone) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dapsone topical:
Incidence not known
- Bluish-colored lips, fingernails, or palms
- dark urine
- difficult breathing
- dizziness or lightheadedness
- pale skin
- rapid heart rate
- sore throat
- unusual bleeding or bruising
- unusual tiredness or weakness
Side effects not requiring immediate medical attention
Some side effects of dapsone topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Dryness, redness, oiliness, or peeling at the application site
For Healthcare Professionals
Applies to dapsone topical: topical gel
Very common (10% or more): Local stinging/burning (up to 23.5%), application site reaction (not otherwise specified [NOS]; 18%), local dryness (up to 17.7%), application site dryness (up to 16%), application site erythema (up to 13%), application site oiliness/peeling (up to 13%), local scaling (up to 12.4%)
Common (1% to 10%): Local erythema, application site burning, application site pruritus
Uncommon (0.1% to 1%): Application site pain[Ref]
Postmarketing reports: Rash (including erythematous rash, application site rash), facial swelling (including lip swelling, eye swelling)
-Frequency not reported: Skin reactions (toxic epidermal necrolysis, erythema multiforme, morbilliform and scarlatiniform reactions, bullous and exfoliative dermatitis, erythema nodosum, urticaria)[Ref]
Postmarketing reports: Methemoglobinemia
Common (1% to 10%): Headache NOS
Frequency not reported: Tonic clonic movements
Frequency not reported: Severe pharyngitis[Ref]
Common (1% to 10%): Pyrexia[Ref]
Common (1% to 10%): Joint sprain[Ref]
Rare (0.01% to 0.1%): Psychosis
Frequency not reported: Suicide attempt[Ref]
1. "Product Information. Aczone (dapsone topical)." QLT USA, Inc, Fort Collins, CO.
2. Cerner Multum, Inc. "Australian Product Information." O 0
More about Aczone (dapsone topical)
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
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- Pricing & Coupons
- En Español
- 221 Reviews
- Generic Availability
- Drug class: topical acne agents
- FDA Approval History
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.