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Atropine / Hyoscyamine / Phenobarbital / Scopolamine Dosage

Applies to the following strengths: 0.0194 mg-0.1037 mg-16.2 mg-0.0065 mg; 0.0194 mg-0.1037 mg-16.2 mg-0.0065 mg/5 mL; 0.0582 mg-0.0582 mg-48.6 mg-0.0195 mg; 0.0582 mg-0.3111 mg-48.6 mg-0.0195 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Duodenal Ulcer

Elixir: 1 or 2 teaspoonfuls orally 3 or 4 times a day according to severity of symptoms

Regular Release Tablets: 1 or 2 tablets orally 3 or 4 times a day according to severity of symptoms

Extended release tablets: 1 tablet orally every 12 hours
-If indicated, 1 tablet orally every 8 hours

Comments:
-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.

Usual Adult Dose for Irritable Bowel Syndrome

Elixir: 1 or 2 teaspoonfuls orally 3 or 4 times a day according to severity of symptoms

Regular Release Tablets: 1 or 2 tablets orally 3 or 4 times a day according to severity of symptoms

Extended release tablets: 1 tablet orally every 12 hours
-If indicated, 1 tablet orally every 8 hours

Comments:
-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.

Usual Adult Dose for Enterocolitis

Elixir: 1 or 2 teaspoonfuls orally 3 or 4 times a day according to severity of symptoms

Regular Release Tablets: 1 or 2 tablets orally 3 or 4 times a day according to severity of symptoms

Extended release tablets: 1 tablet orally every 12 hours
-If indicated, 1 tablet orally every 8 hours

Comments:
-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.

Usual Pediatric Dose for Duodenal Ulcer

Elixir:
Initial oral dose by weight:
4.5 kg: 0.5 mL every 4 hours OR 0.75 mL every 6 hours
9.1 kg: 1 mL every 4 hours OR 1.5 mL every 6 hours
13.6 kg: 1.5 mL every 4 hours OR 2 mL every 6 hours
22.7 kg: 2.5 mL every 4 hours OR 3.75 mL every 6 hours
34 kg: 3.75 mL every 4 hours OR 5 mL every 6 hours
45.4 kg: 5 mL every 4 hours OR 7.5 mL every 6 hours

Comments:
-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.
-Use a pediatric dosing device or oral syringe to measure the dose.

Usual Pediatric Dose for Irritable Bowel Syndrome

Elixir:
Initial oral dose by weight:
4.5 kg: 0.5 mL every 4 hours OR 0.75 mL every 6 hours
9.1 kg: 1 mL every 4 hours OR 1.5 mL every 6 hours
13.6 kg: 1.5 mL every 4 hours OR 2 mL every 6 hours
22.7 kg: 2.5 mL every 4 hours OR 3.75 mL every 6 hours
34 kg: 3.75 mL every 4 hours OR 5 mL every 6 hours
45.4 kg: 5 mL every 4 hours OR 7.5 mL every 6 hours

Comments:
-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.
-Use a pediatric dosing device or oral syringe to measure the dose.

Usual Pediatric Dose for Enterocolitis

Elixir:
Initial oral dose by weight:
4.5 kg: 0.5 mL every 4 hours OR 0.75 mL every 6 hours
9.1 kg: 1 mL every 4 hours OR 1.5 mL every 6 hours
13.6 kg: 1.5 mL every 4 hours OR 2 mL every 6 hours
22.7 kg: 2.5 mL every 4 hours OR 3.75 mL every 6 hours
34 kg: 3.75 mL every 4 hours OR 5 mL every 6 hours
45.4 kg: 5 mL every 4 hours OR 7.5 mL every 6 hours

Comments:
-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.
-Use a pediatric dosing device or oral syringe to measure the dose.

Renal Dose Adjustments

Use with caution.

Liver Dose Adjustments

Use with caution.
-Barbiturates are hepatically metabolized, so initial doses should be small in patients with hepatic dysfunction.

Dialysis

Data not available

Other Comments

General:
-Atropine/hyoscyamine/phenobarbital/scopolamine has been classified as "possibly" effective by the FDA for use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.
-It has not been shown conclusively whether anticholinergic/antispasmodic drugs aid in the healing of duodenal ulcer, decrease the rate of recurrences, or prevent complications.

Patient advice:
-Instruct patients not to increase their dose of this drug without consulting their physician.
-Instruct patients not to share this drug with others.
-This drug has a risk of physical and/or psychological dependence.
-This drug may impair mental and/or physical abilities needed for potentially hazardous tasks such as driving or operating machinery.
-Use of alcohol with this drug may cause additional central nervous system depressant effects.
-This drug may increase the risk of heatstroke because it decreases sweating.
-Avoid becoming overheated in hot weather, saunas, and during exercise or other strenuous activities.
-Patients should tell their healthcare provider if they take antihistamines, anti-seizure medications, medications for sleep or anxiety, narcotic pain relievers, or psychiatric medications.

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