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Chlorpropamide Side Effects

For the Consumer

Applies to chlorpropamide: oral tablet

In addition to its needed effects, some unwanted effects may be caused by chlorpropamide. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking chlorpropamide:

Rare:
  • Abdominal or stomach pain
  • agitation
  • black, tarry stools
  • chills
  • clay-colored stools
  • coma
  • confusion
  • continuing diarrhea
  • continuing stomach pain
  • convulsions
  • dark urine
  • decreased urine output
  • depression
  • diarrhea
  • dizziness
  • fast or irregular heartbeat
  • fever
  • headache
  • hostility
  • increased thirst
  • irritability
  • itching
  • lethargy
  • loss of appetite
  • muscle pain or cramps
  • muscle twitching
  • nausea or vomiting
  • rapid weight gain
  • rash
  • seizures
  • shortness of breath
  • stupor
  • swelling of the face, ankles, or hands
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin
Incidence not known:
  • Anxiety
  • back, leg, or stomach pains
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • chest pain
  • cold sweats
  • cool, pale skin
  • cough or hoarseness
  • depression
  • difficulty with breathing
  • fever with or without chills
  • fluid-filled skin blisters
  • general body swelling
  • general feeling of tiredness or weakness
  • headache
  • high fever
  • increased hunger
  • lower back or side pain
  • nervousness
  • nightmares
  • nosebleeds
  • painful or difficult urination
  • pinpoint red spots on the skin
  • sensitivity to the sun
  • shakiness
  • skin thinness
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen or painful glands
  • tightness in the chest
  • unusual bleeding or bruising
  • wheezing

Severity: Minor

Some of the side effects that can occur with chlorpropamide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Indigestion
  • passing of gas
Less common:
  • Hives or welts
  • redness of the skin
  • weight loss
Rare:
  • Blistering, peeling, or loosening of the skin
  • cracks in the skin
  • loss of heat from the body
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
Incidence not known:
  • Increased sensitivity of the skin to sunlight
  • redness or other discoloration of the skin
  • severe sunburn

For Healthcare Professionals

Applies to chlorpropamide: oral tablet

General

The most commonly reported adverse reactions have included gastrointestinal disturbances such as nausea, diarrhea, vomiting, anorexia, and hunger.[Ref]

Metabolic

Rare (less than 0.1%): Disulfiram-like reactions
Frequency not reported: Hypoglycemia

Sulfonylureas:
Frequency not reported: Hepatic porphyria[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, vomiting, anorexia, hunger
Frequency not reported: Proctocolitis[Ref]

Dermatologic

Uncommon (0.1% to 1%): Pruritus, allergic skin reactions (pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions)

Sulfonylureas:
Frequency not reported: Photosensitivity, porphyria cutanea tarda[Ref]

Hypersensitivity

Frequency not reported: Allergic skin reactions

Hepatic

Rare (less than 0.1%): Cholestatic jaundice, hepatitis
Frequency not reported: Hepatic porphyria[Ref]

Hematologic

Sulfonylureas:
Frequency not reported: Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, pancytopenia, eosinophilia[Ref]

Cardiovascular

Sulfonylureas:
Frequency not reported: Increased cardiovascular mortality[Ref]

In the University Group Diabetes Program (UGDP) study, cardiovascular mortality rate was approximately 2.5 times higher in patients treated for 5 to 8 years with diet plus tolbutamide 1.5 g per day compared with that of patients treated with diet alone. The UGDP study was a long-term prospective clinical trial designed to evaluate the effectiveness of glucose lowering drugs in preventing or delaying vascular complications in patients with type 2 diabetes mellitus (n=823). Tolbutamide was stopped based on the increase in cardiovascular mortality; a significant increase in total mortality was not observed, but stopping the drug may have limited the ability to measure that. In view of the close similarities in mode of action and chemical structure among sulfonylureas, these results may apply to other drug in this class.[Ref]

Nervous system

Frequency not reported: Dizziness, headache[Ref]

References

1. "Product Information. Diabinese (chlorpropamide)." Pfizer US Pharmaceuticals, New York, NY.

Not all side effects for chlorpropamide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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