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Cholestyramine Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 26, 2023.

Applies to cholestyramine: oral powder for suspension.

In some animal studies, cholestyramine was found to cause tumors. It is not known whether cholestyramine causes tumors in humans.

Serious side effects of cholestyramine

Along with its needed effects, cholestyramine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cholestyramine:

Rare

  • black, tarry stools
  • stomach pain (severe) with nausea and vomiting
  • loss of weight (sudden)

Check with your doctor as soon as possible if any of the following side effects occur while taking cholestyramine:

More common

Other side effects of cholestyramine

Some side effects of cholestyramine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • heartburn or indigestion
  • nausea or vomiting
  • stomach pain

Less common

  • belching
  • bloating
  • diarrhea
  • dizziness
  • headache

For healthcare professionals

Applies to cholestyramine: compounding powder, oral powder for reconstitution.

General

The most frequently reported side effect is constipation.[Ref]

Gastrointestinal

Intestinal obstruction occurred rarely and 2 deaths in pediatric patients were reported.[Ref]

Cardiovascular

Musculoskeletal

Hematologic

Metabolic

Dermatologic

Hepatic

Nervous system

Other

Ocular

Genitourinary

Respiratory

Psychiatric

References

1. (2002) "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

4. (2017) "Product Information. Cholestyramine Light (cholestyramine)." Sandoz Laboratories, Eon Division

Further information

Cholestyramine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.