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Xifaxan (rifaximin) Drug Interactions

A total of 29 drugs are known to interact with Xifaxan (rifaximin).

  • 2 major drug interactions
  • 27 moderate drug interactions

Show all medications in the database that may interact with Xifaxan (rifaximin).

Check for interactions

Type in a drug name to check for interactions with Xifaxan (rifaximin).

Most frequently checked interactions

View interaction reports for Xifaxan (rifaximin) and the medicines listed below.

  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Moxatag, Amoxicot, DisperMox, Biomox, Moxilin, Wymox)
  • Benadryl (diphenhydramine)
  • Cipro (ciprofloxacin)
  • Florastor (saccharomyces boulardii lyo)
  • folic acid (Folvite, Folacin-800, FA-8, FaLessa)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • Gas-X (simethicone)
  • ibuprofen (Advil, Motrin, IBU, Motrin IB, Advil Liqui-Gels, Motrin Childrens, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Ibuprofen PMR, Nuprin, NeoProfen, Proprinal, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Advil Infant's Concentrated Drops, Motrin Pediatric, Ibu-Tab, Rufen, Genpril, Haltran, IBU-200, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Motrin Migraine Pain, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Ibu-8, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Advil Film-Coated)
  • Imodium (loperamide)
  • lactulose (Duphalac, Kristalose, Constulose, Generlac, Cephulac, Enulose, Chronulac, Heptalac, Constilac, Cholac, Evalose, Chronulac Syrup)
  • Lasix (furosemide)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Eltroxin, Levothroid, Levothyrox, Euthyrox, Unithroid, Levo-T, Oroxine, L Thyroxine Roche, Eutroxsig, Novothyrox, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • metformin (Glucophage, Glumetza, Fortamet, Glucophage XR, Riomet)
  • neomycin (Mycifradin, Neo-Fradin, Neo-Tab)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Dazidox, Oxyfast, Oxecta, RoxyBond, Oxydose, Percolone, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
  • pantoprazole (Protonix, Protonix IV)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Liquid Pred, Meticorten, Orasone, Prednicen-M)
  • propranolol (Inderal, Inderal LA, Hemangeol, Inderal XL, InnoPran XL)
  • Protonix (pantoprazole)
  • spironolactone (Aldactone, CaroSpir)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramahexal, ConZip, Larapam SR, Ryzolt, Tramal SR, GenRx Tramadol, Tramahexal SR, Tramedo, Zydol, Zamadol, Zydol XL, Rybix ODT, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)

Xifaxan (rifaximin) disease interactions

There are 2 disease interactions with Xifaxan (rifaximin) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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