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Chlordiazepoxide / clidinium Side Effects

For the Consumer

Applies to chlordiazepoxide / clidinium: oral capsule

Along with its needed effects, chlordiazepoxide/clidinium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlordiazepoxide / clidinium:

Incidence not known

  • Abdominal or stomach pain
  • chills
  • clay-colored stools
  • confusion
  • cough or hoarseness
  • dark urine
  • difficulty with speaking
  • dizziness
  • drooling
  • drowsiness
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • itching or rash
  • loss of appetite
  • loss of balance control
  • lower back or side pain
  • muscle trembling, jerking, or stiffness
  • nausea
  • painful or difficult urination
  • pale skin
  • restlessness
  • shakiness and unsteady walk
  • shuffling walk
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the limbs
  • swelling
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unpleasant breath odor
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bruising or bleeding
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking chlordiazepoxide / clidinium:

Symptoms of overdose

  • Blurred vision
  • change in consciousness
  • difficulty having a bowel movement (stool)
  • dry mouth
  • lack of coordination
  • loss of consciousness
  • sleepiness or unusual drowsiness

Some side effects of chlordiazepoxide / clidinium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Inability to have or keep an erection
  • increase or loss in sexual ability, desire, drive, or performance
  • increased or decreased interest in sexual intercourse
  • menstrual changes
  • skin blisters

For Healthcare Professionals

Applies to chlordiazepoxide / clidinium: oral capsule

General

The most common adverse events were sedation, dizziness, somnolence, ataxia, fatigue, and balance disorder.[Ref]

Nervous system

Frequency not reported: Sedation, dizziness, somnolence, ataxia, balance disorder, drowsiness, syncope, extrapyramidal symptoms[Ref]

The elderly and debilitated may be more susceptible to the side effects of chlordiazepoxide-clidinium. Drowsiness, ataxia, and confusion have occasionally been reported at the lower dosage ranges.[Ref]

Gastrointestinal

Rare (less than 0.1%): Gastrointestinal disorder, constipation
Frequency not reported: Nausea, dry mouth[Ref]

Hematologic

Rare (less than 0.1%): Bone marrow depression (e.g. thrombocytopenia, leukopenia, agranulocytosis, pancytopenia)[Ref]

Hepatic

Frequency not reported: Jaundice, blood bilirubin increased, transaminases increase, hepatic dysfunction[Ref]

Other

Common (1% to 10%): Fatigue
Frequency not reported: Blood alkaline phosphatase increased, asthenia, edema, changes in EEG patterns (low-voltage fast activity)[Ref]

Ocular

Uncommon (0.1% to 1%): Lacrimation decreased, accommodation disorders
Rare (less than 0.1%): Visual impairment including diplopia

Frequency not reported: Blurring of vision[Ref]

Genitourinary

Rare (less than 0.1%): Urinary retention, erectile dysfunction, menstrual disorder
Frequency not reported: Minor menstrual irregularities, urinary hesitancy[Ref]

Dermatologic

Rare (less than 0.1%): Skin reaction (e.g. rash, pruritus)
Frequency not reported: Skin eruptions[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity[Ref]

Musculoskeletal

Frequency not reported: Muscular weakness[Ref]

Metabolic

Uncommon (0.1% to 1%): Increased appetite[Ref]

Psychiatric

Rare (less than 0.1%): Libido disorder
Frequency not reported: Amnesia, hallucinations, dependence, depression, restlessness, agitation, irritability, depressed level of consciousness, aggression, delusion, nightmares, psychotic disorder, abnormal behavior, emotional disturbances, paradoxical drug reaction (e.g. anxiety, sleep disorders, insomnia, suicide attempt, suicidal ideation), confusion[Ref]

Respiratory

Frequency not reported: Respiratory depression, increased viscosity of bronchial secretion[Ref]

Cardiovascular

Rare (less than 0.1%): Hypotension
Frequency not reported: Tachycardia, palpitations[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Librax (chlordiazepoxide-clidinium)." Valeant Pharmaceuticals, Costa Mesa, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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