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Chlordiazepoxide / clidinium Side Effects

For the Consumer

Applies to chlordiazepoxide / clidinium: oral capsule


Oral route (Capsule)

Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing for patients with inadequate alternative treatment options. Limit dosages and durations to the minimum required and follow patients for signs and symptoms of respiratory depression and sedation.

Side effects requiring immediate medical attention

Along with its needed effects, chlordiazepoxide/clidinium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlordiazepoxide / clidinium:

Incidence not known

  • Abdominal or stomach pain
  • chills
  • clay-colored stools
  • confusion
  • cough or hoarseness
  • dark urine
  • difficulty with speaking
  • dizziness
  • drooling
  • drowsiness
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • itching or rash
  • loss of appetite
  • loss of balance control
  • lower back or side pain
  • muscle trembling, jerking, or stiffness
  • nausea
  • painful or difficult urination
  • pale skin
  • restlessness
  • shakiness and unsteady walk
  • shuffling walk
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the limbs
  • swelling
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unpleasant breath odor
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bruising or bleeding
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking chlordiazepoxide / clidinium:

Symptoms of overdose

  • Blurred vision
  • change in consciousness
  • difficulty having a bowel movement (stool)
  • dry mouth
  • lack of coordination
  • loss of consciousness
  • sleepiness or unusual drowsiness

Side effects not requiring immediate medical attention

Some side effects of chlordiazepoxide / clidinium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Inability to have or keep an erection
  • increase or loss in sexual ability, desire, drive, or performance
  • increased or decreased interest in sexual intercourse
  • menstrual changes
  • skin blisters

For Healthcare Professionals

Applies to chlordiazepoxide / clidinium: oral capsule


The most commonly reported side effects included anticholinergic effects (e.g., blurred vision, constipation, dry mouth, urinary hesitancy).[Ref]


The elderly and debilitated may be more susceptible to confusion; this side effect has occasionally been reported at the lower dosage ranges.[Ref]

Uncommon (0.1% to 1%): Decreased libido, increased libido

Rare (0.01% to 0.1%): Confusion[Ref]


Constipation most commonly occurred when patients took spasmolytic agents concurrently and/or with a low residue diet.[Ref]

Uncommon (0.1% to 1%): Constipation, nausea

Frequency not reported: Dry mouth[Ref]


Uncommon (0.1% to 1%): Jaundice, liver dysfunction[Ref]


Uncommon (0.1% to 1%): Agranulocytosis, blood dyscrasias[Ref]

Nervous system

Uncommon (0.1% to 1%): Extrapyramidal symptoms

Rare (0.01% to 0.1%): Drowsiness

Very rare (less than 0.01%): Syncope

Frequency not reported: Anticholinergic effects, changes in EEG patterns (low-voltage fast activity)[Ref]

The elderly and debilitated may be more susceptible to drowsiness and syncope; the side effects have occasionally been reported at the lower dosage ranges.[Ref]


Uncommon (0.1% to 1%): Minor menstrual irregularities

Frequency not reported: Urinary hesitancy[Ref]


Uncommon (0.1% to 1%): Edema[Ref]


Uncommon (0.1% to 1%): Skin eruptions[Ref]


The elderly and debilitated may be more susceptible to ataxia; this side effect has occasionally been reported at the lower dosage ranges.[Ref]

Rare (0.01% to 0.1%): Ataxia[Ref]


Frequency not reported: Blurred vision[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Librax (chlordiazepoxide-clidinium)." Valeant Pharmaceuticals, Costa Mesa, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.