Sulfamethoxazole/trimethoprim Patient Tips
How it works
- Sulfamethoxazole/trimethoprim is a fixed combination medicine containing two antibiotics - sulfamethoxazole and trimethoprim.
- Sulfamethoxazole stops bacteria from making dihydrofolic acid and trimethoprim prevents the formation of tetrahydrofolic acid; both significant steps in the formation of nucleic acids and proteins essential to many bacteria.
- The combination of sulfamethoxazole/trimethoprim kills bacteria.
- Sulfamethoxazole/trimethoprim is a combination antibiotic used to treat infections such as those affecting the ear, urinary tract, lungs, or gastrointestinal tract.
- Active against a wide range of different bacteria.
- Effective concentrations of both sulfamethoxazole and trimethoprim are reached in the gastrointestinal tract, urinary tract, lungs, mouth, middle ear, and vagina. Both antibiotics also cross the placenta and are excreted in human milk.
- Bacterial resistance is less likely to develop with the combination of sulfamethoxazole and trimethoprim than if either ingredient (sulfamethoxazole or trimethoprim) is taken alone.
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
- Nausea, vomiting, abdominal pain, diarrhea, mouth or tongue inflammation, weight loss, flatulence, rash, and itchy skin.
- May not be suitable for people with kidney or liver disease, folate deficiency (the elderly, chronic alcoholics, people taking anticonvulsants are at risk of folate deficiency), glucose-6-phosphate deficiency, porphyria, severe allergies, thyroid dysfunction, or bronchial asthma. Elderly people may be more susceptible to the adverse effects of sulfamethoxazole/trimethoprim.
- Rarely, severe, sometimes fatal reactions have been reported, such as Stevens-Johnson syndrome (disorder involving skin and mucous membranes), liver disease, and blood disorders such as thrombocytopenia (low platelets).
Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.
- Discontinue and seek urgent medical advice if a skin rash develops.
- Use only as directed by your doctor and do not share with anyone else as misuse can encourage the development of drug-resistant bacteria and reduce the effectiveness of sulfamethoxazole/trimethoprim.
- Complete the full course as prescribed (unless instructed not to do so by your doctor) to reduce the risk of resistant bacteria developing.
- Should not be used in pregnant or lactating women or in babies less than two months old.
- Seek urgent medical advice if an unexplained cough, shortness of breath, sore throat, fever, muscle or joint pain, paleness or yellowing of the skin, or diarrhea develop.
- Like other antibiotics, sulfamethoxazole/trimethoprim alters the normal flora of the colon and can lead to Clostridium difficile-associated diarrhea. Contact your doctor if diarrhea develops either during treatment or soon after ending treatment.
- Maintain an adequate fluid intake to avoid the development of crystals in the urine or kidney stones.
Response and Effectiveness
- Quickly absorbed with peak levels occurring within one to four hours after administration. Antibacterial effects persist for at least 12 hours.
Sulfamethoxazole/Trimethoprim Oral Suspension. Revised: 03/2014. Qualitest Pharmaceuticals Accessed July 2016 at https://www.drugs.com/pro/sulfamethoxazole-trimethoprim-oral-suspension.html
More about sulfamethoxazole/trimethoprim
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 706 Reviews – Add your own review/rating
- Drug class: sulfonamides
- Sulfamethoxazole/trimethoprim suspension
- Sulfamethoxazole/trimethoprim tablets
- Sulfamethoxazole and trimethoprim
- Sulfamethoxazole/trimethoprim (Advanced Reading)
- Sulfamethoxazole/trimethoprim Intravenous (Advanced Reading)
Related treatment guides
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use sulfamethoxazole/trimethoprim only for the indication prescribed.
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