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Aldactone (spironolactone) Drug Interactions

A total of 655 drugs are known to interact with Aldactone (spironolactone).

  • 102 major drug interactions
  • 486 moderate drug interactions
  • 67 minor drug interactions

Show all medications in the database that may interact with Aldactone (spironolactone).

Check for interactions

Type in a drug name to check for interactions with Aldactone (spironolactone).

Most frequently checked interactions

View interaction reports for Aldactone (spironolactone) and the medicines listed below.

  • Accutane (isotretinoin)
  • Advil (ibuprofen)
  • aspirin (Aspir 81, Ecotrin, Aspirin Low Strength, Acetylsalicylic Acid, Bayer Aspirin, Aspir-Low, Bufferin, Ascriptin, Arthritis Pain, Aspiritab, Aspergum, Fasprin, Halfprin, Easprin, Ecotrin Adult Low Strength, Empirin, Migralex, Aspi-Cor, St. Joseph 81 mg Chewable Aspirin, Bayer Children's Aspirin, Buffered Aspirin, Durlaza, Ecotrin Maximum Strength, Entercote, Bufferin Extra Strength, Ascriptin Enteric, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspirtab, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • carvedilol (Coreg, Coreg CR)
  • Coreg (carvedilol)
  • Coumadin (warfarin)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lasix (furosemide)
  • Lipitor (atorvastatin)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Toprol-XL, Lopressor, Kapspargo Sprinkle)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • Plavix (clopidogrel)
  • potassium chloride (Klor-Con, KCl, K-Dur, Micro-K, K-Tab, Klor-Con M10, Klor-Con M20, Slow-K, K-Lor, Kal Potassium 99, Kaon-CI, Kay Ciel, Klotrix, Klor-Con Sprinkle, K-8, Klor-Con 8, Klor-Con 10, K-Dur 10, Epiklor, Kaochlor, K-Norm, Micro-K 10, Kaochlor S-F, Cena K, Kaon-CL 20%, K-Sol, K + Potassium, Klor-Con/25, K-10, Glu-K, K-Dur 20, Kaon-CL 10, Kato, Ed K+10, PC-10, Ten-K, Klor-Con M15, K-Vescent (Potassium Chloride), K+Care, Klorvess, Rum-K, Gen-K)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • Prilosec (omeprazole)
  • Protonix (pantoprazole)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)

Aldactone (spironolactone) alcohol/food interactions

There is 1 alcohol/food interaction with Aldactone (spironolactone)

Aldactone (spironolactone) disease interactions

There are 7 disease interactions with Aldactone (spironolactone) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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