Generic Name: colesevelam (KOE le SEV e lam)
Brand Name: Welchol, Colesevelam Hydrochloride
What is colesevelam?
Colesevelam is used to treat high cholesterol in adults and children at least 10 years old.
Colesevelam lowers "bad" cholesterol in the blood, which is also called LDL (low-density lipoprotein) cholesterol. Lowering your LDL cholesterol may reduce your risk of hardened arteries, which can lead to heart attacks, stroke, and circulation problems.
Colesevelam may also be used for purposes not listed in this medication guide.
Before taking this medicine
You should not take colesevelam if you are allergic to it, or if you have:
very high levels of triglycerides (a type of fat) in your blood;
diabetic ketoacidosis (call your doctor for treatment);
a history of bowel obstruction; or
a history of pancreatitis caused by high triglycerides.
Colesevelam may increase your triglycerides (a type of fat in your blood), which can increase your risk of and that the long-term effect of hypertriglyceridemia on the risk of coronary artery disease is uncertain
Colesevelam is not for use in girls who have not yet started having menstrual periods.
Colesevelam should not be given to a child younger than 10 years old.
Tell your doctor if you have ever had:
a stomach, intestinal, or digestive disorder;
surgery on your stomach or intestines; or
a vitamin A, D, E, or K deficiency.
Tell your doctor if you are pregnant or if you become pregnant.
The powder form of colesevelam may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
How should I take colesevelam?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take colesevelam with a meal and a full glass of water or other liquid.
You may have to take several tablets at a time each time you take colesevelam. Tell your doctor if you have trouble swallowing the tablet whole.
Colesevelam powder must be mixed with 8 ounces of water, fruit juice, or a diet soft drink. Stir and drink this mixture right away. Add a little more water to the glass, swirl gently and drink right away.
You may need to follow a special diet to prevent constipation while using colesevelam. Follow all instructions of your doctor or dietitian.
Do not change the dose or timing of any other cholesterol or diabetes medications without your doctor's advice.
Colesevelam may increase your triglycerides (a type of fat in your blood), which can lead to pancreatitis (inflammation of the pancreas). You will need frequent blood tests.
Colesevelam is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine (with food and a full glass of water) as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking colesevelam?
Avoid eating foods high in fat or cholesterol, or colesevelam will not be as effective.
Colesevelam side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using colesevelam and call your doctor at once if you have:
severe stomach pain; or
pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect colesevelam?
Colesevelam can make some medicines much less effective when taken at the same time. If you take any of the following medicines, take them 4 hours before you take colesevelam:
levothyroxine or other thyroid medication;
This list is not complete and many other drugs may affect colesevelam. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 11.01.
More about colesevelam
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
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- Drug class: bile acid sequestrants
Other brands: Welchol