Generic Name: chlorpropamide (klor PROE pa mide)
Brand Name: Diabinese
What is chlorpropamide?
Chlorpropamide is an oral diabetes medicine that helps control blood sugar levels by helping your pancreas produce insulin.
Chlorpropamide is used together with diet and exercise to treat type 2 diabetes. Chlorpropamide is sometimes used in combination with other diabetes medicines.
Chlorpropamide should not be used by itself to treat type 1 diabetes.
Chlorpropamide may also be used for purposes not listed in this medication guide.
What is the most important information I should know about chlorpropamide?
You should not use chlorpropamide if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.
What should I discuss with my healthcare provider before taking chlorpropamide?
You should not use chlorpropamide if you are allergic to it, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
To make sure chlorpropamide is safe for you, tell your doctor if you have:
a disorder of your pituitary or adrenal glands;
a history of heart disease; or
if you are malnourished.
Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of taking chlorpropamide.
It is not known whether chlorpropamide will harm an unborn baby. Similar diabetes medicines have caused severe hypoglycemia in newborn babies whose mothers had used the medicine near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using chlorpropamide.
Chlorpropamide can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking chlorpropamide.
How should I take chlorpropamide?
Chlorpropamide is usually taken once per day with breakfast. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.
If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.
Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
Chlorpropamide is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
Use chlorpropamide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember (take the medicine with food if your doctor instructs you to). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A chlorpropamide overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).
What should I avoid while taking chlorpropamide?
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Avoid exposure to sunlight or tanning beds. Chlorpropamide can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Chlorpropamide side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
easy bruising or bleeding, pale skin, fever, unusual weakness;
trouble concentrating, memory problems, hallucinations;
a light-headed feeling, like you might pass out;
throbbing headache, sweating, severe nausea, trouble breathing, fast or pounding heartbeats, blurred vision, spinning sensation;
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
low blood sugar;
nausea, vomiting, diarrhea; or
mild hunger or loss of appetite.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Chlorpropamide dosing information
Usual Adult Dose for Diabetes Type 2:
Initial dose: 100 mg to 250 mg orally once a day
-Adjust dose in increments of 50 to 125 mg no more often than every 3 to 5 days
Maintenance dose: 100 mg to 500 mg per day
Maximum dose: 750 mg per day
-Therapy for the management of type 2 diabetes mellitus should be individualized; lower initial doses should be considered for patients at greater risk of hypoglycemia.
-Patients who do not respond completely to 500 mg/day will usually not respond to higher doses.
-Total daily dose may be taken as a single dose each morning with breakfast; gastrointestinal intolerance may be relieved by dividing the daily dose.
-Transferring patients from other antidiabetic regimens should be done conservatively: see dose adjustments.
Use: As an adjunct to diet and exercise improve glycemic control in patients with type 2 diabetes.
Usual Geriatric Dose for Diabetes Type 2:
Initial dose: 100 mg to 125 mg orally once a day
What other drugs will affect chlorpropamide?
You may be more likely to have hypoglycemia (low blood sugar) if you take chlorpropamide with other drugs that can lower blood sugar, such as:
aspirin or other salicylates (including Pepto Bismol);
a blood thinner (warfarin, Coumadin, Jantoven);
sulfa drugs (Bactrim, SMZ-TMP, and others);
a monoamine oxidase inhibitor (MAOI); or
insulin or other oral diabetes medications.
This list is not complete, and many other medicines can increase or decrease the effects of chlorpropamide on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with chlorpropamide. Not all possible interactions are listed in this medication guide.
See also: Side effects (in more detail)
More about chlorpropamide
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Español
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- Drug class: sulfonylureas
Other brands: Diabinese
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about chlorpropamide.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 6.05.
Date modified: October 13, 2017
Last reviewed: October 15, 2015